Drosophila melanogaster

42 known processes

DNApol-alpha60 (Dmel_CG5553)

DNA polymerase alpha 60kD

(Aliases: Pol,Dmel\CG5553,S(faf)240,Dmpol alpha,DNAprimase,DNA polalpha,GM13640,DNAprim,CG5553,l(3)j10B2,pol alpha,BcDNA:GM13640,l(3)77ABe)

DNApol-alpha60 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organelle fission GO:0048285 340 0.588
nuclear division GO:0000280 332 0.548
meiotic nuclear division GO:0007126 151 0.524
dna replication GO:0006260 48 0.481
dna metabolic process GO:0006259 227 0.342
negative regulation of cell cycle process GO:0010948 109 0.342
chromosome segregation GO:0007059 157 0.295
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.292
nuclear dna replication GO:0033260 1 0.284
negative regulation of cell cycle GO:0045786 116 0.281
regulation of mitotic cell cycle GO:0007346 190 0.272
cell cycle phase transition GO:0044770 140 0.271
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.269
dna replication initiation GO:0006270 6 0.260
mitotic nuclear division GO:0007067 213 0.258
negative regulation of mitotic cell cycle GO:0045930 109 0.256
regulation of cell cycle phase transition GO:1901987 130 0.244
regulation of cell cycle process GO:0010564 181 0.208
meiotic cell cycle process GO:1903046 132 0.205
regulation of mitotic cell cycle phase transition GO:1901990 130 0.185
mitotic sister chromatid separation GO:0051306 30 0.185
eggshell chorion gene amplification GO:0007307 9 0.185
negative regulation of cell cycle phase transition GO:1901988 103 0.184
regulation of mitosis GO:0007088 56 0.180
mitotic cell cycle phase transition GO:0044772 138 0.178
compound eye development GO:0048749 307 0.169
g2 m transition of mitotic cell cycle GO:0000086 19 0.164
negative regulation of cell cycle g2 m phase transition GO:1902750 8 0.164
tube morphogenesis GO:0035239 191 0.145
female meiosis chromosome segregation GO:0016321 33 0.138
mitotic dna integrity checkpoint GO:0044774 75 0.138
mitotic cell cycle checkpoint GO:0007093 88 0.136
cell cycle dna replication GO:0044786 23 0.132
regulation of mitotic sister chromatid separation GO:0010965 28 0.131
male meiosis GO:0007140 52 0.125
cystoblast division GO:0007282 10 0.118
sister chromatid segregation GO:0000819 92 0.115
dna amplification GO:0006277 11 0.112
cell cycle checkpoint GO:0000075 95 0.111
cellular protein modification process GO:0006464 438 0.101
mitotic g2 m transition checkpoint GO:0044818 70 0.093
regulation of mitotic sister chromatid segregation GO:0033047 28 0.091
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.086
intracellular signal transduction GO:0035556 300 0.085
mitotic g2 dna damage checkpoint GO:0007095 69 0.084
body morphogenesis GO:0010171 2 0.084
regulation of cell cycle GO:0051726 291 0.083
eggshell formation GO:0030703 105 0.082
chromosome separation GO:0051304 42 0.081
regulation of chromosome segregation GO:0051983 32 0.080
dna dependent dna replication GO:0006261 17 0.079
negative regulation of chromosome segregation GO:0051985 14 0.078
eye antennal disc development GO:0035214 60 0.076
reciprocal meiotic recombination GO:0007131 19 0.074
epithelial cell differentiation GO:0030855 322 0.074
dna integrity checkpoint GO:0031570 81 0.073
negative regulation of gene expression GO:0010629 387 0.072
appendage morphogenesis GO:0035107 397 0.072
cell division GO:0051301 248 0.072
post embryonic appendage morphogenesis GO:0035120 385 0.070
regulation of cytoskeleton organization GO:0051493 89 0.070
appendage development GO:0048736 401 0.067
ovarian follicle cell development GO:0030707 248 0.066
protein modification process GO:0036211 438 0.066
developmental growth GO:0048589 280 0.064
metaphase anaphase transition of cell cycle GO:0044784 28 0.064
negative regulation of nucleic acid templated transcription GO:1903507 240 0.064
growth GO:0040007 359 0.062
imaginal disc derived appendage development GO:0048737 399 0.062
establishment of tissue polarity GO:0007164 87 0.059
negative regulation of organelle organization GO:0010639 56 0.059
imaginal disc derived appendage morphogenesis GO:0035114 395 0.057
mitotic sister chromatid segregation GO:0000070 87 0.057
wing disc morphogenesis GO:0007472 344 0.054
spindle assembly involved in mitosis GO:0090307 50 0.053
regulation of nuclear division GO:0051783 58 0.052
dna endoreduplication GO:0042023 22 0.051
ras protein signal transduction GO:0007265 88 0.051
tissue morphogenesis GO:0048729 297 0.050
regulation of cell division GO:0051302 72 0.049
compound eye morphogenesis GO:0001745 249 0.049
eye development GO:0001654 323 0.049
female meiotic division GO:0007143 70 0.048
cell proliferation GO:0008283 299 0.048
leg disc morphogenesis GO:0007478 80 0.047
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.046
regulation of cellular catabolic process GO:0031329 157 0.045
sex differentiation GO:0007548 81 0.045
regulation of cell proliferation GO:0042127 163 0.044
g2 dna damage checkpoint GO:0031572 69 0.043
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.042
death GO:0016265 284 0.042
organelle localization GO:0051640 148 0.042
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.042
cellular response to dna damage stimulus GO:0006974 223 0.041
regulation of sister chromatid cohesion GO:0007063 2 0.041
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.040
cell cycle g2 m phase transition GO:0044839 22 0.040
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 10 0.040
spindle elongation GO:0051231 83 0.040
protein modification by small protein conjugation or removal GO:0070647 106 0.040
regulation of apoptotic process GO:0042981 130 0.039
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.038
notch signaling pathway GO:0007219 120 0.038
eggshell chorion assembly GO:0007306 66 0.038
phagocytosis GO:0006909 215 0.037
chorion containing eggshell formation GO:0007304 105 0.037
mitotic dna damage checkpoint GO:0044773 74 0.036
embryo development ending in birth or egg hatching GO:0009792 152 0.036
positive regulation of signaling GO:0023056 243 0.036
negative regulation of rna metabolic process GO:0051253 251 0.035
regulation of organelle organization GO:0033043 196 0.035
determination of adult lifespan GO:0008340 137 0.035
female germ line cyst formation GO:0048135 42 0.034
single organism behavior GO:0044708 391 0.034
mitotic sister chromatid cohesion GO:0007064 6 0.034
segment specification GO:0007379 33 0.034
multicellular organismal aging GO:0010259 140 0.034
negative regulation of cell death GO:0060548 81 0.033
respiratory system development GO:0060541 213 0.033
germarium derived female germ line cyst formation GO:0030727 42 0.033
positive regulation of cell communication GO:0010647 250 0.033
cellular catabolic process GO:0044248 372 0.033
mitotic spindle elongation GO:0000022 81 0.033
positive regulation of developmental growth GO:0048639 62 0.032
meiosis i GO:0007127 59 0.032
endomitotic cell cycle GO:0007113 7 0.031
regulation of growth GO:0040008 233 0.031
response to biotic stimulus GO:0009607 294 0.031
reciprocal dna recombination GO:0035825 19 0.030
regulation of protein depolymerization GO:1901879 27 0.030
centrosome cycle GO:0007098 137 0.030
neurological system process GO:0050877 358 0.030
open tracheal system development GO:0007424 204 0.030
negative regulation of protein complex disassembly GO:0043242 23 0.030
cell type specific apoptotic process GO:0097285 38 0.030
organelle fusion GO:0048284 46 0.030
positive regulation of catabolic process GO:0009896 105 0.029
regulation of nervous system development GO:0051960 248 0.029
imaginal disc derived wing morphogenesis GO:0007476 337 0.029
cell fate determination GO:0001709 91 0.029
chromosome condensation GO:0030261 41 0.029
single organism biosynthetic process GO:0044711 206 0.029
regulation of lipid kinase activity GO:0043550 2 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
heart development GO:0007507 82 0.028
vesicle mediated transport GO:0016192 381 0.028
establishment or maintenance of cell polarity GO:0007163 167 0.028
axonogenesis GO:0007409 290 0.027
dna replication checkpoint GO:0000076 8 0.027
regulation of catabolic process GO:0009894 170 0.027
pronuclear migration GO:0035046 4 0.027
proteolysis GO:0006508 192 0.027
spindle midzone assembly GO:0051255 4 0.027
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.027
peripheral nervous system development GO:0007422 52 0.026
positive regulation of signal transduction GO:0009967 223 0.026
execution phase of apoptosis GO:0097194 7 0.026
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.025
epithelial cell development GO:0002064 274 0.025
phosphorylation GO:0016310 294 0.025
response to light stimulus GO:0009416 124 0.025
organic substance transport GO:0071702 257 0.025
mitotic chromosome condensation GO:0007076 22 0.025
negative regulation of cellular metabolic process GO:0031324 382 0.025
centrosome separation GO:0051299 20 0.025
response to external biotic stimulus GO:0043207 293 0.024
skin development GO:0043588 65 0.024
spindle organization GO:0007051 253 0.024
regulation of response to stress GO:0080134 200 0.024
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.024
positive regulation of mitotic sister chromatid separation GO:1901970 10 0.023
mitotic spindle organization GO:0007052 220 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
digestive tract development GO:0048565 149 0.023
cellular lipid metabolic process GO:0044255 83 0.023
meiotic chromosome segregation GO:0045132 59 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.022
forebrain development GO:0030900 2 0.022
purine nucleotide metabolic process GO:0006163 146 0.021
regulation of protein complex disassembly GO:0043244 29 0.021
regulation of cell development GO:0060284 215 0.021
regionalization GO:0003002 416 0.021
mesoderm development GO:0007498 78 0.021
oocyte maturation GO:0001556 3 0.021
dna damage checkpoint GO:0000077 78 0.021
positive regulation of chromosome segregation GO:0051984 10 0.021
modification dependent protein catabolic process GO:0019941 78 0.021
cellular response to biotic stimulus GO:0071216 4 0.021
asymmetric protein localization involved in cell fate determination GO:0045167 9 0.021
actin filament organization GO:0007015 126 0.021
guanosine containing compound metabolic process GO:1901068 74 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.020
proteasomal protein catabolic process GO:0010498 59 0.020
negative regulation of biosynthetic process GO:0009890 277 0.020
positive regulation of cell proliferation GO:0008284 47 0.020
negative regulation of programmed cell death GO:0043069 72 0.020
neuroblast proliferation GO:0007405 74 0.020
cellular component assembly involved in morphogenesis GO:0010927 151 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.020
larval development GO:0002164 104 0.020
regulation of protein catabolic process GO:0042176 55 0.020
digestive system development GO:0055123 149 0.020
asymmetric cell division GO:0008356 37 0.020
cilium assembly GO:0042384 38 0.020
spindle assembly GO:0051225 80 0.020
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.020
lateral inhibition GO:0046331 206 0.020
negative regulation of transcription dna templated GO:0045892 237 0.020
negative regulation of protein metabolic process GO:0051248 85 0.020
regulation of cellular protein catabolic process GO:1903362 44 0.020
cell cycle g1 s phase transition GO:0044843 31 0.019
gastrulation involving germ band extension GO:0010004 36 0.019
heterocycle catabolic process GO:0046700 166 0.019
organic substance catabolic process GO:1901575 308 0.019
positive regulation of developmental process GO:0051094 143 0.019
response to extracellular stimulus GO:0009991 116 0.019
meiotic cell cycle GO:0051321 171 0.019
columnar cuboidal epithelial cell development GO:0002066 249 0.019
regulation of sister chromatid segregation GO:0033045 28 0.019
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
rho protein signal transduction GO:0007266 14 0.018
protein phosphorylation GO:0006468 169 0.018
chromosome organization GO:0051276 360 0.018
catabolic process GO:0009056 409 0.018
regulation of developmental growth GO:0048638 174 0.018
protein catabolic process GO:0030163 101 0.018
telencephalon development GO:0021537 2 0.018
gastrulation with mouth forming first GO:0001703 36 0.018
regulation of heterochromatin assembly GO:0031445 8 0.017
regulation of catalytic activity GO:0050790 185 0.017
apoptotic process GO:0006915 159 0.017
leg disc development GO:0035218 92 0.017
locomotory behavior GO:0007626 176 0.017
establishment of localization in cell GO:0051649 402 0.017
positive regulation of cellular catabolic process GO:0031331 95 0.017
response to other organism GO:0051707 293 0.017
dna biosynthetic process GO:0071897 24 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
wing disc pattern formation GO:0035222 66 0.017
acylglycerol catabolic process GO:0046464 3 0.017
imaginal disc derived leg morphogenesis GO:0007480 80 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.017
mitotic cell cycle embryonic GO:0045448 38 0.017
peptidyl amino acid modification GO:0018193 105 0.017
positive regulation of nucleoside metabolic process GO:0045979 47 0.017
g1 s transition of mitotic cell cycle GO:0000082 31 0.017
ubiquitin dependent protein catabolic process GO:0006511 78 0.017
gliogenesis GO:0042063 80 0.017
regulation of phosphorylation GO:0042325 147 0.017
cellular response to sterol depletion GO:0071501 3 0.017
response to radiation GO:0009314 155 0.016
non sensory hair organization GO:0035316 47 0.016
response to copper ion GO:0046688 4 0.016
organonitrogen compound metabolic process GO:1901564 318 0.016
negative regulation of cytoskeleton organization GO:0051494 30 0.016
response to endoplasmic reticulum stress GO:0034976 28 0.016
negative regulation of neural precursor cell proliferation GO:2000178 27 0.016
negative regulation of microtubule depolymerization GO:0007026 21 0.016
positive regulation of growth GO:0045927 75 0.016
distributive segregation GO:0032837 6 0.016
epidermal cell differentiation GO:0009913 51 0.016
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.016
cilium organization GO:0044782 41 0.016
mrna metabolic process GO:0016071 124 0.016
dna recombination GO:0006310 32 0.016
biological adhesion GO:0022610 138 0.016
lipid localization GO:0010876 54 0.016
cellular ketone metabolic process GO:0042180 24 0.016
aging GO:0007568 143 0.015
negative regulation of cellular protein metabolic process GO:0032269 85 0.015
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.015
membrane organization GO:0061024 112 0.015
single organism cellular localization GO:1902580 180 0.015
endoplasmic reticulum organization GO:0007029 13 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
positive regulation of mitotic metaphase anaphase transition GO:0045842 10 0.015
signal transduction in response to dna damage GO:0042770 3 0.015
anterior posterior axis specification GO:0009948 109 0.015
negative regulation of cell proliferation GO:0008285 69 0.015
eye photoreceptor cell fate commitment GO:0042706 37 0.015
negative regulation of neurogenesis GO:0050768 53 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.015
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.015
mitotic spindle stabilization GO:0043148 6 0.015
regulation of microtubule cytoskeleton organization GO:0070507 41 0.015
morphogenesis of an epithelium GO:0002009 276 0.015
oocyte differentiation GO:0009994 145 0.015
negative regulation of nervous system development GO:0051961 92 0.015
establishment of protein localization GO:0045184 163 0.015
protein ubiquitination GO:0016567 70 0.014
nucleotide metabolic process GO:0009117 161 0.014
sensory organ precursor cell division GO:0045035 10 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
epidermis development GO:0008544 65 0.014
nucleus localization GO:0051647 34 0.014
regulation of meiosis GO:0040020 3 0.014
protein maturation GO:0051604 71 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
protein modification by small protein conjugation GO:0032446 79 0.014
regulation of cell death GO:0010941 173 0.014
regulation of cellular response to stress GO:0080135 89 0.014
response to organophosphorus GO:0046683 2 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
regulation of hydrolase activity GO:0051336 97 0.014
neural retina development GO:0003407 4 0.014
negative regulation of mitotic metaphase anaphase transition GO:0045841 13 0.014
spindle checkpoint GO:0031577 11 0.014
zymogen activation GO:0031638 20 0.014
germarium derived egg chamber formation GO:0007293 101 0.014
mitotic spindle assembly checkpoint GO:0007094 11 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
negative regulation of protein depolymerization GO:1901880 23 0.014
organ growth GO:0035265 56 0.013
positive regulation of nucleotide metabolic process GO:0045981 55 0.013
smoothened signaling pathway GO:0007224 49 0.013
organophosphate metabolic process GO:0019637 195 0.013
regulation of cell morphogenesis GO:0022604 163 0.013
organophosphate biosynthetic process GO:0090407 46 0.013
purine containing compound metabolic process GO:0072521 155 0.013
negative regulation of sister chromatid segregation GO:0033046 13 0.013
organelle assembly GO:0070925 198 0.013
macromolecule catabolic process GO:0009057 161 0.013
hair cell differentiation GO:0035315 47 0.013
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.013
glial cell differentiation GO:0010001 35 0.013
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.013
development of primary sexual characteristics GO:0045137 50 0.012
regulation of microtubule depolymerization GO:0031114 24 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.012
regulation of programmed cell death GO:0043067 152 0.012
response to fungus GO:0009620 50 0.012
protein hydroxylation GO:0018126 1 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
neural precursor cell proliferation GO:0061351 75 0.012
negative regulation of meiotic cell cycle GO:0051447 2 0.012
cell death GO:0008219 279 0.012
kidney development GO:0001822 3 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
ion transport GO:0006811 145 0.012
organic acid metabolic process GO:0006082 103 0.012
regulation of anatomical structure size GO:0090066 163 0.012
protein processing GO:0016485 68 0.012
gene silencing GO:0016458 138 0.012
meiotic cell cycle phase transition GO:0044771 4 0.012
negative regulation of protein catabolic process GO:0042177 17 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
response to abiotic stimulus GO:0009628 341 0.011
negative regulation of protein processing GO:0010955 31 0.011
gonad development GO:0008406 50 0.011
establishment of planar polarity GO:0001736 87 0.011
programmed cell death GO:0012501 257 0.011
immune system process GO:0002376 347 0.011
negative regulation of chromosome organization GO:2001251 19 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
purine ribonucleotide catabolic process GO:0009154 109 0.011
glycerolipid catabolic process GO:0046503 3 0.011
regulation of neural precursor cell proliferation GO:2000177 35 0.011
negative regulation of cell development GO:0010721 62 0.011
multicellular organism growth GO:0035264 46 0.011
single organism intracellular transport GO:1902582 207 0.011
microtubule organizing center organization GO:0031023 168 0.011
single organism membrane organization GO:0044802 93 0.011
immune response GO:0006955 246 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.011
protein complex biogenesis GO:0070271 201 0.011
central nervous system development GO:0007417 201 0.011
neuroblast fate determination GO:0007400 12 0.011
sensory perception of pain GO:0019233 4 0.011
negative regulation of neuroblast proliferation GO:0007406 27 0.011
negative regulation of cell division GO:0051782 17 0.011
cell recognition GO:0008037 102 0.011
regulation of nucleotide catabolic process GO:0030811 48 0.011
glial cell migration GO:0008347 31 0.011
protein transport GO:0015031 155 0.011
germ line cyst formation GO:0048134 44 0.011
reproductive system development GO:0061458 74 0.011
negative regulation of nuclear division GO:0051784 17 0.011
positive regulation of cell development GO:0010720 61 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.010
establishment of organelle localization GO:0051656 122 0.010
negative regulation of multicellular organismal process GO:0051241 142 0.010
regulation of small gtpase mediated signal transduction GO:0051056 93 0.010
negative regulation of proteolysis GO:0045861 31 0.010
sensory organ morphogenesis GO:0090596 260 0.010
dna repair GO:0006281 54 0.010
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 13 0.010
asymmetric protein localization GO:0008105 33 0.010
multi organism reproductive behavior GO:0044705 121 0.010
regulation of mitotic spindle organization GO:0060236 9 0.010
nucleobase containing compound catabolic process GO:0034655 165 0.010
imaginal disc pattern formation GO:0007447 91 0.010
cytokinetic cell separation GO:0000920 1 0.010
positive regulation of r7 cell differentiation GO:0045678 7 0.010
lipid metabolic process GO:0006629 121 0.010

DNApol-alpha60 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
inherited metabolic disorder DOID:655 0 0.023
disease of metabolism DOID:0014667 0 0.023