The network for 'negative regulation of hormone secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

NameDescriptionProbabilityFunc Analog Organism
per2period homolog 2 (Drosophila)0.382
igf3insulin-like growth factor 30.302
mchr1bmelanin-concentrating hormone receptor 1b0.278
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.239
mchr1amelanin-concentrating hormone receptor 1a0.235
uts1urotensin 10.202
drd2bdopamine receptor D2b0.192
gfra1agdnf family receptor alpha 1a0.177
nlgn1neuroligin 10.158
spry4sprouty (Drosophila) homolog 40.157
hcrthypocretin (orexin) neuropeptide precursor0.151
myh11amyosin, heavy polypeptide 11, smooth muscle a0.143
col7a1lcollagen type VII alpha 1-like0.143
fabp11afatty acid binding protein 11a0.126
ptgs2aprostaglandin-endoperoxide synthase 2a0.123
cldn2claudin 20.122
gfra1bgdnf family receptor alpha 1b0.116
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.114
bmp15bone morphogenetic protein 150.112
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.111
LOC100332193growth hormone secretagogue receptor type 1-like0.110
xgbx globin0.110
inhbaainhibin, beta Aa0.096
maomonoamine oxidase0.095
foxa3forkhead box A30.091
fshbfollicle stimulating hormone, beta polypeptide0.080
gsdfgonadal somatic cell derived factor0.078
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.077
tefthyrotroph embryonic factor0.074
pgrprogesterone receptor0.073
ncam2neural cell adhesion molecule 20.069
sst2somatostatin 20.069
glud1bglutamate dehydrogenase 1b0.068
gli2bGLI-Kruppel family member GLI2b0.066
drd2ldopamine receptor D2 like0.066
ghsragrowth hormone secretagogue receptor a0.062
hcrtr2hypocretin (orexin) receptor 20.062
dab1adisabled homolog 1a (Drosophila)0.055
dbhdopamine beta hydroxylase0.055
mtnr1bamelatonin receptor type 1B a0.054
rag2recombination activating gene 20.054
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.054
ddb2damage-specific DNA binding protein 20.053
paqr7bprogestin and adipoQ receptor family member VII, b0.053
ghrlghrelin/obestatin preprohormone0.053
uts2aurotensin 2, alpha0.051
tnfatumor necrosis factor a (TNF superfamily, member 2)0.050
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.049
neurog3neurogenin 30.049
kiss1rbKISS1 receptor b0.049
cry-dashcryptochrome DASH0.047
zp3zona pellucida glycoprotein 30.047
col4a6collagen, type IV, alpha 60.046
fshrfollicle stimulating hormone receptor0.046
prok2prokineticin 20.046
lhcgrluteinizing hormone/choriogonadotropin receptor0.046
mc4rmelanocortin 4 receptor0.046
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.045
or111-10odorant receptor, family D, subfamily 111, member 100.045
fzd7bfrizzled homolog 7b0.044
cry5cryptochrome 50.044
mef2amyocyte enhancer factor 2a0.043
mapk6mitogen-activated protein kinase 60.042
fanclFanconi anemia, complementation group L0.042
mc2rmelanocortin 2 receptor0.041
cpla2cytosolic phospholipase a20.041
LOC100003330melanocortin-2 receptor accessory protein 2-like0.041
aldobaldolase b, fructose-bisphosphate0.039
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.039
hoxc12bhomeo box C12b0.038
htr1ab5-hydroxytryptamine (serotonin) receptor 1A b0.038
ryr2aryanodine receptor 2a (cardiac)0.037
gata6GATA-binding protein 60.037
th2tyrosine hydroxylase 20.037
ddcdopa decarboxylase0.036
cry1bcryptochrome 1b0.035
gcm2glial cells missing homolog 2 (Drosophila)0.035
ptgeslprostaglandin E synthase 2-like0.034
bcl2l1bcl2-like 10.034
hspb6heat shock protein, alpha-crystallin-related, b60.033
tlr3toll-like receptor 30.033
oprk1opioid receptor, kappa 10.033
dedd1death effector domain-containing 10.033
inhainhibin, alpha0.033
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.032
gdf11growth differentiation factor 110.032
vipr2vasoactive intestinal peptide receptor 20.032
npas2neuronal PAS domain protein 20.031
trpv6transient receptor potential cation channel, subfamily V, member 60.031
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.030
duoxdual oxidase0.029
krt18keratin 180.029
ap1m2adaptor-related protein complex 1, mu 2 subunit0.028
chatcholine acetyltransferase0.028
LOC799612prolactin 20.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Irk3Inwardly rectifying potassium channel 30.017
foxoforkhead box, sub-group O0.014
Eip63F-1Ecdysone-induced protein 63F 10.011
Pde8Phosphodiesterase 80.010
Pink1PTEN-induced putative kinase 10.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC2histone deacetylase 20.608
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.548
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.545
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.357
ADORA2Aadenosine A2a receptor0.298
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.266
LIN7Blin-7 homolog B (C. elegans)0.264
MPDZmultiple PDZ domain protein0.259
MED15mediator complex subunit 150.254
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.243
CRHR1corticotropin releasing hormone receptor 10.232
CRHcorticotropin releasing hormone0.140
IL1R1interleukin 1 receptor, type I0.129
GRB10growth factor receptor-bound protein 100.124
SIRT1sirtuin 10.099
PTPN1protein tyrosine phosphatase, non-receptor type 10.068
VAC14Vac14 homolog (S. cerevisiae)0.062
BMPR1Bbone morphogenetic protein receptor, type IB0.061
ZNF746zinc finger protein 7460.060
IL6Rinterleukin 6 receptor0.060
IRS1insulin receptor substrate 10.056
DLG4discs, large homolog 4 (Drosophila)0.056
INSRinsulin receptor0.050
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.049
SIN3ASIN3 homolog A, transcription regulator (yeast)0.047
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.047
IGF1Rinsulin-like growth factor 1 receptor0.041
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.036
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.035
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.033
NSFN-ethylmaleimide-sensitive factor0.031
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.031
PTENphosphatase and tensin homolog0.023
CHRNA4cholinergic receptor, nicotinic, alpha 40.023
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.023
GAB1GRB2-associated binding protein 10.023
KCNJ11potassium inwardly-rectifying channel, subfamily J, member 110.022
IL1RAPinterleukin 1 receptor accessory protein0.020
RBBP7retinoblastoma binding protein 70.020
BMP8Abone morphogenetic protein 8a0.019
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.018
IL8interleukin 80.018
PINK1PTEN induced putative kinase 10.018
FRS2fibroblast growth factor receptor substrate 20.018
GJD2gap junction protein, delta 2, 36kDa0.017
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.016
FGF18fibroblast growth factor 180.016
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.016
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.016
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.015
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.015
KCNJ16potassium inwardly-rectifying channel, subfamily J, member 160.015
KRTAP4-12keratin associated protein 4-120.014
SH2B1SH2B adaptor protein 10.014
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.013
LIFRleukemia inhibitory factor receptor alpha0.013
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.013
MAGEA11melanoma antigen family A, 110.013
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.013
PDCD2programmed cell death 20.013
RCOR1REST corepressor 10.012
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.012
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.012
WNT2wingless-type MMTV integration site family member 20.012
MTNR1Amelatonin receptor 1A0.011
GPR6G protein-coupled receptor 60.011
SCTRsecretin receptor0.011
COL2A1collagen, type II, alpha 10.011
FOXO3forkhead box O30.011
IL1RNinterleukin 1 receptor antagonist0.011
SHC1SHC (Src homology 2 domain containing) transforming protein 10.011
PTPRNprotein tyrosine phosphatase, receptor type, N0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arntlaryl hydrocarbon receptor nuclear translocator-like0.985
Clockcircadian locomotor output cycles kaput0.978
Insrinsulin receptor0.896
Esr1estrogen receptor 1 (alpha)0.810
Nos3nitric oxide synthase 3, endothelial cell0.781
Per2period homolog 2 (Drosophila)0.729
Nos2nitric oxide synthase 2, inducible0.678
Nr3c1nuclear receptor subfamily 3, group C, member 10.594
Esr2estrogen receptor 2 (beta)0.561
Apcadenomatosis polyposis coli0.388
Cry1cryptochrome 1 (photolyase-like)0.368
Cry2cryptochrome 2 (photolyase-like)0.331
Leprleptin receptor0.266
LOC100048884novel member of the major urinary protein (Mup) gene family0.260
Ghrgrowth hormone receptor0.229
Fshrfollicle stimulating hormone receptor0.219
Mup19major urinary protein 190.212
Mup10major urinary protein 100.181
Ptgs2prostaglandin-endoperoxide synthase 20.169
Tnftumor necrosis factor0.168
Mup1major urinary protein 10.152
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.149
Ccl2chemokine (C-C motif) ligand 20.143
Mup12major urinary protein 120.139
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.121
Nos1nitric oxide synthase 1, neuronal0.112
Mup8major urinary protein 80.102
Ppargperoxisome proliferator activated receptor gamma0.100
Bglapbone gamma carboxyglutamate protein0.099
Pim3proviral integration site 30.096
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.092
Fgf8fibroblast growth factor 80.089
Mup4major urinary protein 40.089
Ctnnb1catenin (cadherin associated protein), beta 10.087
Mup11major urinary protein 110.086
Mup5major urinary protein 50.083
Smad3MAD homolog 3 (Drosophila)0.081
Mup9major urinary protein 90.081
Gata4GATA binding protein 40.081
Mup14major urinary protein 140.076
Mup17major urinary protein 170.072
Mup13major urinary protein 130.072
Bmpr1abone morphogenetic protein receptor, type 1A0.069
Plin1perilipin 10.066
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.066
Mup7major urinary protein 70.065
Gnrh1gonadotropin releasing hormone 10.063
Il1ainterleukin 1 alpha0.062
Tgfbr2transforming growth factor, beta receptor II0.062
Col1a1collagen, type I, alpha 10.060
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.060
Stat3signal transducer and activator of transcription 30.059
Prlrprolactin receptor0.058
Mup15major urinary protein 150.057
Per1period homolog 1 (Drosophila)0.056
LOC100048885major urinary protein LOC1000488850.056
Mup2major urinary protein 20.054
Mup3major urinary protein 30.053
Tlr2toll-like receptor 20.052
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.052
Il1r1interleukin 1 receptor, type I0.050
Thrathyroid hormone receptor alpha0.050
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.049
Plcg1phospholipase C, gamma 10.047
Vegfavascular endothelial growth factor A0.047
Ptpn11protein tyrosine phosphatase, non-receptor type 110.044
Kiss1KiSS-1 metastasis-suppressor0.044
Crhcorticotropin releasing hormone0.043
Arandrogen receptor0.042
Prkg1protein kinase, cGMP-dependent, type I0.042
Svs5seminal vesicle secretory protein 50.042
Ptenphosphatase and tensin homolog0.041
Nf1neurofibromatosis 10.041
Cav1caveolin 1, caveolae protein0.039
Socs1suppressor of cytokine signaling 10.039
Sfrp2secreted frizzled-related protein 20.038
Cideccell death-inducing DFFA-like effector c0.038
Ighimmunoglobulin heavy chain complex0.036
Cd70CD70 antigen0.035
Inhbainhibin beta-A0.035
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.034
Adipoqadiponectin, C1Q and collagen domain containing0.034
Tgfb1transforming growth factor, beta 10.034
Irs2insulin receptor substrate 20.033
Il1binterleukin 1 beta0.033
Pnpla2patatin-like phospholipase domain containing 20.033
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.032
Itgb1integrin beta 1 (fibronectin receptor beta)0.032
Casrcalcium-sensing receptor0.032
Apoeapolipoprotein E0.031
Sstr3somatostatin receptor 30.031
Csf1colony stimulating factor 1 (macrophage)0.030
Cd80CD80 antigen0.029
Cps1carbamoyl-phosphate synthetase 10.027
Orm2orosomucoid 20.027
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.110
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.110
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.090
Phkg1phosphorylase kinase, gamma 10.087
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.077
Fgf16fibroblast growth factor 160.077
Abcc8ATP-binding cassette, subfamily C (CFTR/MRP), member 80.077
Glp1rglucagon-like peptide 1 receptor0.075
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.069
Pla2g5phospholipase A2, group V0.067
Ins2insulin 20.063
Olr1696olfactory receptor 16960.063
Aldh6a1aldehyde dehydrogenase 6 family, member A10.062
Apoa4apolipoprotein A-IV0.062
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.058
Gipgastric inhibitory polypeptide0.058
Grifingalectin-related inter-fiber protein0.058
Sox17SRY (sex determining region Y)-box 170.056
Hcrtr1hypocretin (orexin) receptor 10.056
Avparginine vasopressin0.054
Adrb1adrenergic, beta-1-, receptor0.053
Mapk15mitogen-activated protein kinase 150.052
Egr4early growth response 40.052
Adam1aa disintegrin and metallopeptidase domain 1a0.049
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.049
MrgprfMAS-related GPR, member F0.048
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.046
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.046
Tacr1tachykinin receptor 10.045
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.045
Hand1heart and neural crest derivatives expressed 10.045
Trhr2thyrotropin releasing hormone receptor 20.045
Trim17tripartite motif-containing 170.044
Pax6paired box 60.043
Hrh2histamine receptor H 20.043
Necab2N-terminal EF-hand calcium binding protein 20.042
Lim2lens intrinsic membrane protein 20.042
Sdc3syndecan 30.042
Slc4a3solute carrier family 4 (anion exchanger), member 30.042
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.042
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.041
Hbzhemoglobin, zeta0.040
Crhbpcorticotropin releasing hormone binding protein0.040
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.040
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.040
Cyp51cytochrome P450, family 510.039
GperG protein-coupled estrogen receptor 10.038
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.038
Drd1adopamine receptor D1A0.038
RGD1309821similar to KIAA1161 protein0.037
Prph2peripherin 20.036
Adcyap1adenylate cyclase activating polypeptide 10.036
Tpcr12putative olfactory receptor0.036
Nr4a3nuclear receptor subfamily 4, group A, member 30.036
Rxrgretinoid X receptor gamma0.036
Hcrtr2hypocretin (orexin) receptor 20.035
Necab1N-terminal EF-hand calcium binding protein 10.035
Chrna7cholinergic receptor, nicotinic, alpha 70.035
Syt4synaptotagmin IV0.035
Adora1adenosine A1 receptor0.035
Vipvasoactive intestinal peptide0.034
Tas2r126taste receptor, type 2, member 1260.034
Pnma1paraneoplastic antigen MA10.034
Phox2apaired-like homeobox 2a0.034
Mospd4motile sperm domain containing 40.034
Kcnk3potassium channel, subfamily K, member 30.034
Fasnfatty acid synthase0.033
Mchr1melanin-concentrating hormone receptor 10.033
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.033
Adora2aadenosine A2a receptor0.033
Hpcal4hippocalcin-like 40.033
Htr65-hydroxytryptamine (serotonin) receptor 60.033
Cgm4carcinoembryonic antigen gene family 40.032
Pspparotid secretory protein0.032
Rgs9regulator of G-protein signaling 90.032
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.032
Notch3Notch homolog 3 (Drosophila)0.032
Ghrgrowth hormone receptor0.031
Teddm1transmembrane epididymal protein 10.031
Hrh3histamine receptor H30.031
Syt8synaptotagmin VIII0.031
Col10a1collagen, type X, alpha 10.031
Gpr6G protein-coupled receptor 60.030
Gdf9growth differentiation factor 90.030
Afap1actin filament associated protein 10.030
Rab3bRAB3B, member RAS oncogene family0.029
Rhobtb2Rho-related BTB domain containing 20.029
Mc5rmelanocortin 5 receptor0.029
Neu2sialidase 2 (cytosolic sialidase)0.028
Fbxo2F-box protein 20.028
Cacng4calcium channel, voltage-dependent, gamma subunit 40.028
Sqlesqualene epoxidase0.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism