The network for 'negative regulation of neuron projection regeneration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of neuron projection regeneration

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.

NameDescriptionProbabilityFunc Analog Organism
gro1groucho 10.835
epha4aeph receptor A4a0.815
ephb4beph receptor B4b0.658
atf3activating transcription factor 30.643
cdh2cadherin 2, neuronal0.641
socs3asuppressor of cytokine signaling 3a0.615
efnb3bephrin B3b0.575
dbx1adeveloping brain homeobox 1a0.484
gro2groucho 20.452
prickle2prickle-like 2 (Drosophila)0.446
otx1borthodenticle homolog 1b0.440
junbjun B proto-oncogene0.423
her8ahairy-related 8a0.416
ephb3aeph receptor B3a0.398
znf503zinc finger protein 5030.370
otx1aorthodenticle homolog 1a0.351
notch3notch homolog 30.341
fzd5frizzled homolog 50.310
gli1GLI-Kruppel family member 10.308
efnb2aephrin B2a0.244
bocbrother of CDO0.234
six3bsine oculis homeobox homolog 3b0.233
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.228
neurog1neurogenin 10.221
fosl2fos-like antigen 20.217
ptprkprotein tyrosine phosphatase, receptor type, K0.211
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.208
fgfr1bfibroblast growth factor receptor 1b0.205
sfrp5secreted frizzled-related protein 50.201
efnb1ephrin B10.200
fzd8afrizzled homolog 8a0.196
fgf3fibroblast growth factor 30.193
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.189
flhfloating head0.174
ptproprotein tyrosine phosphatase, receptor type, O0.160
atoh1aatonal homolog 1a0.144
copebcore promoter element binding protein0.141
dusp2dual specificity phosphatase 20.141
zbtb16azinc finger and BTB domain containing 16a0.140
aldh1a3aldehyde dehydrogenase 1 family, member A30.139
prickle1aprickle-like 1 (Drosophila) a0.134
srsf4serine/arginine-rich splicing factor 40.133
irx3biroquois homeobox protein 3b0.123
ntn2netrin 20.121
sox2SRY-box containing gene 20.118
irx1biroquois homeobox protein 1, b0.111
esrrgaestrogen-related receptor gamma a0.111
sema3aasemaphorin 3aa0.102
junbljun B proto-oncogene, like0.100
pcdh10bprotocadherin 10b0.097
ext1aexostoses (multiple) 1a0.096
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.095
ctsl1bcathepsin L, 1 b0.094
hoxb1ahomeo box B1a0.092
pax3apaired box gene 3a0.092
hoxb2ahomeo box B2a0.090
ephb4aeph receptor B4a0.087
smad1MAD homolog 1 (Drosophila)0.087
pax6bpaired box gene 6b0.086
lfnglunatic fringe homolog0.085
pax2apaired box gene 2a0.084
col14a1collagen, type XIV, alpha 10.083
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.083
LOC797832similar to signal peptide, CUB domain, EGF-like 10.081
nova2neuro-oncological ventral antigen 20.079
sox19bSRY-box containing gene 19b0.079
irx5airoquois homeobox protein 5a0.077
scube2signal peptide, CUB domain, EGF-like 20.075
mmp9matrix metalloproteinase 90.075
stat3signal transduction and activation of transcription 30.072
ckap5cytoskeleton associated protein 50.071
meis2.2myeloid ecotropic viral integration site 2.20.071
grcc10gene rich cluster, C10 gene0.070
tbx2bT-box 2b0.064
foxn4forkhead box N40.062
lhx1bLIM homeobox 1b0.062
olig3oligodendrocyte transcription factor 30.062
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.059
efna5aephrin A5a0.059
epb4.1l4erythrocyte protein band 4.1-like 40.058
gbx2gastrulation brain homeo box 20.057
wnt3awingless-type MMTV integration site family, member 3A0.056
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.056
btg2B-cell translocation gene 20.055
pbx4pre-B-cell leukemia transcription factor 40.055
cdc25cell division cycle 25 homolog0.054
smarce1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.054
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.054
hesx1homeo box (expressed in ES cells) 10.052
junjun proto-oncogene0.051
foxb1.2forkhead box B1.20.051
emx1empty spiracles homeobox 10.050
wnt8bwingless-type MMTV integration site family, member 8b0.049
metmet proto-oncogene (hepatocyte growth factor receptor)0.048
pou3f3aPOU class 3 homeobox 3a0.048
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klk1b5kallikrein 1-related peptidase b50.998
Klk1b26kallikrein 1-related petidase b260.996
Efnb2ephrin B20.990
Klk1kallikrein 10.990
Klk1b1kallikrein 1-related peptidase b10.975
Klk1b8kallikrein 1-related peptidase b80.962
Klk1b16kallikrein 1-related peptidase b160.861
Klk1b21kallikrein 1-related peptidase b210.833
Klk1b11kallikrein 1-related peptidase b110.782
Klk1b9kallikrein 1-related peptidase b90.781
Klk1b27kallikrein 1-related peptidase b270.759
Tgfb2transforming growth factor, beta 20.755
Klk1b3kallikrein 1-related peptidase b30.742
Klk1b4kallikrein 1-related pepidase b40.706
Epha4Eph receptor A40.642
Ptpn11protein tyrosine phosphatase, non-receptor type 110.611
Efnb1ephrin B10.506
Ephb2Eph receptor B20.502
Gli3GLI-Kruppel family member GLI30.470
Klk1b24kallikrein 1-related peptidase b240.374
Ptk2PTK2 protein tyrosine kinase 20.317
Ctrb1chymotrypsinogen B10.261
Egfbp2epidermal growth factor binding protein type B0.257
Jag1jagged 10.255
Ephb3Eph receptor B30.248
Zfpm2zinc finger protein, multitype 20.247
Foxc1forkhead box C10.243
Bmp1bone morphogenetic protein 10.240
Trp53transformation related protein 530.224
Cela2achymotrypsin-like elastase family, member 2A0.219
Hey2hairy/enhancer-of-split related with YRPW motif 20.183
Zg16zymogen granule protein 160.179
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.176
Try5trypsin 50.175
Notch1Notch gene homolog 1 (Drosophila)0.170
Ctnnb1catenin (cadherin associated protein), beta 10.168
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.149
Gata4GATA binding protein 40.138
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.132
Plxna4plexin A40.122
Dmbt1deleted in malignant brain tumors 10.118
5430421N21RikRIKEN cDNA 5430421N21 gene0.114
Il6stinterleukin 6 signal transducer0.111
Efna4ephrin A40.111
Gata5GATA binding protein 50.106
Gli2GLI-Kruppel family member GLI20.103
Cyr61cysteine rich protein 610.101
Prss3protease, serine, 30.097
Irs3insulin receptor substrate 30.089
Trpc4transient receptor potential cation channel, subfamily C, member 40.084
Hapln1hyaluronan and proteoglycan link protein 10.084
Smr3asubmaxillary gland androgen regulated protein 3A0.083
Cacna1gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.080
Rspo2R-spondin 2 homolog (Xenopus laevis)0.077
Efna5ephrin A50.077
Dock1dedicator of cytokinesis 10.077
Cdh11cadherin 110.075
Egr1early growth response 10.075
Fxyd2FXYD domain-containing ion transport regulator 20.075
Sox9SRY-box containing gene 90.075
Hnrnpuheterogeneous nuclear ribonucleoprotein U0.073
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.073
Ltbp4latent transforming growth factor beta binding protein 40.072
Pax6paired box gene 60.071
Fgf18fibroblast growth factor 180.068
2210010C04RikRIKEN cDNA 2210010C04 gene0.068
Fat4FAT tumor suppressor homolog 4 (Drosophila)0.067
Efna1ephrin A10.067
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.066
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.064
Irs1insulin receptor substrate 10.062
Hoxb13homeobox B130.059
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.058
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.058
Cxcl2chemokine (C-X-C motif) ligand 20.058
Spry4sprouty homolog 4 (Drosophila)0.058
Zfp36zinc finger protein 360.057
Pcdh12protocadherin 120.057
Aym1activator of yeast meiotic promoters 10.056
Tal2T-cell acute lymphocytic leukemia 20.056
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.056
Grip1glutamate receptor interacting protein 10.056
Crhr1corticotropin releasing hormone receptor 10.056
Adam11a disintegrin and metallopeptidase domain 110.055
Foxf2forkhead box F20.053
Efsembryonal Fyn-associated substrate0.053
Wisp1WNT1 inducible signaling pathway protein 10.052
Lyzl4lysozyme-like 40.051
Tead2TEA domain family member 20.050
Nr0b2nuclear receptor subfamily 0, group B, member 20.050
Clcn2chloride channel 20.049
Gjc1gap junction protein, gamma 10.049
Igfbp2insulin-like growth factor binding protein 20.049
Rprmreprimo, TP53 dependent G2 arrest mediator candidate0.048
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.048
Krt17keratin 170.048
Ntf3neurotrophin 30.048
Col18a1collagen, type XVIII, alpha 10.048
Gpr12G-protein coupled receptor 120.047
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism