The network for 'regulation of skeletal muscle fiber development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of skeletal muscle fiber development

Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.

NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.890
mef2camyocyte enhancer factor 2ca0.884
myod1myogenic differentiation 10.866
myf5myogenic factor 50.628
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.501
xirp1xin actin-binding repeat containing 10.459
tbx5aT-box 5a0.455
hsp90a.1heat shock protein 90-alpha 10.421
sox9aSRY-box containing gene 9a0.417
ttnatitin a0.364
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.346
nppanatriuretic peptide precursor A0.340
smyd1bSET and MYND domain containing 1b0.313
cdh2cadherin 2, neuronal0.299
efnb2aephrin B2a0.280
tgfb3transforming growth factor, beta 30.276
mef2amyocyte enhancer factor 2a0.243
hspb1heat shock protein, alpha-crystallin-related, 10.243
fn1fibronectin 10.231
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.213
jam3bjunctional adhesion molecule 3b0.207
foxh1forkhead box H10.203
skianuclear oncoprotein skia0.180
mef2dmyocyte enhancer factor 2d0.166
hoxa11ahomeo box A11a0.163
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.146
lmnalamin A0.145
unc45bunc-45 homolog B (C. elegans)0.139
nrp2bneuropilin 2b0.139
robo3roundabout homolog 30.138
tbx20T-box 200.136
myhz2myosin, heavy polypeptide 2, fast muscle specific0.136
rereaarginine-glutamic acid dipeptide (RE) repeats a0.135
brd4bromodomain containing 40.128
tfe3atranscription factor binding to IGHM enhancer 3a0.127
notch1anotch homolog 1a0.124
acvr1bactivin A receptor, type IB0.118
igfbp1ainsulin-like growth factor binding protein 1a0.116
bmp4bone morphogenetic protein 40.115
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.105
LOC100332039ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like0.101
sox9bSRY-box containing gene 9b0.098
pitx3paired-like homeodomain transcription factor 30.097
mbnl2muscleblind-like 2 (Drosophila)0.094
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.094
gli2aGLI-Kruppel family member GLI2a0.093
hdac4histone deacetylase 40.092
stc1lstanniocalcin 1, like0.092
rad21RAD21 homolog (S. pombe)0.090
fgf10afibroblast growth factor 10a0.090
grifingalectin related inter-fiber protein0.088
tbx18T-box 180.083
crb2acrumbs homolog 2a0.082
ifnphi1interferon phi 10.078
nexnnexilin (F actin binding protein)0.077
hand2heart and neural crest derivatives expressed transcript 20.076
notch3notch homolog 30.075
col10a1collagen, type X, alpha 10.074
tbx2bT-box 2b0.073
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.073
her6hairy-related 60.071
nrg2aneuregulin 2a0.070
dag1dystroglycan 10.069
hey2hairy/enhancer-of-split related with YRPW motif 20.068
nog3noggin 30.067
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.065
angpt1angiopoietin 10.064
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.064
chrndcholinergic receptor, nicotinic, delta polypeptide0.064
ighzimmunoglobulin heavy constant zeta0.064
lamb2laminin, beta 2 (laminin S)0.063
terttelomerase reverse transcriptase0.063
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.063
ptpraprotein tyrosine phosphatase, receptor type, A0.062
rbm24aRNA binding motif protein 24a0.062
acp5bacid phosphatase 5b, tartrate resistant0.062
foxn4forkhead box N40.062
pth1aparathyroid hormone 1a0.061
znf703zinc finger protein 7030.061
emx2empty spiracles homeobox 20.060
chrna4cholinergic receptor, nicotinic, alpha 40.060
map1lc3amicrotubule-associated protein 1 light chain 3 alpha0.060
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.060
slit3slit (Drosophila) homolog 30.060
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.058
brd2bbromodomain containing 2b0.057
ankrd6ankyrin repeat domain 60.057
hspb7heat shock protein family, alpha-crystallin-related, b70.057
scinlascinderin like a0.057
junjun proto-oncogene0.054
col2a1acollagen type II, alpha-1a0.054
bokbBCL2-related ovarian killer b0.053
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC4histone deacetylase 40.877
NOTCH1notch 10.825
JAG1jagged 10.818
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.568
FSTL1follistatin-like 10.438
SRFserum response factor (c-fos serum response element-binding transcription factor)0.365
MEF2Cmyocyte enhancer factor 2C0.283
TRIM63tripartite motif containing 630.278
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.189
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.176
BMPR1Abone morphogenetic protein receptor, type IA0.127
MEF2Amyocyte enhancer factor 2A0.119
NOTCH3notch 30.099
BCL6B-cell CLL/lymphoma 60.099
PARVAparvin, alpha0.086
IGF2insulin-like growth factor 2 (somatomedin A)0.077
EP300E1A binding protein p3000.053
CNOT8CCR4-NOT transcription complex, subunit 80.052
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.051
CXCL11chemokine (C-X-C motif) ligand 110.050
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.046
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.046
FN1fibronectin 10.045
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.040
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.039
ATF3activating transcription factor 30.037
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.036
ARID1AAT rich interactive domain 1A (SWI-like)0.035
FBLN1fibulin 10.033
DLL1delta-like 1 (Drosophila)0.032
HDAC9histone deacetylase 90.031
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.029
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.027
NCOR1nuclear receptor corepressor 10.026
JUNjun proto-oncogene0.026
BCL2L1BCL2-like 10.025
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.022
H3F3CH3 histone, family 3C0.021
MYOD1myogenic differentiation 10.021
DPP4dipeptidyl-peptidase 40.020
FHL2four and a half LIM domains 20.020
INO80BINO80 complex subunit B0.019
UBDubiquitin D0.018
FUNDC2FUN14 domain containing 20.018
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.017
IQGAP1IQ motif containing GTPase activating protein 10.016
ARandrogen receptor0.015
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.015
ZFYVE9zinc finger, FYVE domain containing 90.015
PNRC1proline-rich nuclear receptor coactivator 10.014
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.014
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.014
COL1A1collagen, type I, alpha 10.013
HSF1heat shock transcription factor 10.013
JAG2jagged 20.012
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.012
DBPD site of albumin promoter (albumin D-box) binding protein0.012
TCAPtitin-cap (telethonin)0.011
DUSP1dual specificity phosphatase 10.011
TGFB3transforming growth factor, beta 30.011
TCF4transcription factor 40.011
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.011
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.011
SPTBN1spectrin, beta, non-erythrocytic 10.010
CREBBPCREB binding protein0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax3paired box gene 31.000
Shhsonic hedgehog0.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.995
Pitx2paired-like homeodomain transcription factor 20.993
Fgfr2fibroblast growth factor receptor 20.989
Rargretinoic acid receptor, gamma0.987
Tcfap2atranscription factor AP-2, alpha0.982
Gli3GLI-Kruppel family member GLI30.978
Vegfavascular endothelial growth factor A0.972
Foxc1forkhead box C10.960
Mapk14mitogen-activated protein kinase 140.948
Tbx1T-box 10.939
Mef2dmyocyte enhancer factor 2D0.913
Runx2runt related transcription factor 20.903
Prrx2paired related homeobox 20.884
Otx2orthodenticle homolog 2 (Drosophila)0.884
Prrx1paired related homeobox 10.882
Smosmoothened homolog (Drosophila)0.880
Hand1heart and neural crest derivatives expressed transcript 10.876
Hand2heart and neural crest derivatives expressed transcript 20.871
Eya1eyes absent 1 homolog (Drosophila)0.862
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.859
Fgfr1fibroblast growth factor receptor 10.853
Bmp7bone morphogenetic protein 70.824
Ednraendothelin receptor type A0.822
Meox2mesenchyme homeobox 20.809
Bcl2B-cell leukemia/lymphoma 20.796
Msx1homeobox, msh-like 10.780
Id3inhibitor of DNA binding 30.778
Tcf3transcription factor 30.772
Il1rninterleukin 1 receptor antagonist0.770
Chd7chromodomain helicase DNA binding protein 70.763
Ccl7chemokine (C-C motif) ligand 70.760
Ltalymphotoxin A0.750
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.749
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.740
Id1inhibitor of DNA binding 10.727
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.712
Zeb1zinc finger E-box binding homeobox 10.687
Ikzf1IKAROS family zinc finger 10.677
Isl1ISL1 transcription factor, LIM/homeodomain0.676
Myod1myogenic differentiation 10.675
Foxg1forkhead box G10.657
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.629
Ptpn11protein tyrosine phosphatase, non-receptor type 110.629
Trp53transformation related protein 530.567
Acvr1activin A receptor, type 10.557
Nf1neurofibromatosis 10.553
Hes1hairy and enhancer of split 1 (Drosophila)0.551
Foxc2forkhead box C20.537
Cd40CD40 antigen0.519
Rararetinoic acid receptor, alpha0.502
Pbx1pre B-cell leukemia transcription factor 10.479
Pax2paired box gene 20.464
Ltblymphotoxin B0.453
Pitx1paired-like homeodomain transcription factor 10.452
Tgfb2transforming growth factor, beta 20.443
Ece1endothelin converting enzyme 10.422
Rxraretinoid X receptor alpha0.418
Ldb3LIM domain binding 30.414
Gli2GLI-Kruppel family member GLI20.412
Casp4caspase 4, apoptosis-related cysteine peptidase0.399
Hesx1homeobox gene expressed in ES cells0.383
Ighimmunoglobulin heavy chain complex0.373
Sox11SRY-box containing gene 110.371
Bmp4bone morphogenetic protein 40.367
Tcfap2ctranscription factor AP-2, gamma0.364
Fgf8fibroblast growth factor 80.342
Cxcl13chemokine (C-X-C motif) ligand 130.340
Rarbretinoic acid receptor, beta0.337
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.332
Ifnginterferon gamma0.331
Egfrepidermal growth factor receptor0.305
Ccl4chemokine (C-C motif) ligand 40.302
Notch2Notch gene homolog 2 (Drosophila)0.299
Ccl2chemokine (C-C motif) ligand 20.294
Sox2SRY-box containing gene 20.290
Emx2empty spiracles homolog 2 (Drosophila)0.289
BaxBCL2-associated X protein0.281
Ctnnb1catenin (cadherin associated protein), beta 10.280
Hoxd13homeobox D130.279
Hoxa3homeobox A30.276
Fgf10fibroblast growth factor 100.259
Actc1actin, alpha, cardiac muscle 10.246
Hrchistidine rich calcium binding protein0.233
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.223
Sox4SRY-box containing gene 40.223
Ccl12chemokine (C-C motif) ligand 120.223
Tnftumor necrosis factor0.220
Gas1growth arrest specific 10.212
Irg1immunoresponsive gene 10.208
Psen1presenilin 10.204
Fuzfuzzy homolog (Drosophila)0.201
En1engrailed 10.201
Hoxa1homeobox A10.200
Disp1dispatched homolog 1 (Drosophila)0.199
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism