Mus musculus

90 known processes

Serpina1b

serine (or cysteine) preptidase inhibitor, clade A, member 1B

(Aliases: Spi1-2,D12Ucla2,PI2,Dom2,MGC117839)

Serpina1b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.586
Mouse
regulation of protein kinase c activity GO:1900019 1 0.585
Mouse
ovarian follicle rupture GO:0001543 2 0.537
Mouse
positive regulation of protein kinase c activity GO:1900020 1 0.531
Mouse
regulation of cholesterol metabolic process GO:0090181 14 0.479
Mouse
regulation of renal output by angiotensin GO:0002019 2 0.372
Mouse
neutral lipid metabolic process GO:0006638 57 0.354
Mouse
negative regulation of serine type endopeptidase activity GO:1900004 2 0.348
Rat
activation of nf kappab inducing kinase activity GO:0007250 4 0.346
Mouse
acylglycerol metabolic process GO:0006639 55 0.341
Mouse
triglyceride metabolic process GO:0006641 51 0.333
Mouse
macromolecule glycosylation GO:0043413 55 0.316
response to chromate GO:0046687 1 0.312
Rat
sterol metabolic process GO:0016125 58 0.300
Mouse
renin angiotensin regulation of aldosterone production GO:0002018 3 0.298
Mouse
astrocyte activation GO:0048143 2 0.276
Mouse
amine metabolic process GO:0009308 45 0.270
protein glycosylation GO:0006486 55 0.256
cellular amino acid metabolic process GO:0006520 103 0.219
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001998 3 0.217
Mouse
alcohol metabolic process GO:0006066 116 0.216
Mouse
regulation of fatty acid biosynthetic process GO:0042304 12 0.208
Mouse
glycerolipid metabolic process GO:0046486 122 0.207
Mouse
glycosylation GO:0070085 62 0.199
hexose metabolic process GO:0019318 98 0.199
Mouse
carboxylic acid biosynthetic process GO:0046394 86 0.193
Mouse
regulation of insulin receptor signaling pathway GO:0046626 21 0.189
Mouse
carbohydrate metabolic process GO:0005975 230 0.187
negative regulation of lipid metabolic process GO:0045833 30 0.184
Mouse
cellular lipid metabolic process GO:0044255 323 0.178
Mouse
cellular amine metabolic process GO:0044106 44 0.177
regulation of cellular amine metabolic process GO:0033238 20 0.174
protein n linked glycosylation GO:0006487 12 0.169
regulation of cellular amino acid metabolic process GO:0006521 5 0.168
cholesterol metabolic process GO:0008203 56 0.164
Mouse
regulation of hydrolase activity GO:0051336 246 0.163
positive regulation of fatty acid biosynthetic process GO:0045723 3 0.159
Mouse
fatty acid metabolic process GO:0006631 121 0.145
Mouse
lipid biosynthetic process GO:0008610 179 0.141
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.138
negative regulation of protein metabolic process GO:0051248 282 0.137
regulation of cellular ketone metabolic process GO:0010565 66 0.132
Mouse
protein maturation GO:0051604 176 0.130
organic acid biosynthetic process GO:0016053 86 0.129
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.129
peptidyl amino acid modification GO:0018193 336 0.127
Mouse
negative regulation of protein processing GO:0010955 79 0.127
regulation of triglyceride metabolic process GO:0090207 17 0.126
Mouse
hexose biosynthetic process GO:0019319 39 0.125
Mouse
negative regulation of hydrolase activity GO:0051346 71 0.124
protein processing GO:0016485 163 0.121
regulation of fatty acid metabolic process GO:0019217 28 0.120
Mouse
regulation of protein maturation GO:1903317 96 0.119
glycoprotein metabolic process GO:0009100 116 0.119
extracellular structure organization GO:0043062 148 0.119
Mouse
regulation of inflammatory response GO:0050727 147 0.118
Mouse
glucose metabolic process GO:0006006 92 0.117
Mouse
protein secretion GO:0009306 111 0.117
Mouse
monocarboxylic acid metabolic process GO:0032787 191 0.116
Mouse
regulation of peptidase activity GO:0052547 96 0.115
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.110
Mouse
regulation of endopeptidase activity GO:0052548 89 0.110
fatty acid biosynthetic process GO:0006633 41 0.109
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.106
Mouse
inflammatory response GO:0006954 244 0.106
Mouse Rat
hormone metabolic process GO:0042445 86 0.105
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.102
regulation of protein processing GO:0070613 96 0.101
organic hydroxy compound metabolic process GO:1901615 203 0.100
Mouse
negative regulation of endopeptidase activity GO:0010951 44 0.100
response to peptide GO:1901652 136 0.098
cellular response to organonitrogen compound GO:0071417 145 0.096
Mouse
regulation of cytokine production GO:0001817 266 0.095
Mouse
regulation of glucose metabolic process GO:0010906 60 0.095
Mouse
negative regulation of molecular function GO:0044092 258 0.094
positive regulation of protein phosphorylation GO:0001934 242 0.093
Mouse
negative regulation of proteolysis GO:0045861 74 0.092
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.091
Mouse
regulation of defense response GO:0031347 233 0.091
Mouse
cell matrix adhesion GO:0007160 68 0.090
Mouse
muscle cell differentiation GO:0042692 261 0.089
Mouse
negative regulation of gluconeogenesis GO:0045721 9 0.089
Mouse
small molecule biosynthetic process GO:0044283 132 0.085
Mouse
positive regulation of protein modification process GO:0031401 299 0.085
Mouse
steroid metabolic process GO:0008202 119 0.084
Mouse
urogenital system development GO:0001655 261 0.083
Mouse
epithelial tube morphogenesis GO:0060562 303 0.082
Mouse
negative regulation of cell proliferation GO:0008285 296 0.082
Mouse
regulation of establishment of protein localization GO:0070201 181 0.082
Mouse
cellular ketone metabolic process GO:0042180 84 0.081
Mouse
oxidation reduction process GO:0055114 342 0.080
smooth muscle contraction GO:0006939 44 0.079
Mouse
negative regulation of protein maturation GO:1903318 79 0.078
regulation of transferase activity GO:0051338 263 0.078
Mouse
regulation of kinase activity GO:0043549 249 0.078
Mouse
inositol lipid mediated signaling GO:0048017 41 0.077
Mouse
cellular response to insulin stimulus GO:0032869 78 0.077
Mouse
monosaccharide metabolic process GO:0005996 106 0.076
Mouse
monocarboxylic acid biosynthetic process GO:0072330 61 0.076
Mouse
response to peptide hormone GO:0043434 127 0.074
cell substrate adhesion GO:0031589 130 0.071
Mouse
extracellular matrix organization GO:0030198 147 0.071
Mouse
renal system development GO:0072001 225 0.069
Mouse
mapk cascade GO:0000165 281 0.069
Mouse
regulation of proteolysis GO:0030162 164 0.068
cellular response to hormone stimulus GO:0032870 150 0.067
Mouse
spermatogenesis GO:0007283 284 0.066
Mouse
regulation of protein localization GO:0032880 231 0.064
Mouse
female sex differentiation GO:0046660 84 0.063
Mouse
regulation of carbohydrate metabolic process GO:0006109 75 0.063
Mouse
muscle system process GO:0003012 141 0.063
Mouse
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.062
Mouse
blood circulation GO:0008015 195 0.062
Mouse
renal tubule development GO:0061326 87 0.061
Mouse
regulation of protein kinase activity GO:0045859 232 0.061
Mouse
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.059
Mouse
regulation of mapk cascade GO:0043408 248 0.059
Mouse
ovulation cycle GO:0042698 59 0.058
Mouse
nephron morphogenesis GO:0072028 69 0.058
Mouse
rhythmic process GO:0048511 174 0.057
Mouse
glucocorticoid metabolic process GO:0008211 9 0.057
Mouse
regulation of protein transport GO:0051223 163 0.057
Mouse
response to insulin GO:0032868 100 0.057
Mouse
cellular response to peptide hormone stimulus GO:0071375 92 0.057
Mouse
circulatory system process GO:0003013 197 0.056
Mouse
cellular response to peptide GO:1901653 92 0.056
Mouse
cell adhesion GO:0007155 329 0.055
Mouse
negative regulation of peptidase activity GO:0010466 46 0.055
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.055
Mouse
regulation of tube size GO:0035150 57 0.055
Mouse
regulation of protein secretion GO:0050708 82 0.055
Mouse
cytokine production GO:0001816 319 0.055
Mouse
peptidyl serine modification GO:0018209 83 0.054
Mouse
response to acid chemical GO:0001101 111 0.054
Rat
female gonad development GO:0008585 71 0.053
Mouse
renal system process GO:0003014 48 0.053
Mouse
regulation of blood vessel size GO:0050880 56 0.053
Mouse
nephron epithelium development GO:0072009 92 0.053
Mouse
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.052
Mouse
cytokine secretion GO:0050663 72 0.052
Mouse
nephron epithelium morphogenesis GO:0072088 68 0.052
Mouse
positive regulation of transferase activity GO:0051347 167 0.051
Mouse
response to organic cyclic compound GO:0014070 198 0.051
Rat
regulation of hormone levels GO:0010817 211 0.051
Mouse
positive regulation of protein transport GO:0051222 93 0.051
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.051
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.051
Mouse
response to molecule of bacterial origin GO:0002237 143 0.051
Rat
positive regulation of kinase activity GO:0033674 155 0.050
Mouse
ras protein signal transduction GO:0007265 77 0.050
mesonephric tubule development GO:0072164 94 0.050
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.050
negative regulation of neuron death GO:1901215 98 0.050
Mouse
regulation of secretion GO:0051046 274 0.050
Mouse
ureteric bud morphogenesis GO:0060675 62 0.049
Mouse
vascular process in circulatory system GO:0003018 62 0.049
Mouse
positive regulation of secretion GO:0051047 130 0.049
Mouse
development of primary female sexual characteristics GO:0046545 73 0.049
Mouse
kidney development GO:0001822 213 0.049
Mouse
nephron development GO:0072006 109 0.049
Mouse
regulation of secretion by cell GO:1903530 249 0.047
Mouse
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 6 0.047
Mouse
astrocyte development GO:0014002 12 0.047
Mouse
response to inorganic substance GO:0010035 96 0.047
Rat
monosaccharide biosynthetic process GO:0046364 44 0.046
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.046
epithelial cell development GO:0002064 159 0.046
Mouse
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.046
Mouse
gliogenesis GO:0042063 141 0.046
Mouse
positive regulation of lipid biosynthetic process GO:0046889 18 0.046
Mouse
multicellular organism growth GO:0035264 161 0.046
Mouse
response to organonitrogen compound GO:0010243 246 0.046
positive regulation of protein kinase activity GO:0045860 144 0.045
Mouse
endocrine process GO:0050886 39 0.045
Mouse
nik nf kappab signaling GO:0038061 14 0.044
Mouse
negative regulation of carbohydrate metabolic process GO:0045912 19 0.044
Mouse
regulation of steroid metabolic process GO:0019218 39 0.044
Mouse
negative regulation of neuron apoptotic process GO:0043524 92 0.043
Mouse
immune effector process GO:0002252 321 0.042
response to lipopolysaccharide GO:0032496 128 0.041
Rat
kidney epithelium development GO:0072073 121 0.041
Mouse
establishment of blood nerve barrier GO:0008065 3 0.041
Mouse
branching involved in ureteric bud morphogenesis GO:0001658 56 0.041
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.041
positive regulation of cytokine secretion GO:0050715 41 0.041
Mouse
mesonephros development GO:0001823 97 0.040
Mouse
positive regulation of secretion by cell GO:1903532 114 0.040
Mouse
neuron death GO:0070997 154 0.039
Mouse
regulation of neuron death GO:1901214 134 0.039
Mouse
response to decreased oxygen levels GO:0036293 59 0.039
Rat
kidney morphogenesis GO:0060993 83 0.039
Mouse
endothelial cell development GO:0001885 20 0.039
Mouse
regulation of anatomical structure size GO:0090066 178 0.039
Mouse
positive regulation of growth GO:0045927 104 0.038
Mouse
neuron apoptotic process GO:0051402 142 0.038
Mouse
gluconeogenesis GO:0006094 39 0.038
Mouse
positive regulation of cytokine production GO:0001819 174 0.037
Mouse
gonad development GO:0008406 141 0.037
Mouse
regulation of cell activation GO:0050865 289 0.037
regulation of cytokine secretion GO:0050707 61 0.036
Mouse
positive regulation of blood pressure GO:0045777 21 0.036
Mouse
feeding behavior GO:0007631 62 0.036
Mouse
endothelial cell differentiation GO:0045446 41 0.035
Mouse
maintenance of location GO:0051235 89 0.035
cation homeostasis GO:0055080 212 0.035
phasic smooth muscle contraction GO:0014821 8 0.035
Mouse
metal ion homeostasis GO:0055065 189 0.035
regulation of carbohydrate biosynthetic process GO:0043255 40 0.035
Mouse
cation transport GO:0006812 399 0.034
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.034
Mouse
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.034
Mouse
response to metal ion GO:0010038 47 0.034
Rat
regulation of lipid biosynthetic process GO:0046890 54 0.034
Mouse
regulation of neuron apoptotic process GO:0043523 122 0.033
Mouse
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 18 0.033
Mouse
vasoconstriction GO:0042310 27 0.033
Mouse
wound healing GO:0042060 157 0.032
ureteric bud development GO:0001657 94 0.031
Mouse
peptidyl serine phosphorylation GO:0018105 74 0.031
Mouse
lipid localization GO:0010876 126 0.031
transmembrane transport GO:0055085 412 0.031
regulation of blood vessel size by renin angiotensin GO:0002034 5 0.031
Mouse
response to steroid hormone GO:0048545 56 0.030
Rat
astrocyte differentiation GO:0048708 43 0.030
Mouse
regulation of response to wounding GO:1903034 189 0.030
Mouse
positive regulation of protein secretion GO:0050714 52 0.029
Mouse
single organismal cell cell adhesion GO:0016337 131 0.029
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 15 0.029
Mouse
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.029
Mouse
blood vessel morphogenesis GO:0048514 285 0.029
branching morphogenesis of an epithelial tube GO:0048754 159 0.029
Mouse
cell type specific apoptotic process GO:0097285 268 0.028
Mouse
ovulation GO:0030728 15 0.027
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.027
cellular homeostasis GO:0019725 240 0.026
macromolecule catabolic process GO:0009057 281 0.026
cellular chemical homeostasis GO:0055082 215 0.026
regulation of cellular catabolic process GO:0031329 242 0.026
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.026
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
aromatic compound catabolic process GO:0019439 286 0.025
glial cell development GO:0021782 54 0.025
Mouse
peristalsis GO:0030432 8 0.025
Mouse
innate immune response GO:0045087 157 0.025
regulation of cellular response to insulin stimulus GO:1900076 30 0.025
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.024
small gtpase mediated signal transduction GO:0007264 97 0.024
regulation of lipid metabolic process GO:0019216 118 0.024
Mouse
nucleotide metabolic process GO:0009117 332 0.024
organic cyclic compound catabolic process GO:1901361 295 0.024
regulation of organ growth GO:0046620 61 0.024
Mouse
nitrogen compound transport GO:0071705 271 0.024
ovulation from ovarian follicle GO:0001542 9 0.024
Mouse
regulation of nik nf kappab signaling GO:1901222 10 0.023
Mouse
response to transition metal nanoparticle GO:1990267 11 0.023
Rat
purine ribonucleoside metabolic process GO:0046128 241 0.023
single organism cell adhesion GO:0098602 156 0.023
heterocycle catabolic process GO:0046700 280 0.023
adaptive immune response GO:0002250 155 0.023
camera type eye development GO:0043010 266 0.023
regulation of system process GO:0044057 200 0.023
g protein coupled receptor signaling pathway GO:0007186 243 0.023
response to estrogen GO:0043627 24 0.023
Rat
cellular divalent inorganic cation homeostasis GO:0072503 127 0.023
negative regulation of phospholipase activity GO:0010519 4 0.023
regulation of blood volume by renin angiotensin GO:0002016 7 0.022
Mouse
purine nucleotide metabolic process GO:0006163 302 0.022
phosphatidylinositol mediated signaling GO:0048015 41 0.022
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.022
regulation of cell adhesion GO:0030155 154 0.022
ribose phosphate metabolic process GO:0019693 291 0.021
divalent inorganic cation homeostasis GO:0072507 138 0.021
reactive oxygen species metabolic process GO:0072593 84 0.021
angiogenesis GO:0001525 201 0.021
negative regulation of cellular amine metabolic process GO:0033239 1 0.021
sensory perception GO:0007600 245 0.021
nucleoside phosphate catabolic process GO:1901292 222 0.021
peripheral nervous system development GO:0007422 53 0.021
Mouse
regulation of organelle organization GO:0033043 289 0.021
posttranscriptional regulation of gene expression GO:0010608 155 0.021
skeletal system development GO:0001501 356 0.020
rho protein signal transduction GO:0007266 32 0.020
carbohydrate derivative catabolic process GO:1901136 231 0.020
organonitrogen compound catabolic process GO:1901565 264 0.020
positive regulation of systemic arterial blood pressure GO:0003084 9 0.020
Mouse
female gamete generation GO:0007292 74 0.020
Mouse
glycosyl compound metabolic process GO:1901657 246 0.020
positive regulation of hydrolase activity GO:0051345 148 0.020
morphogenesis of a branching structure GO:0001763 203 0.020
Mouse
multicellular organismal homeostasis GO:0048871 164 0.020
striated muscle tissue development GO:0014706 293 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
regulation of reactive oxygen species metabolic process GO:2000377 40 0.020
sequestering of calcium ion GO:0051208 18 0.020
gland development GO:0048732 330 0.020
response to alcohol GO:0097305 48 0.020
Rat
regulation of blood pressure GO:0008217 93 0.020
Mouse
response to oxygen levels GO:0070482 62 0.020
Rat
cellular metal ion homeostasis GO:0006875 151 0.020
myeloid cell differentiation GO:0030099 233 0.019
cytoplasmic transport GO:0016482 234 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
sulfur compound metabolic process GO:0006790 100 0.019
apoptotic signaling pathway GO:0097190 306 0.019
muscle tissue development GO:0060537 308 0.019
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.019
cellular ion homeostasis GO:0006873 165 0.019
insulin receptor signaling pathway GO:0008286 49 0.019
Mouse
muscle cell proliferation GO:0033002 52 0.019
Mouse
organonitrogen compound biosynthetic process GO:1901566 192 0.019
anatomical structure homeostasis GO:0060249 145 0.019
amide transport GO:0042886 138 0.018
protein catabolic process GO:0030163 221 0.018
regulation of body fluid levels GO:0050878 162 0.018
nucleotide catabolic process GO:0009166 217 0.018
excretion GO:0007588 22 0.018
Mouse
positive regulation of cell death GO:0010942 224 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
ossification GO:0001503 216 0.018
organophosphate catabolic process GO:0046434 232 0.018
cell growth GO:0016049 130 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.017
ion transmembrane transport GO:0034220 361 0.017
epidermis development GO:0008544 187 0.017
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.017
purine nucleoside triphosphate metabolic process GO:0009144 226 0.017
positive regulation of cellular response to insulin stimulus GO:1900078 9 0.017
Mouse
positive regulation of apoptotic process GO:0043065 217 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
ribonucleotide metabolic process GO:0009259 291 0.017
purine nucleotide catabolic process GO:0006195 211 0.017
purine containing compound metabolic process GO:0072521 311 0.017
regulation of ion transport GO:0043269 215 0.017
synaptic transmission GO:0007268 329 0.017
response to temperature stimulus GO:0009266 55 0.017
Mouse
regulation of vesicle mediated transport GO:0060627 139 0.017
cellular calcium ion homeostasis GO:0006874 119 0.017
leukocyte differentiation GO:0002521 342 0.017
hormone secretion GO:0046879 128 0.016
lymphocyte mediated immunity GO:0002449 139 0.016
carbohydrate homeostasis GO:0033500 128 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
purine nucleoside metabolic process GO:0042278 241 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
respiratory system development GO:0060541 190 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
Mouse
regulation of membrane potential GO:0042391 192 0.016
glial cell differentiation GO:0010001 131 0.016
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 199 0.016
renal tubule morphogenesis GO:0061333 72 0.016
Mouse
male gamete generation GO:0048232 285 0.016
Mouse
glucose homeostasis GO:0042593 128 0.016
positive regulation of cell development GO:0010720 237 0.016
fat cell differentiation GO:0045444 160 0.016
chemotaxis GO:0006935 247 0.016
endothelium development GO:0003158 45 0.016
Mouse
ribonucleoside metabolic process GO:0009119 245 0.016
cellular response to cadmium ion GO:0071276 3 0.016
ribonucleoside catabolic process GO:0042454 206 0.016
positive regulation of organ growth GO:0046622 29 0.016
Mouse
regulation of ras protein signal transduction GO:0046578 114 0.016
organelle localization GO:0051640 179 0.015
nucleoside catabolic process GO:0009164 206 0.015
response to cold GO:0009409 19 0.015
Mouse
cognition GO:0050890 149 0.015
regulation of lymphocyte activation GO:0051249 240 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
purine nucleoside triphosphate catabolic process GO:0009146 203 0.015
cation transmembrane transport GO:0098655 266 0.015
glycosyl compound catabolic process GO:1901658 206 0.015
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.015
endocytosis GO:0006897 168 0.015
regulation of cell motility GO:2000145 236 0.015
ribonucleotide catabolic process GO:0009261 208 0.015
positive regulation of immune effector process GO:0002699 107 0.015
divalent inorganic cation transport GO:0072511 178 0.015
regulation of vasculature development GO:1901342 88 0.014
fat soluble vitamin biosynthetic process GO:0042362 4 0.014
cellular macromolecule catabolic process GO:0044265 206 0.014
transition metal ion homeostasis GO:0055076 54 0.014
meiotic cell cycle GO:0051321 122 0.014
nucleoside metabolic process GO:0009116 246 0.014
calcium ion transport GO:0006816 159 0.014
sequestering of metal ion GO:0051238 19 0.014
cellular response to lipid GO:0071396 145 0.014
small molecule catabolic process GO:0044282 71 0.014
sensory organ morphogenesis GO:0090596 242 0.014
purine nucleoside catabolic process GO:0006152 205 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
purine ribonucleotide catabolic process GO:0009154 208 0.014
muscle contraction GO:0006936 101 0.014
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.014
lymphocyte differentiation GO:0030098 242 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.014
positive regulation of lipid metabolic process GO:0045834 40 0.014
Mouse
membrane organization GO:0061024 245 0.014
response to nutrient levels GO:0031667 109 0.014
protein oligomerization GO:0051259 67 0.014
regulation of cell cycle GO:0051726 281 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.013
developmental maturation GO:0021700 193 0.013
homeostasis of number of cells GO:0048872 210 0.013
retina development in camera type eye GO:0060041 119 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
positive regulation of cellular catabolic process GO:0031331 148 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
multicellular organismal signaling GO:0035637 91 0.013
cellular lipid catabolic process GO:0044242 52 0.013
coagulation GO:0050817 78 0.013
cellular response to external stimulus GO:0071496 88 0.013
intracellular protein transport GO:0006886 204 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
lateral inhibition GO:0046331 1 0.013
forebrain development GO:0030900 302 0.013
negative regulation of immune system process GO:0002683 209 0.013
divalent metal ion transport GO:0070838 172 0.013
cellular protein complex assembly GO:0043623 116 0.013
purine containing compound catabolic process GO:0072523 213 0.013
organ regeneration GO:0031100 2 0.013
peptide transport GO:0015833 133 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
cellular response to inorganic substance GO:0071241 37 0.013
regulation of homeostatic process GO:0032844 182 0.013
blood coagulation GO:0007596 76 0.013
response to stilbenoid GO:0035634 22 0.013
organic hydroxy compound transport GO:0015850 93 0.013
dna metabolic process GO:0006259 303 0.013
regulation of cellular component size GO:0032535 121 0.013
t cell activation GO:0042110 289 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.013
generation of precursor metabolites and energy GO:0006091 103 0.013
regulation of interleukin 8 production GO:0032677 3 0.013
sulfur compound biosynthetic process GO:0044272 37 0.013
response to hypoxia GO:0001666 58 0.013
Rat
learning or memory GO:0007611 148 0.013
regulation of intracellular transport GO:0032386 159 0.013
anion transport GO:0006820 177 0.013
leukocyte mediated immunity GO:0002443 174 0.013
regulation of action potential GO:0098900 4 0.013
production of molecular mediator of immune response GO:0002440 103 0.012
response to testosterone GO:0033574 3 0.012
locomotory behavior GO:0007626 195 0.012
positive regulation of cell adhesion GO:0045785 80 0.012
drinking behavior GO:0042756 5 0.012
Mouse
multi multicellular organism process GO:0044706 109 0.012
meiotic nuclear division GO:0007126 115 0.012
positive regulation of fatty acid oxidation GO:0046321 4 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
regulation of leukocyte mediated immunity GO:0002703 104 0.012
cellular response to organic cyclic compound GO:0071407 87 0.012
protein modification by small protein conjugation GO:0032446 187 0.012
peptide secretion GO:0002790 114 0.012
positive regulation of cell activation GO:0050867 158 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
regulation of cell migration GO:0030334 219 0.012
protein localization to organelle GO:0033365 185 0.012
axonogenesis GO:0007409 274 0.012
calcium ion homeostasis GO:0055074 127 0.012
negative regulation of cellular component organization GO:0051129 194 0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.012
cofactor transport GO:0051181 4 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
olfactory learning GO:0008355 2 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
epithelial cell proliferation GO:0050673 174 0.012
cellular response to extracellular stimulus GO:0031668 81 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.012
regulation of cellular response to growth factor stimulus GO:0090287 82 0.012
organ growth GO:0035265 117 0.012
Mouse
response to radiation GO:0009314 165 0.012
positive regulation of nervous system development GO:0051962 221 0.012
cytokine mediated signaling pathway GO:0019221 115 0.011
negative regulation of protein modification process GO:0031400 163 0.011
porphyrin containing compound metabolic process GO:0006778 22 0.011
organic anion transport GO:0015711 137 0.011
inter male aggressive behavior GO:0002121 3 0.011
membrane lipid metabolic process GO:0006643 53 0.011
lipid transport GO:0006869 98 0.011
regulation of hormone secretion GO:0046883 88 0.011
negative regulation of response to wounding GO:1903035 77 0.011

Serpina1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
alpha 1 antitrypsin deficiency DOID:13372 0 0.680
Human
plasma protein metabolism disease DOID:2345 0 0.680
Human
inherited metabolic disorder DOID:655 0 0.680
Human
disease of metabolism DOID:0014667 0 0.680
Human
immune system disease DOID:2914 0 0.059
hematopoietic system disease DOID:74 0 0.059
disease of anatomical entity DOID:7 0 0.059
nervous system disease DOID:863 0 0.029
blood coagulation disease DOID:1247 0 0.019
inherited blood coagulation disease DOID:2214 0 0.018
musculoskeletal system disease DOID:17 0 0.014
connective tissue disease DOID:65 0 0.014
vascular disease DOID:178 0 0.014
cardiovascular system disease DOID:1287 0 0.014
acquired metabolic disease DOID:0060158 0 0.013
primary immunodeficiency disease DOID:612 0 0.012