The network for 'negative regulation of extrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
bcl2l1bcl2-like 10.546
kdrlkinase insert domain receptor like0.466
mcl1amyeloid cell leukemia sequence 1a0.363
nrp2aneuropilin 2a0.328
nrg2aneuregulin 2a0.251
osr1odd-skipped related 1 (Drosophila)0.227
dlx2adistal-less homeobox gene 2a0.221
pax7bpaired box gene 7b0.199
hbae1hemoglobin alpha embryonic-10.188
frem3Fras1 related extracellular matrix 30.177
tbx22T-box 220.167
ntn2netrin 20.162
hmx2H6 family homeobox 20.152
fzd7bfrizzled homolog 7b0.145
hoxa13ahomeo box A13a0.144
cav1caveolin 10.133
gyltl1bglycosyltransferase-like 1b0.131
mcl1bmyeloid cell leukemia sequence 1b0.127
osr2odd-skipped related 2 (Drosophila)0.126
hbbe3hemoglobin beta embryonic-30.124
plxna4plexin A40.115
cmybtranscription factor cmyb0.114
foxc1aforkhead box C1a0.112
pcnaproliferating cell nuclear antigen0.112
lhx2bLIM homeobox 2b0.105
lcp1lymphocyte cytosolic plastin 10.105
runx1runt-related transcription factor 10.101
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.097
mapk6mitogen-activated protein kinase 60.097
hbbe1.1hemoglobin beta embryonic-1.10.097
fggfibrinogen, gamma polypeptide0.096
il6rinterleukin 6 receptor0.093
per3period homolog 3 (Drosophila)0.093
dusp1dual specificity phosphatase 10.090
notch3notch homolog 30.090
cdh23cadherin-like 230.089
cdh5cadherin 50.089
baxabcl2-associated X protein, a0.087
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.085
lmx1b.1LIM homeobox transcription factor 1, beta 10.085
zmynd11zinc finger, MYND domain containing 110.085
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.082
tnfatumor necrosis factor a (TNF superfamily, member 2)0.082
hbae3hemoglobin alpha embryonic-30.081
igf1rbinsulin-like growth factor 1b receptor0.080
hmgb2ahigh-mobility group box 2a0.080
aldh7a1aldehyde dehydrogenase 7 family, member A10.077
mapk4mitogen-activated protein kinase 40.077
sulf1sulfatase 10.075
myhz2myosin, heavy polypeptide 2, fast muscle specific0.075
evx1even-skipped homeobox 10.074
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.074
itgb3bintegrin beta 3b0.073
lef1lymphocyte enhancer binding factor 10.072
dctdopachrome tautomerase0.072
prdm16PR domain containing 160.072
epha4aeph receptor A4a0.071
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.070
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.069
nrg2bneuregulin 2b0.066
cbr1lcarbonyl reductase 1-like0.066
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.065
vat1vesicle amine transport protein 1 homolog (T californica)0.065
txnrd1thioredoxin reductase 10.065
sh3gl1bSH3-domain GRB2-like 1b0.064
scrt1ascratch homolog 1, zinc finger protein a (Drosophila)0.064
slit3slit (Drosophila) homolog 30.062
cntn2contactin 20.061
hmgb2bhigh-mobility group box 2b0.061
pak1p21/Cdc42/Rac1-activated kinase 10.061
pcdh18bprotocadherin 18b0.060
trpm7transient receptor potential cation channel, subfamily M, member 70.059
mapk3mitogen-activated protein kinase 30.059
efnb2aephrin B2a0.058
LOC797832similar to signal peptide, CUB domain, EGF-like 10.058
LOC567131calcitonin gene-related peptide type 1 receptor-like0.058
stc1lstanniocalcin 1, like0.057
csf3rcolony stimulating factor 3 receptor (granulocyte)0.056
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.056
adh5alcohol dehydrogenase 50.055
col4a2collagen, type IV, alpha 20.055
sox9aSRY-box containing gene 9a0.054
hgfbhepatocyte growth factor b0.054
nos1nitric oxide synthase 1 (neuronal)0.054
ptgs1prostaglandin-endoperoxide synthase 10.054
wnt10awingless-type MMTV integration site family, member 10a0.054
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.053
sgk1serum/glucocorticoid regulated kinase 10.052
h3f3aH3 histone, family 3A0.052
tfectranscription factor EC0.051
prdx2peroxiredoxin 20.050
kitakit receptor a0.050
nrp1aneuropilin 1a0.049
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.049
sfrp1bsecreted frizzled-related protein 1b0.049
hic1hypermethylated in cancer 10.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
BCL2L1BCL2-like 11.000
BIRC3baculoviral IAP repeat containing 30.999
FHL2four and a half LIM domains 20.999
FLNAfilamin A, alpha0.996
TRAF1TNF receptor-associated factor 10.994
BIRC2baculoviral IAP repeat containing 20.994
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.994
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.991
BCL2B-cell CLL/lymphoma 20.990
CASP8caspase 8, apoptosis-related cysteine peptidase0.989
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.989
HCKhemopoietic cell kinase0.984
FN1fibronectin 10.984
TRAF6TNF receptor-associated factor 60.981
BCL2L11BCL2-like 11 (apoptosis facilitator)0.976
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.967
IL8interleukin 80.964
TEKTEK tyrosine kinase, endothelial0.963
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.958
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.953
HSPA1Bheat shock 70kDa protein 1B0.948
FYNFYN oncogene related to SRC, FGR, YES0.947
PMLpromyelocytic leukemia0.929
BAXBCL2-associated X protein0.923
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.919
TAL1T-cell acute lymphocytic leukemia 10.918
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.903
BADBCL2-associated agonist of cell death0.901
FASFas (TNF receptor superfamily, member 6)0.898
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.895
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.881
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.879
PTPN1protein tyrosine phosphatase, non-receptor type 10.867
NRP1neuropilin 10.856
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.856
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.848
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.829
TP53BP2tumor protein p53 binding protein, 20.822
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.821
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.816
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.811
IL1Binterleukin 1, beta0.801
XIAPX-linked inhibitor of apoptosis0.798
MAP3K3mitogen-activated protein kinase kinase kinase 30.768
CXCL2chemokine (C-X-C motif) ligand 20.767
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.757
FGBfibrinogen beta chain0.753
VEGFAvascular endothelial growth factor A0.733
GRB2growth factor receptor-bound protein 20.699
HSPA1Aheat shock 70kDa protein 1A0.699
FADDFas (TNFRSF6)-associated via death domain0.686
TGFB1transforming growth factor, beta 10.675
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.668
BIDBH3 interacting domain death agonist0.668
MAPK8mitogen-activated protein kinase 80.657
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.656
IL1R1interleukin 1 receptor, type I0.649
TNFtumor necrosis factor0.647
TGIF1TGFB-induced factor homeobox 10.642
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.641
FLNBfilamin B, beta0.635
PSEN1presenilin 10.621
CCL20chemokine (C-C motif) ligand 200.590
FGAfibrinogen alpha chain0.589
CCL2chemokine (C-C motif) ligand 20.587
TRAF3TNF receptor-associated factor 30.585
TP53tumor protein p530.584
VCAM1vascular cell adhesion molecule 10.581
BMP2bone morphogenetic protein 20.572
IL6interleukin 6 (interferon, beta 2)0.567
BCL3B-cell CLL/lymphoma 30.562
IRAK1interleukin-1 receptor-associated kinase 10.560
PSME2proteasome (prosome, macropain) activator subunit 2 (PA28 beta)0.556
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.544
ICAM1intercellular adhesion molecule 10.527
SH3KBP1SH3-domain kinase binding protein 10.505
SMAD7SMAD family member 70.503
TRADDTNFRSF1A-associated via death domain0.499
TGFBR1transforming growth factor, beta receptor 10.487
FKBP1AFK506 binding protein 1A, 12kDa0.475
CD63CD63 molecule0.468
CXCL5chemokine (C-X-C motif) ligand 50.455
SHC1SHC (Src homology 2 domain containing) transforming protein 10.437
CALCOCO2calcium binding and coiled-coil domain 20.431
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.420
TNFAIP3tumor necrosis factor, alpha-induced protein 30.415
PLAURplasminogen activator, urokinase receptor0.410
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.401
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.397
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.388
TRAF2TNF receptor-associated factor 20.388
SOD1superoxide dismutase 1, soluble0.386
CXCL3chemokine (C-X-C motif) ligand 30.386
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)0.373
TLN1talin 10.370
CASP10caspase 10, apoptosis-related cysteine peptidase0.369
THBS1thrombospondin 10.366
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 11.000
Tnftumor necrosis factor0.999
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.999
Itgb1integrin beta 1 (fibronectin receptor beta)0.998
Ctnnb1catenin (cadherin associated protein), beta 10.996
Trp53transformation related protein 530.989
Fbn1fibrillin 10.975
Ptgs2prostaglandin-endoperoxide synthase 20.974
Mmp9matrix metallopeptidase 90.968
Ptenphosphatase and tensin homolog0.956
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.952
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.951
Notch2Notch gene homolog 2 (Drosophila)0.944
Esr1estrogen receptor 1 (alpha)0.939
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.936
Map3k14mitogen-activated protein kinase kinase kinase 140.935
Ikzf1IKAROS family zinc finger 10.933
Tlr4toll-like receptor 40.916
FasFas (TNF receptor superfamily member 6)0.915
Lyz2lysozyme 20.915
Thbs1thrombospondin 10.913
Apcadenomatosis polyposis coli0.908
Vegfavascular endothelial growth factor A0.902
Ifnginterferon gamma0.897
Nos2nitric oxide synthase 2, inducible0.889
Nos1nitric oxide synthase 1, neuronal0.888
Runx1runt related transcription factor 10.882
Cd44CD44 antigen0.875
Il10interleukin 100.870
Csf1colony stimulating factor 1 (macrophage)0.856
Nos3nitric oxide synthase 3, endothelial cell0.838
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.817
Tnfaip3tumor necrosis factor, alpha-induced protein 30.815
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.807
Foxp3forkhead box P30.786
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.761
Ccl2chemokine (C-C motif) ligand 20.734
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.715
Ccr1chemokine (C-C motif) receptor 10.698
Ptpn11protein tyrosine phosphatase, non-receptor type 110.689
Ighimmunoglobulin heavy chain complex0.688
Smad3MAD homolog 3 (Drosophila)0.684
Kitkit oncogene0.668
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.652
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.640
Efnb2ephrin B20.600
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.572
Tgfbr2transforming growth factor, beta receptor II0.562
Loxlysyl oxidase0.553
Ccr2chemokine (C-C motif) receptor 20.548
Retret proto-oncogene0.514
Arandrogen receptor0.514
Ptk2PTK2 protein tyrosine kinase 20.509
Kitlkit ligand0.491
Notch1Notch gene homolog 1 (Drosophila)0.482
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.466
Lmnalamin A0.459
Sfrp2secreted frizzled-related protein 20.454
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.448
Ltalymphotoxin A0.443
Nf1neurofibromatosis 10.442
Il2rginterleukin 2 receptor, gamma chain0.439
Yap1yes-associated protein 10.435
Gclmglutamate-cysteine ligase, modifier subunit0.418
Tgfb1transforming growth factor, beta 10.416
Gclcglutamate-cysteine ligase, catalytic subunit0.413
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.413
Snai1snail homolog 1 (Drosophila)0.409
Ldlrlow density lipoprotein receptor0.402
Itgalintegrin alpha L0.388
Inpp5dinositol polyphosphate-5-phosphatase D0.385
Hif1ahypoxia inducible factor 1, alpha subunit0.384
Il18rapinterleukin 18 receptor accessory protein0.370
Meox2mesenchyme homeobox 20.364
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.356
Wwtr1WW domain containing transcription regulator 10.344
Gdnfglial cell line derived neurotrophic factor0.341
Apoeapolipoprotein E0.340
Plauplasminogen activator, urokinase0.332
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.327
Gpr132G protein-coupled receptor 1320.326
Ctnna1catenin (cadherin associated protein), alpha 10.325
Leprleptin receptor0.324
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.319
Bmpr1abone morphogenetic protein receptor, type 1A0.304
Cyldcylindromatosis (turban tumor syndrome)0.304
Tnctenascin C0.303
Insrinsulin receptor0.298
Egfrepidermal growth factor receptor0.297
Acvr1activin A receptor, type 10.294
Bcl2B-cell leukemia/lymphoma 20.288
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.283
Elk4ELK4, member of ETS oncogene family0.282
Itgb3integrin beta 30.276
Selpselectin, platelet0.274
Smad4MAD homolog 4 (Drosophila)0.273
Gja1gap junction protein, alpha 10.271
Adam17a disintegrin and metallopeptidase domain 170.266
Amhr2anti-Mullerian hormone type 2 receptor0.265
Tlr2toll-like receptor 20.262
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sirpasignal-regulatory protein alpha0.376
Leprleptin receptor0.163
Fgfr2fibroblast growth factor receptor 20.149
Prdm2PR domain containing 2, with ZNF domain0.137
Mpripmyosin phosphatase Rho interacting protein0.113
Dock8dedicator of cytokinesis 80.110
Ptafrplatelet-activating factor receptor0.110
Vat1vesicle amine transport protein 1 homolog (T californica)0.101
Nfibnuclear factor I/B0.096
Ptprcprotein tyrosine phosphatase, receptor type, C0.095
Gnrhrgonadotropin releasing hormone receptor0.094
Fgafibrinogen alpha chain0.093
Cd14CD14 molecule0.092
Il1binterleukin 1 beta0.088
Cd86CD86 molecule0.080
F2rl1coagulation factor II (thrombin) receptor-like 10.079
Anxa5annexin A50.079
Itgamintegrin, alpha M0.070
Prkcdprotein kinase C, delta0.070
Il1ainterleukin 1 alpha0.070
Ptgfrprostaglandin F receptor0.069
Anxa2annexin A20.069
Olaholeoyl-ACP hydrolase0.068
TcrbT-cell receptor beta chain0.067
Adora2aadenosine A2a receptor0.067
Tmsb10thymosin, beta 100.066
Ptpn7protein tyrosine phosphatase, non-receptor type 70.064
Smad7SMAD family member 70.064
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.061
Creb1cAMP responsive element binding protein 10.060
Ccl3chemokine (C-C motif) ligand 30.058
Cfpcomplement factor properdin0.057
Csf1colony stimulating factor 1 (macrophage)0.057
Ptpn6protein tyrosine phosphatase, non-receptor type 60.057
Smad1SMAD family member 10.056
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.054
Adrbk1adrenergic, beta, receptor kinase 10.053
Slc12a4solute carrier family 12 (potassium/chloride transporters), member 40.051
Marcksmyristoylated alanine rich protein kinase C substrate0.051
Metrnlmeteorin, glial cell differentiation regulator-like0.051
Metmet proto-oncogene0.050
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.047
Gja5gap junction protein, alpha 50.047
Cd37CD37 molecule0.046
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.046
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.045
Il1rl1interleukin 1 receptor-like 10.045
Cd9CD9 molecule0.044
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.044
Sprnshadow of prion protein homolog (zebrafish)0.044
Slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.044
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.043
Zbp1Z-DNA binding protein 10.043
Il18interleukin 180.042
Apobapolipoprotein B0.042
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.042
Ftlferritin, light polypeptide0.042
Fgf5fibroblast growth factor 50.041
Neurl3neuralized homolog 3 (Drosophila)0.041
Gzmmgranzyme M (lymphocyte met-ase 1)0.041
Fggfibrinogen gamma chain0.040
Capgcapping protein (actin filament), gelsolin-like0.040
Arpc1bactin related protein 2/3 complex, subunit 1B0.039
Hbp1HMG-box transcription factor 10.039
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.039
Tcf4transcription factor 40.038
Nrp1neuropilin 10.038
Mov10Moloney leukemia virus 100.038
Trhr2thyrotropin releasing hormone receptor 20.037
Nfianuclear factor I/A0.037
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.036
Litaflipopolysaccharide-induced TNF factor0.036
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.036
Pttg1ippituitary tumor-transforming 1 interacting protein0.036
Anxa1annexin A10.035
Pde6dphosphodiesterase 6D, cGMP-specific, rod, delta0.035
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.035
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.035
Ggt1gamma-glutamyltransferase 10.035
Ednrbendothelin receptor type B0.034
Timp2TIMP metallopeptidase inhibitor 20.034
Pde3aphosphodiesterase 3A, cGMP inhibited0.034
Cxcl10chemokine (C-X-C motif) ligand 100.033
Hckhemopoietic cell kinase0.033
Ddr1discoidin domain receptor tyrosine kinase 10.033
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.033
Sellselectin L0.033
RT1-DaRT1 class II, locus Da0.032
Icam1intercellular adhesion molecule 10.032
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.032
Ccl4chemokine (C-C motif) ligand 40.032
Cfdcomplement factor D (adipsin)0.032
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.031
Slc22a13solute carrier family 22 (organic anion transporter), member 130.031
Hspb1heat shock protein 10.031
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism