|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.993
|
Yeast |
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.991
|
Yeast |
|
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.965
|
Human |
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.960
|
Yeast |
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.958
|
Yeast |
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.955
|
Yeast |
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.955
|
Yeast |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.946
|
Human Yeast Fly |
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.942
|
Yeast |
|
|
regulation of adenylate cyclase activity
|
GO:0045761 |
17 |
0.873
|
Yeast |
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.871
|
Yeast |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.857
|
Human Yeast Fly |
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.852
|
Yeast |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.794
|
Human Yeast Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.737
|
Human Yeast Fly |
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.717
|
Yeast |
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.687
|
Yeast |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.683
|
Human Yeast Fly |
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.682
|
Yeast |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.680
|
Human Yeast Fly |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.676
|
Worm Fly |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.674
|
Human Yeast Fly |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.642
|
Human Yeast |
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.637
|
Yeast |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.630
|
Yeast |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.619
|
Human Yeast Fly |
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.616
|
Human |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.599
|
Human |
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.589
|
Yeast |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.582
|
Human |
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.567
|
Human Yeast |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.526
|
Human Yeast Fly |
|
|
exocytosis
|
GO:0006887 |
71 |
0.519
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.516
|
Yeast |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.503
|
Human Yeast Fly |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.501
|
Human |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.501
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.483
|
Human |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.469
|
Human Fly |
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.461
|
Yeast |
|
|
cell development
|
GO:0048468 |
328 |
0.450
|
Yeast Worm Fly |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.449
|
Human Yeast Fly |
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.446
|
Human |
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.429
|
Human |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.427
|
Human Yeast Fly |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.426
|
Human |
|
|
membrane raft localization
|
GO:0051665 |
1 |
0.416
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.415
|
Human Yeast Fly |
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.413
|
Yeast |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.405
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.401
|
Human Yeast Fly |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.397
|
Human Yeast Fly |
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.392
|
Yeast |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.385
|
Human Yeast Fly |
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.382
|
Yeast |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.371
|
Human Yeast |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.369
|
Human |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.368
|
Human |
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.363
|
Yeast |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.359
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.357
|
Human Yeast Fly |
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.349
|
Human |
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.340
|
Human |
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.339
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.337
|
Human Yeast Fly |
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.333
|
Human Yeast Fly |
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.328
|
Human Yeast Fly |
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.324
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.307
|
Human Yeast Fly |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.294
|
Human |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.290
|
Human Yeast Fly |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.285
|
Human Yeast |
|
|
cytokinesis
|
GO:0000910 |
96 |
0.285
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.281
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.280
|
Human |
|
|
oogenesis
|
GO:0048477 |
2 |
0.277
|
Worm Fly |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.271
|
Human |
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.269
|
Yeast |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.268
|
Human |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.267
|
Human |
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.266
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.265
|
Human |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.264
|
Human |
|
|
regulation of ruffle assembly
|
GO:1900027 |
8 |
0.263
|
Human |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.258
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.242
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.241
|
Human |
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.239
|
Human |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.233
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.230
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.230
|
Human Yeast |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.229
|
Human Fly |
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.229
|
Human Yeast Fly |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.228
|
Human |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.227
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.224
|
|
|
|
golgi vesicle fusion to target membrane
|
GO:0048210 |
2 |
0.220
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.218
|
Yeast |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.217
|
Human |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.215
|
Human |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.213
|
Yeast |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.212
|
Human Yeast Fly |
|
|
muscle system process
|
GO:0003012 |
81 |
0.210
|
|
|
|
growth
|
GO:0040007 |
202 |
0.206
|
Yeast |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.201
|
Human |
|
|
positive regulation of cyclase activity
|
GO:0031281 |
13 |
0.198
|
Yeast |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.194
|
Human |
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.190
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.184
|
Fly |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.184
|
Human |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.178
|
Human |
|
|
positive regulation of lyase activity
|
GO:0051349 |
16 |
0.176
|
Yeast |
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.175
|
Yeast |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.175
|
Human |
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.173
|
Human |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.170
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.170
|
Human Fly |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.168
|
Human Yeast Fly |
|
|
heart process
|
GO:0003015 |
62 |
0.165
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.164
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.159
|
Human Worm |
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.158
|
Human |
|
|
positive regulation of transcription by galactose
|
GO:0000411 |
1 |
0.154
|
Yeast |
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.151
|
Human |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.151
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.146
|
Human |
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.146
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.141
|
Human Fly |
|
|
negative regulation of nucleotide catabolic process
|
GO:0030812 |
16 |
0.140
|
Human |
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.140
|
Yeast |
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.139
|
Human |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.138
|
Human |
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.138
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.137
|
Human |
|
|
secretion
|
GO:0046903 |
254 |
0.136
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.136
|
Yeast |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.134
|
Human |
|
|
cellular response to nutrient
|
GO:0031670 |
12 |
0.133
|
Yeast |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.129
|
|
|
|
heart contraction
|
GO:0060047 |
62 |
0.124
|
|
|
|
detection of calcium ion
|
GO:0005513 |
8 |
0.124
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.123
|
Human Fly |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.123
|
Human Fly |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.121
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.121
|
Fly |
|
|
establishment of protein localization to endoplasmic reticulum membrane
|
GO:0097051 |
3 |
0.120
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.120
|
Human Fly |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.119
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.116
|
Human Fly |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.115
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.114
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.113
|
Human Fly |
|
|
regulation of cyclic nucleotide phosphodiesterase activity
|
GO:0051342 |
4 |
0.112
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.112
|
Human |
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.111
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.108
|
Worm |
|
|
activation of adenylate cyclase activity
|
GO:0007190 |
5 |
0.107
|
Yeast |
|
|
positive regulation of cyclic nucleotide phosphodiesterase activity
|
GO:0051343 |
4 |
0.106
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.105
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.104
|
Human |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.104
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.104
|
Human |
|
|
circulatory system process
|
GO:0003013 |
113 |
0.103
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.102
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.099
|
Human Fly |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.098
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.097
|
Human |
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.093
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.093
|
Human Fly |
|
|
replicative cell aging
|
GO:0001302 |
3 |
0.092
|
Yeast |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.091
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.091
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.091
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.090
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.089
|
Human |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.088
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.088
|
Yeast |
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.088
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.088
|
Human Fly |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.088
|
Human |
|
|
ruffle assembly
|
GO:0097178 |
10 |
0.088
|
Human |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.087
|
Fly |
|
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.086
|
Human |
|
|
ossification
|
GO:0001503 |
121 |
0.086
|
Human |
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.085
|
Human |
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.084
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.084
|
Yeast |
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.082
|
Human |
|
|
regulation of filopodium assembly
|
GO:0051489 |
13 |
0.082
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.081
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.081
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.081
|
Human |
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.080
|
|
|
|
protein o linked glycosylation via serine
|
GO:0018242 |
3 |
0.079
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.079
|
Human |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.079
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.077
|
Worm |
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.077
|
Human |
|
|
endocytosis
|
GO:0006897 |
159 |
0.077
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.077
|
Yeast |
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.076
|
Human |
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.076
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.074
|
Worm |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.073
|
Human |
|
|
cell aging
|
GO:0007569 |
52 |
0.073
|
Human Yeast |
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.071
|
Human |
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.070
|
|
|
|
carbon catabolite activation of transcription
|
GO:0045991 |
3 |
0.070
|
Yeast |
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.070
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.069
|
Yeast |
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.066
|
Human |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.066
|
Human |
|
|
cell fate determination
|
GO:0001709 |
3 |
0.066
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.066
|
Yeast |
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.065
|
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.065
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.064
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.064
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.064
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.064
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.064
|
Yeast |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.063
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.063
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.061
|
Yeast Worm Fly |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.060
|
|
|
|
regulation of mirna metabolic process
|
GO:2000628 |
5 |
0.060
|
Human |
|
|
epithelial fluid transport
|
GO:0042045 |
1 |
0.060
|
|
|
|
endocytic recycling
|
GO:0032456 |
12 |
0.058
|
|
|
|
system process
|
GO:0003008 |
349 |
0.058
|
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.058
|
Yeast |
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.058
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.057
|
Human |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.057
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.056
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.056
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.056
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.055
|
|
|
|
filopodium assembly
|
GO:0046847 |
18 |
0.055
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.055
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.055
|
Human |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.055
|
Human |
|
|
membrane organization
|
GO:0061024 |
292 |
0.054
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.054
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.054
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.053
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.053
|
Human |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.052
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.051
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.051
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.051
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.050
|
Human |
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.050
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.050
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.049
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.049
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.049
|
Human |
|
|
head development
|
GO:0060322 |
108 |
0.048
|
Human |
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.048
|
Human |
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
8 |
0.048
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.048
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.048
|
Yeast |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.048
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.048
|
Human |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.047
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.047
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.047
|
Yeast Worm Fly |
|
|
positive regulation of ruffle assembly
|
GO:1900029 |
4 |
0.047
|
Human |
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.047
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.047
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.046
|
Fly |
|
|
action potential
|
GO:0001508 |
34 |
0.045
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.045
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.045
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.045
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.045
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.044
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.044
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.044
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
45 |
0.043
|
|
|
|
striated muscle contraction
|
GO:0006941 |
52 |
0.043
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.043
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.043
|
Human |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.043
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.042
|
|
|
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.042
|
Human |
|
|
camp mediated signaling
|
GO:0019933 |
23 |
0.042
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.042
|
Human |
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.042
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.042
|
Human |
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.042
|
|
|
|
negative regulation of nucleoside metabolic process
|
GO:0045978 |
18 |
0.042
|
Human |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.041
|
Human |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.041
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.041
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.041
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.041
|
|
|
|
negative regulation of voltage gated calcium channel activity
|
GO:1901386 |
4 |
0.041
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.041
|
Human |
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.041
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.041
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.040
|
Yeast Worm |
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.040
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.040
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.040
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.039
|
Human |
|
|
tube development
|
GO:0035295 |
125 |
0.039
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.039
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.039
|
Fly |
|
|
epithelium development
|
GO:0060429 |
227 |
0.038
|
Fly |
|
|
protein maturation
|
GO:0051604 |
233 |
0.038
|
|
|
|
cardiac muscle contraction
|
GO:0060048 |
34 |
0.038
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.038
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.038
|
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.038
|
|
|
|
mirna metabolic process
|
GO:0010586 |
10 |
0.038
|
Human |
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.037
|
Yeast |
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.037
|
Human |
|
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.037
|
Human |
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.037
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.037
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.037
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.037
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.037
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.037
|
|
|
|
sa node cell action potential
|
GO:0086015 |
1 |
0.036
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.036
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.036
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.036
|
Fly |
|
|
nucleus localization
|
GO:0051647 |
1 |
0.036
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.035
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.035
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.035
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.035
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.035
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.035
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.035
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.035
|
Yeast Worm Fly |
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.035
|
Worm Fly |
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.035
|
Yeast |
|
|
establishment or maintenance of apical basal cell polarity
|
GO:0035088 |
2 |
0.034
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.034
|
Worm |
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.034
|
Human |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.033
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.033
|
|
|
|
carbon catabolite regulation of transcription
|
GO:0045990 |
5 |
0.033
|
Yeast |
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.033
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.032
|
|
|
|
nuclear migration
|
GO:0007097 |
1 |
0.032
|
|
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.032
|
Human |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.032
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.032
|
Yeast Worm Fly |
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.031
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.031
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.031
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.031
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.031
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.031
|
Human |
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.031
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.031
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.030
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.029
|
|
|
|
positive regulation of mirna metabolic process
|
GO:2000630 |
4 |
0.029
|
Human |
|
|
maintenance of location
|
GO:0051235 |
112 |
0.029
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.029
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.029
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.029
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.029
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.028
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.028
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.028
|
Human |
|
|
cardiac muscle cell action potential
|
GO:0086001 |
23 |
0.028
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.028
|
Human |
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.027
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.027
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.027
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.027
|
Human Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.027
|
Human |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.027
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.027
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.027
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.027
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.026
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.026
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.026
|
|
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.026
|
|
|
|
regulation of striated muscle contraction
|
GO:0006942 |
37 |
0.026
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.026
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.026
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.026
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.026
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.026
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.025
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.025
|
|
|
|
negative regulation of nucleotide metabolic process
|
GO:0045980 |
29 |
0.025
|
Human |
|
|
membrane repolarization during sa node cell action potential
|
GO:0086052 |
1 |
0.025
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.025
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.025
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.025
|
Human |
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.025
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.025
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.025
|
Human |
|
|
viral process
|
GO:0016032 |
146 |
0.025
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.025
|
Human |
|
|
face development
|
GO:0060324 |
12 |
0.024
|
Human |
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.024
|
|
|
|
regulation of ryanodine sensitive calcium release channel activity
|
GO:0060314 |
12 |
0.024
|
|
|
|
regulation of rap protein signal transduction
|
GO:0032487 |
9 |
0.024
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.024
|
Worm |
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.024
|
Human |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.024
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.024
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.024
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.024
|
|
|
|
regulation of actin cytoskeleton reorganization
|
GO:2000249 |
12 |
0.024
|
Human |
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.024
|
|
|
|
glycoprotein metabolic process
|
GO:0009100 |
110 |
0.023
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.023
|
Fly |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.023
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.023
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.023
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.023
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.023
|
Fly |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.023
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.023
|
Human |
|
|
neuron development
|
GO:0048666 |
113 |
0.023
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.023
|
Yeast Worm Fly |
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.023
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.023
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.023
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.022
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.022
|
Human |
|
|
positive regulation of ion transmembrane transport
|
GO:0034767 |
40 |
0.022
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.022
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.022
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.022
|
Fly |
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.022
|
Fly |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.022
|
Human |
|
|
positive regulation of developmental growth
|
GO:0048639 |
16 |
0.022
|
|
|
|
detection of chemical stimulus
|
GO:0009593 |
55 |
0.021
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.021
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.021
|
Fly |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.021
|
Fly |
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.021
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.021
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.021
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.021
|
|
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.021
|
|
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.021
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.020
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.020
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.020
|
|
|
|
single organism membrane fusion
|
GO:0044801 |
37 |
0.020
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.020
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.020
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.020
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
37 |
0.020
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.020
|
Human |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.020
|
Fly |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.020
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.020
|
|
|
|
response to disaccharide
|
GO:0034285 |
1 |
0.020
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.020
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.020
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.020
|
Human |
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.020
|
Human |
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.020
|
|
|
|
skeletal system development
|
GO:0001501 |
79 |
0.020
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.020
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.020
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.020
|
Fly |
|
|
positive regulation of cell size
|
GO:0045793 |
3 |
0.020
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.020
|
Fly |
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.020
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.020
|
Fly |
|
|
spindle organization
|
GO:0007051 |
53 |
0.020
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.019
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.019
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.019
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.019
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.019
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.019
|
|
|
|
translation
|
GO:0006412 |
132 |
0.019
|
|
|
|
regulation of transcription by galactose
|
GO:0000409 |
1 |
0.019
|
Yeast |
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.019
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.019
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.019
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.019
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.019
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.019
|
|
