The network for 'regulation of cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cell activation

Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.506
lcp1lymphocyte cytosolic plastin 10.467
mmp9matrix metalloproteinase 90.464
lrrc33leucine rich repeat containing 330.397
coro1acoronin, actin binding protein, 1A0.349
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.294
shhasonic hedgehog a0.263
mmp13amatrix metalloproteinase 13a0.235
clic2chloride intracellular channel 20.201
pdgfaaplatelet-derived growth factor alpha a0.200
ikzf1IKAROS family zinc finger 1 (Ikaros)0.185
axin2axin 2 (conductin, axil)0.184
ptpn6protein tyrosine phosphatase, non-receptor type 60.167
cldn5bclaudin 5b0.160
gata3GATA-binding protein 30.154
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.153
lta4hleukotriene A4 hydrolase0.150
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.149
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.136
fn1fibronectin 10.135
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.135
impdh1binosine 5'-phosphate dehydrogenase 1b0.133
bocbrother of CDO0.130
ncf1neutrophil cytosolic factor 10.130
znf703zinc finger protein 7030.128
ighzimmunoglobulin heavy constant zeta0.127
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.121
bmp4bone morphogenetic protein 40.118
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.117
tlr3toll-like receptor 30.117
cdx4caudal type homeo box transcription factor 40.109
lgals9l1lectin, galactoside-binding, soluble, 9 (galectin 9)-like 10.108
runx2arunt-related transcription factor 2a0.106
smoc2secreted modular calcium binding protein 20.105
tp63tumor protein p630.105
igfbp1ainsulin-like growth factor binding protein 1a0.104
foxi3bforkhead box I3b0.103
sla1Src-like-adaptor 10.101
il7rinterleukin 7 receptor0.099
ncor2nuclear receptor co-repressor 20.098
angptl2angiopoietin-like 20.097
tmem144btransmembrane protein 144b0.096
lgals3bpblectin, galactoside-binding, soluble, 3 binding protein b0.096
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.096
LOC100151049lysosomal-associated protein transmembrane 50.094
pax5paired box gene 50.093
egr2bearly growth response 2b0.093
col11a1acollagen, type XI, alpha 1a0.093
lfnglunatic fringe homolog0.091
dnmt4DNA (cytosine-5-)-methyltransferase 40.088
mpxmyeloid-specific peroxidase0.087
cxcr4bchemokine (C-X-C motif), receptor 4b0.084
epas1bendothelial PAS domain protein 1b0.082
tal1T-cell acute lymphocytic leukemia 10.081
pglyrp5peptidoglycan recognition protein 50.080
irx3airoquois homeobox protein 3a0.078
rbp4retinol binding protein 4, plasma0.078
ctssb.2cathepsin S, b.20.077
nr2f5nuclear receptor subfamily 2, group F, member 50.076
fgf8afibroblast growth factor 8 a0.075
fzd7afrizzled homolog 7a0.075
msnamoesin a0.074
nkx2.3NK2 transcription factor related 30.074
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.074
gmnngeminin, DNA replication inhibitor0.074
rif1RAP1 interacting factor homolog (yeast)0.074
adam8aa disintegrin and metalloproteinase domain 8a0.074
tgm2btransglutaminase 2b0.074
pglyrp6peptidoglycan recognition protein 60.073
glulaglutamate-ammonia ligase (glutamine synthase) a0.073
rhogbras homolog gene family, member Gb0.073
eya2eyes absent homolog 2 (Drosophila)0.072
pax6apaired box gene 6a0.071
foxp1bforkhead box P1b0.071
cxcr3.2chemokine (C-X-C motif) receptor 3.20.071
il8interleukin 80.071
lygl1lysozyme g-like 10.070
irx5airoquois homeobox protein 5a0.070
capns1bcalpain, small subunit 1 b0.070
runx3runt-related transcription factor 30.070
LOC100003514protein kinase C alpha type-like0.069
hoxb3ahomeo box B3a0.069
cx43connexin 430.069
dctdopachrome tautomerase0.069
pfn1profilin 10.069
tgfbitransforming growth factor, beta-induced0.068
st8sia7.1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.10.068
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.067
rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.067
col5a1procollagen, type V, alpha 10.066
arl4abADP-ribosylation factor-like 4ab0.066
znf536zinc finger protein 5360.066
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.999
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.997
SYKspleen tyrosine kinase0.996
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.995
LATlinker for activation of T cells0.987
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.983
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.982
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.980
PTPN6protein tyrosine phosphatase, non-receptor type 60.969
CAV1caveolin 1, caveolae protein, 22kDa0.954
PLCG1phospholipase C, gamma 10.947
FGFR2fibroblast growth factor receptor 20.933
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.900
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.895
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.894
PTPRCprotein tyrosine phosphatase, receptor type, C0.888
SHC1SHC (Src homology 2 domain containing) transforming protein 10.837
PTPN11protein tyrosine phosphatase, non-receptor type 110.829
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.821
TNFAIP3tumor necrosis factor, alpha-induced protein 30.812
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.807
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.798
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.794
NCF4neutrophil cytosolic factor 4, 40kDa0.793
VEGFAvascular endothelial growth factor A0.787
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.777
EGFRepidermal growth factor receptor0.774
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.773
C1QAcomplement component 1, q subcomponent, A chain0.773
IRAK1interleukin-1 receptor-associated kinase 10.763
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.760
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.755
IL1Binterleukin 1, beta0.744
HLA-Fmajor histocompatibility complex, class I, F0.739
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.728
H2AFXH2A histone family, member X0.728
CFLARCASP8 and FADD-like apoptosis regulator0.719
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.712
GRB2growth factor receptor-bound protein 20.697
MYD88myeloid differentiation primary response gene (88)0.695
BIRC3baculoviral IAP repeat containing 30.690
SH2D1ASH2 domain containing 1A0.675
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.674
CARD11caspase recruitment domain family, member 110.655
HLA-Bmajor histocompatibility complex, class I, B0.652
HLA-Cmajor histocompatibility complex, class I, C0.646
TGIF1TGFB-induced factor homeobox 10.629
PTPN1protein tyrosine phosphatase, non-receptor type 10.629
BTN3A1butyrophilin, subfamily 3, member A10.626
AXLAXL receptor tyrosine kinase0.618
ICAM1intercellular adhesion molecule 10.603
BCL2L1BCL2-like 10.597
HLA-Amajor histocompatibility complex, class I, A0.595
IL10RAinterleukin 10 receptor, alpha0.582
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.570
CD2CD2 molecule0.565
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.564
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.564
HLA-Gmajor histocompatibility complex, class I, G0.562
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.547
HLA-DMBmajor histocompatibility complex, class II, DM beta0.545
BRCA1breast cancer 1, early onset0.540
CCR7chemokine (C-C motif) receptor 70.534
LST1leukocyte specific transcript 10.529
FASFas (TNF receptor superfamily, member 6)0.528
IL2RGinterleukin 2 receptor, gamma0.527
CTLA4cytotoxic T-lymphocyte-associated protein 40.526
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.513
IL4Rinterleukin 4 receptor0.510
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.508
CXCL9chemokine (C-X-C motif) ligand 90.505
SLAMF1signaling lymphocytic activation molecule family member 10.505
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.498
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.486
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.468
ABI1abl-interactor 10.458
CCL4chemokine (C-C motif) ligand 40.453
CD247CD247 molecule0.448
IFNGR1interferon gamma receptor 10.447
METmet proto-oncogene (hepatocyte growth factor receptor)0.446
CD80CD80 molecule0.444
BTN3A3butyrophilin, subfamily 3, member A30.439
CCR5chemokine (C-C motif) receptor 50.435
NCOA3nuclear receptor coactivator 30.429
FYNFYN oncogene related to SRC, FGR, YES0.417
BCL2B-cell CLL/lymphoma 20.410
MS4A6Amembrane-spanning 4-domains, subfamily A, member 6A0.407
TICAM2toll-like receptor adaptor molecule 20.404
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.401
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.398
BTN3A2butyrophilin, subfamily 3, member A20.397
CD86CD86 molecule0.390
CREBBPCREB binding protein0.386
CCL5chemokine (C-C motif) ligand 50.383
TRAF6TNF receptor-associated factor 60.382
MAPTmicrotubule-associated protein tau0.368
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.364
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.363
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.354
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
FasFas (TNF receptor superfamily member 6)1.000
Tnftumor necrosis factor1.000
Ikzf1IKAROS family zinc finger 10.999
Tlr4toll-like receptor 40.999
Lyz2lysozyme 20.999
Stat3signal transducer and activator of transcription 30.999
Il1r1interleukin 1 receptor, type I0.996
Myd88myeloid differentiation primary response gene 880.994
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.992
Il2rginterleukin 2 receptor, gamma chain0.992
Il10interleukin 100.991
Ptprcprotein tyrosine phosphatase, receptor type, C0.990
Ifnginterferon gamma0.988
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.986
Cd247CD247 antigen0.984
Nos3nitric oxide synthase 3, endothelial cell0.983
Latlinker for activation of T cells0.982
Cd19CD19 antigen0.981
Zeb1zinc finger E-box binding homeobox 10.978
Foxp3forkhead box P30.977
Ccr2chemokine (C-C motif) receptor 20.976
FaslFas ligand (TNF superfamily, member 6)0.975
Lcklymphocyte protein tyrosine kinase0.975
Icosinducible T-cell co-stimulator0.972
Itgb2integrin beta 20.971
Nlrp3NLR family, pyrin domain containing 30.970
Rnf2ring finger protein 20.969
Cd40CD40 antigen0.968
Ltalymphotoxin A0.967
Map3k14mitogen-activated protein kinase kinase kinase 140.966
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.966
Leprleptin receptor0.963
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.962
Tnfaip3tumor necrosis factor, alpha-induced protein 30.961
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.960
Cd86CD86 antigen0.956
Il6interleukin 60.955
Mmp9matrix metallopeptidase 90.953
Il27rainterleukin 27 receptor, alpha0.950
Ccr1chemokine (C-C motif) receptor 10.945
Cd28CD28 antigen0.945
Il4interleukin 40.942
Ptpn11protein tyrosine phosphatase, non-receptor type 110.939
Smad6MAD homolog 6 (Drosophila)0.939
Cd4CD4 antigen0.939
Il10rainterleukin 10 receptor, alpha0.939
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.937
AF251705cDNA sequence AF2517050.936
Batfbasic leucine zipper transcription factor, ATF-like0.927
Cd44CD44 antigen0.925
Csf1rcolony stimulating factor 1 receptor0.924
Il2rbinterleukin 2 receptor, beta chain0.924
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.921
Il6stinterleukin 6 signal transducer0.913
Casp8caspase 80.911
Casp4caspase 4, apoptosis-related cysteine peptidase0.911
BtkBruton agammaglobulinemia tyrosine kinase0.904
Cd180CD180 antigen0.904
Fgfr2fibroblast growth factor receptor 20.903
Selpselectin, platelet0.895
Il1binterleukin 1 beta0.893
TyrobpTYRO protein tyrosine kinase binding protein0.893
Pdcd1programmed cell death 10.888
Cd6CD6 antigen0.887
Ptgs2prostaglandin-endoperoxide synthase 20.887
Tgfb2transforming growth factor, beta 20.886
Egfrepidermal growth factor receptor0.877
Cd14CD14 antigen0.868
Tbx3T-box 30.868
C3ar1complement component 3a receptor 10.866
Itgalintegrin alpha L0.864
Kitkit oncogene0.863
Ccr7chemokine (C-C motif) receptor 70.857
Ltblymphotoxin B0.852
AxlAXL receptor tyrosine kinase0.847
Jak2Janus kinase 20.843
Emx1empty spiracles homolog 1 (Drosophila)0.840
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.836
Smad3MAD homolog 3 (Drosophila)0.836
Clec4dC-type lectin domain family 4, member d0.836
Lcp2lymphocyte cytosolic protein 20.832
Pitx3paired-like homeodomain transcription factor 30.831
Stat5bsignal transducer and activator of transcription 5B0.825
Fcgr2bFc receptor, IgG, low affinity IIb0.825
Slamf1signaling lymphocytic activation molecule family member 10.824
FynFyn proto-oncogene0.823
Cxcl13chemokine (C-X-C motif) ligand 130.821
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.821
Card11caspase recruitment domain family, member 110.820
Gdnfglial cell line derived neurotrophic factor0.819
MefvMediterranean fever0.817
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.812
Ccr6chemokine (C-C motif) receptor 60.812
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.811
Ighimmunoglobulin heavy chain complex0.808
Sellselectin, lymphocyte0.807
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.807
Birc3baculoviral IAP repeat-containing 30.797
Cd7CD7 antigen0.796
Ifnar1interferon (alpha and beta) receptor 10.795
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.647
Hckhemopoietic cell kinase0.639
Cfpcomplement factor properdin0.513
Casp1caspase 10.436
Cd37CD37 molecule0.409
RT1-BaRT1 class II, locus Ba0.365
Icam1intercellular adhesion molecule 10.341
Il2rbinterleukin 2 receptor, beta0.338
RT1-Db1RT1 class II, locus Db10.318
Inpp5dinositol polyphosphate-5-phosphatase D0.289
Cd4Cd4 molecule0.288
Cd5Cd5 molecule0.281
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.248
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.243
Ccr5chemokine (C-C motif) receptor 50.242
RT1-DMbRT1 class II, locus DMb0.238
RT1-BbRT1 class II, locus Bb0.235
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.229
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.223
Gzmkgranzyme K0.214
Lyz2lysozyme 20.197
C1qccomplement component 1, q subcomponent, C chain0.187
Il1r1interleukin 1 receptor, type I0.183
Cd53Cd53 molecule0.178
Il8rbinterleukin 8 receptor, beta0.173
Scamp2secretory carrier membrane protein 20.158
Cd44Cd44 molecule0.158
Syt8synaptotagmin VIII0.150
Fgfr2fibroblast growth factor receptor 20.148
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.133
Laptm5lysosomal protein transmembrane 50.130
Napsanapsin A aspartic peptidase0.127
Cmklr1chemokine-like receptor 10.125
Itgadintegrin, alpha D0.124
Cxcr3chemokine (C-X-C motif) receptor 30.114
Il1rl1interleukin 1 receptor-like 10.109
Itgamintegrin, alpha M0.109
Reg3bregenerating islet-derived 3 beta0.107
Rassf5Ras association (RalGDS/AF-6) domain family member 50.103
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.101
Alox5arachidonate 5-lipoxygenase0.101
Arl11ADP-ribosylation factor-like 110.100
Mamdc4MAM domain containing 40.099
Calcrcalcitonin receptor0.096
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.095
Socs3suppressor of cytokine signaling 30.090
Alox5aparachidonate 5-lipoxygenase activating protein0.089
Olr1500olfactory receptor 15000.086
Csf1colony stimulating factor 1 (macrophage)0.084
Cd2Cd2 molecule0.084
RT1-DMaRT1 class II, locus DMa0.082
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.078
Olr1496olfactory receptor 14960.076
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.075
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.074
Cd247Cd247 molecule0.073
Mc5rmelanocortin 5 receptor0.073
Vipvasoactive intestinal peptide0.072
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.072
Fcnbficolin B0.071
Ncf4neutrophil cytosolic factor 40.071
Prl8a9prolactin family 8, subfamily a, member 90.070
Cd14CD14 molecule0.070
Flt1FMS-related tyrosine kinase 10.069
Ciitaclass II, major histocompatibility complex, transactivator0.069
Cpxm2carboxypeptidase X (M14 family), member 20.068
RGD1310262hypothetical LOC3046500.068
Chrnb3cholinergic receptor, nicotinic, beta 30.067
Ltalymphotoxin alpha (TNF superfamily, member 1)0.066
Ctsscathepsin S0.066
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.065
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.064
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.064
C3complement component 30.064
Ptger4prostaglandin E receptor 4 (subtype EP4)0.064
Lst1leukocyte specific transcript 10.061
Scn11asodium channel, voltage-gated, type XI, alpha0.061
Edn1endothelin 10.061
Vcam1vascular cell adhesion molecule 10.060
Cd38CD38 molecule0.059
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.058
Ptpn6protein tyrosine phosphatase, non-receptor type 60.058
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.057
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.057
Nr5a2nuclear receptor subfamily 5, group A, member 20.056
Nek9NIMA (never in mitosis gene a)- related kinase 90.056
Cd68Cd68 molecule0.056
Iappislet amyloid polypeptide0.056
Pecam1platelet/endothelial cell adhesion molecule 10.055
Itpr2inositol 1,4,5-triphosphate receptor, type 20.054
Ptger2prostaglandin E receptor 2 (subtype EP2)0.054
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.054
Tp53tumor protein p530.053
Il17rainterleukin 17 receptor A0.053
Cybbcytochrome b-245, beta polypeptide0.053
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism