The network for 'positive regulation of blood circulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of blood circulation

Any process that activates or increases the frequency, rate or extent of blood circulation.

NameDescriptionProbabilityFunc Analog Organism
actc1aactin, alpha, cardiac muscle 1a0.606
calcrlacalcitonin receptor-like a0.590
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.570
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.559
vmhcventricular myosin heavy chain0.422
nkx2.5NK2 transcription factor related 50.398
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.372
tnnt2atroponin T2a, cardiac0.365
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.336
unc45bunc-45 homolog B (C. elegans)0.316
avplarginine vasopressin-like0.316
ttnatitin a0.306
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.306
cmlc1cardiac myosin light chain-10.300
ptgs2aprostaglandin-endoperoxide synthase 2a0.261
ckmacreatine kinase, muscle a0.243
tnnc1btroponin C type 1b (slow)0.222
sgk1serum/glucocorticoid regulated kinase 10.199
tnnc2troponin C type 2 (fast)0.193
gnrh2gonadotropin-releasing hormone 20.184
hsp90a.1heat shock protein 90-alpha 10.178
lrrc50leucine rich repeat containing 500.177
hrh3histamine receptor H30.168
copebcore promoter element binding protein0.161
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.160
ppargperoxisome proliferator activated receptor gamma0.155
tpm4tropomyosin 40.149
ahcyl1S-adenosylhomocysteine hydrolase-like 10.136
agr2anterior gradient homolog 2 (Xenopus laevis)0.131
myl1myosin, light chain 1, alkali; skeletal, fast0.130
adrb2aadrenergic receptor, beta 2a0.128
fggfibrinogen, gamma polypeptide0.125
npas2neuronal PAS domain protein 20.125
smyd1bSET and MYND domain containing 1b0.121
acsl3aacyl-CoA synthetase long-chain family member 3a0.120
dusp5dual specificity phosphatase 50.118
itgavintegrin, alpha V0.112
lama1laminin, alpha 10.105
crip2cysteine-rich protein 20.104
acta1aactin, alpha 1a, skeletal muscle0.101
xirp1xin actin-binding repeat containing 10.099
phlda2pleckstrin homology-like domain, family A, member 20.098
sst1.1somatostatin 1, tandem duplicate 10.097
bcl2l1bcl2-like 10.096
emx3empty spiracles homeobox 30.095
adrb2badrenergic receptor, beta 2b0.093
tgfb3transforming growth factor, beta 30.091
fgbfibrinogen, B beta polypeptide0.091
ip6k2inositol hexaphosphate kinase 20.090
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.090
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.089
tagln2transgelin 20.086
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.086
hsp70lheat shock cognate 70-kd protein, like0.085
nexnnexilin (F actin binding protein)0.085
pvalb8parvalbumin 80.084
ambplalpha-1-microglobulin/bikunin precursor, like0.080
actn3bactinin alpha 3b0.079
cav1caveolin 10.077
gria2bglutamate receptor, ionotropic, AMPA 2b0.074
paqr7bprogestin and adipoQ receptor family member VII, b0.073
flncbfilamin C, gamma b (actin binding protein 280)0.073
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.073
mylk3myosin light chain kinase 30.071
dzip1DAZ interacting protein 10.070
tbx1T-box 10.070
scn4basodium channel, voltage-gated, type IV, beta a0.070
epas1bendothelial PAS domain protein 1b0.070
krt18keratin 180.069
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.067
vegfabvascular endothelial growth factor Ab0.066
scn2bsodium channel, voltage-gated, type II, beta0.065
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.065
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.065
nppanatriuretic peptide precursor A0.064
csrp3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.062
lhx6LIM homeobox 60.060
actc1bactin, alpha, cardiac muscle 1b0.059
scn12aasodium channel, voltage gated, type XII, alpha a0.059
rbm24bRNA binding motif protein 24b0.058
macc1metastasis associated in colon cancer 10.057
tmem88atransmembrane protein 88 a0.056
slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.056
lrrc10leucine rich repeat containing 100.055
aldoabaldolase a, fructose-bisphosphate, b0.053
gdf6bgrowth differentiation factor 6b0.053
pvalb2parvalbumin 20.053
ccbe1collagen and calcium binding EGF domains 10.052
cldnaclaudin a0.052
ttnbtitin b0.051
ppm1fprotein phosphatase 1F (PP2C domain containing)0.051
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TEKTEK tyrosine kinase, endothelial0.933
FGAfibrinogen alpha chain0.731
FGBfibrinogen beta chain0.686
FOSFBJ murine osteosarcoma viral oncogene homolog0.682
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.569
JUNjun proto-oncogene0.449
TBX5T-box 50.445
COTL1coactosin-like 1 (Dictyostelium)0.336
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.254
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.251
NOSTRINnitric oxide synthase trafficker0.234
PTENphosphatase and tensin homolog0.218
CAV2caveolin 20.203
VAC14Vac14 homolog (S. cerevisiae)0.192
TIMP3TIMP metallopeptidase inhibitor 30.179
FGGfibrinogen gamma chain0.162
ATF3activating transcription factor 30.153
SNTG2syntrophin, gamma 20.120
DUSP1dual specificity phosphatase 10.095
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.094
CYR61cysteine-rich, angiogenic inducer, 610.085
JUNDjun D proto-oncogene0.084
JUNBjun B proto-oncogene0.070
CRPC-reactive protein, pentraxin-related0.065
RLN3relaxin 30.061
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.054
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.049
TGFB3transforming growth factor, beta 30.036
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.036
CAV1caveolin 1, caveolae protein, 22kDa0.027
F2Rcoagulation factor II (thrombin) receptor0.025
FSTL1follistatin-like 10.023
DDIT3DNA-damage-inducible transcript 30.020
EGR1early growth response 10.019
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.018
PDZK1PDZ domain containing 10.018
APPamyloid beta (A4) precursor protein0.017
THBS1thrombospondin 10.017
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.016
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.016
IER2immediate early response 20.016
NR4A1nuclear receptor subfamily 4, group A, member 10.016
PTPN1protein tyrosine phosphatase, non-receptor type 10.016
LRRK2leucine-rich repeat kinase 20.016
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.015
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.015
AKAP6A kinase (PRKA) anchor protein 60.014
FOSL1FOS-like antigen 10.014
TXNRD1thioredoxin reductase 10.013
GATA4GATA binding protein 40.013
TGFB1I1transforming growth factor beta 1 induced transcript 10.013
HDAC6histone deacetylase 60.013
FBN1fibrillin 10.012
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.012
DLG4discs, large homolog 4 (Drosophila)0.012
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.012
CXCL2chemokine (C-X-C motif) ligand 20.012
GRB7growth factor receptor-bound protein 70.012
PRKCDBPprotein kinase C, delta binding protein0.012
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.011
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.011
PTPRFprotein tyrosine phosphatase, receptor type, F0.010
KRT5keratin 50.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.893
Nos1nitric oxide synthase 1, neuronal0.865
Klk1b5kallikrein 1-related peptidase b50.585
Cckbrcholecystokinin B receptor0.578
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.572
Klk1kallikrein 10.483
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.463
Hey2hairy/enhancer-of-split related with YRPW motif 20.444
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.436
Ptpn11protein tyrosine phosphatase, non-receptor type 110.432
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.412
Ppargperoxisome proliferator activated receptor gamma0.385
Leprleptin receptor0.347
Klk1b26kallikrein 1-related petidase b260.345
Hand1heart and neural crest derivatives expressed transcript 10.326
Hand2heart and neural crest derivatives expressed transcript 20.273
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.270
Klk1b16kallikrein 1-related peptidase b160.259
Klk1b11kallikrein 1-related peptidase b110.250
FosFBJ osteosarcoma oncogene0.245
Mas1MAS1 oncogene0.216
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.216
Slc12a1solute carrier family 12, member 10.209
Nos3nitric oxide synthase 3, endothelial cell0.192
Ptgs2prostaglandin-endoperoxide synthase 20.190
Tbx5T-box 50.182
Klk1b21kallikrein 1-related peptidase b210.182
Efnb2ephrin B20.181
Scn5asodium channel, voltage-gated, type V, alpha0.169
Pgrprogesterone receptor0.168
Pdx1pancreatic and duodenal homeobox 10.166
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.160
Klk1b24kallikrein 1-related peptidase b240.159
Zfpm2zinc finger protein, multitype 20.156
Klk1b8kallikrein 1-related peptidase b80.149
Art1ADP-ribosyltransferase 10.144
Vdrvitamin D receptor0.124
Alox5aparachidonate 5-lipoxygenase activating protein0.121
Ryr2ryanodine receptor 2, cardiac0.119
Rxraretinoid X receptor alpha0.116
Hey1hairy/enhancer-of-split related with YRPW motif 10.116
Jag1jagged 10.114
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.112
Vegfavascular endothelial growth factor A0.110
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.108
Galr1galanin receptor 10.105
Gja5gap junction protein, alpha 50.104
Ren1renin 1 structural0.102
Egr1early growth response 10.101
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.101
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.093
Adrb1adrenergic receptor, beta 10.090
Zg16zymogen granule protein 160.090
Dmddystrophin, muscular dystrophy0.090
Mesp1mesoderm posterior 10.079
Pthlhparathyroid hormone-like peptide0.078
Gata4GATA binding protein 40.077
Atf3activating transcription factor 30.076
Pramel7preferentially expressed antigen in melanoma like 70.073
Npy2rneuropeptide Y receptor Y20.072
Agtr1aangiotensin II receptor, type 1a0.068
Ednrbendothelin receptor type B0.067
Ntsr2neurotensin receptor 20.066
Pcdh12protocadherin 120.066
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.065
Grb2growth factor receptor bound protein 20.065
Klk1b3kallikrein 1-related peptidase b30.062
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.061
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.060
Sypl2synaptophysin-like 20.060
Ldb3LIM domain binding 30.059
Foxc2forkhead box C20.058
Otporthopedia homolog (Drosophila)0.056
Klk1b9kallikrein 1-related peptidase b90.056
Fggfibrinogen gamma chain0.056
Lama2laminin, alpha 20.055
Drd4dopamine receptor D40.055
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.055
Slc34a2solute carrier family 34 (sodium phosphate), member 20.054
Dusp1dual specificity phosphatase 10.053
Lalbalactalbumin, alpha0.051
Npy1rneuropeptide Y receptor Y10.050
Lhx6LIM homeobox protein 60.050
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.049
Prox1prospero-related homeobox 10.048
Chrm1cholinergic receptor, muscarinic 1, CNS0.047
Plauplasminogen activator, urokinase0.047
Zeb1zinc finger E-box binding homeobox 10.047
Ccl2chemokine (C-C motif) ligand 20.044
Itgb1integrin beta 1 (fibronectin receptor beta)0.044
Lmnalamin A0.044
Ghgrowth hormone0.043
Klk1b27kallikrein 1-related peptidase b270.043
Smyd1SET and MYND domain containing 10.043
Galr2galanin receptor 20.042
Gja1gap junction protein, alpha 10.042
Adrb3adrenergic receptor, beta 30.042
Xirp1xin actin-binding repeat containing 10.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hrh2histamine receptor H 20.224
Notch3Notch homolog 3 (Drosophila)0.172
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.136
Mmp10matrix metallopeptidase 100.135
LOC100362824caveolin 2-like0.123
Ins2insulin 20.120
Olr226olfactory receptor 2260.120
Prlhrprolactin releasing hormone receptor0.118
Prkcgprotein kinase C, gamma0.116
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.114
Iappislet amyloid polypeptide0.112
Smgbneonatal submandibular gland protein B0.112
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.111
Tff1trefoil factor 10.109
Ednraendothelin receptor type A0.103
F9coagulation factor IX0.102
Aqp6aquaporin 6, kidney specific0.101
Rgs9regulator of G-protein signaling 90.099
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.097
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.096
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.093
Vom2r27vomeronasal 2 receptor, 270.092
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.091
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.091
Aplnrapelin receptor0.088
Nmuneuromedin U0.086
Prlhprolactin releasing hormone0.085
Foxi2forkhead box I20.084
Lim2lens intrinsic membrane protein 20.082
Nrg1neuregulin 10.082
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.082
Trhthyrotropin releasing hormone0.081
Il4interleukin 40.081
Agtr2angiotensin II receptor, type 20.080
Edn1endothelin 10.079
Nos3nitric oxide synthase 3, endothelial cell0.079
Tacr2tachykinin receptor 20.077
Hcrtr2hypocretin (orexin) receptor 20.076
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.076
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.075
Olr287olfactory receptor 2870.075
Magmyelin-associated glycoprotein0.074
Foxe1forkhead box E1 (thyroid transcription factor 2)0.074
Cntn3contactin 3 (plasmacytoma associated)0.073
Nrcamneuronal cell adhesion molecule0.072
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.072
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.072
Scnn1bsodium channel, nonvoltage-gated 1, beta0.070
Ascl1achaete-scute complex homolog 1 (Drosophila)0.068
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.067
Scnn1asodium channel, nonvoltage-gated 1 alpha0.067
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.065
Chrnb4cholinergic receptor, nicotinic, beta 40.065
Eef2eukaryotic translation elongation factor 20.065
Car5acarbonic anhydrase 5a, mitochondrial0.064
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.063
Sisucrase-isomaltase (alpha-glucosidase)0.063
Testintestin gene0.063
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.062
LOC299282Serine protease inhibitor0.062
Adora2aadenosine A2a receptor0.062
Pparaperoxisome proliferator activated receptor alpha0.061
Pou2f3POU class 2 homeobox 30.061
Hspa8heat shock protein 80.061
Adam18ADAM metallopeptidase domain 180.061
Il1rninterleukin 1 receptor antagonist0.060
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.060
Folh1folate hydrolase 10.059
Hrh3histamine receptor H30.059
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.059
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.058
Olr1082olfactory receptor 10820.058
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.058
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.057
Rgs14regulator of G-protein signaling 140.057
Prm3protamine 30.057
Cd4Cd4 molecule0.056
Il3interleukin 30.056
Hnmthistamine N-methyltransferase0.056
Uoxurate oxidase0.055
Adra1aadrenergic, alpha-1A-, receptor0.055
Klk8kallikrein related-peptidase 80.054
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.054
Grb2growth factor receptor bound protein 20.054
Crhbpcorticotropin releasing hormone binding protein0.054
Aspgasparaginase homolog (S. cerevisiae)0.053
Pecam1platelet/endothelial cell adhesion molecule 10.053
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.052
Dio2deiodinase, iodothyronine, type II0.052
Hoxb7homeo box B70.052
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.052
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.052
Foxd3forkhead box D30.051
Vipvasoactive intestinal peptide0.051
Ppyr1pancreatic polypeptide receptor 10.051
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism