The network for 'positive regulation of fatty acid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of fatty acid metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
INSRinsulin receptor0.960
SMURF2SMAD specific E3 ubiquitin protein ligase 20.940
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.843
PEX19peroxisomal biogenesis factor 190.684
NOXA1NADPH oxidase activator 10.516
GRB10growth factor receptor-bound protein 100.451
PPARGperoxisome proliferator-activated receptor gamma0.427
HNF4Ahepatocyte nuclear factor 4, alpha0.369
IGF1Rinsulin-like growth factor 1 receptor0.364
RARAretinoic acid receptor, alpha0.313
RXRAretinoid X receptor, alpha0.303
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.257
SMAD4SMAD family member 40.212
ESRRGestrogen-related receptor gamma0.190
NEDD4neural precursor cell expressed, developmentally down-regulated 40.178
NCF1neutrophil cytosolic factor 10.171
FBXL15F-box and leucine-rich repeat protein 150.160
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.158
NCOR2nuclear receptor corepressor 20.137
SETD8SET domain containing (lysine methyltransferase) 80.108
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.105
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.101
PRKCZprotein kinase C, zeta0.091
ZFYVE9zinc finger, FYVE domain containing 90.089
ALBalbumin0.068
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.066
WWP1WW domain containing E3 ubiquitin protein ligase 10.061
NCOA1nuclear receptor coactivator 10.055
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.054
HPhaptoglobin0.053
SUFUsuppressor of fused homolog (Drosophila)0.051
SQSTM1sequestosome 10.050
CDCP1CUB domain containing protein 10.044
PROX1prospero homeobox 10.036
PEX14peroxisomal biogenesis factor 140.034
APOC1apolipoprotein C-I0.033
IRS1insulin receptor substrate 10.030
PEX11Bperoxisomal biogenesis factor 11 beta0.030
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.029
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.027
RUNX1runt-related transcription factor 10.027
EDF1endothelial differentiation-related factor 10.026
APOA2apolipoprotein A-II0.025
CYBAcytochrome b-245, alpha polypeptide0.024
APOC3apolipoprotein C-III0.024
SH2B1SH2B adaptor protein 10.024
APOEapolipoprotein E0.024
PDX1pancreatic and duodenal homeobox 10.023
ANKRD13Aankyrin repeat domain 13A0.023
PGRMC1progesterone receptor membrane component 10.023
SHC1SHC (Src homology 2 domain containing) transforming protein 10.022
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.021
APOA1apolipoprotein A-I0.020
SH3RF1SH3 domain containing ring finger 10.019
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.019
GATA2GATA binding protein 20.018
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.017
BADBCL2-associated agonist of cell death0.017
XPO7exportin 70.017
PEX3peroxisomal biogenesis factor 30.017
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.016
PEX16peroxisomal biogenesis factor 160.016
MED25mediator complex subunit 250.016
TSC22D1TSC22 domain family, member 10.016
CREBBPCREB binding protein0.016
TRIM9tripartite motif containing 90.016
IRS2insulin receptor substrate 20.015
GLI1GLI family zinc finger 10.015
GATA1GATA binding protein 1 (globin transcription factor 1)0.015
LCATlecithin-cholesterol acyltransferase0.015
CCL14chemokine (C-C motif) ligand 140.014
SREBF2sterol regulatory element binding transcription factor 20.014
WWP2WW domain containing E3 ubiquitin protein ligase 20.014
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.014
PDPK13-phosphoinositide dependent protein kinase-10.014
PRKCBprotein kinase C, beta0.013
SH3KBP1SH3-domain kinase binding protein 10.013
PEX26peroxisomal biogenesis factor 260.013
MYOD1myogenic differentiation 10.013
OPTNoptineurin0.013
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.013
PXMP2peroxisomal membrane protein 2, 22kDa0.012
JUNjun proto-oncogene0.012
APOBapolipoprotein B (including Ag(x) antigen)0.011
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.011
F11RF11 receptor0.011
XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble0.011
SMURF1SMAD specific E3 ubiquitin protein ligase 10.010
PICK1protein interacting with PRKCA 10.010
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.010
STAT5Bsignal transducer and activator of transcription 5B0.010
TRAF4TNF receptor-associated factor 40.010
PRKCAprotein kinase C, alpha0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
C1qacomplement component 1, q subcomponent, alpha polypeptide0.896
Lepleptin0.842
C1qccomplement component 1, q subcomponent, C chain0.824
C1qbcomplement component 1, q subcomponent, beta polypeptide0.617
Leprleptin receptor0.577
Pnpla2patatin-like phospholipase domain containing 20.565
Ppargperoxisome proliferator activated receptor gamma0.525
Ly86lymphocyte antigen 860.371
Cav1caveolin 1, caveolae protein0.302
Ghrgrowth hormone receptor0.284
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.228
Nos1nitric oxide synthase 1, neuronal0.210
Insrinsulin receptor0.180
TyrobpTYRO protein tyrosine kinase binding protein0.136
Plin1perilipin 10.136
Npc1Niemann Pick type C10.118
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.116
Apoa1apolipoprotein A-I0.112
Rxrgretinoid X receptor gamma0.110
Apoeapolipoprotein E0.108
Rxraretinoid X receptor alpha0.080
Nr0b2nuclear receptor subfamily 0, group B, member 20.077
Prlrprolactin receptor0.073
Esr1estrogen receptor 1 (alpha)0.072
Agpat21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)0.071
Kiss1KiSS-1 metastasis-suppressor0.063
Col1a1collagen, type I, alpha 10.062
Ctsscathepsin S0.060
Akt1thymoma viral proto-oncogene 10.055
Nr5a1nuclear receptor subfamily 5, group A, member 10.052
Aif1allograft inflammatory factor 10.051
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.051
Cideccell death-inducing DFFA-like effector c0.048
Abhd5abhydrolase domain containing 50.047
Klklotho0.047
Arandrogen receptor0.046
Agtr1aangiotensin II receptor, type 1a0.045
Igf1insulin-like growth factor 10.044
Csf1rcolony stimulating factor 1 receptor0.043
Hnf4ahepatic nuclear factor 4, alpha0.043
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.042
Otcornithine transcarbamylase0.042
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.040
Lhcgrluteinizing hormone/choriogonadotropin receptor0.040
C4bcomplement component 4B (Childo blood group)0.040
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.038
Apoc4apolipoprotein C-IV0.038
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.036
Dmgdhdimethylglycine dehydrogenase precursor0.036
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.035
Nr1h4nuclear receptor subfamily 1, group H, member 40.032
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.031
Cyldcylindromatosis (turban tumor syndrome)0.030
Apohapolipoprotein H0.030
Ahsgalpha-2-HS-glycoprotein0.029
Nr3c1nuclear receptor subfamily 3, group C, member 10.028
F2coagulation factor II0.028
Tgfb1transforming growth factor, beta 10.027
Nos3nitric oxide synthase 3, endothelial cell0.027
Mark2MAP/microtubule affinity-regulating kinase 20.027
Aldobaldolase B, fructose-bisphosphate0.026
Nrxn1neurexin I0.025
Fgafibrinogen alpha chain0.025
Serpina1eserine (or cysteine) peptidase inhibitor, clade A, member 1E0.024
Adipoqadiponectin, C1Q and collagen domain containing0.023
Gcgroup specific component0.023
Irs2insulin receptor substrate 20.023
Rnf11ring finger protein 110.023
Thrathyroid hormone receptor alpha0.022
G6pcglucose-6-phosphatase, catalytic0.022
Nrxn3neurexin III0.021
Mapk14mitogen-activated protein kinase 140.021
Nr1h3nuclear receptor subfamily 1, group H, member 30.021
F12coagulation factor XII (Hageman factor)0.021
Scd1stearoyl-Coenzyme A desaturase 10.020
Gcgrglucagon receptor0.020
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.020
Apoa4apolipoprotein A-IV0.019
Csf1colony stimulating factor 1 (macrophage)0.019
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.018
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 20.018
Pparaperoxisome proliferator activated receptor alpha0.018
Arntlaryl hydrocarbon receptor nuclear translocator-like0.017
Plin4perilipin 40.017
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.017
C3complement component 30.017
Ppargc1bperoxisome proliferative activated receptor, gamma, coactivator 1 beta0.016
Cdkn1bcyclin-dependent kinase inhibitor 1B0.016
Agtr2angiotensin II receptor, type 20.016
Tmem64transmembrane protein 640.016
Apobapolipoprotein B0.016
Mrc1mannose receptor, C type 10.015
Rdh7retinol dehydrogenase 70.015
Egfrepidermal growth factor receptor0.015
Gnrh1gonadotropin releasing hormone 10.015
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.015
Azgp1alpha-2-glycoprotein 1, zinc0.015
Mrapmelanocortin 2 receptor accessory protein0.015
Neurog3neurogenin 30.014
Slc22a1solute carrier family 22 (organic cation transporter), member 10.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lgals3lectin, galactoside-binding, soluble, 30.152
S100a11S100 calcium binding protein A11 (calizzarin)0.075
Vimvimentin0.060
S100a10S100 calcium binding protein A100.037
Muc3amucin 3A, cell surface associated0.024
MdficMyoD family inhibitor domain containing0.022
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.021
Aqp7aquaporin 70.020
Acot2acyl-CoA thioesterase 20.019
Prlrprolactin receptor0.018
Cd36CD36 molecule (thrombospondin receptor)0.018
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.017
Syt4synaptotagmin IV0.015
Hnf4ahepatocyte nuclear factor 4, alpha0.015
Itgb1integrin, beta 10.015
Vamp1vesicle-associated membrane protein 10.015
Ctsbcathepsin B0.014
Crybb1crystallin, beta B10.014
Capn2calpain 20.014
Catcatalase0.014
Etfdhelectron-transferring-flavoprotein dehydrogenase0.013
Mettl7bmethyltransferase like 7B0.013
Rab1bRAB1B, member RAS oncogene family0.013
Tff3trefoil factor 3, intestinal0.013
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.012
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.012
Pfkpphosphofructokinase, platelet0.012
Aldh6a1aldehyde dehydrogenase 6 family, member A10.012
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.012
Myadmmyeloid-associated differentiation marker0.011
Acadlacyl-Coenzyme A dehydrogenase, long-chain0.011
Ctsccathepsin C0.011
Arpc1bactin related protein 2/3 complex, subunit 1B0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PHO80Pho80p0.012