The network for 'desmosome assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

desmosome assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.

NameDescriptionProbabilityFunc Analog Organism
esrp1epithelial splicing regulatory protein 10.601
pkp3plakophilin 30.401
krt4keratin 40.385
dspadesmoplakin a0.365
perpPERP, TP53 apoptosis effector0.247
shhasonic hedgehog a0.180
jupjunction plakoglobin0.170
dag1dystroglycan 10.144
krt5keratin 50.125
cldnbclaudin b0.112
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.100
dsg2desmoglein 20.097
spint1aserine peptidase inhibitor, Kunitz type 1 a0.091
llgl2lethal giant larvae homolog 2 (Drosophila)0.067
pkp1plakophilin 10.066
pbx4pre-B-cell leukemia transcription factor 40.047
ahnakAHNAK nucleoprotein0.044
appaamyloid beta (A4) precursor protein a0.042
dsc2ldesmocollin 2 like0.038
crb2acrumbs homolog 2a0.035
prkciprotein kinase C, iota0.034
slc38a3solute carrier family 38, member 30.034
gata5GATA-binding protein 50.034
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.034
hhiphedgehog interacting protein0.033
ctnnb1catenin (cadherin-associated protein), beta 10.032
ef1ETS-related factor10.029
foxa3forkhead box A30.028
sf3b1splicing factor 3b, subunit 10.026
epcamepithelial cell adhesion molecule0.025
esrp2epithelial splicing regulatory protein 20.025
snai1asnail homolog 1a (Drosophila)0.024
ptpraprotein tyrosine phosphatase, receptor type, A0.024
igf2ainsulin-like growth factor 2a0.023
cldn7bclaudin 7b0.023
lfnglunatic fringe homolog0.023
aldh1a2aldehyde dehydrogenase 1 family, member A20.022
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.021
anxa2aannexin A2a0.019
net1neuroepithelial cell transforming gene 10.019
ripk4receptor-interacting serine-threonine kinase 40.018
klf2aKruppel-like factor 2a0.017
lamc1laminin, gamma 10.017
rasgef1baRasGEF domain family, member 1Ba0.017
anxa1aannexin A1a0.017
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.017
aim1aabsent in melanoma 1a0.017
her9hairy-related 90.017
lsrlipolysis stimulated lipoprotein receptor0.017
tjp2atight junction protein 2a (zona occludens 2)0.016
capn9calpain 90.015
hnf1baHNF1 homeobox Ba0.015
acvr1bactivin A receptor, type IB0.015
klf3Kruppel-like factor 3 (basic)0.015
krt18keratin 180.014
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.014
tbeta-abeta thymosin-like protein 20.013
pvrl1apoliovirus receptor-related 1a0.013
ndrg1N-myc downstream regulated gene 10.013
cdh1cadherin 1, epithelial0.013
fam3cfamily with sequence similarity 3, member C0.013
axin1axin 10.013
entpd3ectonucleoside triphosphate diphosphohydrolase 30.013
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.013
tp53tumor protein p530.012
fabp2fatty acid binding protein 2, intestinal0.012
lsm14abLSM14 homolog Ab (SCD6, S. cerevisiae)0.012
osr1odd-skipped related 1 (Drosophila)0.011
trpv1transient receptor potential cation channel subfamily V member 10.011
cd9bCD9 antigen, b0.011
spred1sprouty-related, EVH1 domain containing 10.011
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.011
cfl1cofilin 1 (non-muscle)0.011
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.011
mychmyelocytomatosis oncogene homolog0.011
epha2eph receptor A20.011
s100uS100 calcium binding protein U0.010
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.010
fam168afamily with sequence similarity 168, member A0.010
tp63tumor protein p630.010
trpm7transient receptor potential cation channel, subfamily M, member 70.010
wlswntless homolog (Drosophila)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
CDH1cadherin 1, type 1, E-cadherin (epithelial)1.000
PSEN1presenilin 10.998
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.975
DSG2desmoglein 20.927
JUPjunction plakoglobin0.916
APCadenomatous polyposis coli0.739
NCF1neutrophil cytosolic factor 10.683
PTPRJprotein tyrosine phosphatase, receptor type, J0.542
MARK3MAP/microtubule affinity-regulating kinase 30.450
KRT8keratin 80.408
KRT14keratin 140.407
CTNND1catenin (cadherin-associated protein), delta 10.382
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.373
KRT18keratin 180.340
CTNNBIP1catenin, beta interacting protein 10.318
PKP4plakophilin 40.262
ERBB2IPerbb2 interacting protein0.256
PKP2plakophilin 20.252
DSC2desmocollin 20.198
BRAFv-raf murine sarcoma viral oncogene homolog B10.145
LAD1ladinin 10.114
TRIM9tripartite motif containing 90.096
CDH3cadherin 3, type 1, P-cadherin (placental)0.092
FLNBfilamin B, beta0.073
KRT5keratin 50.071
SPINT1serine peptidase inhibitor, Kunitz type 10.068
HDAC6histone deacetylase 60.064
PRKCDprotein kinase C, delta0.059
PRKCAprotein kinase C, alpha0.040
EGFRepidermal growth factor receptor0.035
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.028
RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 20.027
ITGB4integrin, beta 40.026
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.026
RICTORRPTOR independent companion of MTOR, complex 20.024
DSG3desmoglein 30.024
DSG1desmoglein 10.021
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.020
GSK3Bglycogen synthase kinase 3 beta0.019
DSC3desmocollin 30.019
CYBAcytochrome b-245, alpha polypeptide0.017
PLEKHA7pleckstrin homology domain containing, family A member 70.016
PTPRFprotein tyrosine phosphatase, receptor type, F0.016
PRKCBprotein kinase C, beta0.015
OSGEPO-sialoglycoprotein endopeptidase0.015
AHNAKAHNAK nucleoprotein0.013
RALBP1ralA binding protein 10.011
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.011
CDH15cadherin 15, type 1, M-cadherin (myotubule)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apcadenomatosis polyposis coli0.186
Ptenphosphatase and tensin homolog0.075
Bmpr1abone morphogenetic protein receptor, type 1A0.048
Lrp6low density lipoprotein receptor-related protein 60.045
Lgals7lectin, galactose binding, soluble 70.037
Gsk3bglycogen synthase kinase 3 beta0.033
Ptpn11protein tyrosine phosphatase, non-receptor type 110.030
Ctnna1catenin (cadherin associated protein), alpha 10.025
Trp63transformation related protein 630.022
Ldb3LIM domain binding 30.022
Krt19keratin 190.016
Axin1axin 10.015
Numbnumb gene homolog (Drosophila)0.014
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.013
Fgfr2fibroblast growth factor receptor 20.012
Rac1RAS-related C3 botulinum substrate 10.012
Smad4MAD homolog 4 (Drosophila)0.012
Psen1presenilin 10.012
Stat3signal transducer and activator of transcription 30.012
Ccnd1cyclin D10.011
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.011
Ctnnd1catenin (cadherin associated protein), delta 10.011
Krt14keratin 140.010
Trp53transformation related protein 530.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism