The network for 'embryonic digestive tract development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic digestive tract development

The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.

NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.938
ptch2patched 20.771
shhasonic hedgehog a0.741
hnf1baHNF1 homeobox Ba0.661
fgf8afibroblast growth factor 8 a0.631
ptch1patched 10.512
smosmoothened homolog (Drosophila)0.427
osr2odd-skipped related 2 (Drosophila)0.359
mibmind bomb0.332
tp53tumor protein p530.326
gata6GATA-binding protein 60.251
lamc1laminin, gamma 10.185
aldh1a2aldehyde dehydrogenase 1 family, member A20.184
trpm7transient receptor potential cation channel, subfamily M, member 70.173
tbx5aT-box 5a0.170
jag1bjagged 1b0.165
col11a2collagen type XI alpha-20.161
wnt5bwingless-type MMTV integration site family, member 5b0.160
sox10SRY-box containing gene 100.158
tll1tolloid-like 10.155
wif1wnt inhibitory factor 10.139
gata5GATA-binding protein 50.138
gata4GATA-binding protein 40.138
notch3notch homolog 30.135
hand2heart and neural crest derivatives expressed transcript 20.129
cdx4caudal type homeo box transcription factor 40.122
pax8paired box gene 80.119
gli2aGLI-Kruppel family member GLI2a0.118
hhexhematopoietically expressed homeobox0.116
hoxa2bhomeo box A2b0.115
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.113
sim1asingle-minded homolog 1a (Drosophila)0.111
pcnaproliferating cell nuclear antigen0.108
hnf4ahepatocyte nuclear factor 4, alpha0.105
pax2apaired box gene 2a0.098
ahctf1AT hook containing transcription factor 10.088
tbx20T-box 200.079
fli1afriend leukemia integration 1a0.077
sephs1selenophosphate synthetase 10.077
fn1fibronectin 10.076
pax9paired box gene 90.073
tbx24T-box 240.072
nkx2.5NK2 transcription factor related 50.072
tgfbitransforming growth factor, beta-induced0.072
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.071
wnt2bbwingless-type MMTV integration site family, member 2Bb0.070
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.070
ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.067
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.067
sox17SRY-box containing gene 170.060
ventventral expressed homeobox0.059
gata1aGATA binding protein 1a0.055
tbx22T-box 220.054
sfrp5secreted frizzled-related protein 50.054
myh11amyosin, heavy polypeptide 11, smooth muscle a0.054
fli1bfriend leukemia integration 1b0.054
vangl2vang-like 2 (van gogh, Drosophila)0.053
elk4ELK4, ETS-domain protein0.053
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.052
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.052
ca15bcarbonic anhydrase XV b0.052
col8a1acollagen, type VIII, alpha 1a0.052
wnt2bawingless-type MMTV integration site family, member 2Ba0.051
lamb1alaminin, beta 1a0.050
ndr2nodal-related 20.050
cdh17cadherin 17, LI cadherin (liver-intestine)0.049
ildr1bimmunoglobulin-like domain containing receptor 1b0.047
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.047
cse1lchromosome segregation 1-like (S. cerevisiae)0.047
mecomMDS1 and EVI1 complex locus0.046
epha4beph receptor A4b0.046
ptgs1prostaglandin-endoperoxide synthase 10.045
foxa2forkhead box A20.044
crip2cysteine-rich protein 20.044
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.043
pycrlpyrroline-5-carboxylate reductase-like0.043
wt1bwilms tumor 1b0.042
nkx2.2aNK2 transcription factor related 2a0.042
col10a1collagen, type X, alpha 10.041
cdh2cadherin 2, neuronal0.040
stat5.1signal transducer and activator of transcription 5.10.039
wnt3wingless-type MMTV integration site family, member 30.038
tal1T-cell acute lymphocytic leukemia 10.037
dbx1adeveloping brain homeobox 1a0.036
bucbucky ball0.036
nanos3nanos homolog 30.035
or111-9odorant receptor, family D, subfamily 111, member 90.035
fancaFanconi anemia, complementation group A0.035
hmgb1bhigh-mobility group box 1b0.035
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.035
hnrnpul1heterogeneous nuclear ribonucleoprotein U-like 10.035
loxl2blysyl oxidase-like 2b0.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
tam-1Protein TAM-10.019
lin-40Protein LIN-400.017
CELE_F54D5.5Protein F54D5.50.014
elt-6Protein ELT-60.013
unc-37Protein UNC-370.011
bar-1Protein BAR-10.011
pry-1Protein PRY-10.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.940
CblCG7037 gene product from transcript CG7037-RB0.219
Rac1CG2248 gene product from transcript CG2248-RA0.217
Rho1CG8416 gene product from transcript CG8416-RB0.212
eyaeyes absent0.188
Cdc42CG12530 gene product from transcript CG12530-RA0.126
frcfringe connection0.091
aopanterior open0.075
CG9772CG9772 gene product from transcript CG9772-RB0.073
Kr-h1Kruppel homolog 10.053
sqhspaghetti squash0.053
myoglianinCG1838 gene product from transcript CG1838-RD0.053
CycACyclin A0.049
Rac2CG8556 gene product from transcript CG8556-RA0.040
stumpsCG31317 gene product from transcript CG31317-RC0.037
reporeversed polarity0.034
EgfrEpidermal growth factor receptor0.032
SmoxSmad on X0.031
ik2IkappaB kinase-like 20.025
emcextra macrochaetae0.023
Myo31DFMyosin 31DF0.022
RbfRetinoblastoma-family protein0.019
CG42863CG42863 gene product from transcript CG42863-RB0.018
Kap-alpha3karyopherin alpha30.018
PvrPDGF- and VEGF-receptor related0.018
Rab7Rab-protein 70.018
debcldeath executioner Bcl-2 homologue0.016
Rab5Rab-protein 50.015
gcmglial cells missing0.015
Cap-GCG34438 gene product from transcript CG34438-RF0.014
Adgf-AAdenosine deaminase-related growth factor A0.014
Mpk2CG5475 gene product from transcript CG5475-RB0.013
HandCG18144 gene product from transcript CG18144-RA0.012
S6kRPS6-p70-protein kinase0.012
Spn27ASerpin 27A0.011
toytwin of eyeless0.011
HLH54FCG5005 gene product from transcript CG5005-RA0.010
Su(var)205Suppressor of variegation 2050.010
Upf2CG2253 gene product from transcript CG2253-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SIN3ASIN3 homolog A, transcription regulator (yeast)0.596
CXCL3chemokine (C-X-C motif) ligand 30.564
IL8interleukin 80.563
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.548
RBBP4retinoblastoma binding protein 40.506
CXCL2chemokine (C-X-C motif) ligand 20.435
RB1retinoblastoma 10.317
FGF10fibroblast growth factor 100.220
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.220
CCL20chemokine (C-C motif) ligand 200.171
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.167
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.158
FGFR1fibroblast growth factor receptor 10.148
DPP4dipeptidyl-peptidase 40.141
RBBP7retinoblastoma binding protein 70.127
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.109
HDAC1histone deacetylase 10.103
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.094
RXRAretinoid X receptor, alpha0.092
CXCL11chemokine (C-X-C motif) ligand 110.088
JUNjun proto-oncogene0.088
MAP2K4mitogen-activated protein kinase kinase 40.078
CREBBPCREB binding protein0.073
APCadenomatous polyposis coli0.065
RBL2retinoblastoma-like 2 (p130)0.052
IL6interleukin 6 (interferon, beta 2)0.052
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.047
ARRB1arrestin, beta 10.045
CXCL5chemokine (C-X-C motif) ligand 50.045
PTCH1patched 10.044
PKP4plakophilin 40.043
ATF2activating transcription factor 20.043
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.042
MAPK8mitogen-activated protein kinase 80.040
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.037
MAP3K1mitogen-activated protein kinase kinase kinase 10.035
MED25mediator complex subunit 250.033
NCOR1nuclear receptor corepressor 10.032
FGF7fibroblast growth factor 70.031
SKIv-ski sarcoma viral oncogene homolog (avian)0.030
IL1Binterleukin 1, beta0.028
FGF1fibroblast growth factor 1 (acidic)0.028
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.026
NLKnemo-like kinase0.024
HIPK2homeodomain interacting protein kinase 20.024
SOX2SRY (sex determining region Y)-box 20.023
NCF2neutrophil cytosolic factor 20.023
PSEN1presenilin 10.022
TNFAIP3tumor necrosis factor, alpha-induced protein 30.022
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.022
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.021
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.020
ICAM1intercellular adhesion molecule 10.020
TGFB3transforming growth factor, beta 30.020
TRIP6thyroid hormone receptor interactor 60.020
SUZ12suppressor of zeste 12 homolog (Drosophila)0.019
SAP30Sin3A-associated protein, 30kDa0.016
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.016
SORBS3sorbin and SH3 domain containing 30.016
LIN9lin-9 homolog (C. elegans)0.016
CCL8chemokine (C-C motif) ligand 80.015
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.015
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.014
ATF3activating transcription factor 30.014
CLTCclathrin, heavy chain (Hc)0.014
HIC1hypermethylated in cancer 10.014
BCL2A1BCL2-related protein A10.013
TNFAIP2tumor necrosis factor, alpha-induced protein 20.013
GATAD2BGATA zinc finger domain containing 2B0.013
NR2E3nuclear receptor subfamily 2, group E, member 30.013
STK36serine/threonine kinase 360.013
FSTL1follistatin-like 10.013
RNF8ring finger protein 80.013
RBBP8retinoblastoma binding protein 80.012
PF4platelet factor 40.012
FOSFBJ murine osteosarcoma viral oncogene homolog0.012
NCOR2nuclear receptor corepressor 20.012
FOXF1forkhead box F10.012
NCOA6nuclear receptor coactivator 60.012
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.012
TBX5T-box 50.011
TGFBR1transforming growth factor, beta receptor 10.011
ZFYVE9zinc finger, FYVE domain containing 90.011
NRP1neuropilin 10.010
CBX1chromobox homolog 10.010
ITGB1BP2integrin beta 1 binding protein (melusin) 20.010
GLIS2GLIS family zinc finger 20.010
MAPK14mitogen-activated protein kinase 140.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI30.998
Shhsonic hedgehog0.993
Fgfr2fibroblast growth factor receptor 20.975
Pax3paired box gene 30.955
Meox2mesenchyme homeobox 20.931
Sox2SRY-box containing gene 20.866
Fgf10fibroblast growth factor 100.835
Tbx3T-box 30.834
Fgf9fibroblast growth factor 90.831
Sall4sal-like 4 (Drosophila)0.826
Gli2GLI-Kruppel family member GLI20.815
Lef1lymphoid enhancer binding factor 10.802
Bmp4bone morphogenetic protein 40.770
Ctnnb1catenin (cadherin associated protein), beta 10.729
Fgf8fibroblast growth factor 80.726
Fgfr3fibroblast growth factor receptor 30.707
Pax6paired box gene 60.695
Rargretinoic acid receptor, gamma0.695
Id3inhibitor of DNA binding 30.622
Sox9SRY-box containing gene 90.617
Prrx1paired related homeobox 10.583
Hes1hairy and enhancer of split 1 (Drosophila)0.583
Gata6GATA binding protein 60.543
Sox4SRY-box containing gene 40.534
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.532
Id1inhibitor of DNA binding 10.493
Foxf1aforkhead box F1a0.475
Hand1heart and neural crest derivatives expressed transcript 10.443
Kdrkinase insert domain protein receptor0.429
Pitx2paired-like homeodomain transcription factor 20.405
Ror2receptor tyrosine kinase-like orphan receptor 20.387
Tbx2T-box 20.383
Sox7SRY-box containing gene 70.360
Eya1eyes absent 1 homolog (Drosophila)0.357
Sox11SRY-box containing gene 110.330
Smad6MAD homolog 6 (Drosophila)0.320
Zeb1zinc finger E-box binding homeobox 10.297
Hic1hypermethylated in cancer 10.267
Gata4GATA binding protein 40.257
Alx4aristaless-like homeobox 40.249
Foxc2forkhead box C20.229
Msx2homeobox, msh-like 20.224
Ezh2enhancer of zeste homolog 2 (Drosophila)0.221
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.214
Rbl1retinoblastoma-like 1 (p107)0.211
Hdac1histone deacetylase 10.202
Tcf21transcription factor 210.199
Vegfavascular endothelial growth factor A0.195
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.172
Wnt5awingless-related MMTV integration site 5A0.169
Dkk1dickkopf homolog 1 (Xenopus laevis)0.167
Gbx2gastrulation brain homeobox 20.160
Pax2paired box gene 20.156
Pthlhparathyroid hormone-like peptide0.153
Atoh7atonal homolog 7 (Drosophila)0.150
Tcf4transcription factor 40.146
Gscgoosecoid homeobox0.142
Hdac2histone deacetylase 20.136
Twist2twist homolog 2 (Drosophila)0.135
Jag1jagged 10.133
Jarid2jumonji, AT rich interactive domain 20.132
Edn3endothelin 30.131
Hhexhematopoietically expressed homeobox0.130
Mta2metastasis-associated gene family, member 20.128
Arid1bAT rich interactive domain 1B (SWI-like)0.118
Tal1T-cell acute lymphocytic leukemia 10.115
Epha1Eph receptor A10.114
Alx3aristaless-like homeobox 30.113
Nf1neurofibromatosis 10.113
Trp53transformation related protein 530.111
Ptenphosphatase and tensin homolog0.110
Efnb2ephrin B20.108
Foxc1forkhead box C10.108
Cdkn1bcyclin-dependent kinase inhibitor 1B0.108
Arid1aAT rich interactive domain 1A (SWI-like)0.097
Flt4FMS-like tyrosine kinase 40.096
Tcf3transcription factor 30.093
Tcfap2atranscription factor AP-2, alpha0.091
Insm1insulinoma-associated 10.090
Dll1delta-like 1 (Drosophila)0.089
En1engrailed 10.088
Shesrc homology 2 domain-containing transforming protein E0.086
Zfpm2zinc finger protein, multitype 20.085
Ikzf1IKAROS family zinc finger 10.083
Pitx1paired-like homeodomain transcription factor 10.083
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.082
Tcf7transcription factor 7, T-cell specific0.081
Robo3roundabout homolog 3 (Drosophila)0.081
Isl1ISL1 transcription factor, LIM/homeodomain0.081
Chd7chromodomain helicase DNA binding protein 70.080
Flt1FMS-like tyrosine kinase 10.078
Gata1GATA binding protein 10.077
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.076
Mapk14mitogen-activated protein kinase 140.076
Suz12suppressor of zeste 12 homolog (Drosophila)0.075
Hoxa1homeobox A10.073
Gata3GATA binding protein 30.072
Btbd17BTB (POZ) domain containing 170.071
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pcnaproliferating cell nuclear antigen0.020
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.015
Syt4synaptotagmin IV0.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism