Mus musculus

394 known processes

Il1b

interleukin 1 beta

(Aliases: IL-1beta,Il-1b)

Il1b biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
granulocyte chemotaxis GO:0071621 39 0.989
response to molecule of bacterial origin GO:0002237 143 0.988
positive regulation of cytokine production GO:0001819 174 0.986
t helper 2 cell cytokine production GO:0035745 4 0.976
defense response to other organism GO:0098542 197 0.975
Zebrafish
cytokine production GO:0001816 319 0.975
inflammatory response GO:0006954 244 0.971
neutrophil migration GO:1990266 37 0.971
response to atp GO:0033198 8 0.970
regulation of inflammatory response GO:0050727 147 0.967
regulation of adaptive immune response GO:0002819 90 0.965
dendritic cell dendrite assembly GO:0097026 2 0.964
regulation of stress activated mapk cascade GO:0032872 69 0.958
regulation of cytokine production GO:0001817 266 0.955
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.955
defense response to bacterium GO:0042742 119 0.950
Zebrafish
cellular response to lipopolysaccharide GO:0071222 77 0.948
Human
adaptive immune response GO:0002250 155 0.938
regulation of defense response GO:0031347 233 0.937
positive regulation of defense response GO:0031349 124 0.935
myeloid leukocyte migration GO:0097529 57 0.932
cell chemotaxis GO:0060326 81 0.929
regulation of protein transport GO:0051223 163 0.927
Human
positive regulation of neutrophil mediated killing of symbiont cell GO:0070961 1 0.924
inflammatory response to wounding GO:0090594 4 0.922
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.919
Human
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.919
positive regulation of jnk cascade GO:0046330 46 0.916
t cell activation GO:0042110 289 0.916
Human
regulation of lymphocyte activation GO:0051249 240 0.914
Human
interleukin 1 beta production GO:0032611 30 0.908
response to lipopolysaccharide GO:0032496 128 0.905
positive regulation of leukocyte mediated immunity GO:0002705 70 0.905
cellular response to cytokine stimulus GO:0071345 189 0.902
Human
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.902
leukocyte migration GO:0050900 124 0.899
positive regulation of inflammatory response GO:0050729 47 0.896
regulation of cell activation GO:0050865 289 0.893
Human
positive regulation of cytokine secretion GO:0050715 41 0.892
leukocyte chemotaxis GO:0030595 69 0.892
neutrophil chemotaxis GO:0030593 36 0.890
stress activated protein kinase signaling cascade GO:0031098 81 0.882
chemotaxis GO:0006935 247 0.881
positive regulation of monocyte chemotaxis GO:0090026 2 0.879
positive regulation of leukocyte differentiation GO:1902107 86 0.877
regulation of protein localization GO:0032880 231 0.877
Human
regulation of defense response to bacterium GO:1900424 3 0.868
acute phase response GO:0006953 10 0.867
adiponectin secretion GO:0070162 2 0.865
leukocyte activation involved in immune response GO:0002366 126 0.861
positive regulation of lymphocyte proliferation GO:0050671 70 0.858
Human
regulation of interleukin 6 production GO:0032675 55 0.857
i kappab kinase nf kappab signaling GO:0007249 85 0.856
jnk cascade GO:0007254 72 0.851
regulation of secretion by cell GO:1903530 249 0.848
regulation of acute inflammatory response GO:0002673 27 0.845
regulation of t cell activation GO:0050863 170 0.844
Human
positive regulation of secretion by cell GO:1903532 114 0.832
regulation of protein secretion GO:0050708 82 0.826
cellular response to biotic stimulus GO:0071216 92 0.824
Human
blood vessel morphogenesis GO:0048514 285 0.822
regulation of response to wounding GO:1903034 189 0.821
protein secretion GO:0009306 111 0.820
cellular response to molecule of bacterial origin GO:0071219 83 0.819
Human
regulation of establishment of protein localization GO:0070201 181 0.817
Human
regulation of t cell proliferation GO:0042129 92 0.817
Human
regulation of neutrophil chemotaxis GO:0090022 14 0.813
production of molecular mediator of immune response GO:0002440 103 0.809
mature dendritic cell differentiation GO:0097029 3 0.808
regulation of chemokine production GO:0032642 30 0.808
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.807
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.798
positive regulation of protein secretion GO:0050714 52 0.796
neutrophil mediated killing of gram negative bacterium GO:0070945 4 0.789
antibacterial peptide biosynthetic process GO:0002780 2 0.782
cytokine secretion GO:0050663 72 0.777
positive regulation of secretion GO:0051047 130 0.777
regulation of cytokine secretion GO:0050707 61 0.776
regulation of t helper 2 cell cytokine production GO:2000551 3 0.774
regulation of secretion GO:0051046 274 0.769
t cell proliferation GO:0042098 120 0.764
Human
granulocyte migration GO:0097530 43 0.762
regulation of monocyte chemotaxis GO:0090025 3 0.756
positive regulation of myoblast differentiation GO:0045663 8 0.755
positive regulation of granulocyte chemotaxis GO:0071624 12 0.753
negative regulation of immune system process GO:0002683 209 0.751
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.743
nitrogen compound transport GO:0071705 271 0.742
Human Mouse
positive regulation of stress activated mapk cascade GO:0032874 48 0.737
positive regulation of neutrophil chemotaxis GO:0090023 12 0.732
positive regulation of macrophage chemotaxis GO:0010759 5 0.717
regulation of vascular endothelial growth factor production GO:0010574 13 0.712
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.706
negative regulation of molecular function GO:0044092 258 0.700
regulation of protein serine threonine kinase activity GO:0071900 157 0.696
leukocyte proliferation GO:0070661 172 0.693
Human
signal transduction in absence of ligand GO:0038034 55 0.683
regulation of protein kinase activity GO:0045859 232 0.682
positive regulation of type 2 immune response GO:0002830 9 0.663
negative regulation of adaptive immune response GO:0002820 25 0.657
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.653
defense response to gram positive bacterium GO:0050830 50 0.653
acute inflammatory response GO:0002526 41 0.652
regulation of cell motility GO:2000145 236 0.648
positive regulation of phagocytosis GO:0050766 26 0.647
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.645
b cell chemotaxis GO:0035754 3 0.641
t helper cell differentiation GO:0042093 28 0.638
regulation of t helper 1 cell cytokine production GO:2000554 1 0.638
regulation of neutrophil migration GO:1902622 14 0.638
myeloid cell differentiation GO:0030099 233 0.638
wound healing involved in inflammatory response GO:0002246 4 0.636
Mouse
positive regulation of interleukin 1 secretion GO:0050716 14 0.635
regulation of b cell chemotaxis GO:2000537 2 0.633
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.630
thymocyte migration GO:0072679 2 0.622
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.622
lymphocyte activation involved in immune response GO:0002285 93 0.620
detection of fungus GO:0016046 2 0.617
positive regulation of b cell chemotaxis GO:2000538 2 0.617
immunoglobulin production in mucosal tissue GO:0002426 3 0.617
positive regulation of protein transport GO:0051222 93 0.613
Human
regulation of tumor necrosis factor production GO:0032680 49 0.604
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.603
regulation of b cell mediated immunity GO:0002712 37 0.602
t helper 1 cell differentiation GO:0045063 13 0.602
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.602
regulation of cell migration GO:0030334 219 0.589
t cell activation involved in immune response GO:0002286 43 0.586
positive regulation of eosinophil migration GO:2000418 2 0.586
positive regulation of acute inflammatory response GO:0002675 16 0.585
negative regulation of cytokine production GO:0001818 84 0.585
Mouse
positive regulation of neuron death GO:1901216 28 0.583
positive regulation of thymocyte migration GO:2000412 2 0.578
chemokine biosynthetic process GO:0042033 8 0.578
leukocyte differentiation GO:0002521 342 0.576
angiogenesis GO:0001525 201 0.575
antibacterial peptide production GO:0002778 2 0.575
regulation of t helper 1 type immune response GO:0002825 17 0.574
positive regulation of cellular amine metabolic process GO:0033240 5 0.572
chemokine production GO:0032602 34 0.569
b cell mediated immunity GO:0019724 71 0.568
regulation of myoblast differentiation GO:0045661 29 0.568
positive regulation of programmed cell death GO:0043068 218 0.564
regulation of leukocyte proliferation GO:0070663 121 0.564
Human
negative regulation of cell proliferation GO:0008285 296 0.562
Human
regulation of fever generation GO:0031620 6 0.560
defense response to virus GO:0051607 68 0.556
positive regulation of apoptotic process GO:0043065 217 0.555
peptide transport GO:0015833 133 0.553
Human Mouse
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.552
regulation of thymocyte migration GO:2000410 2 0.552
amide transport GO:0042886 138 0.550
Human Mouse
antibacterial humoral response GO:0019731 8 0.548
interleukin 1 beta secretion GO:0050702 16 0.545
tumor necrosis factor production GO:0032640 50 0.545
regulation of transferase activity GO:0051338 263 0.544
positive regulation of immune effector process GO:0002699 107 0.544
cdc42 protein signal transduction GO:0032488 0 0.543
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.540
regulation of myotube differentiation GO:0010830 62 0.535
regulation of intracellular transport GO:0032386 159 0.535
Human
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.534
negative regulation of cell activation GO:0050866 111 0.525
regulation of immunoglobulin mediated immune response GO:0002889 37 0.525
regulation of t cell differentiation GO:0045580 83 0.525
regulation of jnk cascade GO:0046328 62 0.524
negative regulation of necroptotic process GO:0060546 9 0.522
phagocytosis GO:0006909 66 0.521
t helper 1 type immune response GO:0042088 25 0.520
wound healing GO:0042060 157 0.519
Mouse
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.519
regulation of fatty acid transport GO:2000191 10 0.519
macrophage chemotaxis GO:0048246 14 0.518
regulation of kinase activity GO:0043549 249 0.518
inflammatory cell apoptotic process GO:0006925 11 0.516
negative regulation of macrophage apoptotic process GO:2000110 3 0.516
positive regulation of angiogenesis GO:0045766 46 0.515
regulation of leukocyte mediated immunity GO:0002703 104 0.506
lymphocyte proliferation GO:0046651 164 0.506
Human
positive regulation of t cell proliferation GO:0042102 52 0.505
Human
chemokine metabolic process GO:0050755 10 0.504
regulation of natural killer cell chemotaxis GO:2000501 1 0.503
regulation of cytokine biosynthetic process GO:0042035 59 0.496
immunoglobulin mediated immune response GO:0016064 69 0.496
response to organonitrogen compound GO:0010243 246 0.493
immune effector process GO:0002252 321 0.490
negative regulation of t cell proliferation GO:0042130 38 0.482
negative regulation of transferase activity GO:0051348 85 0.481
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.477
innate immune response GO:0045087 157 0.469
regulation of interleukin 2 production GO:0032663 28 0.467
Human
positive regulation of lipid catabolic process GO:0050996 6 0.467
regulation of leukocyte differentiation GO:1902105 159 0.467
antimicrobial peptide production GO:0002775 2 0.461
positive regulation of t cell activation GO:0050870 101 0.460
Human
alpha beta t cell differentiation GO:0046632 69 0.459
natural killer cell chemotaxis GO:0035747 1 0.457
lymphocyte differentiation GO:0030098 242 0.455
skeletal muscle fiber development GO:0048741 58 0.452
microglial cell activation GO:0001774 3 0.443
interleukin 12 secretion GO:0072610 3 0.443
regulation of muscle tissue development GO:1901861 97 0.442
regulation of lymphocyte proliferation GO:0050670 117 0.439
Human
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.437
apoptotic signaling pathway GO:0097190 306 0.436
regulation of mapk cascade GO:0043408 248 0.429
positive regulation of chemokine secretion GO:0090197 4 0.419
regulation of lymphocyte mediated immunity GO:0002706 84 0.413
positive regulation of neuron apoptotic process GO:0043525 25 0.411
positive regulation of chemokine production GO:0032722 22 0.407
negative regulation of t cell activation GO:0050868 65 0.406
leukocyte mediated immunity GO:0002443 174 0.405
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.405
t helper 1 cell cytokine production GO:0035744 1 0.405
interleukin 18 mediated signaling pathway GO:0035655 2 0.403
positive regulation of lymphocyte migration GO:2000403 11 0.402
regulation of granulocyte chemotaxis GO:0071622 17 0.396
regulation of vasculature development GO:1901342 88 0.393
antimicrobial peptide biosynthetic process GO:0002777 2 0.392
cytoplasmic transport GO:0016482 234 0.387
Human
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.384
positive regulation of protein phosphorylation GO:0001934 242 0.383
Human
regulation of type 2 immune response GO:0002828 18 0.381
regulation of t helper 1 cell differentiation GO:0045625 7 0.380
prostaglandin transport GO:0015732 7 0.378
regulation of t cell mediated immunity GO:0002709 34 0.378
negative regulation of interleukin 12 production GO:0032695 10 0.377
regulation of antimicrobial humoral response GO:0002759 3 0.376
response to organic cyclic compound GO:0014070 198 0.373
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.372
cellular response to peptidoglycan GO:0071224 4 0.371
engulfment of apoptotic cell GO:0043652 3 0.370
cell activation involved in immune response GO:0002263 126 0.370
regulation of apoptotic signaling pathway GO:2001233 197 0.368
Human
interspecies interaction between organisms GO:0044419 83 0.366
cytokine metabolic process GO:0042107 71 0.366
regulation of cellular response to stress GO:0080135 159 0.365
activation of innate immune response GO:0002218 56 0.363
regulation of chemotaxis GO:0050920 53 0.363
glucose transport GO:0015758 56 0.360
regulation of map kinase activity GO:0043405 120 0.360
macrophage activation GO:0042116 27 0.360
release of sequestered calcium ion into cytosol GO:0051209 42 0.356
negative regulation of intracellular signal transduction GO:1902532 167 0.352
regulation of adiponectin secretion GO:0070163 2 0.352
negative regulation of leukocyte mediated immunity GO:0002704 29 0.351
positive regulation of homeostatic process GO:0032846 64 0.351
positive regulation of ion transport GO:0043270 65 0.351
negative regulation of phosphorus metabolic process GO:0010563 184 0.347
positive regulation of t helper 1 type immune response GO:0002827 12 0.346
negative regulation of leukocyte proliferation GO:0070664 46 0.342
regulation of interleukin 1 alpha secretion GO:0050705 3 0.341
negative regulation of phosphate metabolic process GO:0045936 184 0.341
macrophage apoptotic process GO:0071888 7 0.341
carbohydrate transport GO:0008643 62 0.338
defense response to gram negative bacterium GO:0050829 28 0.337
regulation of neutrophil mediated cytotoxicity GO:0070948 2 0.335
regulation of eosinophil migration GO:2000416 2 0.335
positive regulation of neutrophil migration GO:1902624 12 0.333
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.333
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.329
positive regulation vascular endothelial growth factor production GO:0010575 10 0.327
regulation of lymphocyte differentiation GO:0045619 107 0.326
positive regulation of lymphocyte differentiation GO:0045621 61 0.325
regulation of vesicle mediated transport GO:0060627 139 0.322
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.322
regulation of interleukin 1 beta secretion GO:0050706 15 0.318
activation of mapk activity involved in innate immune response GO:0035419 2 0.317
keratinocyte migration GO:0051546 3 0.314
regulation of protein targeting GO:1903533 61 0.314
Human
regulation of chemokine secretion GO:0090196 4 0.309
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.308
membrane invagination GO:0010324 17 0.307
positive regulation of chemokine biosynthetic process GO:0045080 6 0.300
regulation of prostaglandin secretion GO:0032306 5 0.296
regulation of cellular amine metabolic process GO:0033238 20 0.294
membrane organization GO:0061024 245 0.291
regulation of anion transport GO:0044070 27 0.290
sequestering of calcium ion GO:0051208 18 0.287
t cell mediated immunity GO:0002456 50 0.287
peptide secretion GO:0002790 114 0.287
Human Mouse
positive regulation of interleukin 12 production GO:0032735 21 0.286
vascular endothelial growth factor production GO:0010573 13 0.286
activation of jun kinase activity GO:0007257 15 0.284
negative regulation of myoblast differentiation GO:0045662 18 0.284
t cell differentiation GO:0030217 174 0.283
dendrite development GO:0016358 115 0.283
regulation of insulin receptor signaling pathway GO:0046626 21 0.280
alpha beta t cell proliferation GO:0046633 21 0.277
regulation of interleukin 1 secretion GO:0050704 15 0.275
regulation of interleukin 1 beta production GO:0032651 25 0.274
interleukin 2 biosynthetic process GO:0042094 15 0.274
Human
regulation of dendritic cell dendrite assembly GO:2000547 2 0.273
positive regulation of cell activation GO:0050867 158 0.273
Human
positive regulation of behavior GO:0048520 40 0.272
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.272
Mouse
activation of immune response GO:0002253 138 0.270
nik nf kappab signaling GO:0038061 14 0.269
Zebrafish
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.267
alpha beta t cell activation involved in immune response GO:0002287 31 0.265
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.263
Human
immunoglobulin production GO:0002377 73 0.263
positive regulation of cell death GO:0010942 224 0.263
interaction with symbiont GO:0051702 14 0.262
homeostasis of number of cells GO:0048872 210 0.261
organonitrogen compound biosynthetic process GO:1901566 192 0.261
Human
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.259
positive regulation of jun kinase activity GO:0043507 30 0.259
positive regulation of lymphocyte activation GO:0051251 140 0.258
Human
pyroptosis GO:0070269 8 0.255
negative regulation of cellular protein metabolic process GO:0032269 247 0.254
second messenger mediated signaling GO:0019932 73 0.253
positive regulation of interleukin 6 production GO:0032755 37 0.253
regulation of lymphocyte migration GO:2000401 14 0.251
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.250
single organism nuclear import GO:1902593 95 0.249
Human
organ or tissue specific immune response GO:0002251 13 0.249
negative regulation of kinase activity GO:0033673 81 0.247
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.244
cytokine biosynthetic process GO:0042089 68 0.244
cellular amine metabolic process GO:0044106 44 0.244
cytokine production involved in immune response GO:0002367 34 0.244
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.243
regulation of neutrophil mediated killing of bacterium GO:0070950 1 0.241
t cell chemotaxis GO:0010818 6 0.241
leukocyte apoptotic process GO:0071887 71 0.237
regulation of antigen processing and presentation GO:0002577 10 0.236
interleukin 6 biosynthetic process GO:0042226 12 0.236
detection of yeast GO:0001879 2 0.235
humoral immune response GO:0006959 57 0.235
negative regulation of secretion GO:0051048 61 0.234
positive regulation of fever generation GO:0031622 6 0.233
mature natural killer cell chemotaxis GO:0035782 1 0.233
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.230
positive regulation of adaptive immune response GO:0002821 61 0.229
eosinophil migration GO:0072677 3 0.229
regulation of intracellular protein transport GO:0033157 82 0.228
Human
negative regulation of map kinase activity GO:0043407 34 0.227
pattern recognition receptor signaling pathway GO:0002221 47 0.226
regulation of peptide transport GO:0090087 91 0.226
Human
positive regulation of organic acid transport GO:0032892 11 0.226
positive regulation of response to wounding GO:1903036 66 0.226
t cell costimulation GO:0031295 14 0.225
neuron death GO:0070997 154 0.224
negative regulation of protein modification process GO:0031400 163 0.223
positive regulation of macrophage activation GO:0043032 10 0.222
regulation of cell cycle GO:0051726 281 0.222
Human
positive regulation of antimicrobial humoral response GO:0002760 2 0.220
regulation of myeloid cell apoptotic process GO:0033032 19 0.219
regulation of organic acid transport GO:0032890 16 0.219
positive regulation of prostaglandin secretion GO:0032308 5 0.219
positive regulation of cell motility GO:2000147 116 0.218
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.217
Human
muscle cell differentiation GO:0042692 261 0.216
mapk cascade GO:0000165 281 0.215
negative regulation of mapk cascade GO:0043409 65 0.215
type 2 immune response GO:0042092 23 0.211
muscle fiber development GO:0048747 76 0.211
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.211
dendritic cell chemotaxis GO:0002407 7 0.210
positive regulation of interleukin 1 beta production GO:0032731 16 0.210
activation of mapk activity GO:0000187 59 0.209
Human
sequestering of metal ion GO:0051238 19 0.208
sperm individualization GO:0007291 1 0.208
cellular amino acid metabolic process GO:0006520 103 0.208
negative regulation of lipopolysaccharide mediated signaling pathway GO:0031665 3 0.207
regulation of cellular amino acid metabolic process GO:0006521 5 0.206
interleukin 1 secretion GO:0050701 16 0.206
icosanoid secretion GO:0032309 12 0.205
endocytosis GO:0006897 168 0.203
fever generation GO:0001660 7 0.201
metal ion homeostasis GO:0055065 189 0.200
positive regulation of map kinase activity GO:0043406 84 0.200
Human
cellular response to organic cyclic compound GO:0071407 87 0.200
Human
positive regulation of cytokine biosynthetic process GO:0042108 40 0.199
negative regulation of protein metabolic process GO:0051248 282 0.197
negative regulation of muscle cell differentiation GO:0051148 33 0.196
response to peptide GO:1901652 136 0.196
rho protein signal transduction GO:0007266 32 0.196
protein processing GO:0016485 163 0.194
monosaccharide transport GO:0015749 58 0.193
response to transforming growth factor beta GO:0071559 88 0.193
regulation of cellular catabolic process GO:0031329 242 0.192
Human
regulation of leukocyte apoptotic process GO:2000106 56 0.192
regulation of cytokine production involved in immune response GO:0002718 26 0.191
positive regulation of leukocyte proliferation GO:0070665 73 0.191
Human
interleukin 1 production GO:0032612 31 0.191
positive regulation of innate immune response GO:0045089 80 0.190
negative regulation of lymphocyte activation GO:0051250 91 0.189
negative regulation of glucose transport GO:0010829 9 0.188
positive regulation of interferon gamma production GO:0032729 39 0.185
Human
syncytium formation GO:0006949 43 0.185
lymphocyte chemotaxis GO:0048247 10 0.184
regulation of nucleocytoplasmic transport GO:0046822 73 0.184
Human
regulation of skeletal muscle fiber development GO:0048742 36 0.183
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.183
carboxylic acid transport GO:0046942 100 0.181
stress activated mapk cascade GO:0051403 80 0.180
peptide hormone secretion GO:0030072 109 0.179
Human Mouse
cation homeostasis GO:0055080 212 0.179
positive regulation of t cell differentiation GO:0045582 52 0.178
regulation of neuron apoptotic process GO:0043523 122 0.177
positive regulation of lipid transport GO:0032370 22 0.176
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.176
positive regulation of transferase activity GO:0051347 167 0.176
Human
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.176
icosanoid transport GO:0071715 14 0.175
organic anion transport GO:0015711 137 0.174
response to arsenic containing substance GO:0046685 5 0.173
Zebrafish
interleukin 33 mediated signaling pathway GO:0038172 1 0.172
positive regulation of muscle cell differentiation GO:0051149 39 0.172
interleukin 1 alpha secretion GO:0050703 3 0.171
response to alcohol GO:0097305 48 0.171
positive regulation of chemotaxis GO:0050921 38 0.170
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.169
regulation of hormone levels GO:0010817 211 0.168
antibacterial peptide secretion GO:0002779 1 0.167
extrinsic apoptotic signaling pathway GO:0097191 126 0.167
interleukin 2 production GO:0032623 33 0.166
Human
toll like receptor signaling pathway GO:0002224 38 0.166
regulation of dendritic cell antigen processing and presentation GO:0002604 7 0.166
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.165
regulation of interferon gamma production GO:0032649 57 0.165
Human
negative regulation of lymphocyte proliferation GO:0050672 45 0.164
regulation of antibacterial peptide production GO:0002786 1 0.164
myeloid leukocyte mediated immunity GO:0002444 42 0.163
response to tumor necrosis factor GO:0034612 26 0.162
regulation of hematopoietic stem cell proliferation GO:1902033 3 0.162
peptide metabolic process GO:0006518 46 0.162
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.162
cytosolic calcium ion transport GO:0060401 48 0.162
positive regulation of killing of cells of other organism GO:0051712 3 0.160
germ cell development GO:0007281 185 0.160
syncytium formation by plasma membrane fusion GO:0000768 42 0.160
organic cyclic compound catabolic process GO:1901361 295 0.159
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.159
developmental maturation GO:0021700 193 0.159
regulation of interleukin 1 production GO:0032652 26 0.159
positive regulation of neutrophil mediated killing of fungus GO:0070965 1 0.159
regulation of innate immune response GO:0045088 91 0.158
positive regulation of hematopoietic stem cell proliferation GO:1902035 2 0.157
regulation of dendritic cell chemotaxis GO:2000508 1 0.157
disruption by host of symbiont cells GO:0051852 11 0.156
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.156
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.155
myotube cell development GO:0014904 60 0.155
positive regulation of immunological synapse formation GO:2000522 1 0.155
t helper 17 cell chemotaxis GO:0035705 1 0.154
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.153
positive regulation of alpha beta t cell activation GO:0046635 39 0.152
astrocyte cell migration GO:0043615 3 0.151
cellular homeostasis GO:0019725 240 0.150
muscle tissue development GO:0060537 308 0.149
positive regulation of antimicrobial peptide production GO:0002225 1 0.148
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.148
skeletal muscle organ development GO:0060538 163 0.147
heat generation GO:0031649 13 0.146
regulation of neuron death GO:1901214 134 0.144
positive regulation of glycoprotein metabolic process GO:1903020 6 0.143
regulation of production of molecular mediator of immune response GO:0002700 65 0.142
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.142
negative regulation of chemokine production GO:0032682 4 0.142
neutrophil mediated killing of bacterium GO:0070944 6 0.142
regulation of jun kinase activity GO:0043506 40 0.142
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.139
organic acid transport GO:0015849 101 0.137
cellular calcium ion homeostasis GO:0006874 119 0.137
myoblast differentiation GO:0045445 52 0.135
positive regulation of striated muscle cell differentiation GO:0051155 35 0.135
regulation of icosanoid secretion GO:0032303 8 0.135
dendritic cell antigen processing and presentation GO:0002468 7 0.134
regulation of endocytosis GO:0030100 69 0.133
heterocycle catabolic process GO:0046700 280 0.132
negative regulation of inflammatory response GO:0050728 61 0.131
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.131
lymphocyte migration GO:0072676 26 0.131
lymphocyte mediated immunity GO:0002449 139 0.130
cd4 positive alpha beta t cell activation GO:0035710 45 0.128
mucosal immune response GO:0002385 13 0.128
negative regulation of necrotic cell death GO:0060547 11 0.128
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.127
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.126
intracellular protein transport GO:0006886 204 0.126
Human
macromolecule catabolic process GO:0009057 281 0.126
Human
negative regulation of b cell proliferation GO:0030889 13 0.124
detection of bacterium GO:0016045 7 0.124
t cell extravasation GO:0072683 4 0.124
response to organophosphorus GO:0046683 22 0.124
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.121
regulation of t cell costimulation GO:2000523 2 0.121
cellular chemical homeostasis GO:0055082 215 0.120
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.120
zymogen activation GO:0031638 41 0.120
myeloid leukocyte activation GO:0002274 83 0.120
cellular amide metabolic process GO:0043603 58 0.119
epithelial cell proliferation GO:0050673 174 0.119
epithelial tube morphogenesis GO:0060562 303 0.118
anion transport GO:0006820 177 0.118
response to dsrna GO:0043331 30 0.117
Zebrafish

Il1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org