|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
181 |
0.943
|
|
|
proteolysis
|
GO:0006508 |
268 |
0.932
|
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
46 |
0.926
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
137 |
0.911
|
|
|
protein folding
|
GO:0006457 |
94 |
0.908
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
181 |
0.832
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
363 |
0.769
|
|
|
cellular protein catabolic process
|
GO:0044257 |
213 |
0.760
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.704
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
203 |
0.701
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
141 |
0.474
|
|
|
protein targeting to er
|
GO:0045047 |
39 |
0.432
|
Yeast |
|
establishment of protein localization to membrane
|
GO:0090150 |
99 |
0.390
|
|
|
cytoskeleton organization
|
GO:0007010 |
230 |
0.320
|
Worm |
|
regulation of phosphorus metabolic process
|
GO:0051174 |
230 |
0.297
|
Human Yeast |
|
nucleus organization
|
GO:0006997 |
62 |
0.295
|
|
|
protein localization to endoplasmic reticulum
|
GO:0070972 |
47 |
0.287
|
Yeast |
|
signal transduction
|
GO:0007165 |
208 |
0.256
|
Human |
|
organelle fusion
|
GO:0048284 |
85 |
0.246
|
|
|
response to starvation
|
GO:0042594 |
96 |
0.238
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
198 |
0.237
|
|
|
cotranslational protein targeting to membrane
|
GO:0006613 |
15 |
0.234
|
|
|
regulation of phosphate metabolic process
|
GO:0019220 |
230 |
0.228
|
Human Yeast |
|
establishment of protein localization to endoplasmic reticulum
|
GO:0072599 |
40 |
0.226
|
Yeast |
|
signaling
|
GO:0023052 |
208 |
0.210
|
Human |
|
karyogamy involved in conjugation with cellular fusion
|
GO:0000742 |
15 |
0.186
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
150 |
0.186
|
|
|
positive regulation of phosphorus metabolic process
|
GO:0010562 |
147 |
0.160
|
Yeast |
|
regulation of cellular protein metabolic process
|
GO:0032268 |
232 |
0.151
|
Human |
|
cellular response to nutrient levels
|
GO:0031669 |
144 |
0.146
|
|
|
response to nutrient levels
|
GO:0031667 |
150 |
0.143
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
278 |
0.142
|
Yeast |
|
maintenance of location in cell
|
GO:0051651 |
58 |
0.142
|
|
|
multi organism reproductive process
|
GO:0044703 |
216 |
0.141
|
|
|
positive regulation of nucleobase containing compound metabolic process
|
GO:0045935 |
409 |
0.140
|
Yeast |
|
regulation of protein metabolic process
|
GO:0051246 |
237 |
0.137
|
Human |
|
protein localization to membrane
|
GO:0072657 |
102 |
0.132
|
|
|
negative regulation of macromolecule metabolic process
|
GO:0010605 |
375 |
0.132
|
Human |
|
single organism cellular localization
|
GO:1902580 |
375 |
0.129
|
Yeast |
|
protein targeting to membrane
|
GO:0006612 |
52 |
0.127
|
|
|
protein transport
|
GO:0015031 |
345 |
0.117
|
Human Yeast |
|
carbohydrate derivative metabolic process
|
GO:1901135 |
549 |
0.116
|
Yeast |
|
peptidyl amino acid modification
|
GO:0018193 |
116 |
0.116
|
|
|
positive regulation of nitrogen compound metabolic process
|
GO:0051173 |
412 |
0.113
|
Yeast |
|
positive regulation of kinase activity
|
GO:0033674 |
24 |
0.110
|
|
|
regulation of catalytic activity
|
GO:0050790 |
307 |
0.108
|
Human Yeast |
|
regulation of kinase activity
|
GO:0043549 |
71 |
0.108
|
Human |
|
protein localization to organelle
|
GO:0033365 |
337 |
0.106
|
Human Yeast |
|
microtubule cytoskeleton organization
|
GO:0000226 |
109 |
0.104
|
Worm |
|
cell communication
|
GO:0007154 |
345 |
0.101
|
Human |
|
cellular response to starvation
|
GO:0009267 |
90 |
0.096
|
|
|
intracellular protein transport
|
GO:0006886 |
319 |
0.096
|
Yeast |
|
membrane organization
|
GO:0061024 |
276 |
0.095
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
112 |
0.092
|
Yeast |
|
protein targeting
|
GO:0006605 |
272 |
0.088
|
Yeast |
|
sexual reproduction
|
GO:0019953 |
216 |
0.086
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
50 |
0.086
|
|
|
positive regulation of macromolecule metabolic process
|
GO:0010604 |
394 |
0.085
|
|
|
maintenance of location
|
GO:0051235 |
66 |
0.084
|
|
|
regulation of phosphorylation
|
GO:0042325 |
86 |
0.083
|
Human |
|
organophosphate biosynthetic process
|
GO:0090407 |
182 |
0.081
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
89 |
0.081
|
|
|
regulation of molecular function
|
GO:0065009 |
320 |
0.080
|
Human Yeast |
|
alcohol metabolic process
|
GO:0006066 |
112 |
0.079
|
|
|
protein phosphorylation
|
GO:0006468 |
197 |
0.079
|
Human |
|
ion transport
|
GO:0006811 |
274 |
0.078
|
|
|
golgi vesicle transport
|
GO:0048193 |
188 |
0.075
|
|
|
positive regulation of phosphate metabolic process
|
GO:0045937 |
147 |
0.072
|
Yeast |
|
protein modification by small protein conjugation or removal
|
GO:0070647 |
172 |
0.071
|
Human Yeast |
|
response to extracellular stimulus
|
GO:0009991 |
156 |
0.070
|
|
|
single organism membrane organization
|
GO:0044802 |
275 |
0.069
|
|
|
regulation of transferase activity
|
GO:0051338 |
83 |
0.069
|
Human |
|
response to topologically incorrect protein
|
GO:0035966 |
38 |
0.068
|
|
|
multi organism process
|
GO:0051704 |
233 |
0.068
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
133 |
0.067
|
Yeast |
|
phosphatidylinositol metabolic process
|
GO:0046488 |
62 |
0.067
|
|
|
srp dependent cotranslational protein targeting to membrane
|
GO:0006614 |
14 |
0.067
|
|
|
regulation of biological quality
|
GO:0065008 |
391 |
0.065
|
|
|
multi organism cellular process
|
GO:0044764 |
120 |
0.063
|
|
|
er to golgi vesicle mediated transport
|
GO:0006888 |
86 |
0.063
|
|
|
transmembrane transport
|
GO:0055085 |
349 |
0.062
|
Yeast |
|
maintenance of protein location
|
GO:0045185 |
53 |
0.061
|
|
|
organophosphate metabolic process
|
GO:0019637 |
597 |
0.061
|
Yeast |
|
negative regulation of gene expression
|
GO:0010629 |
312 |
0.060
|
|
|
conjugation with cellular fusion
|
GO:0000747 |
106 |
0.059
|
|
|
establishment of protein localization
|
GO:0045184 |
367 |
0.058
|
Human Yeast |
|
positive regulation of molecular function
|
GO:0044093 |
185 |
0.057
|
Yeast |
|
glycoprotein metabolic process
|
GO:0009100 |
62 |
0.057
|
|
|
regulation of protein modification process
|
GO:0031399 |
110 |
0.057
|
Human |
|
response to external stimulus
|
GO:0009605 |
158 |
0.057
|
|
|
protein complex biogenesis
|
GO:0070271 |
314 |
0.055
|
|
|
single organism signaling
|
GO:0044700 |
208 |
0.053
|
Human |
|
cellular lipid metabolic process
|
GO:0044255 |
229 |
0.053
|
|
|
microtubule organizing center organization
|
GO:0031023 |
33 |
0.052
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
237 |
0.052
|
|
|
cellular response to topologically incorrect protein
|
GO:0035967 |
32 |
0.051
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
22 |
0.048
|
|
|
macromolecule catabolic process
|
GO:0009057 |
383 |
0.047
|
|
|
positive regulation of cellular protein metabolic process
|
GO:0032270 |
89 |
0.046
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
491 |
0.045
|
Yeast |
|
protein modification by small protein conjugation
|
GO:0032446 |
144 |
0.045
|
Human Yeast |
|
regulation of signaling
|
GO:0023051 |
119 |
0.043
|
Human |
|
positive regulation of catalytic activity
|
GO:0043085 |
178 |
0.042
|
Yeast |
|
gene silencing
|
GO:0016458 |
151 |
0.041
|
|
|
ribonucleoprotein complex subunit organization
|
GO:0071826 |
152 |
0.040
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
71 |
0.040
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
108 |
0.039
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
98 |
0.038
|
|
|
mrna metabolic process
|
GO:0016071 |
269 |
0.037
|
|
|
regulation of localization
|
GO:0032879 |
127 |
0.037
|
Human |
|
posttranslational protein targeting to membrane
|
GO:0006620 |
17 |
0.037
|
|
|
negative regulation of macromolecule biosynthetic process
|
GO:0010558 |
291 |
0.036
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
389 |
0.036
|
Yeast |
|
regulation of gene expression epigenetic
|
GO:0040029 |
147 |
0.035
|
|
|
response to chemical
|
GO:0042221 |
390 |
0.034
|
|
|
conjugation
|
GO:0000746 |
107 |
0.034
|
|
|
reproductive process
|
GO:0022414 |
248 |
0.034
|
|
|
protein complex assembly
|
GO:0006461 |
302 |
0.033
|
|
|
intracellular signal transduction
|
GO:0035556 |
112 |
0.033
|
Human |
|
positive regulation of protein metabolic process
|
GO:0051247 |
93 |
0.033
|
|
|
nucleoside metabolic process
|
GO:0009116 |
394 |
0.032
|
Yeast |
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
181 |
0.032
|
|
|
regulation of cellular component organization
|
GO:0051128 |
334 |
0.031
|
Human |
|
karyogamy
|
GO:0000741 |
17 |
0.030
|
|
|
death
|
GO:0016265 |
30 |
0.030
|
Human |
|
macromolecule glycosylation
|
GO:0043413 |
57 |
0.030
|
|
|
homeostatic process
|
GO:0042592 |
227 |
0.029
|
|
|
cellular response to organic substance
|
GO:0071310 |
159 |
0.029
|
|
|
lipid biosynthetic process
|
GO:0008610 |
170 |
0.029
|
|
|
phosphorylation
|
GO:0016310 |
291 |
0.029
|
Human |
|
negative regulation of nucleobase containing compound metabolic process
|
GO:0045934 |
295 |
0.029
|
|
|
posttranslational protein targeting to membrane translocation
|
GO:0031204 |
9 |
0.028
|
|
|
microtubule based process
|
GO:0007017 |
117 |
0.028
|
Worm |
|
response to endoplasmic reticulum stress
|
GO:0034976 |
23 |
0.028
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
331 |
0.028
|
Yeast |
|
cellular protein complex assembly
|
GO:0043623 |
209 |
0.027
|
|
|
intracellular protein transmembrane transport
|
GO:0065002 |
80 |
0.027
|
Yeast |
|
positive regulation of transferase activity
|
GO:0051347 |
28 |
0.027
|
|
|
protein processing
|
GO:0016485 |
64 |
0.027
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
8 |
0.027
|
|
|
response to biotic stimulus
|
GO:0009607 |
8 |
0.026
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
195 |
0.025
|
Yeast |
|
cellular component movement
|
GO:0006928 |
20 |
0.025
|
|
|
cellular ion homeostasis
|
GO:0006873 |
112 |
0.025
|
|
|
negative regulation of nitrogen compound metabolic process
|
GO:0051172 |
300 |
0.025
|
|
|
programmed cell death
|
GO:0012501 |
30 |
0.024
|
Human |
|
regulation of intracellular signal transduction
|
GO:1902531 |
78 |
0.024
|
Human |
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
115 |
0.023
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
123 |
0.023
|
|
|
protein ubiquitination
|
GO:0016567 |
118 |
0.023
|
Human |
|
fungal type cell wall biogenesis
|
GO:0009272 |
80 |
0.022
|
|
|
regulation of signal transduction
|
GO:0009966 |
114 |
0.022
|
Human |
|
negative regulation of cellular macromolecule biosynthetic process
|
GO:2000113 |
289 |
0.022
|
|
|
lipid metabolic process
|
GO:0006629 |
269 |
0.022
|
|
|
mitotic cell cycle
|
GO:0000278 |
306 |
0.022
|
Worm |
|
methylation
|
GO:0032259 |
101 |
0.021
|
|
|
organelle fission
|
GO:0048285 |
272 |
0.021
|
|
|
negative regulation of nucleic acid templated transcription
|
GO:1903507 |
260 |
0.021
|
|
|
positive regulation of gene expression
|
GO:0010628 |
321 |
0.021
|
|
|
developmental process
|
GO:0032502 |
261 |
0.021
|
Worm Fly |
|
positive regulation of cell death
|
GO:0010942 |
3 |
0.021
|
Human |
|
carbohydrate derivative catabolic process
|
GO:1901136 |
339 |
0.020
|
Yeast |
|
negative regulation of transcription dna templated
|
GO:0045892 |
258 |
0.020
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
67 |
0.020
|
Human |
|
single organism developmental process
|
GO:0044767 |
258 |
0.020
|
Worm Fly |
|
ribonucleoside catabolic process
|
GO:0042454 |
332 |
0.020
|
Yeast |
|
regulation of cell communication
|
GO:0010646 |
124 |
0.020
|
Human |
|
negative regulation of cellular biosynthetic process
|
GO:0031327 |
312 |
0.020
|
|
|
single organism catabolic process
|
GO:0044712 |
619 |
0.020
|
Yeast |
|
negative regulation of rna biosynthetic process
|
GO:1902679 |
260 |
0.019
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
7 |
0.019
|
|
|
protein maturation
|
GO:0051604 |
76 |
0.019
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
499 |
0.019
|
Yeast |
|
cation homeostasis
|
GO:0055080 |
105 |
0.019
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
354 |
0.018
|
Yeast |
|
positive regulation of protein modification process
|
GO:0031401 |
49 |
0.018
|
|
|
regulation of response to stimulus
|
GO:0048583 |
157 |
0.018
|
Human |
|
metal ion transport
|
GO:0030001 |
75 |
0.018
|
|
|
phospholipid metabolic process
|
GO:0006644 |
125 |
0.018
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
20 |
0.018
|
Human |
|
purine ribonucleoside catabolic process
|
GO:0046130 |
330 |
0.017
|
Yeast |
|
negative regulation of cellular metabolic process
|
GO:0031324 |
407 |
0.017
|
Human |
|
protein folding in endoplasmic reticulum
|
GO:0034975 |
13 |
0.017
|
|
|
chemical homeostasis
|
GO:0048878 |
137 |
0.017
|
|
|
regulation of organelle organization
|
GO:0033043 |
243 |
0.016
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
29 |
0.016
|
Human |
|
positive regulation of cellular biosynthetic process
|
GO:0031328 |
336 |
0.016
|
|
|
cell wall organization or biogenesis
|
GO:0071554 |
190 |
0.016
|
|
|
response to organic substance
|
GO:0010033 |
182 |
0.016
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
106 |
0.016
|
Yeast |
|
glycosyl compound catabolic process
|
GO:1901658 |
335 |
0.016
|
Yeast |
|
cation transport
|
GO:0006812 |
166 |
0.016
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
380 |
0.016
|
Yeast |
|
response to temperature stimulus
|
GO:0009266 |
74 |
0.015
|
|
|
apoptotic process
|
GO:0006915 |
30 |
0.015
|
Human |
|
response to unfolded protein
|
GO:0006986 |
29 |
0.015
|
|
|
regulation of transport
|
GO:0051049 |
85 |
0.015
|
Human |
|
negative regulation of biosynthetic process
|
GO:0009890 |
312 |
0.015
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
3 |
0.015
|
Human |
|
endoplasmic reticulum unfolded protein response
|
GO:0030968 |
23 |
0.015
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
80 |
0.015
|
|
|
organophosphate catabolic process
|
GO:0046434 |
338 |
0.015
|
Yeast |
|
nucleobase containing compound catabolic process
|
GO:0034655 |
479 |
0.015
|
Yeast |
|
chromatin organization
|
GO:0006325 |
242 |
0.015
|
|
|
nucleoside catabolic process
|
GO:0009164 |
335 |
0.015
|
Yeast |
|
response to toxic substance
|
GO:0009636 |
9 |
0.015
|
|
|
endomembrane system organization
|
GO:0010256 |
74 |
0.015
|
|
|
cellular response to unfolded protein
|
GO:0034620 |
23 |
0.015
|
|
|
srp dependent cotranslational protein targeting to membrane translocation
|
GO:0006616 |
9 |
0.015
|
|
|
rna splicing
|
GO:0008380 |
131 |
0.015
|
|
|
peptidyl histidine modification
|
GO:0018202 |
9 |
0.015
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
329 |
0.014
|
Yeast |
|
ribose phosphate metabolic process
|
GO:0019693 |
384 |
0.014
|
Yeast |
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
327 |
0.014
|
Yeast |
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
364 |
0.014
|
Yeast |
|
purine containing compound catabolic process
|
GO:0072523 |
332 |
0.014
|
Yeast |
|
mitotic cell cycle process
|
GO:1903047 |
294 |
0.014
|
Worm |
|
negative regulation of rna metabolic process
|
GO:0051253 |
262 |
0.014
|
|
|
establishment of organelle localization
|
GO:0051656 |
96 |
0.014
|
|
|
protein n linked glycosylation
|
GO:0006487 |
34 |
0.014
|
|
|
anatomical structure development
|
GO:0048856 |
160 |
0.014
|
Worm Fly |
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
327 |
0.013
|
Yeast |
|
positive regulation of programmed cell death
|
GO:0043068 |
3 |
0.013
|
Human |
|
ribonucleotide metabolic process
|
GO:0009259 |
377 |
0.013
|
Yeast |
|
regulation of dna metabolic process
|
GO:0051052 |
100 |
0.013
|
|
|
meiotic nuclear division
|
GO:0007126 |
163 |
0.012
|
|
|
ion homeostasis
|
GO:0050801 |
118 |
0.012
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
252 |
0.012
|
|
|
glycosylation
|
GO:0070085 |
66 |
0.012
|
|
|
vesicle mediated transport
|
GO:0016192 |
335 |
0.012
|
|
|
cellular modified amino acid metabolic process
|
GO:0006575 |
51 |
0.012
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
109 |
0.012
|
Yeast |
|
protein transmembrane transport
|
GO:0071806 |
82 |
0.012
|
Yeast |
|
ncrna processing
|
GO:0034470 |
330 |
0.012
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
32 |
0.012
|
|
|
cellular homeostasis
|
GO:0019725 |
138 |
0.012
|
|
|
cell wall macromolecule biosynthetic process
|
GO:0044038 |
24 |
0.012
|
|
|
rna localization
|
GO:0006403 |
112 |
0.012
|
|
|
oxidation reduction process
|
GO:0055114 |
353 |
0.012
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
376 |
0.011
|
Yeast |
|
lipid modification
|
GO:0030258 |
37 |
0.011
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
110 |
0.011
|
Yeast |
|
regulation of mitosis
|
GO:0007088 |
65 |
0.011
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
400 |
0.011
|
Yeast |
|
ribonucleotide catabolic process
|
GO:0009261 |
327 |
0.011
|
Yeast |
|
transition metal ion homeostasis
|
GO:0055076 |
59 |
0.011
|
|
|
organelle assembly
|
GO:0070925 |
118 |
0.011
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
329 |
0.011
|
Yeast |
|
purine nucleotide catabolic process
|
GO:0006195 |
328 |
0.011
|
Yeast |
|
regulation of lipid metabolic process
|
GO:0019216 |
45 |
0.011
|
|
|
glycerophospholipid biosynthetic process
|
GO:0046474 |
68 |
0.011
|
|
|
cellular response to chemical stimulus
|
GO:0070887 |
315 |
0.011
|
|
|
mrna processing
|
GO:0006397 |
185 |
0.011
|
|
|
histone modification
|
GO:0016570 |
119 |
0.010
|
|
|
cell aging
|
GO:0007569 |
70 |
0.010
|
|
|
regulation of catabolic process
|
GO:0009894 |
199 |
0.010
|
Yeast |
|
regulation of nucleoside metabolic process
|
GO:0009118 |
106 |
0.010
|
Yeast |
|
nuclear division
|
GO:0000280 |
263 |
0.010
|
|
|
regulation of metal ion transport
|
GO:0010959 |
2 |
0.010
|
|
|
lipid localization
|
GO:0010876 |
60 |
0.010
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
125 |
0.010
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
458 |
0.010
|
Yeast |
|
cellular cation homeostasis
|
GO:0030003 |
100 |
0.010
|
|