The network for 'lytic vacuole organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lytic vacuole organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.

NameDescriptionProbabilityFunc Analog Organism
snx4sorting nexin 40.075
ctszcathepsin Z0.050
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.047
cpvlcarboxypeptidase, vitellogenic-like0.040
ctsbacathepsin B, a0.039
atp6v1fATPase, H+ transporting, V1 subunit F0.038
chmp4bchromatin modifying protein 4B0.037
cpne1copine I0.034
npc2Niemann-Pick disease, type C20.033
mxtx2mix-type homeobox gene 20.032
litaflipopolysaccharide-induced TNF factor0.030
cyb5r3cytochrome b5 reductase 30.028
cyfip2cytoplasmic FMR1 interacting protein 20.027
ap3m1adaptor-related protein complex 3, mu 1 subunit0.027
snx5sorting nexin 50.027
march5lmembrane-associated ring finger (C3HC4) 5, like0.027
tbx1T-box 10.025
frem1aFras1 related extracellular matrix 1a0.025
arl4caADP-ribosylation factor-like 4Ca0.024
snx9lsorting nexin 9-like0.023
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.022
apg3lAPG3 autophagy 3-like0.021
rab5cRAB5C, member RAS oncogene family0.021
ctsccathepsin C0.021
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.020
stxbp2syntaxin binding protein 20.019
calm1acalmodulin 1a0.019
asah1bN-acylsphingosine amidohydrolase (acid ceramidase) 1b0.019
clcn7chloride channel 70.018
extl3exostoses (multiple)-like 30.018
sypl2bsynaptophysin-like 2b0.018
ctsfcathepsin F0.018
tbc1d15TBC1 domain family, member 150.018
ptpn6protein tyrosine phosphatase, non-receptor type 60.018
rab13RAB13, member RAS oncogene family0.018
arcn1larchain 1 like0.018
calubcalumenin b0.018
atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.018
selenbp1selenium binding protein 10.018
scpep1serine carboxypeptidase 10.018
slc30a7solute carrier family 30 (zinc transporter), member 70.017
cyp20a1cytochrome P450, family 20, subfamily A, polypeptide 10.017
nenfneuron derived neurotrophic factor0.017
s1pr2sphingosine-1-phosphate receptor 20.017
snx3sorting nexin 30.017
gnpda1glucosamine-6-phosphate deaminase 10.017
ptprcprotein tyrosine phosphatase, receptor type, C0.016
tax1bp1bTax1 (human T-cell leukemia virus type I) binding protein 1b0.016
creb3l3lcAMP responsive element binding protein 3-like 3 like0.016
uap1l1UDP-N-acteylglucosamine pyrophosphorylase 1, like 10.016
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.016
serinc2serine incorporator 20.016
napaN-ethylmaleimide sensitive fusion protein attachment protein alpha0.016
rab25RAB25, member RAS oncogene family0.016
wipi1WD repeat domain, phosphoinositide interacting 10.016
acadlacyl-Coenzyme A dehydrogenase, long chain0.016
fuca2fucosidase, alpha-L- 2, plasma0.015
cbr1lcarbonyl reductase 1-like0.015
ifi30interferon gamma inducible protein 300.015
disp1dispatched homolog 1 (Drosophila)0.015
arf5ADP-ribosylation factor 50.015
ugcgUDP-glucose ceramide glucosyltransferase0.015
sqstm1sequestosome 10.015
chrndcholinergic receptor, nicotinic, delta polypeptide0.015
ap2m1aadaptor-related protein complex 2, mu 1 subunit, a0.014
bsdc1BSD domain containing 10.014
pdcd6ipprogrammed cell death 6 interacting protein0.014
ctbschitobiase, di-N-acetyl-0.014
acvr1bactivin A receptor, type IB0.014
sept2septin 20.013
kctd15apotassium channel tetramerisation domain containing 15a0.013
ctsacathepsin A0.013
pgdphosphogluconate hydrogenase0.013
chid1chitinase domain containing 10.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
skn-1Protein SKN-10.087
F48F7.6Protein F48F7.60.033
K04G2.6Protein K04G2.60.023
snx-1Protein SNX-10.022
pho-5Protein PHO-50.020
ZC13.1Protein ZC13.10.019
sem-5Protein SEM-50.017
CELE_H19N07.3Protein H19N07.30.017
atg-16.2Protein ATG-16.20.016
cdk-9Protein CDK-90.014
Y17G7B.10Protein Y17G7B.100.014
vps-35Protein VPS-350.014
CELE_R09F10.3Protein R09F10.30.013
F57B7.2Protein F57B7.20.012
D1044.2Protein D1044.20.012
ctn-1Protein CTN-10.011
chc-1Protein CHC-10.011
CELE_C09G9.1Protein C09G9.10.011
CELE_F10G7.9Protein F10G7.90.010
mig-22Protein MIG-220.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
AKTIPAKT interacting protein0.835
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.734
MON1BMON1 homolog B (yeast)0.516
VPS33Bvacuolar protein sorting 33 homolog B (yeast)0.497
GDI2GDP dissociation inhibitor 20.329
SNX33sorting nexin 330.203
OCRLoculocerebrorenal syndrome of Lowe0.191
SNX6sorting nexin 60.167
VPS41vacuolar protein sorting 41 homolog (S. cerevisiae)0.158
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.136
FKBP8FK506 binding protein 8, 38kDa0.131
AMBRA1autophagy/beclin-1 regulator 10.129
GOLGA2golgin A20.124
BCL2L1BCL2-like 10.088
BCL2B-cell CLL/lymphoma 20.087
HOOK2hook homolog 2 (Drosophila)0.085
ATF2activating transcription factor 20.082
FNBP1formin binding protein 10.081
SH3KBP1SH3-domain kinase binding protein 10.075
USP22ubiquitin specific peptidase 220.074
RAB5ARAB5A, member RAS oncogene family0.072
MAPK8mitogen-activated protein kinase 80.067
ITSN1intersectin 1 (SH3 domain protein)0.057
BCL2L11BCL2-like 11 (apoptosis facilitator)0.048
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.048
RAB1ARAB1A, member RAS oncogene family0.046
GLB1galactosidase, beta 10.040
GM2AGM2 ganglioside activator0.039
STX12syntaxin 120.039
CDC34cell division cycle 34 homolog (S. cerevisiae)0.038
BIKBCL2-interacting killer (apoptosis-inducing)0.037
WASLWiskott-Aldrich syndrome-like0.037
DZIP3DAZ interacting protein 3, zinc finger0.037
C5orf54chromosome 5 open reading frame 540.036
MFSD1major facilitator superfamily domain containing 10.036
MAN2B1mannosidase, alpha, class 2B, member 10.035
SNX1sorting nexin 10.035
APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 20.033
UVRAGUV radiation resistance associated gene0.032
TYK2tyrosine kinase 20.031
PLD3phospholipase D family, member 30.031
PIK3C3phosphoinositide-3-kinase, class 30.031
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.030
RAB6ARAB6A, member RAS oncogene family0.029
DNM2dynamin 20.028
EIF1Beukaryotic translation initiation factor 1B0.027
SS18synovial sarcoma translocation, chromosome 180.025
REEP6receptor accessory protein 60.025
STAMBPSTAM binding protein0.025
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.024
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.024
BADBCL2-associated agonist of cell death0.022
PICALMphosphatidylinositol binding clathrin assembly protein0.022
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.022
DAPK1death-associated protein kinase 10.022
HEXBhexosaminidase B (beta polypeptide)0.021
TP53BP2tumor protein p53 binding protein, 20.020
ABLIM1actin binding LIM protein 10.020
PACSIN2protein kinase C and casein kinase substrate in neurons 20.020
EEA1early endosome antigen 10.019
FCGRTFc fragment of IgG, receptor, transporter, alpha0.019
NEU1sialidase 1 (lysosomal sialidase)0.018
WASH1WAS protein family homolog 10.017
HOOK3hook homolog 3 (Drosophila)0.017
BAXBCL2-associated X protein0.017
RTN1reticulon 10.017
MAN1B1mannosidase, alpha, class 1B, member 10.017
POLD4polymerase (DNA-directed), delta 40.017
GOLGA7golgin A70.016
ZFYVE1zinc finger, FYVE domain containing 10.016
RAB7ARAB7A, member RAS oncogene family0.016
VPS33Avacuolar protein sorting 33 homolog A (S. cerevisiae)0.016
UNC45Aunc-45 homolog A (C. elegans)0.016
P2RX4purinergic receptor P2X, ligand-gated ion channel, 40.016
ZFYVE26zinc finger, FYVE domain containing 260.015
M6PRmannose-6-phosphate receptor (cation dependent)0.015
LRP10low density lipoprotein receptor-related protein 100.015
MANBAmannosidase, beta A, lysosomal0.015
BBC3BCL2 binding component 30.015
MAPK14mitogen-activated protein kinase 140.014
TMCO1transmembrane and coiled-coil domains 10.014
CTBP2C-terminal binding protein 20.014
SPHARS-phase response (cyclin related)0.014
CLTCclathrin, heavy chain (Hc)0.014
LTA4Hleukotriene A4 hydrolase0.014
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.014
RAB11ARAB11A, member RAS oncogene family0.014
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.014
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.014
ARHGAP4Rho GTPase activating protein 40.014
RUFY1RUN and FYVE domain containing 10.014
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase0.014
PEX2peroxisomal biogenesis factor 20.013
C14orf101chromosome 14 open reading frame 1010.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dpp7dipeptidylpeptidase 70.991
Hexbhexosaminidase B0.986
Hexahexosaminidase A0.972
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.971
Iduaiduronidase, alpha-L-0.815
Mitfmicrophthalmia-associated transcription factor0.791
0610031J06RikRIKEN cDNA 0610031J06 gene0.735
Lystlysosomal trafficking regulator0.708
Apoeapolipoprotein E0.600
Npc1Niemann Pick type C10.574
Rab27aRAB27A, member RAS oncogene family0.447
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.373
Gaaglucosidase, alpha, acid0.343
NagaN-acetyl galactosaminidase, alpha0.338
Gusbglucuronidase, beta0.312
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.284
Renbprenin binding protein0.255
Pld3phospholipase D family, member 30.242
Myo6myosin VI0.225
Ctsacathepsin A0.218
Dscr3Down syndrome critical region gene 30.202
Man2b1mannosidase 2, alpha B10.199
Mfsd1major facilitator superfamily domain containing 10.189
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.186
Itgb5integrin beta 50.179
Ush1gUsher syndrome 1G homolog (human)0.166
Naglualpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)0.157
Adam17a disintegrin and metallopeptidase domain 170.153
Wdr81WD repeat domain 810.136
Lamp1lysosomal-associated membrane protein 10.132
P2rx4purinergic receptor P2X, ligand-gated ion channel 40.120
Gbaglucosidase, beta, acid0.120
Coro1bcoronin, actin binding protein 1B0.117
Neu1neuraminidase 10.115
Gnsglucosamine (N-acetyl)-6-sulfatase0.115
Sgpl1sphingosine phosphate lyase 10.108
Hps6Hermansky-Pudlak syndrome 60.102
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.101
Glb1galactosidase, beta 10.098
Tpra1transmembrane protein, adipocyte asscociated 10.097
Epn1epsin 10.096
Arsaarylsulfatase A0.096
Mpv17MpV17 mitochondrial inner membrane protein0.094
Asah1N-acylsphingosine amidohydrolase 10.088
Arsbarylsulfatase B0.085
Tcn2transcobalamin 20.082
Il10rbinterleukin 10 receptor, beta0.079
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.078
Pmelpremelanosome protein0.078
Gopcgolgi associated PDZ and coiled-coil motif containing0.075
Ctszcathepsin Z0.075
Ctsdcathepsin D0.075
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.075
Pold4polymerase (DNA-directed), delta 40.071
Siaesialic acid acetylesterase0.070
Galnsgalactosamine (N-acetyl)-6-sulfate sulfatase0.063
Yipf3Yip1 domain family, member 30.062
Tpp1tripeptidyl peptidase I0.060
Lgals8lectin, galactose binding, soluble 80.059
Hs1bp3HCLS1 binding protein 30.058
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.057
Mcoln1mucolipin 10.056
RoraRAR-related orphan receptor alpha0.055
Mertkc-mer proto-oncogene tyrosine kinase0.055
Uap1l1UDP-N-acteylglucosamine pyrophosphorylase 1-like 10.054
Zbtb24zinc finger and BTB domain containing 240.050
4833420G17RikRIKEN cDNA 4833420G17 gene0.049
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.048
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.048
Atp13a2ATPase type 13A20.047
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.046
Gm2aGM2 ganglioside activator protein0.046
Pik3r2phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)0.046
Txndc16thioredoxin domain containing 160.045
Lamtor3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.044
Ppt1palmitoyl-protein thioesterase 10.044
Manbamannosidase, beta A, lysosomal0.043
Stard3START domain containing 30.043
Spsb2splA/ryanodine receptor domain and SOCS box containing 20.042
Unc93b1unc-93 homolog B1 (C. elegans)0.042
Cln3ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)0.042
Slc35c2solute carrier family 35, member C20.042
Lipalysosomal acid lipase A0.041
Gnpda1glucosamine-6-phosphate deaminase 10.041
Man2b2mannosidase 2, alpha B20.040
Npc2Niemann Pick type C20.039
Zfp187zinc finger protein 1870.038
Sirpasignal-regulatory protein alpha0.038
Itm2cintegral membrane protein 2C0.038
Sat1spermidine/spermine N1-acetyl transferase 10.037
Dram2VDNA-damage regulated autophagy modulator 20.037
Pex6peroxisomal biogenesis factor 60.037
Tex264testis expressed gene 2640.037
Lrp1low density lipoprotein receptor-related protein 10.036
Pla2g15phospholipase A2, group XV0.036
AW549877expressed sequence AW5498770.036
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism