The network for 'embryonic skeletal system morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic skeletal system morphogenesis

The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.

NameDescriptionProbabilityFunc Analog Organism
sox9aSRY-box containing gene 9a0.999
prdm1aPR domain containing 1a, with ZNF domain0.998
wu:fv91b12wu:fv91b120.996
jag1bjagged 1b0.996
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.996
foxi1forkhead box I10.995
edn1endothelin 10.990
barx1BarH-like homeobox 10.988
brpf1bromodomain and PHD finger containing, 10.985
sec24dSEC24 family, member D (S. cerevisiae)0.983
hoxb5bhomeo box B5b0.970
hoxb3ahomeo box B3a0.956
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.951
hoxa3ahomeo box A3a0.939
bmp4bone morphogenetic protein 40.938
hand2heart and neural crest derivatives expressed transcript 20.938
foxd3forkhead box D30.936
tbx1T-box 10.936
rereaarginine-glutamic acid dipeptide (RE) repeats a0.935
bocbrother of CDO0.929
hoxb2ahomeo box B2a0.928
furinafurin (paired basic amino acid cleaving enzyme) a0.927
atoh1aatonal homolog 1a0.927
uxs1UDP-glucuronic acid decarboxylase 10.926
hoxa2bhomeo box A2b0.925
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.924
csnk1a1casein kinase 1, alpha 10.921
twist1atwist1a0.920
wnt5bwingless-type MMTV integration site family, member 5b0.916
tbx5aT-box 5a0.916
gata3GATA-binding protein 30.914
mab21l2mab-21-like 20.903
zgc:158603zgc:1586030.903
pitx2paired-like homeodomain transcription factor 20.899
pax8paired box gene 80.898
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.880
xylt1xylosyltransferase 10.863
gbx2gastrulation brain homeo box 20.855
col2a1acollagen type II, alpha-1a0.848
nkx3.2NK3 homeobox 20.848
hoxb6ahomeo box B6a0.834
six4bsine oculis homeobox homolog 4b0.825
twist1btwist1b0.820
myod1myogenic differentiation 10.814
aldh1a2aldehyde dehydrogenase 1 family, member A20.797
pax9paired box gene 90.782
gli2aGLI-Kruppel family member GLI2a0.781
hoxd3ahomeo box D3a0.776
crabp2acellular retinoic acid binding protein 2, a0.762
pbx4pre-B-cell leukemia transcription factor 40.760
shhbsonic hedgehog b0.757
meis3myeloid ecotropic viral integration site 30.756
fn1fibronectin 10.752
hmx4H6 family homeobox 40.739
disc1disrupted in schizophrenia 10.737
osr1odd-skipped related 1 (Drosophila)0.733
raraaretinoic acid receptor, alpha a0.732
hoxb4ahomeo box B4a0.732
lhx5LIM homeobox 50.731
six2asine oculis-related homeobox 2a0.719
disp1dispatched homolog 1 (Drosophila)0.708
s1pr2sphingosine-1-phosphate receptor 20.708
bmp2abone morphogenetic protein 2a0.690
shhasonic hedgehog a0.684
hoxa9bhomeo box A9b0.671
bmp2bbone morphogenetic protein 2b0.669
hoxb1ahomeo box B1a0.662
nkx2.3NK2 transcription factor related 30.656
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.647
tp53tumor protein p530.644
ptch2patched 20.638
mecomMDS1 and EVI1 complex locus0.638
dlx2adistal-less homeobox gene 2a0.634
eya1eyes absent homolog 10.631
pcdh18aprotocadherin 18a0.622
pax6apaired box gene 6a0.620
fgf3fibroblast growth factor 30.617
runx2arunt-related transcription factor 2a0.615
msxcmuscle segment homeobox C0.605
hoxa4ahomeo box A4a0.596
rargbretinoic acid receptor, gamma b0.575
rargaretinoic acid receptor gamma a0.572
frem2aFras1 related extracellular matrix protein 2a0.571
ptch1patched 10.565
hoxa5ahomeo box A5a0.564
pcdh8protocadherin 80.562
mef2camyocyte enhancer factor 2ca0.561
unc45bunc-45 homolog B (C. elegans)0.561
pcsk5aproprotein convertase subtilisin/kexin type 5a0.559
wnt11rwingless-type MMTV integration site family, member 11, related0.558
wif1wnt inhibitory factor 10.551
hoxd4ahomeo box D4a0.545
tp63tumor protein p630.544
hoxc4ahomeo box C4a0.535
msxdmuscle segment homeobox D0.532
LOC100000500sclerostin-like0.527
snai1bsnail homolog 1b (Drosophila)0.523
smad1MAD homolog 1 (Drosophila)0.521
unc45aunc-45 homolog A (C. elegans)0.518
pax2apaired box gene 2a0.518
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HOXB5homeobox B50.894
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.848
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.821
COL1A1collagen, type I, alpha 10.677
FGF1fibroblast growth factor 1 (acidic)0.608
SMAD3SMAD family member 30.495
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.463
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.449
HOXA10homeobox A100.396
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.394
COL1A2collagen, type I, alpha 20.348
COL3A1collagen, type III, alpha 10.337
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.331
COL6A1collagen, type VI, alpha 10.247
HOXA5homeobox A50.239
TAL1T-cell acute lymphocytic leukemia 10.193
HOXA11homeobox A110.172
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.148
TP53tumor protein p530.145
HOXB9homeobox B90.133
RUNX1runt-related transcription factor 10.132
FSTL1follistatin-like 10.122
HOXB3homeobox B30.121
PBX1pre-B-cell leukemia homeobox 10.103
HOXA4homeobox A40.103
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.094
HOXB6homeobox B60.094
SMAD7SMAD family member 70.094
SMAD2SMAD family member 20.089
RING1ring finger protein 10.088
EP300E1A binding protein p3000.082
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.081
HOXA7homeobox A70.078
HOXA6homeobox A60.073
COL5A1collagen, type V, alpha 10.072
HOXD9homeobox D90.067
MDFIMyoD family inhibitor0.062
CREBBPCREB binding protein0.058
MEF2Amyocyte enhancer factor 2A0.058
BMI1BMI1 polycomb ring finger oncogene0.058
PTCH1patched 10.057
HOXA3homeobox A30.057
COL5A2collagen, type V, alpha 20.054
COL4A1collagen, type IV, alpha 10.052
RNF31ring finger protein 310.049
HOXA9homeobox A90.049
CABP1calcium binding protein 10.046
PMLpromyelocytic leukemia0.044
HOXC8homeobox C80.044
TWIST1twist homolog 1 (Drosophila)0.043
HOXC6homeobox C60.043
MMP14matrix metallopeptidase 14 (membrane-inserted)0.043
DAXXdeath-domain associated protein0.041
BMP1bone morphogenetic protein 10.039
TRIP6thyroid hormone receptor interactor 60.039
CBX8chromobox homolog 80.038
HOXD10homeobox D100.038
HOXD13homeobox D130.037
PAX3paired box 30.035
GATA2GATA binding protein 20.035
COL6A2collagen, type VI, alpha 20.035
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.035
HOXA2homeobox A20.034
COL2A1collagen, type II, alpha 10.034
HOXB13homeobox B130.032
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.032
FOXF2forkhead box F20.031
MSX1msh homeobox 10.031
PDGFAplatelet-derived growth factor alpha polypeptide0.031
APCadenomatous polyposis coli0.029
HOXD3homeobox D30.029
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.029
BARX1BARX homeobox 10.029
TCF4transcription factor 40.028
POSTNperiostin, osteoblast specific factor0.028
ELNelastin0.027
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.027
ADAM17ADAM metallopeptidase domain 170.026
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.026
HOXD11homeobox D110.026
HOXC11homeobox C110.026
HOXC10homeobox C100.025
TJP1tight junction protein 1 (zona occludens 1)0.025
HOXB4homeobox B40.024
NRP1neuropilin 10.024
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.024
MEF2Cmyocyte enhancer factor 2C0.024
TGFB1transforming growth factor, beta 10.023
COL11A1collagen, type XI, alpha 10.023
HOXA13homeobox A130.023
PTENphosphatase and tensin homolog0.023
LUMlumican0.023
FOXA2forkhead box A20.022
COL16A1collagen, type XVI, alpha 10.022
HOXC13homeobox C130.021
USP11ubiquitin specific peptidase 110.021
FOXC1forkhead box C10.021
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.021
PRRX2paired related homeobox 20.020
NRP2neuropilin 20.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Foxc1forkhead box C11.000
Tbx1T-box 11.000
Pitx2paired-like homeodomain transcription factor 21.000
Tcfap2atranscription factor AP-2, alpha1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Msx1homeobox, msh-like 11.000
Dlx5distal-less homeobox 51.000
Bmp7bone morphogenetic protein 71.000
Sox9SRY-box containing gene 91.000
Gli2GLI-Kruppel family member GLI21.000
Prrx1paired related homeobox 11.000
Pax3paired box gene 31.000
Pax2paired box gene 21.000
Pax6paired box gene 61.000
Runx2runt related transcription factor 21.000
Foxc2forkhead box C21.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.999
Bmp4bone morphogenetic protein 40.999
Tgfb2transforming growth factor, beta 20.999
Eya1eyes absent 1 homolog (Drosophila)0.999
Rnf2ring finger protein 20.999
Pbx1pre B-cell leukemia transcription factor 10.998
Hoxa13homeobox A130.998
Hoxa1homeobox A10.998
Rargretinoic acid receptor, gamma0.998
Lhx1LIM homeobox protein 10.998
Smosmoothened homolog (Drosophila)0.998
Rarbretinoic acid receptor, beta0.997
Pax9paired box gene 90.997
Hoxd11homeobox D110.997
Hoxa11homeobox A110.997
Pitx1paired-like homeodomain transcription factor 10.997
Fgf8fibroblast growth factor 80.996
Fgf10fibroblast growth factor 100.996
Twist2twist homolog 2 (Drosophila)0.996
Msx2homeobox, msh-like 20.994
Hand1heart and neural crest derivatives expressed transcript 10.993
Pax8paired box gene 80.993
Col1a1collagen, type I, alpha 10.991
Chrdchordin0.991
Fgfr3fibroblast growth factor receptor 30.991
Fgfr1fibroblast growth factor receptor 10.990
Hoxd13homeobox D130.988
Col2a1collagen, type II, alpha 10.988
Hoxa5homeobox A50.988
Tbx15T-box 150.986
Ror2receptor tyrosine kinase-like orphan receptor 20.985
Emx2empty spiracles homolog 2 (Drosophila)0.983
Rspo2R-spondin 2 homolog (Xenopus laevis)0.982
Hoxb3homeobox B30.982
Apcadenomatosis polyposis coli0.981
Nodalnodal0.980
Gbx2gastrulation brain homeobox 20.980
Hand2heart and neural crest derivatives expressed transcript 20.980
Prrx2paired related homeobox 20.978
Wnt3awingless-related MMTV integration site 3A0.977
Hoxd3homeobox D30.974
Hoxa2homeobox A20.974
Hoxa9homeobox A90.973
Lmx1aLIM homeobox transcription factor 1 alpha0.969
Smad4MAD homolog 4 (Drosophila)0.969
Ctnnb1catenin (cadherin associated protein), beta 10.967
Hoxa10homeobox A100.961
Ptch1patched homolog 10.957
Gdnfglial cell line derived neurotrophic factor0.954
Tgfbr2transforming growth factor, beta receptor II0.953
Hoxa3homeobox A30.943
Foxg1forkhead box G10.942
Sox2SRY-box containing gene 20.942
Lef1lymphoid enhancer binding factor 10.937
Nkx2-1NK2 homeobox 10.936
Smad6MAD homolog 6 (Drosophila)0.929
Meox2mesenchyme homeobox 20.929
Gas1growth arrest specific 10.923
Pthlhparathyroid hormone-like peptide0.923
Ptenphosphatase and tensin homolog0.922
RybpRING1 and YY1 binding protein0.921
Pkd1polycystic kidney disease 1 homolog0.919
Ptf1apancreas specific transcription factor, 1a0.916
Dlx2distal-less homeobox 20.916
Rararetinoic acid receptor, alpha0.915
Tcfcp2l1transcription factor CP2-like 10.914
Fgf3fibroblast growth factor 30.914
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.913
Gscgoosecoid homeobox0.905
Vegfavascular endothelial growth factor A0.904
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.899
Emx1empty spiracles homolog 1 (Drosophila)0.898
Ascl1achaete-scute complex homolog 1 (Drosophila)0.886
Zeb1zinc finger E-box binding homeobox 10.883
Isl1ISL1 transcription factor, LIM/homeodomain0.872
Nr5a1nuclear receptor subfamily 5, group A, member 10.872
Hoxd9homeobox D90.867
Dlx1distal-less homeobox 10.858
Smad3MAD homolog 3 (Drosophila)0.855
Gdf11growth differentiation factor 110.855
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a1nuclear receptor subfamily 4, group A, member 10.711
Col12a1collagen, type XII, alpha 10.541
FosFBJ osteosarcoma oncogene0.506
Lamc1laminin, gamma 10.495
Twist2twist homolog 2 (Drosophila)0.408
Dusp6dual specificity phosphatase 60.335
Tgfbr2transforming growth factor, beta receptor II0.312
Junbjun B proto-oncogene0.287
Igfbp5insulin-like growth factor binding protein 50.287
Prrx1paired related homeobox 10.253
Dusp1dual specificity phosphatase 10.236
Efna5ephrin A50.234
Bgnbiglycan0.208
Vcanversican0.205
Hoxc4homeo box C40.200
Shox2short stature homeobox 20.190
Tcfe2atranscription factor E2a0.184
Ptpn14protein tyrosine phosphatase, non-receptor type 140.183
Aebp1AE binding protein 10.176
Loxlysyl oxidase0.169
Cercamcerebral endothelial cell adhesion molecule0.167
Nek9NIMA (never in mitosis gene a)- related kinase 90.154
Gria4glutamate receptor, ionotrophic, AMPA 40.153
Gdf11growth differentiation factor 110.149
Mybpc2myosin binding protein C, fast-type0.147
RestRE1-silencing transcription factor0.142
Fgfr2fibroblast growth factor receptor 20.140
Cyr61cysteine-rich, angiogenic inducer, 610.140
Znf503zinc finger protein 5030.138
Ier2immediate early response 20.135
Arntaryl hydrocarbon receptor nuclear translocator0.133
Mstnmyostatin0.130
Egr2early growth response 20.126
Col5a1collagen, type V, alpha 10.124
Slit3slit homolog 3 (Drosophila)0.124
Btg2BTG family, member 20.115
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.115
Ptbp1polypyrimidine tract binding protein 10.111
Prrx2paired related homeobox 20.105
Ebf1early B-cell factor 10.105
Foxc2forkhead box C20.102
Scarf2scavenger receptor class F, member 20.102
Baiap2BAI1-associated protein 20.098
Pick1protein interacting with PRKCA 10.098
Galr3galanin receptor 30.098
Add3adducin 3 (gamma)0.090
Nfyanuclear transcription factor-Y alpha0.086
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.082
Hand2heart and neural crest derivatives expressed 20.082
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.082
Figfc-fos induced growth factor0.080
Myh10myosin, heavy chain 10, non-muscle0.079
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.075
Nr5a1nuclear receptor subfamily 5, group A, member 10.074
Dmddystrophin0.073
Tnctenascin C0.072
Bmp6bone morphogenetic protein 60.072
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.070
Fn1fibronectin 10.069
Gprc5cG protein-coupled receptor, family C, group 5, member C0.069
Rnf138ring finger protein 1380.069
Galr2galanin receptor 20.068
Ephb3Eph receptor B30.066
Col9a1collagen, type IX, alpha 10.065
Isl1ISL LIM homeobox 10.064
Lef1lymphoid enhancer binding factor 10.063
Unc5bunc-5 homolog B (C. elegans)0.060
JunJun oncogene0.060
Ntf4neurotrophin 40.059
Six1SIX homeobox 10.059
Grip1glutamate receptor interacting protein 10.058
Kctd15potassium channel tetramerisation domain containing 150.058
Col8a1collagen, type VIII, alpha 10.057
Jak2Janus kinase 20.057
Nppcnatriuretic peptide precursor C0.057
Ddr2discoidin domain receptor tyrosine kinase 20.055
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.053
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.053
Sfrp4secreted frizzled-related protein 40.052
Hist1h1dhistone cluster 1, H1d0.051
Arrb1arrestin, beta 10.051
Adarb2adenosine deaminase, RNA-specific, B20.050
Gal3st4galactose-3-O-sulfotransferase 40.049
RGD1310262hypothetical LOC3046500.049
Dnah8dynein, axonemal, heavy chain 80.048
Megf6multiple EGF-like-domains 60.048
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.048
Snai2snail homolog 2 (Drosophila)0.047
Hoxb7homeo box B70.047
Robo1roundabout homolog 1 (Drosophila)0.047
LOC100362331rCG59612-like0.046
Epha8Eph receptor A80.046
Tgfb2transforming growth factor, beta 20.043
Acanaggrecan0.043
Ncam1neural cell adhesion molecule 10.043
Mapk8mitogen-activated protein kinase 80.042
KlKlotho0.042
Sirpasignal-regulatory protein alpha0.041
Fkbp10FK506 binding protein 100.041
Homer3homer homolog 3 (Drosophila)0.041
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism