The network for 'regulation of establishment or maintenance of cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of establishment or maintenance of cell polarity

Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.

NameDescriptionProbabilityFunc Analog Organism
ncf1neutrophil cytosolic factor 10.300
wacaWW domain containing adaptor with coiled-coil a0.149
ilkintegrin linked kinase0.126
gata2aGATA-binding protein 2a0.125
smad5MAD homolog 5 (Drosophila)0.089
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.083
ccm2cerebral cavernous malformation 20.082
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.076
ptpn6protein tyrosine phosphatase, non-receptor type 60.076
cnn2calponin 20.067
coro1acoronin, actin binding protein, 1A0.060
ube2iubiquitin-conjugating enzyme E2I0.057
ptgs1prostaglandin-endoperoxide synthase 10.051
stxbp2syntaxin binding protein 20.050
si:dkey-12o15.1si:dkey-12o15.10.048
runx3runt-related transcription factor 30.046
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.043
cds2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 20.042
yrkYes-related kinase0.040
six4bsine oculis homeobox homolog 4b0.034
lta4hleukotriene A4 hydrolase0.034
im:7154036im:71540360.034
tal1T-cell acute lymphocytic leukemia 10.033
arpc5bactin related protein 2/3 complex, subunit 5B0.031
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.030
kdm4blysine (K)-specific demethylase 4B0.030
lyzlysozyme0.029
rpsaribosomal protein SA0.029
faf1Fas associated factor 10.028
lrrc33leucine rich repeat containing 330.028
xbp1X-box binding protein 10.028
rplp0ribosomal protein, large, P00.028
si:dkeyp-22b2.3si:dkeyp-22b2.30.027
phactr4bphosphatase and actin regulator 4b0.027
psen1presenilin 10.027
cdk8cyclin-dependent kinase 80.027
gab1GRB2-associated binding protein 10.026
gnaiaguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a0.026
zgc:66100zgc:661000.026
prkciprotein kinase C, iota0.025
ythdf1YTH domain family, member 10.025
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.024
anxa3bannexin A3b0.024
ap1g1adaptor-related protein complex 1, gamma 1 subunit0.024
ighzimmunoglobulin heavy constant zeta0.024
vhlvon Hippel-Lindau tumor suppressor0.023
bactin1bactin10.023
cyt1type I cytokeratin, enveloping layer0.023
smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.023
entpd4ectonucleoside triphosphate diphosphohydrolase 40.023
mmp9matrix metalloproteinase 90.023
pak2ap21 (CDKN1A)-activated kinase 2a0.022
birc2baculoviral IAP repeat-containing 20.022
oxsr1aoxidative-stress responsive 1a0.022
zgc:77517zgc:775170.022
wu:fb54a03wu:fb54a030.021
trim71tripartite motif-containing 710.021
acvrl1activin A receptor type II-like 10.021
si:dkeyp-50f5.1si:dkeyp-50f5.10.021
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.020
pfn2profilin 20.020
eml2echinoderm microtubule associated protein like 20.020
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.020
ubiad1UbiA prenyltransferase domain containing 10.020
igfbp7insulin-like growth factor binding protein 70.020
lgals9l1lectin, galactoside-binding, soluble, 9 (galectin 9)-like 10.020
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.019
dvl3dishevelled, dsh homolog 3 (Drosophila)0.019
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.019
zdhhc15bzinc finger, DHHC domain containing 15b0.019
krit1KRIT1, ankyrin repeat containing0.019
si:ch211-173o4.2si:ch211-173o4.20.019
pias4aprotein inhibitor of activated STAT, 4a0.019
gna12guanine nucleotide binding protein (G protein) alpha 120.019
dll4delta-like 4 (Drosophila)0.018
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.017
cxcr3.2chemokine (C-X-C motif) receptor 3.20.017
tnfaip8l2atumor necrosis factor, alpha-induced protein 8, like 2a0.017
cstf3cleavage stimulation factor, 3' pre-RNA, subunit 30.016
rbm4.1RNA binding motif protein 4.10.016
ggnbp2gametogenetin binding protein 20.016
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.016
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.016
sept6septin 60.016
rargaretinoic acid receptor gamma a0.016
rpl5aribosomal protein L5a0.016
gmfgglia maturation factor, gamma0.016
cdc42lcell division cycle 42, like0.016
clic1chloride intracellular channel 10.016
pvrl3lpoliovirus receptor-related 3 like0.016
tp53tumor protein p530.015
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.015
taf1TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.015
zp3zona pellucida glycoprotein 30.015
tjp2atight junction protein 2a (zona occludens 2)0.015
ptk2.1protein tyrosine kinase 2a0.015
adora2aaadenosine A2a receptor a0.015
ikzf1IKAROS family zinc finger 1 (Ikaros)0.015
rps9ribosomal protein S90.015
wnt5awingless-type MMTV integration site family, member 5a0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.579
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.392
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.170
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.136
ANGPT2angiopoietin 20.134
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.098
DVL1dishevelled, dsh homolog 1 (Drosophila)0.096
ANGPT1angiopoietin 10.060
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.059
NCOA1nuclear receptor coactivator 10.047
SHC1SHC (Src homology 2 domain containing) transforming protein 10.038
SNIP1Smad nuclear interacting protein 10.035
ARRB1arrestin, beta 10.023
CSNK1Ecasein kinase 1, epsilon0.022
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.020
EEF2eukaryotic translation elongation factor 20.017
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.016
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.016
AKAP10A kinase (PRKA) anchor protein 100.015
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.014
RPL8ribosomal protein L80.013
RUNDC3ARUN domain containing 3A0.012
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.011
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.011
CEP164centrosomal protein 164kDa0.010
PTPRBprotein tyrosine phosphatase, receptor type, B0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dvl2dishevelled 2, dsh homolog (Drosophila)0.122
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.110
Vangl1vang-like 1 (van gogh, Drosophila)0.105
Vangl2vang-like 2 (van gogh, Drosophila)0.062
Ptpn11protein tyrosine phosphatase, non-receptor type 110.028
Usp8ubiquitin specific peptidase 80.021
Rpl8ribosomal protein L80.020
Gata6GATA binding protein 60.017
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.017
Ptprbprotein tyrosine phosphatase, receptor type, B0.017
Egfrepidermal growth factor receptor0.017
Gata4GATA binding protein 40.016
Grb2growth factor receptor bound protein 20.013
AxlAXL receptor tyrosine kinase0.013
Emcnendomucin0.013
Tal1T-cell acute lymphocytic leukemia 10.012
Lmx1aLIM homeobox transcription factor 1 alpha0.012
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.012
Birc6baculoviral IAP repeat-containing 60.012
Smurf2SMAD specific E3 ubiquitin protein ligase 20.012
Insrinsulin receptor0.012
Grb10growth factor receptor bound protein 100.011
SrcRous sarcoma oncogene0.011
Zfpm2zinc finger protein, multitype 20.011
Dvl3dishevelled 3, dsh homolog (Drosophila)0.011
Ghrgrowth hormone receptor0.011
Gucy1b3guanylate cyclase 1, soluble, beta 30.010
Cdh23cadherin 23 (otocadherin)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism