Mus musculus

362 known processes

Six1

sine oculis-related homeobox 1 homolog (Drosophila)

(Aliases: BB138287)

Six1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 1.000
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 1.000
midbrain hindbrain boundary morphogenesis GO:0021555 4 1.000
auditory receptor cell fate determination GO:0042668 3 1.000
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 1.000
pyramidal neuron migration GO:0021852 1 1.000
embryonic skeletal system development GO:0048706 120 1.000
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 1.000
neural tube closure GO:0001843 90 1.000
metanephric capsule specification GO:0072267 1 1.000
facial nerve morphogenesis GO:0021610 11 1.000
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 1.000
ear morphogenesis GO:0042471 118 1.000
embryonic organ morphogenesis GO:0048562 276 1.000
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 1.000
regionalization GO:0003002 337 1.000
positive regulation of transcription by glucose GO:0046016 3 1.000
regulation of somitogenesis GO:0014807 6 1.000
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 1.000
somitogenesis GO:0001756 69 1.000
appendage morphogenesis GO:0035107 149 1.000
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 1.000
endodermal cell fate commitment GO:0001711 12 1.000
embryonic epithelial tube formation GO:0001838 130 1.000
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 1.000
embryonic viscerocranium morphogenesis GO:0048703 8 1.000
closure of optic fissure GO:0061386 2 1.000
locus ceruleus development GO:0021703 1 1.000
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 1.000
metanephric nephron tubule formation GO:0072289 4 1.000
olfactory lobe development GO:0021988 32 1.000
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 1.000
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 1.000
positive regulation of auditory receptor cell differentiation GO:0045609 1 1.000
sinoatrial node cell differentiation GO:0060921 3 1.000
embryonic skeletal system morphogenesis GO:0048704 91 1.000
endodermal cell fate specification GO:0001714 4 1.000
regulation of auditory receptor cell differentiation GO:0045607 4 1.000
cerebral cortex neuron differentiation GO:0021895 19 1.000
negative regulation of cardiac chamber morphogenesis GO:1901220 2 1.000
pituitary gland development GO:0021983 38 1.000
Zebrafish Mouse
forebrain neuron fate commitment GO:0021877 13 1.000
rhombomere 2 development GO:0021568 2 1.000
ascending aorta morphogenesis GO:0035910 3 0.999
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.999
rhombomere morphogenesis GO:0021593 2 0.999
brain segmentation GO:0035284 3 0.999
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.999
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.999
renal system development GO:0072001 225 0.999
epithelial tube formation GO:0072175 130 0.999
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.999
visceral motor neuron differentiation GO:0021524 3 0.999
regulation of vascular wound healing GO:0061043 2 0.999
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.999
neuron fate specification GO:0048665 30 0.999
negative regulation of cell fate specification GO:0009996 4 0.999
forebrain anterior posterior pattern specification GO:0021797 5 0.999
Mouse
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.999
peripheral nervous system neuron axonogenesis GO:0048936 3 0.999
cell proliferation in hindbrain GO:0021534 10 0.999
positive regulation of ureteric bud formation GO:0072107 3 0.999
noradrenergic neuron differentiation GO:0003357 6 0.999
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 0.999
neural tube formation GO:0001841 108 0.999
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.999
astrocyte fate commitment GO:0060018 4 0.999
lateral motor column neuron migration GO:0097477 3 0.999
skeletal system development GO:0001501 356 0.999
inner ear morphogenesis GO:0042472 101 0.999
heart formation GO:0060914 16 0.999
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.999
rhombomere 3 morphogenesis GO:0021658 2 0.999
regulation of chondrocyte differentiation GO:0032330 33 0.998
Mouse
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.998
cerebral cortex radially oriented cell migration GO:0021799 31 0.998
telencephalon development GO:0021537 186 0.998
Mouse
axon guidance GO:0007411 141 0.998
hindbrain tangential cell migration GO:0021934 2 0.998
cell fate commitment GO:0045165 210 0.998
anterior commissure morphogenesis GO:0021960 6 0.998
regulation of mechanoreceptor differentiation GO:0045631 5 0.998
Zebrafish
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.998
renal capsule specification GO:0072130 1 0.998
regulation of mesodermal cell fate specification GO:0042661 5 0.998
spinal cord motor neuron differentiation GO:0021522 35 0.998
central nervous system neuron differentiation GO:0021953 162 0.998
metanephric dct cell differentiation GO:0072240 3 0.998
embryonic heart tube formation GO:0003144 1 0.998
atrioventricular bundle cell differentiation GO:0003167 1 0.998
cerebellar granule cell precursor proliferation GO:0021930 10 0.997
metanephric nephron morphogenesis GO:0072273 19 0.997
Mouse
gastrulation GO:0007369 116 0.997
Mouse
cochlea morphogenesis GO:0090103 22 0.997
central nervous system neuron development GO:0021954 67 0.997
mesodermal cell fate commitment GO:0001710 17 0.997
Mouse
forebrain regionalization GO:0021871 25 0.997
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.997
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.997
negative regulation of glial cell proliferation GO:0060253 4 0.997
forebrain morphogenesis GO:0048853 17 0.997
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.997
regulation of cardioblast proliferation GO:0003264 9 0.997
olfactory bulb development GO:0021772 30 0.997
inner ear receptor cell differentiation GO:0060113 61 0.997
Zebrafish
cardiac muscle cell differentiation GO:0055007 69 0.996
cell differentiation in hindbrain GO:0021533 24 0.996
branching involved in ureteric bud morphogenesis GO:0001658 56 0.996
mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis GO:0072309 3 0.996
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 5 0.996
preganglionic parasympathetic nervous system development GO:0021783 17 0.996
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.996
renal vesicle induction GO:0072034 3 0.996
middle ear morphogenesis GO:0042474 23 0.996
retinal ganglion cell axon guidance GO:0031290 18 0.996
embryonic heart tube development GO:0035050 65 0.995
hindbrain development GO:0030902 128 0.995
neuron projection guidance GO:0097485 141 0.995
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.995
regulation of skeletal muscle fiber development GO:0048742 36 0.995
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.995
axis elongation involved in somitogenesis GO:0090245 4 0.995
neural tube patterning GO:0021532 43 0.995
hair cell differentiation GO:0035315 40 0.995
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.995
regulation of cardiac chamber formation GO:1901210 1 0.995
midbrain hindbrain boundary development GO:0030917 9 0.995
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.995
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.995
glomerular mesangial cell development GO:0072144 3 0.995
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.994
segmentation GO:0035282 93 0.994
glomerular mesangial cell differentiation GO:0072008 3 0.994
otic placode formation GO:0043049 1 0.994
forebrain neuron differentiation GO:0021879 52 0.994
cell differentiation in spinal cord GO:0021515 53 0.994
primary neural tube formation GO:0014020 95 0.994
regulation of heart morphogenesis GO:2000826 22 0.994
carbon catabolite repression of transcription GO:0045013 1 0.994
somite specification GO:0001757 4 0.994
regulation of lens epithelial cell proliferation GO:2001109 1 0.993
paraxial mesodermal cell differentiation GO:0048342 2 0.993
cartilage condensation GO:0001502 18 0.993
specification of organ identity GO:0010092 30 0.993
forebrain generation of neurons GO:0021872 63 0.993
mesenchymal cell development GO:0014031 93 0.993
pallium development GO:0021543 120 0.993
face morphogenesis GO:0060325 29 0.993
semicircular canal formation GO:0060876 1 0.993
mesoderm development GO:0007498 100 0.993
Mouse
metanephric capsule formation GO:0072266 1 0.993
telencephalon regionalization GO:0021978 14 0.993
Mouse
striated muscle tissue development GO:0014706 293 0.993
regulation of transcription from rna polymerase ii promoter involved in forebrain neuron fate commitment GO:0021882 3 0.993
connective tissue development GO:0061448 179 0.992
Mouse
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.992
inner cell mass cellular morphogenesis GO:0001828 1 0.992
retinal bipolar neuron differentiation GO:0060040 5 0.992
appendage development GO:0048736 166 0.992
negative regulation of cell development GO:0010721 169 0.992
Mouse
cerebral cortex tangential migration GO:0021800 7 0.992
olfactory bulb interneuron development GO:0021891 7 0.992
neural crest cell development GO:0014032 48 0.992
neuroblast differentiation GO:0014016 2 0.991
Mouse
aorta morphogenesis GO:0035909 22 0.991
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.991
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.991
mammary placode formation GO:0060596 4 0.991
mesodermal cell differentiation GO:0048333 22 0.991
Mouse
neural tube development GO:0021915 160 0.990
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.990
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.990
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.990
cerebral cortex radial glia guided migration GO:0021801 17 0.990
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.990
subpallium neuron fate commitment GO:0060163 2 0.990
cerebral cortex gabaergic interneuron fate commitment GO:0021893 2 0.990
nephron epithelium morphogenesis GO:0072088 68 0.990
skeletal system morphogenesis GO:0048705 203 0.989
negative regulation of transcription by glucose GO:0045014 1 0.989
spinal cord motor neuron migration GO:0097476 4 0.989
primitive streak formation GO:0090009 10 0.989
hypophysis morphogenesis GO:0048850 3 0.989
regulation of bmp signaling pathway GO:0030510 60 0.989
primary prostatic bud elongation GO:0060516 2 0.989
cell proliferation in forebrain GO:0021846 30 0.989
Mouse
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.988
endocardial cushion formation GO:0003272 13 0.988
brain morphogenesis GO:0048854 32 0.988
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.988
negative regulation of mesodermal cell fate specification GO:0042662 3 0.988
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.988
noradrenergic neuron development GO:0003358 3 0.988
mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072038 7 0.988
Mouse
muscle cell development GO:0055001 133 0.988
Zebrafish Mouse
midbrain hindbrain boundary maturation GO:0021732 1 0.988
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.988
spinal cord development GO:0021510 81 0.987
granulosa cell differentiation GO:0060014 1 0.987
vascular wound healing GO:0061042 3 0.987
nephron tubule morphogenesis GO:0072078 68 0.987
globus pallidus development GO:0021759 2 0.987
trophectodermal cell differentiation GO:0001829 21 0.987
carbon catabolite activation of transcription GO:0045991 4 0.987
spinal cord association neuron differentiation GO:0021527 14 0.987
myotube cell development GO:0014904 60 0.987
Zebrafish
epithelial tube morphogenesis GO:0060562 303 0.987
somatotropin secreting cell differentiation GO:0060126 4 0.987
lung induction GO:0060492 3 0.987
muscle fiber development GO:0048747 76 0.986
Zebrafish
rhombomere 3 development GO:0021569 4 0.986
diencephalon morphogenesis GO:0048852 6 0.986
renal capsule formation GO:0072129 1 0.986
embryonic heart tube anterior posterior pattern specification GO:0035054 3 0.986
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.986
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.986
renal tubule development GO:0061326 87 0.986
determination of heart left right asymmetry GO:0061371 48 0.985
nephric duct formation GO:0072179 4 0.985
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.985
chondrocyte differentiation GO:0002062 72 0.985
Mouse
mesonephric tubule morphogenesis GO:0072171 63 0.985
negative regulation of epidermis development GO:0045683 9 0.985
regulation of astrocyte differentiation GO:0048710 20 0.985
diencephalon development GO:0021536 63 0.985
Zebrafish Mouse
regulation of cardiac chamber morphogenesis GO:1901219 2 0.984
semicircular canal morphogenesis GO:0048752 7 0.984
neural plate morphogenesis GO:0001839 9 0.984
muscle cell proliferation GO:0033002 52 0.983
ventral spinal cord interneuron specification GO:0021521 11 0.983
ear development GO:0043583 200 0.983
forebrain development GO:0030900 302 0.983
Zebrafish Mouse
mesodermal cell fate specification GO:0007501 11 0.982
Mouse
neuron fate determination GO:0048664 9 0.981
cardiac atrium morphogenesis GO:0003209 23 0.981
spinal cord motor neuron cell fate specification GO:0021520 13 0.981
parasympathetic nervous system development GO:0048486 19 0.981
nucleus accumbens development GO:0021768 1 0.980
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 3 0.980
somite rostral caudal axis specification GO:0032525 13 0.980
mesenchymal to epithelial transition GO:0060231 12 0.980
Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.980
outer ear morphogenesis GO:0042473 5 0.980
limb morphogenesis GO:0035108 149 0.980
forebrain neuron development GO:0021884 30 0.979
specification of organ position GO:0010159 3 0.979
olfactory bulb interneuron differentiation GO:0021889 12 0.979
cardioblast proliferation GO:0003263 8 0.979
negative regulation of heart looping GO:1901208 1 0.979
negative regulation of astrocyte differentiation GO:0048712 10 0.978
central nervous system segmentation GO:0035283 3 0.978
gland development GO:0048732 330 0.978
negative regulation of gastrulation GO:2000542 3 0.978
trachea formation GO:0060440 3 0.977
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.977
morphogenesis of a branching epithelium GO:0061138 193 0.977
embryonic appendage morphogenesis GO:0035113 126 0.977
cell proliferation in midbrain GO:0033278 2 0.977
branching morphogenesis of an epithelial tube GO:0048754 159 0.976
ventricular zone neuroblast division GO:0021847 3 0.976
epithelial cell maturation GO:0002070 15 0.976
Mouse
myotube differentiation GO:0014902 105 0.975
Zebrafish Mouse
axonogenesis GO:0007409 274 0.975
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 0.975
sensory organ morphogenesis GO:0090596 242 0.975
digestive tract development GO:0048565 190 0.975
Zebrafish Mouse
pancreatic pp cell fate commitment GO:0003329 2 0.975
negative regulation of glial cell differentiation GO:0045686 21 0.974
corticotropin hormone secreting cell differentiation GO:0060128 3 0.974
ureter morphogenesis GO:0072197 4 0.974
peripheral nervous system neuron development GO:0048935 9 0.974
Zebrafish
epithelial cell fate commitment GO:0072148 13 0.973
myoblast proliferation GO:0051450 11 0.973
neural crest cell fate commitment GO:0014034 1 0.973
cell fate specification GO:0001708 72 0.973
skeletal muscle satellite cell differentiation GO:0014816 6 0.972
Mouse
positive regulation of lens epithelial cell proliferation GO:2001111 1 0.972
sensory perception of sound GO:0007605 97 0.972
positive regulation of stem cell proliferation GO:2000648 59 0.972
stem cell maintenance GO:0019827 130 0.972
Mouse
rhombomere development GO:0021546 8 0.972
tube closure GO:0060606 91 0.972
regulation of heart looping GO:1901207 1 0.972
regulation of endodermal cell fate specification GO:0042663 2 0.971
auditory receptor cell differentiation GO:0042491 37 0.971
negative regulation of axon extension GO:0030517 19 0.971
chondrocyte development GO:0002063 24 0.971
respiratory system development GO:0060541 190 0.970
pattern specification involved in metanephros development GO:0072268 4 0.970
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.970
Mouse
determination of left right symmetry GO:0007368 80 0.970
ventral spinal cord interneuron differentiation GO:0021514 16 0.969
forebrain ventricular zone progenitor cell division GO:0021869 6 0.969
oligodendrocyte development GO:0014003 20 0.968
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.968
cardiac atrium development GO:0003230 24 0.968
negative regulation of neuron differentiation GO:0045665 101 0.967
Mouse
cerebellum formation GO:0021588 1 0.967
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.967
dorsal ventral neural tube patterning GO:0021904 28 0.967
otolith morphogenesis GO:0032474 3 0.967
cranial suture morphogenesis GO:0060363 8 0.966
muscle tissue morphogenesis GO:0060415 53 0.966
neural crest cell migration GO:0001755 32 0.966
cranial nerve development GO:0021545 41 0.966
somite development GO:0061053 81 0.965
oculomotor nerve morphogenesis GO:0021622 2 0.965
rhombomere 5 development GO:0021571 4 0.965
submandibular salivary gland formation GO:0060661 1 0.965
metanephros morphogenesis GO:0003338 24 0.965
Mouse
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.965
regulation of neural retina development GO:0061074 3 0.964
Mouse
ventral spinal cord interneuron fate commitment GO:0060579 14 0.964
regulation of tongue muscle cell differentiation GO:2001035 2 0.964
cardiac right atrium morphogenesis GO:0003213 3 0.962
motor neuron migration GO:0097475 4 0.961
striated muscle cell proliferation GO:0014855 39 0.961
regulation of skeletal muscle cell differentiation GO:2001014 11 0.961
kidney morphogenesis GO:0060993 83 0.960
hindlimb morphogenesis GO:0035137 42 0.960
positive regulation of neuroblast proliferation GO:0002052 19 0.959
heart field specification GO:0003128 6 0.959
negative regulation of endodermal cell differentiation GO:1903225 1 0.959
heart morphogenesis GO:0003007 178 0.959
regulation of cell fate specification GO:0042659 10 0.959
optic vesicle morphogenesis GO:0003404 2 0.958
Mouse
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.957
cardiac chamber morphogenesis GO:0003206 93 0.957
nephron morphogenesis GO:0072028 69 0.957
endocardial cell differentiation GO:0060956 4 0.957
dopaminergic neuron differentiation GO:0071542 14 0.957
lymphocyte differentiation GO:0030098 242 0.956
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.956
outflow tract morphogenesis GO:0003151 53 0.956
midbrain hindbrain boundary maturation during brain development GO:0022004 1 0.956
endothelial cell differentiation GO:0045446 41 0.956
cartilage development GO:0051216 140 0.956
Mouse
endodermal cell fate determination GO:0007493 2 0.954
tube formation GO:0035148 140 0.954
tendon formation GO:0035992 4 0.954
semicircular canal development GO:0060872 9 0.954
skeletal muscle organ development GO:0060538 163 0.953
commitment of multipotent stem cells to neuronal lineage in forebrain GO:0021898 3 0.952
cerebellar purkinje cell granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0021937 6 0.952
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.951
glomerular epithelial cell differentiation GO:0072311 10 0.951
skeletal muscle fiber development GO:0048741 58 0.951
Zebrafish
metanephric renal vesicle morphogenesis GO:0072283 12 0.950
Mouse
regulation of neuron maturation GO:0014041 5 0.950
cardiac chamber formation GO:0003207 10 0.950
forebrain radial glial cell differentiation GO:0021861 4 0.949
embryonic heart tube morphogenesis GO:0003143 51 0.949
stem cell differentiation GO:0048863 268 0.948
Mouse
ectoderm formation GO:0001705 3 0.948
negative regulation of branching involved in ureteric bud morphogenesis GO:0090191 4 0.948
ureteric bud morphogenesis GO:0060675 62 0.948
oligodendrocyte differentiation GO:0048709 53 0.947
paraxial mesodermal cell fate commitment GO:0048343 2 0.947
regulation of retina development in camera type eye GO:1902866 3 0.947
Mouse
artery development GO:0060840 53 0.946
endocrine system development GO:0035270 98 0.946
eye photoreceptor cell fate commitment GO:0042706 2 0.946
atrial septum primum morphogenesis GO:0003289 3 0.946
cell proliferation in external granule layer GO:0021924 10 0.946
skeletal muscle fiber differentiation GO:0098528 5 0.945
Mouse
growth plate cartilage chondrocyte growth GO:0003430 2 0.945
pharyngeal system development GO:0060037 17 0.945
cardiac left ventricle formation GO:0003218 1 0.945
facial nucleus development GO:0021754 2 0.944
morphogenesis of embryonic epithelium GO:0016331 159 0.944
notochord formation GO:0014028 5 0.944
neuron projection extension involved in neuron projection guidance GO:1902284 14 0.944
regulation of cerebellar granule cell precursor proliferation GO:0021936 12 0.943
negative regulation of auditory receptor cell differentiation GO:0045608 2 0.942
trochlear nerve development GO:0021558 3 0.942
regulation of transcription from rna polymerase ii promoter by glucose GO:0000430 3 0.942
autonomic nervous system development GO:0048483 43 0.942
lung proximal distal axis specification GO:0061115 1 0.940
regulation of cartilage development GO:0061035 44 0.939
Mouse
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 2 0.938
mesenchymal cell differentiation GO:0048762 107 0.938
Mouse
mitral valve morphogenesis GO:0003183 4 0.937
regulation of neuron projection development GO:0010975 169 0.937
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.937
regulation of myoblast differentiation GO:0045661 29 0.937
cardiac muscle tissue development GO:0048738 130 0.937
ventricular septum morphogenesis GO:0060412 27 0.936
embryonic neurocranium morphogenesis GO:0048702 3 0.936
negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 2 0.935
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.934
formation of primary germ layer GO:0001704 77 0.934
Mouse
bmp signaling pathway involved in heart development GO:0061312 2 0.934
medial motor column neuron differentiation GO:0021526 2 0.934
myoblast migration GO:0051451 8 0.933
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.933
retinal rod cell differentiation GO:0060221 2 0.933
mesangial cell differentiation GO:0072007 4 0.933
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.933
inner cell mass cell differentiation GO:0001826 7 0.932
regulation of endodermal cell differentiation GO:1903224 2 0.931
nose development GO:0043584 12 0.931
regulation of neuroblast proliferation GO:1902692 27 0.931
Mouse
lens morphogenesis in camera type eye GO:0002089 24 0.930
Mouse
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.930
positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 0.929
cardiac endothelial cell differentiation GO:0003348 4 0.929
eye photoreceptor cell development GO:0042462 31 0.928
bmp signaling pathway GO:0030509 93 0.928
retina development in camera type eye GO:0060041 119 0.927
Mouse
cardiac neural crest cell development involved in outflow tract morphogenesis GO:0061309 6 0.927
neuron projection extension GO:1990138 64 0.927
cerebral cortex cell migration GO:0021795 44 0.926
lens induction in camera type eye GO:0060235 7 0.926
Mouse
prostate gland stromal morphogenesis GO:0060741 2 0.926
rhombomere 4 development GO:0021570 3 0.925
trachea cartilage morphogenesis GO:0060535 4 0.925
epidermis development GO:0008544 187 0.923
muscle tissue development GO:0060537 308 0.923
urogenital system development GO:0001655 261 0.922
mitral valve development GO:0003174 4 0.921
his purkinje system cell differentiation GO:0060932 2 0.921
regulation of myoblast proliferation GO:2000291 8 0.920
mesonephric tubule development GO:0072164 94 0.920
segment specification GO:0007379 15 0.920
regulation of transcription from rna polymerase ii promoter involved in definitive endodermal cell fate specification GO:0060807 1 0.919
negative regulation of cardiac chamber formation GO:1901211 1 0.918
growth plate cartilage development GO:0003417 14 0.918
cell proliferation involved in heart morphogenesis GO:0061323 15 0.918
olfactory nerve development GO:0021553 3 0.917
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.917
metanephric nephron tubule epithelial cell differentiation GO:0072257 5 0.917
mesenchyme development GO:0060485 152 0.917
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.917
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.916
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.915
cranial nerve formation GO:0021603 4 0.915
stem cell proliferation GO:0072089 117 0.915
pronephric field specification GO:0039003 2 0.915
metencephalon development GO:0022037 89 0.915
neural crest cell differentiation GO:0014033 54 0.915
metanephric nephron tubule morphogenesis GO:0072282 7 0.914
nephric duct elongation GO:0035849 1 0.912
sinoatrial node development GO:0003163 4 0.912
cerebellar granule cell differentiation GO:0021707 9 0.910
lung cell differentiation GO:0060479 30 0.910
cerebellar purkinje cell layer development GO:0021680 26 0.909
dichotomous subdivision of terminal units involved in ureteric bud branching GO:0060678 1 0.907
cardiac muscle cell myoblast differentiation GO:0060379 8 0.907
cardiac cell fate specification GO:0060912 2 0.907
neuroblast proliferation GO:0007405 49 0.906
Mouse
cellular component assembly involved in morphogenesis GO:0010927 139 0.906
Mouse
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.905
positive regulation of wound healing GO:0090303 17 0.904
positive regulation of epithelial cell proliferation GO:0050679 68 0.904
cartilage morphogenesis GO:0060536 11 0.904
positive regulation of glial cell differentiation GO:0045687 21 0.904
negative regulation of neuron projection development GO:0010977 50 0.903
otic vesicle morphogenesis GO:0071600 10 0.903
salivary gland morphogenesis GO:0007435 33 0.902
camera type eye development GO:0043010 266 0.902
Zebrafish Mouse
regulation of neuron differentiation GO:0045664 281 0.901
regulation of branch elongation involved in ureteric bud branching GO:0072095 3 0.901
regulation of ureteric bud formation GO:0072106 3 0.900
positive regulation of transcription from rna polymerase iii promoter GO:0045945 1 0.900
mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9 0.899
Mouse
tongue morphogenesis GO:0043587 8 0.899
mesonephric epithelium development GO:0072163 94 0.899
lung development GO:0030324 164 0.898
embryonic olfactory bulb interneuron precursor migration GO:0021831 2 0.897
cardiac right ventricle formation GO:0003219 3 0.896
eye photoreceptor cell differentiation GO:0001754 41 0.895
hindbrain formation GO:0021576 1 0.895
negative regulation of chondrocyte differentiation GO:0032331 13 0.895
thalamus development GO:0021794 11 0.894
lateral mesoderm morphogenesis GO:0048369 3 0.894
pericardium development GO:0060039 16 0.893
face development GO:0060324 38 0.892
cardiac muscle cell development GO:0055013 39 0.891
somatic motor neuron differentiation GO:0021523 6 0.890
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.889
blastocyst development GO:0001824 80 0.889
pulmonary valve formation GO:0003193 1 0.889
hindbrain morphogenesis GO:0021575 46 0.888
establishment of neuroblast polarity GO:0045200 1 0.887
metanephric comma shaped body morphogenesis GO:0072278 1 0.886
telencephalon cell migration GO:0022029 55 0.885
skeletal muscle tissue regeneration GO:0043403 20 0.885
cardiogenic plate morphogenesis GO:0003142 1 0.884
chromatin modification GO:0016568 187 0.884
pons development GO:0021548 13 0.883
positive regulation of kidney development GO:0090184 28 0.883
mesenchymal cell differentiation involved in kidney development GO:0072161 6 0.883
Mouse
embryonic genitalia morphogenesis GO:0030538 4 0.883
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 4 0.882
regulation of stem cell proliferation GO:0072091 78 0.881
renal vesicle morphogenesis GO:0072077 15 0.878
Mouse
cardiac septum morphogenesis GO:0060411 46 0.877

Six1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.916
Human
musculoskeletal system disease DOID:17 0 0.916