The network for 'regulation of production of molecular mediator of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of production of molecular mediator of immune response

Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.

NameDescriptionProbabilityFunc Analog Organism
gata6GATA-binding protein 60.963
tlr3toll-like receptor 30.515
grnagranulin a0.473
bmp2bbone morphogenetic protein 2b0.381
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.302
irf6interferon regulatory factor 60.280
foxa2forkhead box A20.266
nod1nucleotide-binding oligomerization domain containing 10.263
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.235
LOC557722similar to transient receptor potential cation channel, subfamily M, member 50.228
gata5GATA-binding protein 50.163
cd40lgCD40 ligand0.155
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.150
relv-rel reticuloendotheliosis viral oncogene homolog0.143
caspacaspase a0.141
nkx2.2aNK2 transcription factor related 2a0.140
eporerythropoietin receptor0.138
ahctf1AT hook containing transcription factor 10.130
gata4GATA-binding protein 40.128
zfp36l1azinc finger protein 36, C3H type-like 1a0.128
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.127
LOC100534776toll-like receptor 7-like0.125
wnt3wingless-type MMTV integration site family, member 30.124
tbx5bT-box 5b0.121
bmp7bbone morphogenetic protein 7b0.118
tlr9toll-like receptor 90.115
crb2acrumbs homolog 2a0.113
tp53tumor protein p530.110
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.104
grn1granulin 10.098
emx3empty spiracles homeobox 30.092
rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.092
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.088
unc5cunc-5 homolog C (C. elegans)0.084
foxp3aforkhead box P3a0.083
anxa5bannexin A5b0.083
tbx21T-box 210.083
mycamyelocytomatosis oncogene a0.082
mibmind bomb0.082
shhasonic hedgehog a0.082
ifnphi1interferon phi 10.081
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.079
il1binterleukin 1, beta and interleukin 1, beta0.079
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.079
pdcd2programmed cell death 20.077
nccrp1nonspecific cytotoxic cell receptor protein 10.076
c1qccomplement component 1, q subcomponent, C chain0.076
tlr18toll-like receptor 180.074
pycardPYD and CARD domain containing0.073
mef2cbmyocyte enhancer factor 2cb0.070
angptl1angiopoietin-like 10.068
tlr2toll-like receptor 20.068
atp2b1bATPase, Ca++ transporting, plasma membrane 1b0.068
osr1odd-skipped related 1 (Drosophila)0.068
otpborthopedia homolog b0.068
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.067
jak1Janus kinase 10.067
c1qbcomplement component 1, q subcomponent, B chain0.066
ets2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.066
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.066
foxi2forkhead box I20.066
ifng1-2interferon, gamma 1-20.066
smyd3SET and MYND domain containing 30.065
mychmyelocytomatosis oncogene homolog0.064
spry2sprouty homolog 20.063
npatnuclear protein, ataxia-telangiectasia locus0.063
eya2eyes absent homolog 2 (Drosophila)0.062
nos2bnitric oxide synthase 2b, inducible0.062
vdrbvitamin D receptor b0.062
dusp1dual specificity phosphatase 10.061
irak4interleukin-1 receptor-associated kinase 40.060
tll1tolloid-like 10.059
flhfloating head0.058
vcanbversican b0.058
ptk6aPTK6 protein tyrosine kinase 6a0.058
sema3fbsemaphorin 3fb0.058
adipor1badiponectin receptor 1b0.057
vsx2visual system homeobox 20.057
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.057
il7rinterleukin 7 receptor0.056
fli1bfriend leukemia integration 1b0.055
flt4fms-related tyrosine kinase 40.055
illr1immune-related, lectin-like receptor 10.055
myl7myosin, light polypeptide 7, regulatory0.055
tlr20atoll-like receptor 20a0.054
nos2anitric oxide synthase 2a, inducible0.054
f2rcoagulation factor II (thrombin) receptor0.052
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.052
kitlgbkit ligand b0.052
pcsk7proprotein convertase subtilisin/kexin type 70.051
cd74CD74 molecule, major histocompatibility complex, class II invariant chain0.051
myh11amyosin, heavy polypeptide 11, smooth muscle a0.050
cxcr3.2chemokine (C-X-C motif) receptor 3.20.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.962
Spn27ASerpin 27A0.807
SPESpatzle-Processing Enzyme0.695
grassGram-positive Specific Serine protease0.648
ird5immune response deficient 50.631
PGRP-SDCG7496 gene product from transcript CG7496-RA0.520
Spn28DSerpin 28D0.485
PGRP-SAPeptidoglycan recognition protein SA0.398
IrcImmune-regulated catalase0.351
Sp7Serine protease 70.323
imdimmune deficiency0.281
PvrPDGF- and VEGF-receptor related0.218
Gef64CGuanine nucleotide exchange factor GEF64C0.197
BG4CG12297 gene product from transcript CG12297-RA0.172
Mpk2CG5475 gene product from transcript CG5475-RB0.164
CG18594CG18594 gene product from transcript CG18594-RA0.143
Myd88CG2078 gene product from transcript CG2078-RA0.138
pirkpoor Imd response upon knock-in0.127
p38bCG7393 gene product from transcript CG7393-RA0.117
CG9184CG9184 gene product from transcript CG9184-RB0.112
MP1Melanization Protease 10.111
ird1immune response deficient 10.110
CG15917CG15917 gene product from transcript CG15917-RA0.105
18w18 wheeler0.095
CG9171CG9171 gene product from transcript CG9171-RC0.091
Octbeta2RCG33976 gene product from transcript CG33976-RA0.090
CG7910CG7910 gene product from transcript CG7910-RA0.088
CG42863CG42863 gene product from transcript CG42863-RB0.087
Spn1Serine protease inhibitor 10.084
GNBP3Gram-negative bacteria binding protein 30.083
Eip71CDEcdysone-induced protein 28/29kD0.083
Tsp42EfTetraspanin 42Ef0.075
Lip3CG8823 gene product from transcript CG8823-RA0.073
m2E(spl) region transcript m20.072
Tab2TAK1-associated binding protein 20.070
Traf6TNF-receptor-associated factor 60.068
Hrb87FHeterogeneous nuclear ribonucleoprotein at 87F0.065
CG10680CG10680 gene product from transcript CG10680-RA0.065
GNBP1Gram-negative bacteria binding protein 10.059
amosabsent MD neurons and olfactory sensilla0.058
CG1347CG1347 gene product from transcript CG1347-RB0.058
DreddDeath related ced-3/Nedd2-like protein0.057
Hr39Hormone receptor-like in 390.057
CG12766CG12766 gene product from transcript CG12766-RA0.057
eaterCG6124 gene product from transcript CG6124-RB0.055
HLHmgammaE(spl) region transcript mgamma0.053
InRInsulin-like receptor0.053
CG8586CG8586 gene product from transcript CG8586-RA0.051
modSPmodular serine protease0.048
PGRP-LBPeptidoglycan recognition protein LB0.048
Fkbp13CG9847 gene product from transcript CG9847-RC0.048
E(spl)Enhancer of split0.047
skpACG16983 gene product from transcript CG16983-RD0.046
cortoCG2530 gene product from transcript CG2530-RA0.044
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.044
hipkhomeodomain interacting protein kinase0.043
Ubc-E2HCG2257 gene product from transcript CG2257-RA0.042
eastenhanced adult sensory threshold0.041
l(3)mbnlethal (3) malignant blood neoplasm0.041
Atg13Autophagy-specific gene 130.039
Rpn2CG11888 gene product from transcript CG11888-RA0.039
DuoxDual oxidase0.039
MED14Mediator complex subunit 140.039
gcmglial cells missing0.039
PGRP-LEPeptidoglycan recognition protein LE0.039
JhI-21CG12317 gene product from transcript CG12317-RB0.038
JupiterCG31363 gene product from transcript CG31363-RD0.038
CG11873CG11873 gene product from transcript CG11873-RA0.038
Atg18Autophagy-specific gene 180.038
Pabp2CG2163 gene product from transcript CG2163-RA0.038
Sema-1aCG18405 gene product from transcript CG18405-RD0.037
CG18284CG18284 gene product from transcript CG18284-RB0.037
OatOrnithine aminotransferase precursor0.037
Tao-1CG14217 gene product from transcript CG14217-RF0.036
CG13641CG13641 gene product from transcript CG13641-RA0.036
Tak1TGF-beta activated kinase 10.036
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.913
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.905
TRAF6TNF receptor-associated factor 60.830
PTPN6protein tyrosine phosphatase, non-receptor type 60.824
IL4Rinterleukin 4 receptor0.759
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.723
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.696
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.569
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.531
CCR5chemokine (C-C motif) receptor 50.489
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.446
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.440
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.436
TRAF1TNF receptor-associated factor 10.429
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.338
PILRApaired immunoglobin-like type 2 receptor alpha0.317
TRAF5TNF receptor-associated factor 50.316
TRAF2TNF receptor-associated factor 20.293
CD40CD40 molecule, TNF receptor superfamily member 50.282
GRAP2GRB2-related adaptor protein 20.244
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.236
SOX10SRY (sex determining region Y)-box 100.204
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.195
NCOR2nuclear receptor corepressor 20.195
PAX3paired box 30.179
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.179
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.175
IRAK1interleukin-1 receptor-associated kinase 10.165
IL2RGinterleukin 2 receptor, gamma0.159
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.158
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.138
CCR1chemokine (C-C motif) receptor 10.129
TGIF1TGFB-induced factor homeobox 10.124
TRADDTNFRSF1A-associated via death domain0.122
TICAM2toll-like receptor adaptor molecule 20.119
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.118
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.113
TRAF3TNF receptor-associated factor 30.106
CCL2chemokine (C-C motif) ligand 20.105
CCL13chemokine (C-C motif) ligand 130.101
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.100
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.098
IRAK2interleukin-1 receptor-associated kinase 20.091
CCL4chemokine (C-C motif) ligand 40.091
TNFRSF9tumor necrosis factor receptor superfamily, member 90.088
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.088
TEKTEK tyrosine kinase, endothelial0.088
CXCL9chemokine (C-X-C motif) ligand 90.087
TYMPthymidine phosphorylase0.083
CALCOCO2calcium binding and coiled-coil domain 20.082
RIPK2receptor-interacting serine-threonine kinase 20.079
IL10RAinterleukin 10 receptor, alpha0.077
RXRAretinoid X receptor, alpha0.075
APOC1apolipoprotein C-I0.073
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.069
RBBP4retinoblastoma binding protein 40.065
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.065
SIGLEC7sialic acid binding Ig-like lectin 70.063
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.061
IL4interleukin 40.059
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.058
LAIR1leukocyte-associated immunoglobulin-like receptor 10.056
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.056
CXCL10chemokine (C-X-C motif) ligand 100.055
IL22RA1interleukin 22 receptor, alpha 10.055
SQSTM1sequestosome 10.049
CCL8chemokine (C-C motif) ligand 80.048
HDAC9histone deacetylase 90.047
RARAretinoic acid receptor, alpha0.046
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.044
TLR2toll-like receptor 20.043
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.041
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.038
FCN1ficolin (collagen/fibrinogen domain containing) 10.038
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.037
CD33CD33 molecule0.037
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.037
HK3hexokinase 3 (white cell)0.036
PMLpromyelocytic leukemia0.036
IL22RA2interleukin 22 receptor, alpha 20.035
IFNGinterferon, gamma0.034
CCL7chemokine (C-C motif) ligand 70.034
FZD1frizzled homolog 1 (Drosophila)0.034
SMURF1SMAD specific E3 ubiquitin protein ligase 10.034
CCR7chemokine (C-C motif) receptor 70.033
CD22CD22 molecule0.033
CARD11caspase recruitment domain family, member 110.033
ZNF282zinc finger protein 2820.032
ZNF830zinc finger protein 8300.032
LY96lymphocyte antigen 960.032
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.032
MDC1mediator of DNA-damage checkpoint 10.032
ANGPT1angiopoietin 10.031
CD48CD48 molecule0.030
CD86CD86 molecule0.030
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.030
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.976
Map3k14mitogen-activated protein kinase kinase kinase 140.970
Cd40CD40 antigen0.967
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.937
Tlr4toll-like receptor 40.934
Myd88myeloid differentiation primary response gene 880.911
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.810
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.788
Casp4caspase 4, apoptosis-related cysteine peptidase0.748
Ptprcprotein tyrosine phosphatase, receptor type, C0.743
Il10interleukin 100.707
Stat3signal transducer and activator of transcription 30.696
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.656
Ccl2chemokine (C-C motif) ligand 20.641
Cd28CD28 antigen0.598
Traf6TNF receptor-associated factor 60.559
Ccr1chemokine (C-C motif) receptor 10.557
Irf9interferon regulatory factor 90.554
Pitx2paired-like homeodomain transcription factor 20.554
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.546
Gata4GATA binding protein 40.508
Il2rginterleukin 2 receptor, gamma chain0.497
Socs1suppressor of cytokine signaling 10.487
Ltblymphotoxin B0.463
Casp1caspase 10.432
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.431
FynFyn proto-oncogene0.421
Ikbkginhibitor of kappaB kinase gamma0.410
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.407
Birc3baculoviral IAP repeat-containing 30.375
Il1r1interleukin 1 receptor, type I0.354
Jak2Janus kinase 20.308
Il6stinterleukin 6 signal transducer0.289
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.269
Tbx3T-box 30.265
Csf1colony stimulating factor 1 (macrophage)0.261
Ccr7chemokine (C-C motif) receptor 70.256
Stat5asignal transducer and activator of transcription 5A0.251
Cd19CD19 antigen0.243
Pitx1paired-like homeodomain transcription factor 10.238
FaslFas ligand (TNF superfamily, member 6)0.227
Ccl4chemokine (C-C motif) ligand 40.218
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.215
Stat5bsignal transducer and activator of transcription 5B0.209
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.208
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.205
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.204
Rxraretinoid X receptor alpha0.199
FasFas (TNF receptor superfamily member 6)0.186
Cd44CD44 antigen0.182
Foxc2forkhead box C20.177
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.174
Csf1rcolony stimulating factor 1 receptor0.173
Ccl12chemokine (C-C motif) ligand 120.161
H2-Ab1histocompatibility 2, class II antigen A, beta 10.157
Nckap1lNCK associated protein 1 like0.156
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.155
Socs3suppressor of cytokine signaling 30.155
TcraT-cell receptor alpha chain0.153
Tnfaip3tumor necrosis factor, alpha-induced protein 30.152
Bmp5bone morphogenetic protein 50.151
Cyldcylindromatosis (turban tumor syndrome)0.150
Il7rinterleukin 7 receptor0.150
Tbx5T-box 50.148
Il1binterleukin 1 beta0.142
Gdf3growth differentiation factor 30.138
Pax2paired box gene 20.133
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.128
Lcklymphocyte protein tyrosine kinase0.128
Tlr2toll-like receptor 20.127
Ccr2chemokine (C-C motif) receptor 20.125
Bcl6B-cell leukemia/lymphoma 60.124
Ifnginterferon gamma0.124
Ctsscathepsin S0.123
S1pr2sphingosine-1-phosphate receptor 20.122
Cdx2caudal type homeobox 20.122
Foxp3forkhead box P30.120
Il12rb2interleukin 12 receptor, beta 20.118
Lag3lymphocyte-activation gene 30.117
Il6interleukin 60.114
Cd14CD14 antigen0.114
Pdcd1lg2programmed cell death 1 ligand 20.114
Ticam1toll-like receptor adaptor molecule 10.113
H2-Aahistocompatibility 2, class II antigen A, alpha0.112
C3ar1complement component 3a receptor 10.109
Inpp5dinositol polyphosphate-5-phosphatase D0.106
Ifngr1interferon gamma receptor 10.106
Ighimmunoglobulin heavy chain complex0.101
Il2interleukin 20.099
Gm12185predicted gene 121850.096
C1qbcomplement component 1, q subcomponent, beta polypeptide0.093
Gpr132G protein-coupled receptor 1320.090
Sh2d2aSH2 domain protein 2A0.089
Ccr6chemokine (C-C motif) receptor 60.087
Ccl9chemokine (C-C motif) ligand 90.086
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.086
Fcgr2bFc receptor, IgG, low affinity IIb0.085
Selpselectin, platelet0.084
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.083
Zap70zeta-chain (TCR) associated protein kinase0.083
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-Db1RT1 class II, locus Db10.067
RT1-DaRT1 class II, locus Da0.023
RT1-BaRT1 class II, locus Ba0.022
Il2rginterleukin 2 receptor, gamma0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism