Drosophila melanogaster

46 known processes

Kmn1 (Dmel_CG1558)

kinetochore Mis12-Ndc80 network component 1

(Aliases: Nsl1,l(1)G0237,CT4038,CG1558,anon-WO03040301.201,Dmel\CG1558,dmNsl1R)

Kmn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sister chromatid segregation GO:0000819 92 0.984
chromosome segregation GO:0007059 157 0.946
mitotic sister chromatid segregation GO:0000070 87 0.943
mitotic metaphase plate congression GO:0007080 13 0.942
mitotic spindle organization GO:0007052 220 0.866
mitotic nuclear division GO:0007067 213 0.832
chromosome localization GO:0050000 20 0.798
chromosome organization GO:0051276 360 0.762
nuclear division GO:0000280 332 0.646
spindle assembly involved in mitosis GO:0090307 50 0.641
cell cycle phase transition GO:0044770 140 0.623
spindle assembly GO:0051225 80 0.603
establishment of localization in cell GO:0051649 402 0.532
negative regulation of rna biosynthetic process GO:1902679 240 0.504
regulation of neurogenesis GO:0050767 158 0.487
metaphase plate congression GO:0051310 19 0.463
establishment of chromosome localization GO:0051303 20 0.455
regulation of cell cycle phase transition GO:1901987 130 0.448
regulation of mitotic cell cycle phase transition GO:1901990 130 0.421
dendrite development GO:0016358 204 0.411
mitotic spindle elongation GO:0000022 81 0.405
mitotic sister chromatid separation GO:0051306 30 0.371
dendrite morphogenesis GO:0048813 199 0.367
spindle organization GO:0007051 253 0.358
muscle structure development GO:0061061 224 0.358
regulation of cell differentiation GO:0045595 302 0.317
positive regulation of mitotic cell cycle GO:0045931 34 0.313
cellular response to dna damage stimulus GO:0006974 223 0.304
intracellular signal transduction GO:0035556 300 0.288
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.282
organelle fission GO:0048285 340 0.270
negative regulation of gene expression GO:0010629 387 0.254
establishment of organelle localization GO:0051656 122 0.249
negative regulation of cellular metabolic process GO:0031324 382 0.248
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.248
rna processing GO:0006396 147 0.240
regulation of mitotic sister chromatid segregation GO:0033047 28 0.239
organelle localization GO:0051640 148 0.229
mitotic cell cycle phase transition GO:0044772 138 0.195
cell proliferation GO:0008283 299 0.192
metaphase anaphase transition of cell cycle GO:0044784 28 0.188
dna conformation change GO:0071103 105 0.165
positive regulation of cell cycle process GO:0090068 28 0.157
negative regulation of cell cycle process GO:0010948 109 0.157
meiotic chromosome segregation GO:0045132 59 0.151
kinetochore organization GO:0051383 9 0.143
recombinational repair GO:0000725 13 0.138
protein complex assembly GO:0006461 200 0.138
meiotic cell cycle process GO:1903046 132 0.136
macromolecule catabolic process GO:0009057 161 0.133
organic substance transport GO:0071702 257 0.131
negative regulation of mitotic cell cycle GO:0045930 109 0.130
protein complex biogenesis GO:0070271 201 0.130
exocrine system development GO:0035272 162 0.130
regulation of mitotic cell cycle GO:0007346 190 0.127
muscle organ development GO:0007517 127 0.126
cellular protein catabolic process GO:0044257 83 0.123
dna damage checkpoint GO:0000077 78 0.123
neuroblast proliferation GO:0007405 74 0.122
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.121
cell death GO:0008219 279 0.118
positive regulation of phosphate metabolic process GO:0045937 139 0.117
negative regulation of transcription dna templated GO:0045892 237 0.117
cellular catabolic process GO:0044248 372 0.117
dna metabolic process GO:0006259 227 0.116
proteolysis GO:0006508 192 0.112
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.110
cellular macromolecule catabolic process GO:0044265 136 0.108
negative regulation of cellular biosynthetic process GO:0031327 277 0.097
positive regulation of r7 cell differentiation GO:0045678 7 0.095
regulation of phosphate metabolic process GO:0019220 210 0.092
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.092
positive regulation of phosphorus metabolic process GO:0010562 139 0.088
regulation of proteasomal protein catabolic process GO:0061136 39 0.082
positive regulation of neurogenesis GO:0050769 41 0.081
regulation of mitotic sister chromatid separation GO:0010965 28 0.080
regulation of small gtpase mediated signal transduction GO:0051056 93 0.077
single organism catabolic process GO:0044712 228 0.077
negative regulation of cell differentiation GO:0045596 143 0.076
photoreceptor cell differentiation GO:0046530 170 0.071
cell cycle checkpoint GO:0000075 95 0.070
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.068
modification dependent macromolecule catabolic process GO:0043632 79 0.067
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.066
body morphogenesis GO:0010171 2 0.066
response to abiotic stimulus GO:0009628 341 0.065
regulation of cell division GO:0051302 72 0.065
regulation of chromosome segregation GO:0051983 32 0.065
protein localization GO:0008104 284 0.062
negative regulation of gene expression epigenetic GO:0045814 77 0.062
proteasomal protein catabolic process GO:0010498 59 0.061
positive regulation of cell cycle GO:0045787 43 0.061
rna localization GO:0006403 115 0.060
cellular protein modification process GO:0006464 438 0.058
microtubule based movement GO:0007018 51 0.057
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.057
ras protein signal transduction GO:0007265 88 0.056
negative regulation of biosynthetic process GO:0009890 277 0.056
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.055
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.055
mitotic cell cycle checkpoint GO:0007093 88 0.054
negative regulation of nucleic acid templated transcription GO:1903507 240 0.054
organic substance catabolic process GO:1901575 308 0.054
chromosome movement towards spindle pole GO:0051305 4 0.053
regulation of mapk cascade GO:0043408 92 0.053
regulation of phosphorylation GO:0042325 147 0.052
regulation of multicellular organismal development GO:2000026 414 0.051
modification dependent protein catabolic process GO:0019941 78 0.051
gliogenesis GO:0042063 80 0.051
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.051
small gtpase mediated signal transduction GO:0007264 88 0.051
embryo development ending in birth or egg hatching GO:0009792 152 0.051
negative regulation of meiotic cell cycle GO:0051447 2 0.049
protein localization to organelle GO:0033365 82 0.047
atp dependent chromatin remodeling GO:0043044 22 0.047
regulation of cellular protein metabolic process GO:0032268 243 0.046
cardiovascular system development GO:0072358 82 0.045
ubiquitin dependent protein catabolic process GO:0006511 78 0.043
establishment of rna localization GO:0051236 47 0.043
positive regulation of phosphorylation GO:0042327 87 0.042
regulation of cellular catabolic process GO:0031329 157 0.042
positive regulation of molecular function GO:0044093 136 0.041
regulation of phosphorus metabolic process GO:0051174 210 0.041
lateral inhibition GO:0046331 206 0.041
positive regulation of response to stimulus GO:0048584 323 0.041
chromatin modification GO:0016568 147 0.040
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.040
cellular macromolecule localization GO:0070727 220 0.040
regulation of dendrite development GO:0050773 37 0.040
mitotic g2 m transition checkpoint GO:0044818 70 0.039
nitrogen compound transport GO:0071705 85 0.039
regulation of intracellular signal transduction GO:1902531 236 0.038
eye photoreceptor cell differentiation GO:0001754 145 0.037
cellular amino acid metabolic process GO:0006520 61 0.036
dna packaging GO:0006323 91 0.036
regulation of sister chromatid segregation GO:0033045 28 0.035
protein modification by small protein conjugation or removal GO:0070647 106 0.035
negative regulation of cell cycle phase transition GO:1901988 103 0.035
dna integrity checkpoint GO:0031570 81 0.034
chromatin remodeling GO:0006338 72 0.034
regulation of neuroblast proliferation GO:1902692 34 0.033
rho protein signal transduction GO:0007266 14 0.033
regulation of response to stress GO:0080134 200 0.033
histone exchange GO:0043486 21 0.033
dna endoreduplication GO:0042023 22 0.032
chromatin silencing GO:0006342 76 0.032
regulation of r7 cell differentiation GO:0045676 15 0.032
mitotic chromosome condensation GO:0007076 22 0.032
regulation of neuron differentiation GO:0045664 103 0.032
catabolic process GO:0009056 409 0.032
regulation of chromosome organization GO:0033044 64 0.031
regulation of catalytic activity GO:0050790 185 0.031
organic acid metabolic process GO:0006082 103 0.031
regulation of nervous system development GO:0051960 248 0.031
protein phosphorylation GO:0006468 169 0.030
regulation of molecular function GO:0065009 217 0.030
regulation of meiosis GO:0040020 3 0.030
positive regulation of cellular protein metabolic process GO:0032270 118 0.029
regulation of gene silencing GO:0060968 63 0.029
positive regulation of protein modification process GO:0031401 58 0.029
regulation of cell proliferation GO:0042127 163 0.029
gene silencing GO:0016458 138 0.029
regulation of gene expression epigenetic GO:0040029 128 0.029
protein modification process GO:0036211 438 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
compound eye photoreceptor cell differentiation GO:0001751 140 0.029
signal transduction by phosphorylation GO:0023014 107 0.029
purine ribonucleotide catabolic process GO:0009154 109 0.028
phagocytosis GO:0006909 215 0.028
positive regulation of gtpase activity GO:0043547 43 0.028
centrosome cycle GO:0007098 137 0.028
positive regulation of cellular component organization GO:0051130 156 0.027
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.027
positive regulation of cell proliferation GO:0008284 47 0.027
carboxylic acid metabolic process GO:0019752 92 0.027
positive regulation of catalytic activity GO:0043085 118 0.026
regulation of cellular amine metabolic process GO:0033238 3 0.026
regulation of ras protein signal transduction GO:0046578 93 0.026
positive regulation of cellular amine metabolic process GO:0033240 0 0.026
centromere complex assembly GO:0034508 7 0.025
cell cell signaling involved in cell fate commitment GO:0045168 210 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
positive regulation of photoreceptor cell differentiation GO:0046534 12 0.025
female meiosis i GO:0007144 8 0.024
macromolecular complex assembly GO:0065003 256 0.023
germarium derived female germ line cyst formation GO:0030727 42 0.023
meiotic spindle organization GO:0000212 36 0.023
negative regulation of organelle organization GO:0010639 56 0.023
regulation of catabolic process GO:0009894 170 0.023
endocytosis GO:0006897 310 0.022
positive regulation of cellular catabolic process GO:0031331 95 0.022
nucleobase containing compound transport GO:0015931 56 0.022
negative regulation of neuroblast proliferation GO:0007406 27 0.022
regulation of protein metabolic process GO:0051246 256 0.022
chromosome condensation GO:0030261 41 0.022
positive regulation of protein metabolic process GO:0051247 128 0.022
regulation of cellular protein catabolic process GO:1903362 44 0.022
mitotic dna damage checkpoint GO:0044773 74 0.022
regulation of cell cycle GO:0051726 291 0.022
gland morphogenesis GO:0022612 145 0.021
negative regulation of neurogenesis GO:0050768 53 0.021
sarcomere organization GO:0045214 26 0.021
salivary gland development GO:0007431 162 0.021
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.020
regulation of cell death GO:0010941 173 0.020
regulation of cell cycle process GO:0010564 181 0.020
positive regulation of gliogenesis GO:0014015 5 0.020
positive regulation of chromatin silencing GO:0031937 16 0.019
intracellular transport GO:0046907 228 0.019
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.019
aging GO:0007568 143 0.019
axon development GO:0061564 297 0.018
protein catabolic process GO:0030163 101 0.018
striated muscle tissue development GO:0014706 27 0.018
cellular protein localization GO:0034613 160 0.018
negative regulation of developmental process GO:0051093 201 0.018
circulatory system development GO:0072359 82 0.018
regulation of photoreceptor cell differentiation GO:0046532 34 0.018
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.018
gland development GO:0048732 191 0.018
axonogenesis GO:0007409 290 0.018
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.017
regulation of proteolysis GO:0030162 87 0.017
regulation of organelle organization GO:0033043 196 0.017
cell cycle dna replication GO:0044786 23 0.017
g2 dna damage checkpoint GO:0031572 69 0.017
positive regulation of dna endoreduplication GO:0032877 4 0.017
regulation of chromatin silencing GO:0031935 36 0.017
dorsal ventral pattern formation GO:0009953 133 0.016
phosphorylation GO:0016310 294 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.016
regulation of nucleotide metabolic process GO:0006140 62 0.016
chromosome separation GO:0051304 42 0.016
nuclear transport GO:0051169 72 0.015
rna transport GO:0050658 46 0.015
muscle cell differentiation GO:0042692 103 0.015
stem cell maintenance GO:0019827 67 0.015
death GO:0016265 284 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
chemosensory behavior GO:0007635 106 0.015
r7 cell differentiation GO:0045466 43 0.014
erk1 and erk2 cascade GO:0070371 39 0.014
response to organic substance GO:0010033 284 0.014
protein localization to nucleus GO:0034504 55 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
histolysis GO:0007559 102 0.014
regulation of erk1 and erk2 cascade GO:0070372 39 0.014
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.014
synapse organization GO:0050808 196 0.014
negative regulation of cellular catabolic process GO:0031330 34 0.014
positive regulation of catabolic process GO:0009896 105 0.014
mitotic g2 dna damage checkpoint GO:0007095 69 0.014
stem cell development GO:0048864 79 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
protein modification by small protein conjugation GO:0032446 79 0.013
meiotic cell cycle GO:0051321 171 0.013
regulation of cell development GO:0060284 215 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
response to temperature stimulus GO:0009266 106 0.013
single organism behavior GO:0044708 391 0.013
regulation of dna metabolic process GO:0051052 34 0.013
acylglycerol catabolic process GO:0046464 3 0.013
germ line cyst formation GO:0048134 44 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
mitotic cell cycle embryonic GO:0045448 38 0.013
regulation of cellular response to stress GO:0080135 89 0.013
developmental programmed cell death GO:0010623 138 0.013
oxoacid metabolic process GO:0043436 103 0.013
regulation of double strand break repair GO:2000779 3 0.013
aromatic compound catabolic process GO:0019439 166 0.013
organelle assembly GO:0070925 198 0.013
maintenance of protein location in cell GO:0032507 26 0.013
regulation of nucleotide catabolic process GO:0030811 48 0.013
regulation of transcription by chromatin organization GO:0034401 3 0.013
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
poly a mrna export from nucleus GO:0016973 5 0.012
mapk cascade GO:0000165 107 0.012
regulation of triglyceride catabolic process GO:0010896 1 0.012
camera type eye morphogenesis GO:0048593 2 0.012
intracellular protein transport GO:0006886 104 0.012
cellular response to endogenous stimulus GO:0071495 80 0.012
positive regulation of macromolecule metabolic process GO:0010604 405 0.012
neuron recognition GO:0008038 101 0.012
positive regulation of nucleotide catabolic process GO:0030813 46 0.012
response to biotic stimulus GO:0009607 294 0.012
chromatin organization GO:0006325 207 0.012
vesicle mediated transport GO:0016192 381 0.012
response to uv GO:0009411 24 0.012
positive regulation of mapk cascade GO:0043410 63 0.012
wing disc morphogenesis GO:0007472 344 0.011
negative regulation of wnt signaling pathway GO:0030178 28 0.011
negative regulation of cellular component organization GO:0051129 108 0.011
positive regulation of cell differentiation GO:0045597 64 0.011
single organism biosynthetic process GO:0044711 206 0.011
macromolecular complex disassembly GO:0032984 37 0.011
regulation of protein processing GO:0070613 32 0.011
positive regulation of organelle organization GO:0010638 65 0.011
negative regulation of cell communication GO:0010648 223 0.011
mitotic dna integrity checkpoint GO:0044774 75 0.011
negative regulation of catabolic process GO:0009895 36 0.011
response to organic cyclic compound GO:0014070 89 0.011
heterocycle catabolic process GO:0046700 166 0.011
mrna processing GO:0006397 104 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
positive regulation of binding GO:0051099 4 0.010
purine ribonucleoside metabolic process GO:0046128 127 0.010
regulation of transferase activity GO:0051338 58 0.010
response to radiation GO:0009314 155 0.010
nucleus localization GO:0051647 34 0.010
actomyosin structure organization GO:0031032 56 0.010
oocyte maturation GO:0001556 3 0.010
larval development GO:0002164 104 0.010
synaptic transmission GO:0007268 288 0.010
positive regulation of cellular component biogenesis GO:0044089 80 0.010

Kmn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.027
nervous system disease DOID:863 0 0.018