Mus musculus

627 known processes

Notch1

Notch gene homolog 1 (Drosophila)

(Aliases: 9930111A19Rik,Mis6,lin-12,Tan1)

Notch1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
somite specification GO:0001757 4 1.000
compartment pattern specification GO:0007386 4 1.000
ventricular trabecula myocardium morphogenesis GO:0003222 11 1.000
blood vessel lumenization GO:0072554 2 1.000
regulation of somitogenesis GO:0014807 6 1.000
dorsal aorta morphogenesis GO:0035912 5 1.000
cell migration involved in endocardial cushion formation GO:0003273 3 1.000
neuroblast fate determination GO:0007400 1 1.000
Fly
inner ear receptor cell fate commitment GO:0060120 6 1.000
arterial endothelial cell differentiation GO:0060842 5 1.000
lateral inhibition GO:0046331 1 1.000
Fly
endothelial tube morphogenesis GO:0061154 2 1.000
morphogenesis of an endothelium GO:0003159 2 1.000
positive regulation of transcription of notch receptor target GO:0007221 4 1.000
blood vessel endothelial cell differentiation GO:0060837 6 1.000
segment specification GO:0007379 15 1.000
regulation of epidermal cell differentiation GO:0045604 21 1.000
ciliary body morphogenesis GO:0061073 3 1.000
Mouse
negative regulation of mechanoreceptor differentiation GO:0045632 3 1.000
notch signaling involved in heart development GO:0061314 5 1.000
negative regulation of auditory receptor cell differentiation GO:0045608 2 1.000
regulation of auditory receptor cell differentiation GO:0045607 4 1.000
clara cell differentiation GO:0060486 4 1.000
positive regulation of notch signaling pathway GO:0045747 18 1.000
Fly
dorsal aorta development GO:0035907 6 1.000
regulation of pro b cell differentiation GO:2000973 5 1.000
embryonic organ morphogenesis GO:0048562 276 1.000
negative regulation of blood vessel endothelial cell migration GO:0043537 3 1.000
Human
negative regulation of epithelial cell migration GO:0010633 9 1.000
Human
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 1.000
heart trabecula morphogenesis GO:0061384 26 1.000
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 1.000
negative regulation of fat cell differentiation GO:0045599 36 1.000
interleukin 4 secretion GO:0072602 5 1.000
proximal tubule development GO:0072014 5 1.000
Mouse
epithelial tube morphogenesis GO:0060562 303 1.000
regulation of astrocyte differentiation GO:0048710 20 0.999
negative regulation of epidermal cell differentiation GO:0045605 7 0.999
auditory receptor cell differentiation GO:0042491 37 0.999
negative regulation of endothelial cell migration GO:0010596 4 0.999
Human
notch signaling pathway GO:0007219 71 0.999
stem cell development GO:0048864 219 0.999
cell cell signaling involved in cell fate commitment GO:0045168 35 0.999
Worm Fly
myeloid cell differentiation GO:0030099 233 0.999
Mouse
sensory organ boundary specification GO:0008052 1 0.999
Fly
atrioventricular node development GO:0003162 3 0.998
negative regulation of inner ear receptor cell differentiation GO:2000981 3 0.998
gamma delta t cell differentiation GO:0042492 11 0.998
stem cell maintenance GO:0019827 130 0.998
Human Zebrafish Fly
regionalization GO:0003002 337 0.998
negative regulation of myeloid cell differentiation GO:0045638 38 0.998
regulation of endothelial cell migration GO:0010594 22 0.997
Human
response to muramyl dipeptide GO:0032495 9 0.996
cardiac left ventricle morphogenesis GO:0003214 9 0.996
segmentation GO:0035282 93 0.996
negative regulation of epidermis development GO:0045683 9 0.996
regulation of mechanoreceptor differentiation GO:0045631 5 0.996
cardiac ventricle morphogenesis GO:0003208 50 0.996
axonogenesis GO:0007409 274 0.996
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.996
epithelial cell fate commitment GO:0072148 13 0.995
ephrin receptor signaling pathway GO:0048013 20 0.995
stem cell differentiation GO:0048863 268 0.995
glial cell migration GO:0008347 7 0.995
Fly
renal tubule development GO:0061326 87 0.995
keratinocyte differentiation GO:0030216 48 0.995
mechanoreceptor differentiation GO:0042490 67 0.995
dendritic cell differentiation GO:0097028 26 0.995
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.995
gland development GO:0048732 330 0.995
compound eye development GO:0048749 1 0.994
Fly
pericardium morphogenesis GO:0003344 5 0.993
neuroblast differentiation GO:0014016 2 0.992
Fly
leukocyte differentiation GO:0002521 342 0.992
Mouse
choline transport GO:0015871 3 0.992
somite development GO:0061053 81 0.992
endocardium morphogenesis GO:0003160 6 0.991
gliogenesis GO:0042063 141 0.991
heart valve morphogenesis GO:0003179 21 0.991
cardiocyte differentiation GO:0035051 87 0.991
regulation of cardiac muscle tissue growth GO:0055021 26 0.991
cardiac cell fate specification GO:0060912 2 0.990
Fly
vascular smooth muscle cell differentiation GO:0035886 11 0.990
cardiac right atrium morphogenesis GO:0003213 3 0.990
myeloid dendritic cell differentiation GO:0043011 16 0.990
Mouse
growth involved in heart morphogenesis GO:0003241 4 0.990
distal tubule development GO:0072017 8 0.990
negative regulation of pro b cell differentiation GO:2000974 1 0.990
regulation of cardiac cell fate specification GO:2000043 1 0.990
Fly
cardiac muscle cell myoblast differentiation GO:0060379 8 0.989
mesenchyme development GO:0060485 152 0.989
determination of heart left right asymmetry GO:0061371 48 0.989
hair cell differentiation GO:0035315 40 0.989
skin morphogenesis GO:0043589 38 0.989
glomerular epithelial cell development GO:0072310 6 0.989
Mouse
endocardial cushion formation GO:0003272 13 0.988
kidney development GO:0001822 213 0.988
positive regulation of heart growth GO:0060421 18 0.988
regulation of cardiac muscle tissue development GO:0055024 31 0.988
cardiac septum development GO:0003279 59 0.988
glial cell fate determination GO:0007403 3 0.988
Fly
cell fate specification GO:0001708 72 0.987
positive regulation of astrocyte differentiation GO:0048711 8 0.987
endocardial cushion cell differentiation GO:0061443 1 0.986
inner ear receptor cell differentiation GO:0060113 61 0.986
regulation of cellular amine metabolic process GO:0033238 20 0.986
cell adhesion GO:0007155 329 0.986
Human Fly
regulation of epidermis development GO:0045682 33 0.986
regulation of neural retina development GO:0061074 3 0.986
regulation of inner ear receptor cell differentiation GO:2000980 5 0.985
forebrain development GO:0030900 302 0.985
regulation of cardioblast differentiation GO:0051890 3 0.985
Fly
central nervous system neuron differentiation GO:0021953 162 0.985
Zebrafish
myeloid dendritic cell activation GO:0001773 25 0.985
Mouse
cardiac conduction system development GO:0003161 12 0.983
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.983
regulation of neuron differentiation GO:0045664 281 0.983
regulation of blood vessel endothelial cell migration GO:0043535 12 0.983
Human
embryonic heart tube development GO:0035050 65 0.982
cardiac septum morphogenesis GO:0060411 46 0.982
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.982
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.981
Mouse
cardiac neural crest cell differentiation involved in heart development GO:0061307 8 0.981
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.981
neural tube development GO:0021915 160 0.980
regulation of ossification GO:0030278 112 0.980
glomerular epithelial cell differentiation GO:0072311 10 0.980
Mouse
endocardial cushion development GO:0003197 26 0.980
cardiac muscle tissue morphogenesis GO:0055008 44 0.979
cardiac chamber development GO:0003205 108 0.979
cardiac chamber morphogenesis GO:0003206 93 0.978
regulation of osteoblast differentiation GO:0045667 67 0.978
left right pattern formation GO:0060972 23 0.978
germ line stem cell maintenance GO:0030718 6 0.978
Fly
positive regulation of cardiac muscle tissue development GO:0055025 19 0.977
epidermis development GO:0008544 187 0.977
regulation of neural precursor cell proliferation GO:2000177 70 0.977
Rat
somitogenesis GO:0001756 69 0.977
cardiac neural crest cell development involved in heart development GO:0061308 7 0.977
regulation of cardiac muscle cell proliferation GO:0060043 23 0.977
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 4 0.976
bmp signaling pathway GO:0030509 93 0.975
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.974
cardiac cell development GO:0055006 41 0.974
nephron development GO:0072006 109 0.974
embryonic heart tube morphogenesis GO:0003143 51 0.974
endocardial cushion cell development GO:0061444 1 0.973
mesenchymal cell differentiation GO:0048762 107 0.973
negative regulation of molecular function GO:0044092 258 0.972
positive regulation of keratinocyte differentiation GO:0045618 3 0.972
t cell activation GO:0042110 289 0.971
hematopoietic progenitor cell differentiation GO:0002244 143 0.970
mesoderm development GO:0007498 100 0.970
Zebrafish Fly
mesenchymal cell development GO:0014031 93 0.970
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.970
glomerular mesangial cell development GO:0072144 3 0.970
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.969
epithelial cell apoptotic process involved in palatal shelf morphogenesis GO:1990134 1 0.968
regulation of mitotic cell cycle phase transition GO:1901990 73 0.968
Fly
endocardial cushion morphogenesis GO:0003203 18 0.967
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.966
ventral spinal cord interneuron differentiation GO:0021514 16 0.966
blood vessel endothelial cell migration GO:0043534 23 0.966
Human
renal system development GO:0072001 225 0.965
aortic valve morphogenesis GO:0003180 4 0.965
Human
ossification GO:0001503 216 0.965
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.964
regulation of cellular ketone metabolic process GO:0010565 66 0.964
response to symbiont GO:0009608 2 0.963
Fly
striated muscle tissue development GO:0014706 293 0.962
regulation of myeloid cell differentiation GO:0045637 96 0.962
Mouse
positive regulation of cardiac muscle cell differentiation GO:2000727 6 0.962
loop of henle development GO:0072070 10 0.960
negative regulation of glial cell proliferation GO:0060253 4 0.960
lymphocyte differentiation GO:0030098 242 0.959
embryonic skeletal system development GO:0048706 120 0.959
pulmonary valve morphogenesis GO:0003184 5 0.959
Human
regulation of gliogenesis GO:0014013 50 0.958
atrioventricular valve morphogenesis GO:0003181 13 0.958
epithelial cell differentiation involved in kidney development GO:0035850 23 0.957
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.956
cardiac right ventricle morphogenesis GO:0003215 13 0.956
epidermal cell fate specification GO:0009957 1 0.955
regulation of fat cell differentiation GO:0045598 81 0.955
cardiac endothelial cell differentiation GO:0003348 4 0.955
branching morphogenesis of an epithelial tube GO:0048754 159 0.955
negative regulation of glial cell differentiation GO:0045686 21 0.954
cardiac atrium development GO:0003230 24 0.953
striated muscle cell proliferation GO:0014855 39 0.952
aorta morphogenesis GO:0035909 22 0.952
epithelial cell proliferation GO:0050673 174 0.951
cardiac neural crest cell development involved in outflow tract morphogenesis GO:0061309 6 0.950
apoptotic process involved in morphogenesis GO:0060561 25 0.949
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.949
negative regulation of protein phosphorylation GO:0001933 126 0.948
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.947
Fly
cardiac muscle cell differentiation GO:0055007 69 0.947
regulation of cellular amino acid metabolic process GO:0006521 5 0.947
ventricular cardiac muscle tissue development GO:0003229 38 0.946
nephron epithelium development GO:0072009 92 0.945
cerebral cortex neuron differentiation GO:0021895 19 0.944
urogenital system development GO:0001655 261 0.943
tissue migration GO:0090130 68 0.943
Human Fly
appendage morphogenesis GO:0035107 149 0.942
negative regulation of notch signaling pathway GO:0045746 14 0.939
anagen GO:0042640 13 0.938
paraxial mesoderm development GO:0048339 18 0.937
negative regulation of cellular amine metabolic process GO:0033239 1 0.935
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.935
pericardium development GO:0060039 16 0.934
muscle tissue development GO:0060537 308 0.934
epithelial to mesenchymal transition GO:0001837 47 0.934
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.934
regulation of mitotic cell cycle GO:0007346 126 0.933
Fly
myeloid leukocyte activation GO:0002274 83 0.929
Mouse
response to peptide GO:1901652 136 0.929
formation of organ boundary GO:0010160 1 0.929
Fly
regulation of notch signaling pathway GO:0008593 35 0.928
Fly
wnt signaling pathway GO:0016055 188 0.928
gamma delta t cell activation GO:0046629 13 0.927
negative regulation of oligodendrocyte differentiation GO:0048715 11 0.927
blood vessel morphogenesis GO:0048514 285 0.925
regulation of binding GO:0051098 111 0.924
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.924
response to oxygen levels GO:0070482 62 0.923
regulation of cell cycle phase transition GO:1901987 77 0.920
Fly
regulation of glial cell differentiation GO:0045685 41 0.919
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.919
venous blood vessel development GO:0060841 13 0.918
i kappab phosphorylation GO:0007252 6 0.917
Fly
cardiac muscle tissue development GO:0048738 130 0.917
positive regulation of epithelial to mesenchymal transition GO:0010718 13 0.916
regulation of leukocyte differentiation GO:1902105 159 0.916
Mouse
regulation of retina development in camera type eye GO:1902866 3 0.916
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.913
Fly
outflow tract morphogenesis GO:0003151 53 0.913
sprouting angiogenesis GO:0002040 26 0.912
regulation of cell migration GO:0030334 219 0.911
organelle assembly GO:0070925 177 0.909
placenta blood vessel development GO:0060674 31 0.908
Mouse
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.906
mitotic cell cycle process GO:1903047 159 0.905
Fly
cardiac muscle tissue growth GO:0055017 37 0.905
negative regulation of ossification GO:0030279 49 0.900
negative regulation of neuron projection development GO:0010977 50 0.899
venous blood vessel morphogenesis GO:0048845 7 0.899
myeloid leukocyte differentiation GO:0002573 119 0.897
Mouse
ear development GO:0043583 200 0.896
secondary heart field specification GO:0003139 6 0.896
nephron tubule development GO:0072080 84 0.896
mitotic cell cycle GO:0000278 195 0.893
Fly
skeletal system development GO:0001501 356 0.891
negative regulation of calcium ion dependent exocytosis GO:0045955 3 0.889
negative regulation of cell development GO:0010721 169 0.886
kidney epithelium development GO:0072073 121 0.885
axon guidance GO:0007411 141 0.881
Fly
determination of left right symmetry GO:0007368 80 0.881
negative regulation of nervous system development GO:0051961 156 0.879
regulation of resting membrane potential GO:0060075 3 0.879
endothelium development GO:0003158 45 0.879
heart morphogenesis GO:0003007 178 0.878
regulation of bmp signaling pathway GO:0030510 60 0.878
positive regulation of osteoblast differentiation GO:0045669 34 0.877
cell fate commitment involved in pattern specification GO:0060581 14 0.876
Fly
ventricular septum morphogenesis GO:0060412 27 0.875
Human
heart valve development GO:0003170 23 0.873
muscle cell differentiation GO:0042692 261 0.872
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.871
regulation of neuron projection development GO:0010975 169 0.870
hepaticobiliary system development GO:0061008 67 0.870
positive regulation of myeloid cell differentiation GO:0045639 43 0.868
Mouse
ameboidal type cell migration GO:0001667 128 0.868
Human Fly
aorta development GO:0035904 23 0.866
canonical wnt signaling pathway GO:0060070 130 0.862
positive regulation of osteoclast differentiation GO:0045672 15 0.862
Mouse
cell fate determination GO:0001709 32 0.861
Fly
developmental maturation GO:0021700 193 0.859
somatic stem cell maintenance GO:0035019 47 0.859
interleukin 4 production GO:0032633 24 0.857
positive regulation of mitotic cell cycle GO:0045931 41 0.857
Fly
labyrinthine layer blood vessel development GO:0060716 21 0.856
positive regulation of g1 s transition of mitotic cell cycle GO:1900087 9 0.855
Fly
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.854
neural precursor cell proliferation GO:0061351 121 0.854
Rat
neuron projection guidance GO:0097485 141 0.852
Fly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.849
cellular response to starvation GO:0009267 57 0.848
regulation of oligodendrocyte differentiation GO:0048713 23 0.847
negative regulation of cell proliferation GO:0008285 296 0.846
activation of mapkk activity GO:0000186 15 0.846
lymph vessel morphogenesis GO:0036303 11 0.845
Zebrafish
regulation of epithelial cell migration GO:0010632 35 0.843
Human
apoptotic process involved in development GO:1902742 28 0.842
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.841
Fly
carbohydrate derivative biosynthetic process GO:1901137 183 0.840
limb development GO:0060173 166 0.838
spinal cord development GO:0021510 81 0.838
Zebrafish Rat
glomerulus development GO:0032835 40 0.835
glomerular mesangial cell differentiation GO:0072008 3 0.833
peripheral nervous system development GO:0007422 53 0.833
Zebrafish Fly
exocytosis GO:0006887 121 0.832
cardioblast proliferation GO:0003263 8 0.830
Rat
negative regulation of ligase activity GO:0051352 3 0.830
positive regulation of epidermal cell differentiation GO:0045606 6 0.828
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.827
positive regulation of mapk cascade GO:0043410 170 0.827
thymic t cell selection GO:0045061 22 0.827
positive regulation of apoptotic process GO:0043065 217 0.827
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.824
cellular response to dna damage stimulus GO:0006974 207 0.821
glial cell proliferation GO:0014009 10 0.816
positive regulation of muscle tissue development GO:1901863 32 0.814
cardiac right ventricle formation GO:0003219 3 0.814
regulation of cardiac muscle cell differentiation GO:2000725 9 0.812
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.810
glomerular capillary formation GO:0072104 6 0.809
Mouse
endocardial cell differentiation GO:0060956 4 0.807
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.807
pallium development GO:0021543 120 0.806
cell fate commitment GO:0045165 210 0.806
regulation of epithelial to mesenchymal transition GO:0010717 22 0.802
copper ion transport GO:0006825 10 0.798
regulation of ubiquitin protein transferase activity GO:0051438 7 0.797
positive regulation of apoptotic signaling pathway GO:2001235 95 0.796
positive regulation of cell development GO:0010720 237 0.795
negative regulation of cell motility GO:2000146 61 0.790
Human
heart growth GO:0060419 45 0.788
cellular ketone metabolic process GO:0042180 84 0.788
neuroblast fate commitment GO:0014017 1 0.786
Fly
regulation of cell motility GO:2000145 236 0.784
regulation of myeloid leukocyte differentiation GO:0002761 58 0.783
Mouse
camera type eye development GO:0043010 266 0.783
Mouse
respiratory system development GO:0060541 190 0.783
skeletal system morphogenesis GO:0048705 203 0.782
embryonic placenta development GO:0001892 98 0.781
blood circulation GO:0008015 195 0.780
cardiac muscle cell proliferation GO:0060038 31 0.778
regulation of cardioblast proliferation GO:0003264 9 0.776
neuronal stem cell maintenance GO:0097150 17 0.774
Human Zebrafish
gonad development GO:0008406 141 0.773
Worm
trabecula morphogenesis GO:0061383 40 0.773
g1 s transition of mitotic cell cycle GO:0000082 57 0.771
Fly
cellular component assembly involved in morphogenesis GO:0010927 139 0.770
Fly
cerebral cortex development GO:0021987 86 0.768
negative regulation of protein modification process GO:0031400 163 0.767
cell type specific apoptotic process GO:0097285 268 0.767
memory GO:0007613 58 0.766
Fly
regulation of cell cycle g1 s phase transition GO:1902806 35 0.764
Fly
astrocyte differentiation GO:0048708 43 0.762
vesicle localization GO:0051648 86 0.761
regulation of stem cell differentiation GO:2000736 50 0.761
mesangial cell differentiation GO:0072007 4 0.761
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.760
heart field specification GO:0003128 6 0.760
humoral immune response GO:0006959 57 0.759
morphogenesis of an epithelial sheet GO:0002011 27 0.757
cardiac epithelial to mesenchymal transition GO:0060317 18 0.756
cardiac vascular smooth muscle cell development GO:0060948 3 0.752
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.751
positive regulation of ossification GO:0045778 47 0.745
striated muscle cell development GO:0055002 125 0.745
Human
extrinsic apoptotic signaling pathway GO:0097191 126 0.743
morphogenesis of embryonic epithelium GO:0016331 159 0.742
negative regulation of cell migration GO:0030336 59 0.738
Human
glial cell fate commitment GO:0021781 14 0.737
Fly
morphogenesis of a branching epithelium GO:0061138 193 0.737
oogenesis GO:0048477 56 0.735
Fly
erythrocyte differentiation GO:0030218 88 0.734
regulation of proteasomal protein catabolic process GO:0061136 46 0.733
positive regulation of cell cycle GO:0045787 92 0.732
Fly
muscle tissue morphogenesis GO:0060415 53 0.732
glomerular visceral epithelial cell development GO:0072015 6 0.728
Mouse
fat cell differentiation GO:0045444 160 0.726
t cell differentiation GO:0030217 174 0.721
regulation of heart growth GO:0060420 31 0.721
positive regulation of gliogenesis GO:0014015 27 0.720
kidney interstitial fibroblast differentiation GO:0072071 5 0.715
positive regulation of epithelial cell proliferation GO:0050679 68 0.714
mesenchyme morphogenesis GO:0072132 32 0.713
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.709
respiratory tube development GO:0030323 167 0.707
defense response to other organism GO:0098542 197 0.706
Mouse
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 1 0.701
epidermis morphogenesis GO:0048730 33 0.700
muscle system process GO:0003012 141 0.696
regulation of extracellular matrix assembly GO:1901201 2 0.692
thymus development GO:0048538 41 0.692
artery development GO:0060840 53 0.691
cell proliferation involved in heart morphogenesis GO:0061323 15 0.688
Rat
cytokine secretion GO:0050663 72 0.687
chromatin organization GO:0006325 206 0.686
positive regulation of cell death GO:0010942 224 0.686
angiogenesis GO:0001525 201 0.686
negative regulation of kinase activity GO:0033673 81 0.685
liver development GO:0001889 66 0.685
regulation of organ morphogenesis GO:2000027 144 0.679
regulation of cell cycle GO:0051726 281 0.675
Worm Fly
regulation of photoreceptor cell differentiation GO:0046532 4 0.673
photoreceptor cell differentiation GO:0046530 52 0.672
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.669
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.666
hematopoietic stem cell differentiation GO:0060218 8 0.663
anatomical structure maturation GO:0071695 49 0.662
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.658
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.657
organelle fission GO:0048285 170 0.650
Worm
positive regulation of bmp signaling pathway GO:0030513 23 0.650
rhombomere morphogenesis GO:0021593 2 0.649
Zebrafish
negative regulation of osteoblast differentiation GO:0045668 30 0.645
regulation of receptor recycling GO:0001919 8 0.645
single organism cell adhesion GO:0098602 156 0.645
neural tube patterning GO:0021532 43 0.644
negative regulation of leukocyte differentiation GO:1902106 51 0.643
neuron migration GO:0001764 122 0.642
glial cell differentiation GO:0010001 131 0.641
lung development GO:0030324 164 0.640
regulation of cell cycle process GO:0010564 160 0.639
Worm Fly
oligodendrocyte differentiation GO:0048709 53 0.630
regulation of dna templated transcription in response to stress GO:0043620 9 0.628
regulation of ligase activity GO:0051340 10 0.626
photoreceptor cell morphogenesis GO:0008594 3 0.622
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.617
endothelial cell differentiation GO:0045446 41 0.616
negative regulation of protein binding GO:0032091 17 0.611
rhombomere formation GO:0021594 1 0.607
Zebrafish
left right axis specification GO:0070986 13 0.607
respiratory system process GO:0003016 25 0.597
heart formation GO:0060914 16 0.596
Rat
stem cell fate commitment GO:0048865 5 0.594
Fly
negative regulation of immune system process GO:0002683 209 0.590
negative regulation of cellular protein catabolic process GO:1903363 22 0.587
t cell receptor signaling pathway GO:0050852 46 0.585
regulation of keratinocyte differentiation GO:0045616 11 0.585
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.580
regulation of organ growth GO:0046620 61 0.578
skin development GO:0043588 220 0.571
t cell differentiation in thymus GO:0033077 77 0.570
regulation of protein serine threonine kinase activity GO:0071900 157 0.569
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 6 0.569
cognition GO:0050890 149 0.563
Fly
face morphogenesis GO:0060325 29 0.563
positive regulation of map kinase activity GO:0043406 84 0.562
negative regulation of astrocyte differentiation GO:0048712 10 0.562
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.562
cell migration involved in heart development GO:0060973 8 0.560
regulation of calcium ion dependent exocytosis GO:0017158 16 0.559
positive regulation of leukocyte differentiation GO:1902107 86 0.559
Mouse
pigment cell differentiation GO:0050931 27 0.549
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.548
Fly
germ cell development GO:0007281 185 0.548
Fly
cell fate determination involved in pattern specification GO:0060582 1 0.546
Fly
positive regulation of cell fate commitment GO:0010455 8 0.546
Zebrafish
embryonic limb morphogenesis GO:0030326 126 0.543
circulatory system process GO:0003013 197 0.542
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.540
vascular smooth muscle cell development GO:0097084 7 0.539
mitral valve development GO:0003174 4 0.538
Human
tissue remodeling GO:0048771 102 0.536
regulation of proteolysis GO:0030162 164 0.536
blood vessel remodeling GO:0001974 33 0.535
regulation of jak stat cascade GO:0046425 34 0.534
cardioblast differentiation GO:0010002 13 0.532
autophagy GO:0006914 45 0.531
negative regulation of myotube differentiation GO:0010832 9 0.528
coronary vasculature morphogenesis GO:0060977 9 0.526
establishment of synaptic vesicle localization GO:0097480 57 0.525
l amino acid transport GO:0015807 32 0.519
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.519
regulation of chromosome organization GO:0033044 83 0.517
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.517
muscle cell proliferation GO:0033002 52 0.516
protein glycosylation GO:0006486 55 0.504
germ line stem cell division GO:0042078 2 0.501
cell cycle g1 s phase transition GO:0044843 57 0.497
Fly
negative regulation of cell cycle GO:0045786 123 0.496
hair follicle morphogenesis GO:0031069 29 0.496
negative regulation of epithelial cell proliferation GO:0050680 64 0.494

Notch1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.974
Human
cardiovascular system disease DOID:1287 0 0.974
Human
disease of cellular proliferation DOID:14566 0 0.964
myopathy DOID:423 0 0.962
muscular disease DOID:0080000 0 0.962
heart disease DOID:114 0 0.962
Human
cardiomyopathy DOID:0050700 0 0.962
dilated cardiomyopathy DOID:12930 0 0.962
intrinsic cardiomyopathy DOID:0060036 0 0.962
musculoskeletal system disease DOID:17 0 0.962
muscle tissue disease DOID:66 0 0.962
gastrointestinal system disease DOID:77 0 0.901
hepatobiliary disease DOID:3118 0 0.788
liver disease DOID:409 0 0.788
disease of mental health DOID:150 0 0.555
cognitive disorder DOID:1561 0 0.555
dementia DOID:1307 0 0.499
alzheimer s disease DOID:10652 0 0.499
central nervous system disease DOID:331 0 0.499
tauopathy DOID:680 0 0.499
neurodegenerative disease DOID:1289 0 0.499
nervous system disease DOID:863 0 0.499