Saccharomyces cerevisiae

100 known processes

MEC1 (YBR136W)

Mec1p

(Aliases: SAD3,ESR1)

MEC1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anatomical structure homeostasis GO:0060249 74 0.987
cellular response to dna damage stimulus GO:0006974 287 0.980
recombinational repair GO:0000725 64 0.976
Fly
dna recombination GO:0006310 172 0.963
meiotic cell cycle process GO:1903046 229 0.901
meiotic cell cycle GO:0051321 272 0.885
telomere maintenance GO:0000723 74 0.883
dna repair GO:0006281 236 0.854
Fly
regulation of biological quality GO:0065008 391 0.854
telomere organization GO:0032200 75 0.850
meiotic nuclear division GO:0007126 163 0.832
meiosis i GO:0007127 92 0.758
homeostatic process GO:0042592 227 0.748
double strand break repair GO:0006302 105 0.691
Fly
telomere maintenance via telomere lengthening GO:0010833 22 0.688
organelle fission GO:0048285 272 0.671
telomere maintenance via telomerase GO:0007004 21 0.632
nuclear division GO:0000280 263 0.616
telomere maintenance via recombination GO:0000722 32 0.601
dna damage checkpoint GO:0000077 29 0.589
Human Fly
double strand break repair via homologous recombination GO:0000724 54 0.559
Fly
dna replication GO:0006260 147 0.555
macromolecule catabolic process GO:0009057 383 0.513
Fly
regulation of dna metabolic process GO:0051052 100 0.511
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.487
Fly
dna dependent dna replication GO:0006261 115 0.481
nucleotide excision repair GO:0006289 50 0.418
reproduction of a single celled organism GO:0032505 191 0.414
signal transduction GO:0007165 208 0.410
Human
dna geometric change GO:0032392 43 0.369
heterocycle catabolic process GO:0046700 494 0.360
Fly
developmental process involved in reproduction GO:0003006 159 0.355
cellular macromolecule catabolic process GO:0044265 363 0.346
Fly
cellular nitrogen compound catabolic process GO:0044270 494 0.345
Fly
response to chemical GO:0042221 390 0.309
Fly
single organism reproductive process GO:0044702 159 0.305
negative regulation of cell cycle process GO:0010948 86 0.303
Fly
nucleobase containing compound catabolic process GO:0034655 479 0.296
Fly
negative regulation of cell cycle phase transition GO:1901988 59 0.283
Fly
negative regulation of dna metabolic process GO:0051053 36 0.279
Human
single organism signaling GO:0044700 208 0.272
Human
cell communication GO:0007154 345 0.271
Human
cell cycle checkpoint GO:0000075 82 0.270
Human Fly
dna duplex unwinding GO:0032508 42 0.252
single organism catabolic process GO:0044712 619 0.228
Fly
organic cyclic compound catabolic process GO:1901361 499 0.226
Fly
sex determination GO:0007530 32 0.224
regulation of cell cycle process GO:0010564 150 0.216
Fly
dna integrity checkpoint GO:0031570 41 0.211
Human Fly
negative regulation of cell division GO:0051782 66 0.209
cell fate commitment GO:0045165 32 0.205
developmental process GO:0032502 261 0.200
Human Fly
mitotic recombination GO:0006312 55 0.199
negative regulation of cellular metabolic process GO:0031324 407 0.197
Human
protein phosphorylation GO:0006468 197 0.193
aromatic compound catabolic process GO:0019439 491 0.193
Fly
dna unwinding involved in dna replication GO:0006268 13 0.189
establishment of protein localization GO:0045184 367 0.189
cell differentiation GO:0030154 161 0.188
response to oxygen containing compound GO:1901700 61 0.188
carbohydrate derivative metabolic process GO:1901135 549 0.185
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.162
Human
regulation of cellular protein metabolic process GO:0032268 232 0.160
reproductive process GO:0022414 248 0.158
organophosphate metabolic process GO:0019637 597 0.158
reproductive process in single celled organism GO:0022413 145 0.158
single organism developmental process GO:0044767 258 0.154
Human Fly
fungal type cell wall organization or biogenesis GO:0071852 169 0.154
protein modification by small protein conjugation GO:0032446 144 0.152
regulation of response to stimulus GO:0048583 157 0.146
Human
cell wall organization or biogenesis GO:0071554 190 0.141
response to extracellular stimulus GO:0009991 156 0.131
mating type switching GO:0007533 28 0.129
protein modification by small protein conjugation or removal GO:0070647 172 0.123
regulation of protein modification process GO:0031399 110 0.120
negative regulation of mitotic cell cycle GO:0045930 63 0.118
Fly
regulation of meiotic cell cycle GO:0051445 43 0.114
lipid metabolic process GO:0006629 269 0.109
mismatch repair GO:0006298 14 0.108
cellular component morphogenesis GO:0032989 97 0.104
Fly
signaling GO:0023052 208 0.104
Human
regulation of cell cycle phase transition GO:1901987 70 0.103
Fly
regulation of meiosis GO:0040020 42 0.101
aging GO:0007568 71 0.101
Human
phosphorylation GO:0016310 291 0.099
regulation of signaling GO:0023051 119 0.097
Human
cell growth GO:0016049 89 0.095
nucleoside triphosphate metabolic process GO:0009141 364 0.093
protein ubiquitination GO:0016567 118 0.092
asexual reproduction GO:0019954 48 0.091
positive regulation of cellular protein metabolic process GO:0032270 89 0.088
negative regulation of cellular biosynthetic process GO:0031327 312 0.088
Human
regulation of dna replication GO:0006275 51 0.086
positive regulation of phosphorus metabolic process GO:0010562 147 0.085
cellular developmental process GO:0048869 191 0.084
Fly
chromatin organization GO:0006325 242 0.084
dna topological change GO:0006265 10 0.083
rna dependent dna replication GO:0006278 25 0.082
positive regulation of protein modification process GO:0031401 49 0.082
nuclear transport GO:0051169 165 0.082
dna catabolic process GO:0006308 42 0.082
Fly
histone modification GO:0016570 119 0.082
double strand break repair via break induced replication GO:0000727 25 0.080
double strand break repair via synthesis dependent strand annealing GO:0045003 12 0.079
Fly
regulation of cell cycle GO:0051726 195 0.079
Fly
cellular protein catabolic process GO:0044257 213 0.078
regulation of cell division GO:0051302 113 0.074
Fly
positive regulation of phosphate metabolic process GO:0045937 147 0.074
cell budding GO:0007114 48 0.073
negative regulation of nuclear division GO:0051784 62 0.071
growth GO:0040007 157 0.070
maintenance of protein location in cell GO:0032507 50 0.069
regulation of transport GO:0051049 85 0.069
cell cycle phase transition GO:0044770 144 0.069
Fly
regulation of cellular component organization GO:0051128 334 0.069
Fly
intracellular protein transport GO:0006886 319 0.068
negative regulation of cellular component organization GO:0051129 109 0.067
reciprocal meiotic recombination GO:0007131 54 0.065
mitotic cell cycle checkpoint GO:0007093 56 0.063
Fly
double strand break repair via single strand annealing GO:0045002 7 0.063
Fly
negative regulation of cell communication GO:0010648 33 0.062
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.061
Fly
purine containing compound catabolic process GO:0072523 332 0.060
positive regulation of gene expression GO:0010628 321 0.059
alcohol metabolic process GO:0006066 112 0.059
reciprocal dna recombination GO:0035825 54 0.058
response to nutrient levels GO:0031667 150 0.058
regulation of molecular function GO:0065009 320 0.057
positive regulation of cellular component organization GO:0051130 116 0.056
filamentous growth GO:0030447 124 0.056
positive regulation of endocytosis GO:0045807 12 0.056
positive regulation of transport GO:0051050 32 0.056
nucleobase containing small molecule metabolic process GO:0055086 491 0.056
rna catabolic process GO:0006401 118 0.054
anion transport GO:0006820 145 0.054
cellular response to external stimulus GO:0071496 150 0.053
monosaccharide transport GO:0015749 24 0.051
response to organic substance GO:0010033 182 0.050
Fly
glucose metabolic process GO:0006006 65 0.050
nucleocytoplasmic transport GO:0006913 163 0.050
cellular lipid metabolic process GO:0044255 229 0.050
translation GO:0006412 230 0.049
ribonucleoside monophosphate metabolic process GO:0009161 265 0.049
heteroduplex formation GO:0030491 9 0.048
regulation of dna repair GO:0006282 14 0.048
purine ribonucleoside monophosphate metabolic process GO:0009167 262 0.048
organic hydroxy compound metabolic process GO:1901615 125 0.047
regulation of cellular component biogenesis GO:0044087 112 0.046
chromosome localization GO:0050000 20 0.045
nucleoside phosphate metabolic process GO:0006753 458 0.045
mating type determination GO:0007531 32 0.045
monocarboxylic acid metabolic process GO:0032787 122 0.044
cellular homeostasis GO:0019725 138 0.044
organonitrogen compound biosynthetic process GO:1901566 314 0.043
regulation of mitotic cell cycle phase transition GO:1901990 68 0.043
Fly
negative regulation of meiotic cell cycle GO:0051447 24 0.043
regulation of signal transduction GO:0009966 114 0.042
Human
cell aging GO:0007569 70 0.042
Human
purine nucleoside metabolic process GO:0042278 380 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.042
Human
nucleoside monophosphate metabolic process GO:0009123 267 0.041
oxoacid metabolic process GO:0043436 351 0.041
maintenance of location GO:0051235 66 0.041
regulation of mitotic cell cycle GO:0007346 107 0.041
Fly
ion transport GO:0006811 274 0.040
purine nucleoside monophosphate metabolic process GO:0009126 262 0.040
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 35 0.040
response to abiotic stimulus GO:0009628 159 0.040
Human
dna strand elongation GO:0022616 29 0.039
regulation of gene silencing GO:0060968 41 0.039
protein transport GO:0015031 345 0.039
cellular amino acid metabolic process GO:0006520 225 0.039
meiotic mismatch repair GO:0000710 9 0.039
fungal type cell wall organization GO:0031505 145 0.038
cell division GO:0051301 205 0.038
Fly
ubiquitin dependent protein catabolic process GO:0006511 181 0.038
intracellular signal transduction GO:0035556 112 0.038
Human
ribonucleoside metabolic process GO:0009119 389 0.038
purine nucleotide metabolic process GO:0006163 376 0.038
negative regulation of cellular protein metabolic process GO:0032269 85 0.037
purine ribonucleotide metabolic process GO:0009150 372 0.037
regulation of catalytic activity GO:0050790 307 0.037
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.037
nuclear export GO:0051168 124 0.037
chemical homeostasis GO:0048878 137 0.036
regulation of response to dna damage stimulus GO:2001020 17 0.036
Human
nucleoside metabolic process GO:0009116 394 0.036
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.035
anatomical structure development GO:0048856 160 0.035
Fly
base excision repair GO:0006284 14 0.035
cellular response to nutrient levels GO:0031669 144 0.035
spindle assembly checkpoint GO:0071173 23 0.034
protein catabolic process GO:0030163 221 0.034
regulation of localization GO:0032879 127 0.034
ribonucleotide metabolic process GO:0009259 377 0.034
positive regulation of protein metabolic process GO:0051247 93 0.034
organelle assembly GO:0070925 118 0.034
non recombinational repair GO:0000726 33 0.033
Fly
purine ribonucleoside metabolic process GO:0046128 380 0.033
covalent chromatin modification GO:0016569 119 0.033
organic acid metabolic process GO:0006082 352 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.033
cellular chemical homeostasis GO:0055082 123 0.033
cellular response to oxidative stress GO:0034599 94 0.033
external encapsulating structure organization GO:0045229 146 0.033
atp metabolic process GO:0046034 251 0.033
posttranscriptional regulation of gene expression GO:0010608 115 0.032
positive regulation of phosphorylation GO:0042327 33 0.032
carbohydrate metabolic process GO:0005975 252 0.032
negative regulation of phosphorylation GO:0042326 28 0.031
cellular response to chemical stimulus GO:0070887 315 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.030
Human
response to starvation GO:0042594 96 0.030
osmosensory signaling pathway GO:0007231 22 0.030
lipid localization GO:0010876 60 0.029
regulation of phosphate metabolic process GO:0019220 230 0.029
regulation of translation GO:0006417 89 0.029
negative regulation of signaling GO:0023057 30 0.029
mitochondrion organization GO:0007005 261 0.029
negative regulation of response to stimulus GO:0048585 40 0.029
protein complex assembly GO:0006461 302 0.029
organophosphate biosynthetic process GO:0090407 182 0.028
glycerophospholipid metabolic process GO:0006650 98 0.028
nucleotide metabolic process GO:0009117 453 0.028
ribose phosphate metabolic process GO:0019693 384 0.028
nucleoside catabolic process GO:0009164 335 0.027
regulation of cell communication GO:0010646 124 0.027
Human
positive regulation of intracellular protein transport GO:0090316 3 0.027
mitotic cell cycle phase transition GO:0044772 141 0.027
Fly
protein dna complex subunit organization GO:0071824 153 0.027
positive regulation of biosynthetic process GO:0009891 336 0.026
negative regulation of organelle organization GO:0010639 103 0.026
organonitrogen compound catabolic process GO:1901565 404 0.026
response to oxidative stress GO:0006979 99 0.026
regulation of protein serine threonine kinase activity GO:0071900 41 0.026
ribonucleoside catabolic process GO:0042454 332 0.025
positive regulation of macromolecule metabolic process GO:0010604 394 0.025
programmed cell death GO:0012501 30 0.025
negative regulation of signal transduction GO:0009968 30 0.025
glycosyl compound catabolic process GO:1901658 335 0.025
microtubule cytoskeleton organization GO:0000226 109 0.025
positive regulation of intracellular transport GO:0032388 4 0.025
gene conversion at mating type locus GO:0007534 11 0.025
regulation of anatomical structure size GO:0090066 50 0.024
carboxylic acid biosynthetic process GO:0046394 152 0.024
response to osmotic stress GO:0006970 83 0.024
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.024
Human
positive regulation of cellular biosynthetic process GO:0031328 336 0.024
nucleoside triphosphate catabolic process GO:0009143 329 0.024
sexual reproduction GO:0019953 216 0.023
regulation of response to stress GO:0080134 57 0.023
Human
purine nucleoside catabolic process GO:0006152 330 0.023
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 24 0.023
purine containing compound metabolic process GO:0072521 400 0.023
regulation of cellular catabolic process GO:0031329 195 0.023
purine nucleoside monophosphate catabolic process GO:0009128 224 0.023
telomere capping GO:0016233 10 0.023
filamentous growth of a population of unicellular organisms GO:0044182 109 0.023
negative regulation of dna replication GO:0008156 15 0.022
Human
dna catabolic process exonucleolytic GO:0000738 19 0.022
Fly
positive regulation of molecular function GO:0044093 185 0.022
protein maturation GO:0051604 76 0.022
negative regulation of intracellular signal transduction GO:1902532 27 0.022
microtubule based process GO:0007017 117 0.022
nucleoside phosphate catabolic process GO:1901292 331 0.022
nucleotide catabolic process GO:0009166 330 0.021
response to drug GO:0042493 41 0.021
mitotic cell cycle process GO:1903047 294 0.021
Fly
atp catabolic process GO:0006200 224 0.021
negative regulation of protein catabolic process GO:0042177 27 0.021
organophosphate catabolic process GO:0046434 338 0.021
modification dependent macromolecule catabolic process GO:0043632 203 0.021
ribonucleotide catabolic process GO:0009261 327 0.021
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 27 0.021
negative regulation of cell cycle GO:0045786 91 0.021
Fly
negative regulation of mitosis GO:0045839 39 0.021
organic hydroxy compound biosynthetic process GO:1901617 81 0.021
dna conformation change GO:0071103 98 0.021
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 224 0.021
purine ribonucleoside catabolic process GO:0046130 330 0.020
negative regulation of gene silencing GO:0060969 27 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.020
ribonucleoside triphosphate metabolic process GO:0009199 356 0.020
cell morphogenesis GO:0000902 30 0.020
Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.019
cellular glucan metabolic process GO:0006073 44 0.019
regulation of intracellular signal transduction GO:1902531 78 0.019
Human
ribonucleoside monophosphate catabolic process GO:0009158 224 0.019
multi organism reproductive process GO:0044703 216 0.019
purine nucleoside triphosphate metabolic process GO:0009144 356 0.018
purine nucleotide catabolic process GO:0006195 328 0.018
purine ribonucleotide catabolic process GO:0009154 327 0.018
regulation of phosphorylation GO:0042325 86 0.018
cellular response to extracellular stimulus GO:0031668 150 0.018
regulation of protein metabolic process GO:0051246 237 0.018
cellular carbohydrate metabolic process GO:0044262 135 0.018
purine nucleoside triphosphate catabolic process GO:0009146 329 0.017
cell development GO:0048468 107 0.017
regulation of dna recombination GO:0000018 24 0.017
actin filament based process GO:0030029 104 0.017
Fly
response to uv GO:0009411 4 0.017
Human
replicative cell aging GO:0001302 46 0.017
nucleoside monophosphate catabolic process GO:0009125 224 0.017
regulation of organelle organization GO:0033043 243 0.017
Fly
ribonucleoside triphosphate catabolic process GO:0009203 327 0.017
spindle checkpoint GO:0031577 35 0.017
anatomical structure morphogenesis GO:0009653 160 0.017
Fly
regulation of endocytosis GO:0030100 17 0.017
alcohol biosynthetic process GO:0046165 75 0.017
transmembrane transport GO:0055085 349 0.017
glycosyl compound metabolic process GO:1901657 398 0.017
response to organic cyclic compound GO:0014070 1 0.016
Fly
dna biosynthetic process GO:0071897 33 0.016
negative regulation of macromolecule metabolic process GO:0010605 375 0.016
Human
modification dependent protein catabolic process GO:0019941 181 0.016
rrna metabolic process GO:0016072 244 0.016
carbohydrate derivative catabolic process GO:1901136 339 0.016
positive regulation of cytoplasmic transport GO:1903651 4 0.016
pseudohyphal growth GO:0007124 75 0.016
regulation of cytoskeleton organization GO:0051493 63 0.016
maintenance of protein location GO:0045185 53 0.015
lipid transport GO:0006869 58 0.015
chromatin assembly or disassembly GO:0006333 60 0.015
lipid biosynthetic process GO:0008610 170 0.015
negative regulation of phosphate metabolic process GO:0045936 49 0.015
regulation of protein phosphorylation GO:0001932 75 0.015
cellular protein complex assembly GO:0043623 209 0.015
ion homeostasis GO:0050801 118 0.015
regulation of chromosome organization GO:0033044 66 0.015
cellular response to organic substance GO:0071310 159 0.014
cell cycle g1 s phase transition GO:0044843 64 0.014
membrane lipid biosynthetic process GO:0046467 54 0.014
regulation of protein kinase activity GO:0045859 67 0.014
meiotic chromosome segregation GO:0045132 31 0.014
Fly
growth of unicellular organism as a thread of attached cells GO:0070783 105 0.014
single organism carbohydrate metabolic process GO:0044723 237 0.014
gene conversion GO:0035822 14 0.014
protein processing GO:0016485 64 0.014
positive regulation of programmed cell death GO:0043068 3 0.014
regulation of dna dependent dna replication GO:0090329 37 0.014
regulation of lipid metabolic process GO:0019216 45 0.014
response to external stimulus GO:0009605 158 0.014
mitotic spindle checkpoint GO:0071174 34 0.014
membrane organization GO:0061024 276 0.014
cellular response to abiotic stimulus GO:0071214 62 0.014
Human
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.014
meiotic dna double strand break processing GO:0000706 5 0.013
Fly
positive regulation of nucleocytoplasmic transport GO:0046824 4 0.013
regulation of nuclear division GO:0051783 103 0.013
Fly
mitotic dna damage checkpoint GO:0044773 11 0.013
Fly
regulation of transferase activity GO:0051338 83 0.013
organelle localization GO:0051640 128 0.013
positive regulation of catalytic activity GO:0043085 178 0.013
dna double strand break processing GO:0000729 8 0.013
Fly
small molecule biosynthetic process GO:0044283 258 0.013
positive regulation of catabolic process GO:0009896 135 0.013
positive regulation of rna metabolic process GO:0051254 294 0.013
maintenance of location in cell GO:0051651 58 0.013
mrna metabolic process GO:0016071 269 0.013
protein localization to organelle GO:0033365 337 0.013
positive regulation of cell death GO:0010942 3 0.013
spore wall biogenesis GO:0070590 52 0.013
protein complex localization GO:0031503 32 0.013
regulation of protein processing GO:0070613 34 0.012
negative regulation of protein processing GO:0010955 33 0.012
cellular response to osmotic stress GO:0071470 50 0.012
mitotic dna integrity checkpoint GO:0044774 18 0.012
Fly
response to inorganic substance GO:0010035 47 0.012
lagging strand elongation GO:0006273 10 0.012
cellular amine metabolic process GO:0044106 51 0.012
nucleoside phosphate biosynthetic process GO:1901293 80 0.012
cell death GO:0008219 30 0.012
negative regulation of phosphorus metabolic process GO:0010563 49 0.012
endocytosis GO:0006897 90 0.012
negative regulation of protein modification process GO:0031400 37 0.012
glycogen metabolic process GO:0005977 30 0.012
negative regulation of dna dependent dna replication GO:2000104 8 0.012
phospholipid metabolic process GO:0006644 125 0.012
regulation of dna templated transcription in response to stress GO:0043620 51 0.012
microtubule anchoring GO:0034453 25 0.012
polyol metabolic process GO:0019751 22 0.011
carbohydrate derivative biosynthetic process GO:1901137 181 0.011
positive regulation of cell cycle process GO:0090068 31 0.011
regulation of translational elongation GO:0006448 25 0.011
apoptotic process GO:0006915 30 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 29 0.011
single organism membrane fusion GO:0044801 71 0.011
proteolysis GO:0006508 268 0.011
regulation of hydrolase activity GO:0051336 133 0.011
positive regulation of protein kinase activity GO:0045860 22 0.011
positive regulation of response to stimulus GO:0048584 37 0.011
Human
cellular ketone metabolic process GO:0042180 63 0.011
cell cycle dna replication GO:0044786 36 0.011
positive regulation of secretion GO:0051047 2 0.011
positive regulation of protein phosphorylation GO:0001934 28 0.011
regulation of homeostatic process GO:0032844 19 0.010
cation homeostasis GO:0055080 105 0.010
rna localization GO:0006403 112 0.010
transposition rna mediated GO:0032197 17 0.010
membrane lipid metabolic process GO:0006643 67 0.010
response to nitrogen compound GO:1901698 18 0.010
Fly
establishment of rna localization GO:0051236 92 0.010
regulation of phosphorus metabolic process GO:0051174 230 0.010

MEC1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.010
cancer DOID:162 0 0.010