The network for 'cgmp metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cgmp metabolic process

The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate.

NameDescriptionProbabilityFunc Analog Organism
gucy2fguanylate cyclase 2F, retinal0.425
gc3guanylyl cyclase 30.409
mchr1amelanin-concentrating hormone receptor 1a0.283
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.179
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.170
opn4lopsin 4, like0.117
pppyrophosphatase (inorganic)0.108
sst3somatostatin 30.069
fgf8afibroblast growth factor 8 a0.069
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.059
opn1mw4opsin 1 (cone pigments), medium-wave-sensitive, 40.056
scinlascinderin like a0.049
guca1cguanylate cyclase activator 1C0.046
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.045
plp1bproteolipid protein 1b0.045
pdcaphosducin a0.042
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.040
crb2bcrumbs homolog 2b0.040
synj1synaptojanin 10.038
gc2guanylyl cyclase 20.038
ptpraprotein tyrosine phosphatase, receptor type, A0.037
grk7aG-protein-coupled receptor kinase 7a0.036
sagaS-antigen; retina and pineal gland (arrestin) a0.035
rbp4lretinol binding protein 4, like0.035
tagln2transgelin 20.034
guca1dguanylate cyclase activator 1d0.034
slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.031
dkk1bdickkopf 1b0.031
aanat2arylalkylamine N-acetyltransferase0.031
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.030
gdnfglial cell derived neurotrophic factor0.029
nrlneural retina leucine zipper0.028
grmaglutamate receptor, metabotropic a0.027
es1es1 protein0.027
rab28RAB28, member RAS oncogene family0.024
hint2histidine triad nucleotide binding protein 20.022
colec11collectin sub-family member 110.021
wnt11wingless-type MMTV integration site family, member 110.021
grid2glutamate receptor, ionotropic, delta 20.020
bsk146brain specific kinase 1460.020
lhfplipoma HMGIC fusion partner0.018
nedd4lneural precursor cell expressed, developmentally down-regulated 4-like0.018
arr3barrestin 3b, retinal (X-arrestin)0.018
LOC799612prolactin 20.017
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.017
osr1odd-skipped related 1 (Drosophila)0.017
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.016
guk1guanylate kinase 10.016
myo7aamyosin VIIAa0.016
mtnr1bbmelatonin receptor 1B b and melatonin receptor 1B0.016
cx55.5connexin 55.50.016
or107-1odorant receptor, family D, subfamily 107, member 10.014
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.014
tdhL-threonine dehydrogenase0.014
atp1b3aATPase, Na+/K+ transporting, beta 3a polypeptide0.014
vangl2vang-like 2 (van gogh, Drosophila)0.014
nr2e3nuclear receptor subfamily 2, group E, member 30.014
sagbS-antigen; retina and pineal gland (arrestin) b0.014
vegfaavascular endothelial growth factor Aa0.013
epb41l5erythrocyte membrane protein band 4.1 like 50.012
id1inhibitor of DNA binding 10.012
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.012
rs1retinoschisis (X-linked, juvenile) 10.012
ghsragrowth hormone secretagogue receptor a0.012
rras2related RAS viral (r-ras) oncogene homolog 20.012
alpalkaline phosphatase0.012
opn1mw1opsin 1 (cone pigments), medium-wave-sensitive, 10.011
thrbthyroid hormone receptor beta0.011
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.010
bmp8abone morphogenetic protein 8a0.010
dusp6dual specificity phosphatase 60.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
tax-2Protein TAX-20.360
tax-4Protein TAX-40.245
daf-11Protein DAF-110.223
pkg-1Protein PKG-10.178
gcy-22Protein GCY-220.110
che-1Protein CHE-10.075
odr-3Protein ODR-30.050
odr-1Protein ODR-10.049
daf-7Protein DAF-70.037
osm-3Protein OSM-30.036
kvs-2Protein KVS-20.027
clp-1Protein CLP-10.027
mml-1Protein MML-10.024
F38H4.5Protein F38H4.50.017
F13B9.1Protein F13B9.10.017
che-3Protein CHE-30.016
cec-1Protein CEC-10.016
pcca-1Protein PCCA-10.013
kcc-1Protein KCC-10.013
aak-2Protein AAK-20.013
pyc-1Protein PYC-10.012
ncr-2Protein NCR-20.012
sca-1Protein SCA-10.012
F09C8.2Protein F09C8.20.011
ZK792.1Protein ZK792.10.011
daf-5Protein DAF-50.011
pccb-1Protein PCCB-10.011
ksr-1Protein KSR-10.011
pxn-2Protein PXN-20.011
clh-1Protein CLH-10.010
clec-121Protein CLEC-1210.010
agr-1Protein AGR-10.010
daf-4Protein DAF-40.010
frm-1Protein FRM-10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
reporeversed polarity0.465
Gyc-89DbGuanylyl cyclase at 89Db0.352
Gyc-89DaGuanylyl cyclase at 89Da0.178
CrkCG1587 gene product from transcript CG1587-RC0.117
CngCyclic-nucleotide-gated ion channel protein0.091
Gyc88EGuanylyl cyclase at 88E0.089
CG14686CG14686 gene product from transcript CG14686-RA0.069
dprdefective proboscis extension response0.051
mGluRAmetabotropic glutamate receptor0.047
GluRIIAGlutamate receptor IIA0.034
Fad2CG7923 gene product from transcript CG7923-RA0.029
Gr33aGustatory receptor 33a0.025
CG9572CG9572 gene product from transcript CG9572-RA0.023
SamDCS-adenosylmethionine decarboxylase0.022
VmatVesicular monoamine transporter0.022
king-tubbyking tubby0.022
CG17826CG17826 gene product from transcript CG17826-RA0.022
inaDinactivation no afterpotential D0.022
GripGlutamate receptor binding protein0.022
ninaBneither inactivation nor afterpotential B0.021
ppk19pickpocket 190.021
Ank2Ankyrin 20.018
Traf-likeTNF-receptor-associated factor-like0.018
ppk28pickpocket 280.018
Ilp3Insulin-like peptide 30.016
Gr64bGustatory receptor 64b0.015
dpr5CG5308 gene product from transcript CG5308-RA0.015
Spn31ASerpin 31A0.014
Ilp5Insulin-like peptide 50.014
ProsapCG30483 gene product from transcript CG30483-RA0.014
l(2)k16918lethal (2) k169180.014
CG9335CG9335 gene product from transcript CG9335-RA0.013
CG31146CG31146 gene product from transcript CG31146-RD0.013
CG34396CG34396 gene product from transcript CG34396-RC0.013
Gr64eGustatory receptor 64e0.012
Syt4Synaptotagmin 40.012
Gr43aGustatory receptor 43a0.012
CG2278CG2278 gene product from transcript CG2278-RA0.012
CG15529CG15529 gene product from transcript CG15529-RA0.011
Or10aOdorant receptor 10a0.011
Gr64fGustatory receptor 64f0.011
CG14191CG14191 gene product from transcript CG14191-RA0.011
CG5149CG5149 gene product from transcript CG5149-RA0.010
Gr59cGustatory receptor 59c0.010
Gr61aGustatory receptor 61a0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.981
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.833
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.799
PDZD3PDZ domain containing 30.648
NR0B1nuclear receptor subfamily 0, group B, member 10.606
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.592
TBC1D10ATBC1 domain family, member 10A0.571
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.547
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.406
VEGFAvascular endothelial growth factor A0.399
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.305
NOSTRINnitric oxide synthase trafficker0.275
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.258
NRP1neuropilin 10.225
MPDZmultiple PDZ domain protein0.225
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.210
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.187
VAC14Vac14 homolog (S. cerevisiae)0.178
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.126
FZD1frizzled homolog 1 (Drosophila)0.110
PTENphosphatase and tensin homolog0.096
PHYHIPLphytanoyl-CoA 2-hydroxylase interacting protein-like0.083
MT1Ametallothionein 1A0.080
RGS20regulator of G-protein signaling 200.053
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.050
APOC1apolipoprotein C-I0.043
PGFplacental growth factor0.042
FYNFYN oncogene related to SRC, FGR, YES0.041
WNT3Awingless-type MMTV integration site family, member 3A0.041
MATKmegakaryocyte-associated tyrosine kinase0.039
CBX1chromobox homolog 10.037
NDPNorrie disease (pseudoglioma)0.036
CALCAcalcitonin-related polypeptide alpha0.034
COL4A1collagen, type IV, alpha 10.033
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.033
DLG2discs, large homolog 2 (Drosophila)0.032
DNM1dynamin 10.032
COL5A1collagen, type V, alpha 10.029
PTK2PTK2 protein tyrosine kinase 20.029
PLXDC1plexin domain containing 10.028
LRP6low density lipoprotein receptor-related protein 60.027
APOC3apolipoprotein C-III0.027
MAPTmicrotubule-associated protein tau0.027
ADRB2adrenergic, beta-2-, receptor, surface0.025
DTX2deltex homolog 2 (Drosophila)0.024
WNT5Awingless-type MMTV integration site family, member 5A0.023
PTPRBprotein tyrosine phosphatase, receptor type, B0.023
LCATlecithin-cholesterol acyltransferase0.022
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.022
LDLRlow density lipoprotein receptor0.021
BMI1BMI1 polycomb ring finger oncogene0.021
NR4A3nuclear receptor subfamily 4, group A, member 30.021
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.021
BBS10Bardet-Biedl syndrome 100.020
ADAMTSL4ADAMTS-like 40.020
SPRR2Asmall proline-rich protein 2A0.019
SLC26A3solute carrier family 26, member 30.018
ARRDC3arrestin domain containing 30.018
TIMP3TIMP metallopeptidase inhibitor 30.017
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.016
KCTD17potassium channel tetramerisation domain containing 170.015
ELF5E74-like factor 5 (ets domain transcription factor)0.015
MTNR1Bmelatonin receptor 1B0.014
FZD8frizzled homolog 8 (Drosophila)0.014
RAP2BRAP2B, member of RAS oncogene family0.014
COL2A1collagen, type II, alpha 10.013
TRIM32tripartite motif containing 320.013
PTPRAprotein tyrosine phosphatase, receptor type, A0.013
APOEapolipoprotein E0.013
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.012
ANGPTL2angiopoietin-like 20.012
PDZK1PDZ domain containing 10.012
WNT2wingless-type MMTV integration site family member 20.012
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.012
APOA2apolipoprotein A-II0.012
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.011
GFI1Bgrowth factor independent 1B transcription repressor0.011
FGF2fibroblast growth factor 2 (basic)0.011
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.011
PTPN21protein tyrosine phosphatase, non-receptor type 210.011
PTGER3prostaglandin E receptor 3 (subtype EP3)0.011
COL6A1collagen, type VI, alpha 10.011
STC1stanniocalcin 10.011
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.011
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.011
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.011
MDFIMyoD family inhibitor0.010
FGF18fibroblast growth factor 180.010
EGFL7EGF-like-domain, multiple 70.010
VEGFCvascular endothelial growth factor C0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nos3nitric oxide synthase 3, endothelial cell0.862
Atxn1ataxin 10.354
Gnrh1gonadotropin releasing hormone 10.292
Notch2Notch gene homolog 2 (Drosophila)0.258
Dlg4discs, large homolog 4 (Drosophila)0.256
Ptgs2prostaglandin-endoperoxide synthase 20.256
Slc34a1solute carrier family 34 (sodium phosphate), member 10.208
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.200
Leprleptin receptor0.164
Ush1gUsher syndrome 1G homolog (human)0.152
Amhr2anti-Mullerian hormone type 2 receptor0.138
Gucy1b3guanylate cyclase 1, soluble, beta 30.113
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.103
Vhlvon Hippel-Lindau tumor suppressor0.100
Gucy1a3guanylate cyclase 1, soluble, alpha 30.088
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.086
Nr5a1nuclear receptor subfamily 5, group A, member 10.084
Nos1nitric oxide synthase 1, neuronal0.083
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.081
Kitkit oncogene0.080
Tcfcp2l1transcription factor CP2-like 10.080
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.076
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.075
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.074
Myo6myosin VI0.073
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.072
Prkg1protein kinase, cGMP-dependent, type I0.071
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.067
Slc26a4solute carrier family 26, member 40.067
Crxcone-rod homeobox containing gene0.067
Fgfr3fibroblast growth factor receptor 30.064
Grid2glutamate receptor, ionotropic, delta 20.063
Nrp1neuropilin 10.062
Vdrvitamin D receptor0.062
Rgs4regulator of G-protein signaling 40.060
Prph2peripherin 20.059
Raxretina and anterior neural fold homeobox0.059
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.058
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.056
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.055
Ror2receptor tyrosine kinase-like orphan receptor 20.055
Lyz2lysozyme 20.054
Atoh7atonal homolog 7 (Drosophila)0.054
Grxcr1glutaredoxin, cysteine rich 10.054
Esr1estrogen receptor 1 (alpha)0.052
Bcar1breast cancer anti-estrogen resistance 10.051
Fzd4frizzled homolog 4 (Drosophila)0.047
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.046
Tspan12tetraspanin 120.046
Itga3integrin alpha 30.045
Nr2f2nuclear receptor subfamily 2, group F, member 20.044
Gdnfglial cell line derived neurotrophic factor0.044
Kiss1KiSS-1 metastasis-suppressor0.043
Lhcgrluteinizing hormone/choriogonadotropin receptor0.042
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.041
Rs1retinoschisis (X-linked, juvenile) 1 (human)0.041
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.040
Slc12a3solute carrier family 12, member 30.038
Aqp2aquaporin 20.038
Pcdh15protocadherin 150.037
Gpr98G protein-coupled receptor 980.036
Pgrprogesterone receptor0.036
Fbn1fibrillin 10.035
Agtr1aangiotensin II receptor, type 1a0.035
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.035
Slc17a1solute carrier family 17 (sodium phosphate), member 10.034
Ptpn5protein tyrosine phosphatase, non-receptor type 50.033
Pdgfbplatelet derived growth factor, B polypeptide0.033
FynFyn proto-oncogene0.033
Vegfavascular endothelial growth factor A0.031
Hnf4ahepatic nuclear factor 4, alpha0.030
Egr1early growth response 10.030
Shhsonic hedgehog0.029
Pscaprostate stem cell antigen0.029
Yap1yes-associated protein 10.029
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.029
Pecam1platelet/endothelial cell adhesion molecule 10.028
Gucy2cguanylate cyclase 2c0.028
Prkceprotein kinase C, epsilon0.027
Col4a3collagen, type IV, alpha 30.027
Drd2dopamine receptor D20.026
Prl2b1prolactin family 2, subfamily b, member 10.026
Mcammelanoma cell adhesion molecule0.026
IhhIndian hedgehog0.026
Adam17a disintegrin and metallopeptidase domain 170.025
SrcRous sarcoma oncogene0.025
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.024
Mkl2MKL/myocardin-like 20.024
Ren1renin 1 structural0.024
Dlg2discs, large homolog 2 (Drosophila)0.024
AI118078expressed sequence AI1180780.023
Eltd1EGF, latrophilin seven transmembrane domain containing 10.023
Guca2bguanylate cyclase activator 2b (retina)0.023
Apcadenomatosis polyposis coli0.022
Gabrr2gamma-aminobutyric acid (GABA) C receptor, subunit rho 20.022
Prap1proline-rich acidic protein 10.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Prl6a1prolactin family 6, subfamily a, member 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism