The network for '4 hydroxyproline metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

4 hydroxyproline metabolic process

The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.

Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hsp-3Protein HSP-30.035
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
P4HBprolyl 4-hydroxylase, beta polypeptide1.000
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.981
PDIA3protein disulfide isomerase family A, member 30.970
ERO1LERO1-like (S. cerevisiae)0.799
CALRcalreticulin0.632
PPIBpeptidylprolyl isomerase B (cyclophilin B)0.585
PDIA4protein disulfide isomerase family A, member 40.513
EPAS1endothelial PAS domain protein 10.194
EGLN1egl nine homolog 1 (C. elegans)0.189
DUSP23dual specificity phosphatase 230.180
EGLN3egl nine homolog 3 (C. elegans)0.144
GANABglucosidase, alpha; neutral AB0.064
VHLvon Hippel-Lindau tumor suppressor0.057
PLOD1procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 10.035
HM13histocompatibility (minor) 130.031
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.024
ARNTaryl hydrocarbon receptor nuclear translocator0.016
GBE1glucan (1,4-alpha-), branching enzyme 10.015
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.014
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.012
ERO1LBERO1-like beta (S. cerevisiae)0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Epas1endothelial PAS domain protein 10.948
Hif1ahypoxia inducible factor 1, alpha subunit0.852
Vegfavascular endothelial growth factor A0.642
Surf4surfeit gene 40.558
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.512
Sdhdsuccinate dehydrogenase complex, subunit D, integral membrane protein0.471
Fam96afamily with sequence similarity 96, member A0.449
P4ha2procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide0.202
Vhlvon Hippel-Lindau tumor suppressor0.189
Adam17a disintegrin and metallopeptidase domain 170.177
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.176
Tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.145
Pgk1phosphoglycerate kinase 10.136
Fh1fumarate hydratase 10.074
P4htmprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)0.068
Calrcalreticulin0.064
Rpn2ribophorin II0.060
Lama4laminin, alpha 40.058
Hsp90b1heat shock protein 90, beta (Grp94), member 10.057
Dbidiazepam binding inhibitor0.055
Hbb-b1hemoglobin, beta adult major chain0.054
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.050
Gm3150predicted gene 31500.050
Pkm2pyruvate kinase, muscle0.047
Hbb-b2hemoglobin, beta adult minor chain0.045
1110008F13RikRIKEN cDNA 1110008F13 gene0.043
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.042
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.040
Ssr3signal sequence receptor, gamma0.038
Bhlhe40basic helix-loop-helix family, member e400.038
Hmgn1high mobility group nucleosomal binding domain 10.038
Kdelr2KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 20.037
Psma5proteasome (prosome, macropain) subunit, alpha type 50.029
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.027
Bag3BCL2-associated athanogene 30.025
Rps27aribosomal protein S27A0.025
Hspa5heat shock protein 50.024
Calucalumenin0.024
Slc2a1solute carrier family 2 (facilitated glucose transporter), member 10.024
Oaz1ornithine decarboxylase antizyme 10.023
Vkorc1vitamin K epoxide reductase complex, subunit 10.023
Tmed2transmembrane emp24 domain trafficking protein 20.023
Adh5alcohol dehydrogenase 5 (class III), chi polypeptide0.021
Rps12ribosomal protein S120.021
Egln1EGL nine homolog 1 (C. elegans)0.021
Shfm1split hand/foot malformation (ectrodactyly) type 10.020
Aldoaaldolase A, fructose-bisphosphate0.020
Rps23ribosomal protein S230.019
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.018
Ppiapeptidylprolyl isomerase A0.018
Spp1secreted phosphoprotein 10.017
Gcshglycine cleavage system protein H (aminomethyl carrier)0.017
Txndc5thioredoxin domain containing 50.016
Esdesterase D/formylglutathione hydrolase0.016
Kdelr3KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 30.016
Cycscytochrome c, somatic0.016
Pgam1phosphoglycerate mutase 10.015
Ldhalactate dehydrogenase A0.015
Xbp1X-box binding protein 10.014
Egln3EGL nine homolog 3 (C. elegans)0.014
Pdha1pyruvate dehydrogenase E1 alpha 10.014
Mrpl13mitochondrial ribosomal protein L130.014
Tbcatubulin cofactor A0.013
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.013
Ero1lERO1-like (S. cerevisiae)0.013
Sar1bSAR1 gene homolog B (S. cerevisiae)0.013
Sec24dSec24 related gene family, member D (S. cerevisiae)0.013
Cyb5cytochrome b-50.013
Nr3c1nuclear receptor subfamily 3, group C, member 10.012
Hint1histidine triad nucleotide binding protein 10.012
Ndufa4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 40.012
Lman1lectin, mannose-binding, 10.012
Lemd2LEM domain containing 20.012
LOC10050381560S ribosomal protein L39-like0.012
Hspa1aheat shock protein 1A0.012
Tmem14ctransmembrane protein 14C0.012
Ddit4DNA-damage-inducible transcript 40.012
Tmco1transmembrane and coiled-coil domains 10.011
Tfrctransferrin receptor0.011
Cnpy2canopy 2 homolog (zebrafish)0.011
Pfkpphosphofructokinase, platelet0.011
Pfklphosphofructokinase, liver, B-type0.011
Fam136afamily with sequence similarity 136, member A0.011
Map2k1mitogen-activated protein kinase kinase 10.010
Ndrg1N-myc downstream regulated gene 10.010
Mcfd2multiple coagulation factor deficiency 20.010
Hspb8heat shock protein 80.010
RanRAN, member RAS oncogene family0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism