The network for 'regulation of leukocyte mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of leukocyte mediated immunity

Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.

NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.133
tlr3toll-like receptor 30.102
crb2acrumbs homolog 2a0.073
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.070
irak4interleukin-1 receptor-associated kinase 40.049
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.040
tmprss4btransmembrane protease, serine 4b0.040
foxj1bforkhead box J1b0.036
coblcordon-bleu homolog (mouse)0.035
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.034
jak1Janus kinase 10.033
pth1aparathyroid hormone 1a0.032
lrrc33leucine rich repeat containing 330.031
LOC557072caspase recruitment domain-containing protein 11-like0.031
alkanaplastic lymphoma kinase (Ki-1)0.029
stat6signal transducer and activator of transcription 6, interleukin-4 induced0.028
ddr2bdiscoidin domain receptor family, member 2b0.027
c3ccomplement component c3c0.027
c1qccomplement component 1, q subcomponent, C chain0.027
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.026
il10interleukin 100.026
ip6k2inositol hexaphosphate kinase 20.026
foxp3aforkhead box P3a0.025
itln1intelectin 10.025
ccdc151coiled-coil domain containing 1510.025
pcsk9proprotein convertase subtilisin/kexin type 90.024
grnagranulin a0.024
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.024
defbl3defensin, beta-like 30.023
tlr9toll-like receptor 90.023
itgb1bintegrin, beta 1b0.023
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.023
c3bcomplement component c3b0.022
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.022
tbx21T-box 210.022
eya2eyes absent homolog 2 (Drosophila)0.022
nitr4anovel immune-type receptor 4a0.021
nitr8novel immune-type receptor 80.021
trim25tripartite motif-containing 250.021
ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.021
foxi2forkhead box I20.021
g6pdglucose-6-phosphate dehydrogenase0.021
npy7rneuropeptide Y receptor Y70.020
aidaaxin interaction partner and dorsalization antagonist0.020
tlr22toll-like receptor 220.020
LOC100001239interferon-induced protein with tetratricopeptide repeats 5-like0.020
il6rinterleukin 6 receptor0.020
dyrk1bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.020
LOC567504interferon-induced protein with tetratricopeptide repeats 5-like0.019
c1qbcomplement component 1, q subcomponent, B chain0.019
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.019
LOC794786interferon-induced protein with tetratricopeptide repeats 1-like0.019
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.019
abcg2cATP-binding cassette, sub-family G (WHITE), member 2c0.019
hirip3HIRA interacting protein 30.019
il6stinterleukin 6 signal transducer0.019
tln1talin 10.019
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.019
tube1tubulin, epsilon 10.019
camk2g2calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 20.019
ezh2enhancer of zeste homolog 2 (Drosophila)0.018
dok2docking protein 20.018
ptpn6protein tyrosine phosphatase, non-receptor type 60.018
ciz1CDKN1A interacting zinc finger protein 10.018
angptl1angiopoietin-like 10.018
camk2acalcium/calmodulin-dependent protein kinase (CaM kinase) II alpha0.018
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.018
pax7bpaired box gene 7b0.018
cd40lgCD40 ligand0.018
LOC793458peptide Y-like0.017
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.017
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.017
angptl6angiopoietin-like 60.017
tlr4bbtoll-like receptor 4b, duplicate b0.017
hspb6heat shock protein, alpha-crystallin-related, b60.017
hnf1bbHNF1 homeobox Bb0.017
itln3intelectin 30.017
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.017
fxr2fragile X mental retardation, autosomal homolog 20.017
cd8aCD8 antigen, alpha polypeptide0.017
illr1immune-related, lectin-like receptor 10.016
nitr12novel immune-type receptor 120.016
ifnphi1interferon phi 10.016
wacaWW domain containing adaptor with coiled-coil a0.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN6protein tyrosine phosphatase, non-receptor type 61.000
IL4Rinterleukin 4 receptor0.996
HLA-Amajor histocompatibility complex, class I, A0.981
HLA-Gmajor histocompatibility complex, class I, G0.959
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.950
SYKspleen tyrosine kinase0.941
HLA-Cmajor histocompatibility complex, class I, C0.921
HLA-Bmajor histocompatibility complex, class I, B0.895
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.892
HLA-Emajor histocompatibility complex, class I, E0.886
TAPBPTAP binding protein (tapasin)0.828
CCL5chemokine (C-C motif) ligand 50.786
IL2RGinterleukin 2 receptor, gamma0.753
SLAMF1signaling lymphocytic activation molecule family member 10.747
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.730
CXCL2chemokine (C-X-C motif) ligand 20.722
IL8interleukin 80.716
CXCL3chemokine (C-X-C motif) ligand 30.711
CCR5chemokine (C-C motif) receptor 50.662
CCL4chemokine (C-C motif) ligand 40.640
LTAlymphotoxin alpha (TNF superfamily, member 1)0.587
SIGLEC7sialic acid binding Ig-like lectin 70.573
IL2RBinterleukin 2 receptor, beta0.568
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.559
LCKlymphocyte-specific protein tyrosine kinase0.541
GRAP2GRB2-related adaptor protein 20.531
CXCL9chemokine (C-X-C motif) ligand 90.510
CARD11caspase recruitment domain family, member 110.478
IL1Binterleukin 1, beta0.466
CD40CD40 molecule, TNF receptor superfamily member 50.462
HLA-Fmajor histocompatibility complex, class I, F0.454
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.442
CCL2chemokine (C-C motif) ligand 20.439
HK3hexokinase 3 (white cell)0.436
THOC5THO complex 50.413
TRAF3TNF receptor-associated factor 30.396
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.391
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.383
CCL8chemokine (C-C motif) ligand 80.362
TRAF6TNF receptor-associated factor 60.362
IL6interleukin 6 (interferon, beta 2)0.308
PILRApaired immunoglobin-like type 2 receptor alpha0.279
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.276
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.266
BIRC3baculoviral IAP repeat containing 30.261
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.260
SHC1SHC (Src homology 2 domain containing) transforming protein 10.253
LAIR1leukocyte-associated immunoglobulin-like receptor 10.240
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.236
FASLGFas ligand (TNF superfamily, member 6)0.231
CCR1chemokine (C-C motif) receptor 10.229
GBAglucosidase, beta, acid0.229
TGIF1TGFB-induced factor homeobox 10.219
ITM2Bintegral membrane protein 2B0.217
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.217
KLRD1killer cell lectin-like receptor subfamily D, member 10.208
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.198
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.195
IFITM2interferon induced transmembrane protein 2 (1-8D)0.191
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.175
TPP1tripeptidyl peptidase I0.174
TRAF1TNF receptor-associated factor 10.171
IFNGinterferon, gamma0.161
CCL13chemokine (C-C motif) ligand 130.157
CD84CD84 molecule0.147
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.144
CD33CD33 molecule0.143
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.141
ARL6IP5ADP-ribosylation-like factor 6 interacting protein 50.141
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.140
IFITM3interferon induced transmembrane protein 3 (1-8U)0.138
TRAF5TNF receptor-associated factor 50.136
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.134
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.129
IFITM1interferon induced transmembrane protein 1 (9-27)0.129
TNFRSF9tumor necrosis factor receptor superfamily, member 90.128
CXCL11chemokine (C-X-C motif) ligand 110.127
CCL22chemokine (C-C motif) ligand 220.123
HCKhemopoietic cell kinase0.122
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.119
MAP3K7mitogen-activated protein kinase kinase kinase 70.119
IL18RAPinterleukin 18 receptor accessory protein0.118
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.116
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.114
CASP8caspase 8, apoptosis-related cysteine peptidase0.113
PRF1perforin 1 (pore forming protein)0.112
ITKIL2-inducible T-cell kinase0.108
IL4interleukin 40.105
INSRinsulin receptor0.100
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.099
TRAF2TNF receptor-associated factor 20.098
CD80CD80 molecule0.094
GZMKgranzyme K (granzyme 3; tryptase II)0.092
KLRB1killer cell lectin-like receptor subfamily B, member 10.091
SIGLEC9sialic acid binding Ig-like lectin 90.089
KIR3DL2killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 20.087
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.087
TNFtumor necrosis factor0.086
ZNF746zinc finger protein 7460.086
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cd40CD40 antigen0.999
Tnftumor necrosis factor0.998
Cd28CD28 antigen0.996
Ighimmunoglobulin heavy chain complex0.995
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.990
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.989
Il4interleukin 40.985
FasFas (TNF receptor superfamily member 6)0.980
Ccr1chemokine (C-C motif) receptor 10.978
Ikzf1IKAROS family zinc finger 10.966
Klrk1killer cell lectin-like receptor subfamily K, member 10.966
Ccr2chemokine (C-C motif) receptor 20.957
Cd19CD19 antigen0.955
Klra9killer cell lectin-like receptor subfamily A, member 90.943
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.926
Icosinducible T-cell co-stimulator0.921
FaslFas ligand (TNF superfamily, member 6)0.919
Ccr6chemokine (C-C motif) receptor 60.918
Il10interleukin 100.906
Prf1perforin 1 (pore forming protein)0.887
Ccl8chemokine (C-C motif) ligand 80.879
Il18rapinterleukin 18 receptor accessory protein0.856
MefvMediterranean fever0.855
Cd22CD22 antigen0.851
Il2interleukin 20.849
Stat3signal transducer and activator of transcription 30.833
Ccl2chemokine (C-C motif) ligand 20.830
Lyz2lysozyme 20.828
Il6interleukin 60.824
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.824
H2-K1histocompatibility 2, K1, K region0.817
Gzmkgranzyme K0.811
Slamf1signaling lymphocytic activation molecule family member 10.807
H2-D1histocompatibility 2, D region locus 10.800
Stat5bsignal transducer and activator of transcription 5B0.796
Ifnginterferon gamma0.795
Ltalymphotoxin A0.788
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.773
Csf1rcolony stimulating factor 1 receptor0.762
Prdm1PR domain containing 1, with ZNF domain0.762
Il2rbinterleukin 2 receptor, beta chain0.756
Pax5paired box gene 50.751
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.747
TapbpTAP binding protein0.746
Klrg1killer cell lectin-like receptor subfamily G, member 10.739
B2mbeta-2 microglobulin0.738
Clec4nC-type lectin domain family 4, member n0.734
Zeb1zinc finger E-box binding homeobox 10.719
Xcl1chemokine (C motif) ligand 10.715
Grap2GRB2-related adaptor protein 20.712
Selpselectin, platelet0.710
Klrd1killer cell lectin-like receptor, subfamily D, member 10.703
Il10rainterleukin 10 receptor, alpha0.684
Cd7CD7 antigen0.684
Foxp3forkhead box P30.677
Inpp5dinositol polyphosphate-5-phosphatase D0.674
Ccl4chemokine (C-C motif) ligand 40.672
Cd247CD247 antigen0.670
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.669
Ptprcprotein tyrosine phosphatase, receptor type, C0.663
Il2rginterleukin 2 receptor, gamma chain0.661
Ifngr1interferon gamma receptor 10.657
Nos2nitric oxide synthase 2, inducible0.654
Cd40lgCD40 ligand0.651
Gzmagranzyme A0.651
Tnfaip3tumor necrosis factor, alpha-induced protein 30.642
Itgaxintegrin alpha X0.635
Cd84CD84 antigen0.632
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.629
Itgalintegrin alpha L0.620
Clec4dC-type lectin domain family 4, member d0.619
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.582
Ncr1natural cytotoxicity triggering receptor 10.580
Cxcr5chemokine (C-X-C motif) receptor 50.578
Socs1suppressor of cytokine signaling 10.568
Ubdubiquitin D0.568
Gzmbgranzyme B0.559
Il12binterleukin 12b0.538
Sfpi1SFFV proviral integration 10.534
Klrc1killer cell lectin-like receptor subfamily C, member 10.530
Cd44CD44 antigen0.528
Clec7aC-type lectin domain family 7, member a0.527
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.515
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.514
Il1binterleukin 1 beta0.506
Itgb2integrin beta 20.499
Trem3triggering receptor expressed on myeloid cells 30.489
Irf9interferon regulatory factor 90.486
Pilrb1paired immunoglobin-like type 2 receptor beta 10.485
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.484
Apoeapolipoprotein E0.479
CblCasitas B-lineage lymphoma0.475
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.458
Cd4CD4 antigen0.457
Cd160CD160 antigen0.456
Il4rainterleukin 4 receptor, alpha0.455
Irg1immunoresponsive gene 10.455
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.449
Fcgr4Fc receptor, IgG, low affinity IV0.447
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.445
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-EC2RT1 class Ib, locus EC20.527
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.108
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.084
Klrd1killer cell lectin-like receptor, subfamily D, member 10.080
Hsph1heat shock 105/110 protein 10.067
Plaurplasminogen activator, urokinase receptor0.059
Nkg7natural killer cell group 7 sequence0.055
Gzmkgranzyme K0.052
Igsf6immunoglobulin superfamily, member 60.051
Csf1colony stimulating factor 1 (macrophage)0.051
RT1-BaRT1 class II, locus Ba0.047
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.046
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.046
Il2rbinterleukin 2 receptor, beta0.041
Hckhemopoietic cell kinase0.038
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.038
Gzmbgranzyme B0.036
Ncr1natural cytotoxicity triggering receptor 10.034
Aif1allograft inflammatory factor 10.034
Cd53Cd53 molecule0.033
RT1-S3RT1 class Ib, locus S30.033
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.033
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.032
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.032
Dnase1l3deoxyribonuclease 1-like 30.031
Cd8aCD8a molecule0.030
RT1-M3-1RT1 class Ib, locus M3, gene 10.029
RT1-ClRT1 class Ib, locus Cl0.029
Pde3aphosphodiesterase 3A, cGMP inhibited0.029
Prf1perforin 1 (pore forming protein)0.028
Ptafrplatelet-activating factor receptor0.027
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.027
Sellselectin L0.026
Slc22a25solute carrier family 22, member 250.023
Stip1stress-induced phosphoprotein 10.022
Icam1intercellular adhesion molecule 10.022
Ccl5chemokine (C-C motif) ligand 50.022
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.021
Casp1caspase 10.020
Clec9aC-type lectin domain family 9, member a0.019
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.019
Cd247Cd247 molecule0.019
C3ar1complement component 3a receptor 10.018
Neurl3neuralized homolog 3 (Drosophila)0.018
Apol3apolipoprotein L, 30.017
Klra17killer cell lectin-like receptor, subfamily A, member 170.017
Cd2Cd2 molecule0.017
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.017
RGD1304644similar to RIKEN cDNA 2310046K010.017
Ripk3receptor-interacting serine-threonine kinase 30.017
Hspb1heat shock protein 10.017
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.016
Ccl4chemokine (C-C motif) ligand 40.016
Fggfibrinogen gamma chain0.016
RT1-A3RT1 class I, locus A30.016
Vom1r93vomeronasal 1 receptor 930.016
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.015
Cxcr4chemokine (C-X-C motif) receptor 40.015
Fgf16fibroblast growth factor 160.015
Cd3gCD3 molecule, gamma0.015
Klrc1killer cell lectin-like receptor subfamily C, member 10.015
Hmox1heme oxygenase (decycling) 10.015
Ptprcprotein tyrosine phosphatase, receptor type, C0.015
Il17rainterleukin 17 receptor A0.014
Phkg1phosphorylase kinase, gamma 10.014
Padi3peptidyl arginine deiminase, type III0.014
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.014
Slfn2schlafen 20.014
Ccl7chemokine (C-C motif) ligand 70.014
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.014
Cd86CD86 molecule0.014
Il1binterleukin 1 beta0.014
Fut2fucosyltransferase 2 (secretor status included)0.014
Bin2bridging integrator 20.013
Sirpasignal-regulatory protein alpha0.013
Mpeg1macrophage expressed 10.013
Mmp12matrix metallopeptidase 120.013
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.013
C1qbcomplement component 1, q subcomponent, B chain0.013
Hspa8heat shock protein 80.013
P2ry14purinergic receptor P2Y, G-protein coupled, 140.013
Psd4pleckstrin and Sec7 domain containing 40.013
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.013
Arhgap4Rho GTPase activating protein 40.013
Apobapolipoprotein B0.013
Klrc2killer cell lectin-like receptor subfamily C, member 20.013
Zcwpw1zinc finger, CW-type with PWWP domain 10.012
Cxcl10chemokine (C-X-C motif) ligand 100.012
Plcg2phospholipase C, gamma 20.012
Npnucleoside phosphorylase0.012
Il7rinterleukin 7 receptor0.012
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.012
Nrasneuroblastoma ras oncogene0.012
FaslgFas ligand (TNF superfamily, member 6)0.012
Litaflipopolysaccharide-induced TNF factor0.011
Ccr5chemokine (C-C motif) receptor 50.011
Dock8dedicator of cytokinesis 80.011
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.011
RT1-CE12RT1 class I, locus CE120.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism