The network for 'cardiac muscle cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell development

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

NameDescriptionProbabilityFunc Analog Organism
tnnc1btroponin C type 1b (slow)0.981
bmp4bone morphogenetic protein 40.966
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.899
smyd1bSET and MYND domain containing 1b0.861
vmhcventricular myosin heavy chain0.837
myl7myosin, light polypeptide 7, regulatory0.826
mef2cbmyocyte enhancer factor 2cb0.801
hey2hairy/enhancer-of-split related with YRPW motif 20.794
myod1myogenic differentiation 10.776
nkx2.5NK2 transcription factor related 50.757
desmadesmin a0.710
gja3gap junction protein, alpha 30.703
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.623
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.598
wnt11rwingless-type MMTV integration site family, member 11, related0.562
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.549
ttnatitin a0.532
rnasel1ribonuclease like 10.530
tnni1altroponin I, skeletal, slow like0.527
tnni1btroponin I, skeletal, slow b0.498
myl1myosin, light chain 1, alkali; skeletal, fast0.490
smyhc1slow myosin heavy chain 10.478
zgc:66286zgc:662860.467
tnnc1atroponin C type 1a (slow)0.447
tbx20T-box 200.425
aldoabaldolase a, fructose-bisphosphate, b0.425
myogmyogenin0.384
cmlc1cardiac myosin light chain-10.320
hspb1heat shock protein, alpha-crystallin-related, 10.302
actn2actinin, alpha 20.268
actc1aactin, alpha, cardiac muscle 1a0.263
rbm24aRNA binding motif protein 24a0.252
tpm2tropomyosin 2 (beta)0.245
mybpc3myosin binding protein C, cardiac0.236
fabp11afatty acid binding protein 11a0.223
actn3bactinin alpha 3b0.216
hspb8heat shock protein, alpha-crystallin-related, b80.207
pdlim7PDZ and LIM domain 70.207
spry4sprouty (Drosophila) homolog 40.207
myf6myogenic factor 60.201
actc1bactin, alpha, cardiac muscle 1b0.188
unc45bunc-45 homolog B (C. elegans)0.186
srlsarcalumenin0.177
tnni2a.4troponin I, skeletal, fast 2a.40.175
wu:fb01h12wu:fb01h120.175
nppanatriuretic peptide precursor A0.159
podxlpodocalyxin-like0.146
synpo2lbsynaptopodin 2-like b0.145
nexnnexilin (F actin binding protein)0.145
tnnc2troponin C type 2 (fast)0.137
tbx5bT-box 5b0.130
lama4laminin, alpha 40.130
tnnt3btroponin T3b, skeletal, fast0.128
dmrt2adoublesex and mab-3 related transcription factor 2a0.122
aldh1a2aldehyde dehydrogenase 1 family, member A20.120
hspb12heat shock protein, alpha-crystallin-related, b120.117
adrb2aadrenergic receptor, beta 2a0.114
myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.113
vdravitamin D receptor a0.111
trpv6transient receptor potential cation channel, subfamily V, member 60.105
hspb7heat shock protein family, alpha-crystallin-related, b70.105
tbx5aT-box 5a0.103
smyhc2slow myosin heavy chain 20.102
wt1awilms tumor 1a0.101
lrrc10leucine rich repeat containing 100.092
casq2calsequestrin 20.089
spawsouthpaw0.086
tbx18T-box 180.086
kdrlkinase insert domain receptor like0.085
rbm24bRNA binding motif protein 24b0.084
bmp10bone morphogenetic protein 100.084
cx30.3connexin 30.30.084
trpv4transient receptor potential cation channel, subfamily V, member 40.083
egr1early growth response 10.080
ripk2receptor-interacting serine-threonine kinase 20.080
txlnbataxilin beta a0.080
wu:fc31e07wu:fc31e070.079
popdc2popeye domain containing 20.079
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.077
tnnt2atroponin T2a, cardiac0.077
gapdhglyceraldehyde-3-phosphate dehydrogenase0.076
ttnbtitin b0.075
pth2parathyroid hormone 20.074
has2hyaluronan synthase 20.074
csrp3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.073
cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.073
lmnalamin A0.070
fxr1fragile X mental retardation, autosomal homolog 10.070
acta1bactin, alpha 1b, skeletal muscle0.069
fabp3fatty acid binding protein 3, muscle and heart0.067
per3period homolog 3 (Drosophila)0.065
mylk3myosin light chain kinase 30.065
acta1aactin, alpha 1a, skeletal muscle0.063
tmem38atransmembrane protein 38A0.063
casrlcalcium-sensing receptor, like0.061
vmhclventricular myosin heavy chain-like0.061
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.060
scn12absodium channel, voltage gated, type XII, alpha b0.059
ldb3aLIM-domain binding factor 3a0.058
ndrg4N-myc downstream regulated gene 40.057
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mysmyospheroid0.012
Cg25CCollagen type IV0.011
vgvestigial0.011
CG12558CG12558 gene product from transcript CG12558-RA0.011
LanB2Laminin B20.010
MhcMyosin heavy chain0.010
CG17658CG17658 gene product from transcript CG17658-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TTNtitin0.880
TRIM63tripartite motif containing 630.808
CDK2cyclin-dependent kinase 20.544
HDAC4histone deacetylase 40.418
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.401
HDAC1histone deacetylase 10.326
YAP1Yes-associated protein 10.309
TBX5T-box 50.230
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.206
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.205
COL4A1collagen, type IV, alpha 10.196
NEBnebulin0.184
BMPR1Abone morphogenetic protein receptor, type IA0.154
COL4A2collagen, type IV, alpha 20.129
ESR1estrogen receptor 10.129
FLNAfilamin A, alpha0.124
NRP1neuropilin 10.106
ZYXzyxin0.092
ATXN1ataxin 10.057
PDGFAplatelet-derived growth factor alpha polypeptide0.049
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.041
MYOD1myogenic differentiation 10.041
ACTN1actinin, alpha 10.040
EIF2C1eukaryotic translation initiation factor 2C, 10.038
MYOZ1myozenin 10.037
NOTCH1notch 10.030
RBBP4retinoblastoma binding protein 40.025
ACTN2actinin, alpha 20.025
HNF4Ahepatocyte nuclear factor 4, alpha0.024
MYL9myosin, light chain 9, regulatory0.021
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.020
TCAPtitin-cap (telethonin)0.019
CREBBPCREB binding protein0.018
FN1fibronectin 10.016
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.016
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.016
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.015
CAPN3calpain 3, (p94)0.015
ACTN4actinin, alpha 40.015
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.014
KAT2BK(lysine) acetyltransferase 2B0.014
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.014
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.014
MAPK9mitogen-activated protein kinase 90.013
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.012
ARandrogen receptor0.012
DAZAP2DAZ associated protein 20.012
MYPNmyopalladin0.012
MYOGmyogenin (myogenic factor 4)0.012
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.012
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.011
MEF2Amyocyte enhancer factor 2A0.011
CCNA2cyclin A20.010
ITGA7integrin, alpha 70.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Shhsonic hedgehog0.999
Hand1heart and neural crest derivatives expressed transcript 10.997
Pitx2paired-like homeodomain transcription factor 20.995
Nos3nitric oxide synthase 3, endothelial cell0.995
Tbx3T-box 30.992
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.989
Fgfr2fibroblast growth factor receptor 20.988
Ror2receptor tyrosine kinase-like orphan receptor 20.987
Sox9SRY-box containing gene 90.981
Foxc2forkhead box C20.970
Gata4GATA binding protein 40.966
Apcadenomatosis polyposis coli0.960
Msx1homeobox, msh-like 10.958
Tgfb2transforming growth factor, beta 20.954
Taglntransgelin0.954
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.952
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.946
Prrx1paired related homeobox 10.945
Ttntitin0.944
Vegfavascular endothelial growth factor A0.943
Foxc1forkhead box C10.942
Col1a1collagen, type I, alpha 10.930
Ldb3LIM domain binding 30.929
Ptpn11protein tyrosine phosphatase, non-receptor type 110.920
Bmp4bone morphogenetic protein 40.910
Dmddystrophin, muscular dystrophy0.894
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.891
Fgf8fibroblast growth factor 80.890
Bmp7bone morphogenetic protein 70.857
Myl3myosin, light polypeptide 30.846
Pax3paired box gene 30.836
Cnn1calponin 10.835
Gli3GLI-Kruppel family member GLI30.835
Actc1actin, alpha, cardiac muscle 10.833
Tnnt3troponin T3, skeletal, fast0.831
Meox2mesenchyme homeobox 20.804
Pitx1paired-like homeodomain transcription factor 10.791
Hrchistidine rich calcium binding protein0.752
Tbx1T-box 10.751
Actn2actinin alpha 20.719
Smad6MAD homolog 6 (Drosophila)0.711
Otx2orthodenticle homolog 2 (Drosophila)0.709
Casq2calsequestrin 20.708
Jag1jagged 10.707
Sox2SRY-box containing gene 20.665
Efnb2ephrin B20.643
Nodalnodal0.629
Csf1colony stimulating factor 1 (macrophage)0.625
Gja1gap junction protein, alpha 10.623
Gscgoosecoid homeobox0.613
Pdlim3PDZ and LIM domain 30.599
Zeb1zinc finger E-box binding homeobox 10.598
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.591
Ctnnb1catenin (cadherin associated protein), beta 10.586
Wt1Wilms tumor 1 homolog0.567
Gli2GLI-Kruppel family member GLI20.557
Tgfbr2transforming growth factor, beta receptor II0.548
Kdrkinase insert domain protein receptor0.542
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.542
Wnt5awingless-related MMTV integration site 5A0.538
Eya1eyes absent 1 homolog (Drosophila)0.534
Tnni2troponin I, skeletal, fast 20.534
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.520
Nppanatriuretic peptide type A0.513
Nognoggin0.494
Yap1yes-associated protein 10.494
Gata6GATA binding protein 60.487
Dlx5distal-less homeobox 50.482
Scn5asodium channel, voltage-gated, type V, alpha0.474
Sall4sal-like 4 (Drosophila)0.469
Itgb1integrin beta 1 (fibronectin receptor beta)0.468
Xirp1xin actin-binding repeat containing 10.429
Actn3actinin alpha 30.428
Bmpr1abone morphogenetic protein receptor, type 1A0.423
Tbx15T-box 150.421
Fgfr3fibroblast growth factor receptor 30.417
Cav3caveolin 30.416
Hspb7heat shock protein family, member 7 (cardiovascular)0.390
Notch1Notch gene homolog 1 (Drosophila)0.390
Notch2Notch gene homolog 2 (Drosophila)0.386
Runx2runt related transcription factor 20.384
Atg12autophagy-related 12 (yeast)0.380
Hey2hairy/enhancer-of-split related with YRPW motif 20.368
Art1ADP-ribosyltransferase 10.367
Flncfilamin C, gamma0.364
Meox1mesenchyme homeobox 10.362
Sox7SRY-box containing gene 70.360
Tnnc1troponin C, cardiac/slow skeletal0.359
Hoxd13homeobox D130.355
Acvr1activin A receptor, type 10.354
Ckmt2creatine kinase, mitochondrial 20.351
Gja5gap junction protein, alpha 50.347
Vangl2vang-like 2 (van gogh, Drosophila)0.347
Tcfap2atranscription factor AP-2, alpha0.346
Ren1renin 1 structural0.345
Pou5f1POU domain, class 5, transcription factor 10.343
Cdh5cadherin 50.342
Rspo2R-spondin 2 homolog (Xenopus laevis)0.329
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.413
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.196
Myh7myosin, heavy chain 7, cardiac muscle, beta0.186
Top2atopoisomerase (DNA) II alpha0.135
Cdk1cyclin-dependent kinase 10.133
Albalbumin0.129
Casq2calsequestrin 2 (cardiac muscle)0.128
Cdkn3cyclin-dependent kinase inhibitor 30.096
Nos3nitric oxide synthase 3, endothelial cell0.092
Cav1caveolin 1, caveolae protein0.089
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.089
Myoz2myozenin 20.087
LOC689399hypothetical protein LOC6893990.082
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.076
Tnni1troponin I type 1 (skeletal, slow)0.073
Spp2secreted phosphoprotein 20.065
Wbp2WW domain binding protein 20.060
Actg2actin, gamma 2, smooth muscle, enteric0.055
Ahsgalpha-2-HS-glycoprotein0.051
Ube2cubiquitin-conjugating enzyme E2C0.051
Traf4af1TRAF4 associated factor 10.051
LOC286980putative pheromone receptor (Go-VN13B)0.050
Pttg1pituitary tumor-transforming 10.049
Tnni3troponin I type 3 (cardiac)0.048
Vom2r27vomeronasal 2 receptor, 270.048
Grik3glutamate receptor, ionotropic, kainate 30.046
Apohapolipoprotein H (beta-2-glycoprotein I)0.044
Hspb7heat shock protein family, member 7 (cardiovascular)0.044
Ccnb1cyclin B10.040
Procprotein C0.040
Mbmyoglobin0.039
Scn5asodium channel, voltage-gated, type V, alpha subunit0.039
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.039
Cckarcholecystokinin A receptor0.039
Emp1epithelial membrane protein 10.037
Fabp1fatty acid binding protein 1, liver0.037
Agtr1aangiotensin II receptor, type 1a0.037
Pzppregnancy-zone protein0.037
Kif2ckinesin family member 2C0.036
Nexnnexilin (F actin binding protein)0.036
Hspb2heat shock protein beta 20.033
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.033
Lifleukemia inhibitory factor0.033
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.033
Asb2ankyrin repeat and SOCS box-containing 20.030
Cav2caveolin 20.030
Rrm2ribonucleotide reductase M20.029
Ccnb2cyclin B20.029
Actn2actinin alpha 20.028
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.027
Cks2CDC28 protein kinase regulatory subunit 20.026
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.026
Hpxhemopexin0.026
Racgap1Rac GTPase-activating protein 10.026
Thpothrombopoietin0.026
Actc1actin, alpha, cardiac muscle 10.026
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.025
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.024
Trim63tripartite motif-containing 630.024
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.023
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.022
Aebp1AE binding protein 10.022
Smpxsmall muscle protein, X-linked0.021
Kifc1kinesin family member C10.021
Hmmrhyaluronan mediated motility receptor (RHAMM)0.021
Mcm6minichromosome maintenance complex component 60.021
Rup2urinary protein 20.020
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.020
Casp2caspase 20.020
Pdha2pyruvate dehydrogenase (lipoamide) alpha 20.020
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.019
Fgf16fibroblast growth factor 160.019
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.018
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.018
Pbsnprobasin0.017
Pgam2phosphoglycerate mutase 2 (muscle)0.017
Pcsk1proprotein convertase subtilisin/kexin type 10.017
Tk1thymidine kinase 1, soluble0.017
Crisp1cysteine-rich secretory protein 10.017
Atn1atrophin 10.016
Myogmyogenin0.016
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.016
Col10a1collagen, type X, alpha 10.016
Pla2g5phospholipase A2, group V0.016
Dlx5distal-less homeobox 50.016
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.015
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.015
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.015
Myf6myogenic factor 60.015
Cyp51cytochrome P450, family 510.015
Stmn1stathmin 10.015
Gcgroup specific component0.015
Wipf3WAS/WASL interacting protein family, member 30.015
Orm1orosomucoid 10.015
Klrb1ckiller cell lectin-like receptor subfamily B member 1C0.015
Mchr1melanin-concentrating hormone receptor 10.014
Fgf18fibroblast growth factor 180.014
Pnmtphenylethanolamine-N-methyltransferase0.014
Pitx3paired-like homeodomain 30.014
Foxi2forkhead box I20.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism