Mus musculus

466 known processes

Lrp6

low density lipoprotein receptor-related protein 6

(Aliases: Gw,C030016K15Rik,Cd)

Lrp6 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
formation of radial glial scaffolds GO:0021943 4 0.999
axis elongation involved in somitogenesis GO:0090245 4 0.997
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.997
non canonical wnt signaling pathway GO:0035567 33 0.996
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.994
endodermal cell fate specification GO:0001714 4 0.992
embryonic organ morphogenesis GO:0048562 276 0.991
regionalization GO:0003002 337 0.991
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.988
neural tube development GO:0021915 160 0.977
mammary placode formation GO:0060596 4 0.977
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.972
endodermal cell fate commitment GO:0001711 12 0.971
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.968
somitogenesis GO:0001756 69 0.965
planar cell polarity pathway involved in heart morphogenesis GO:0061346 3 0.961
canonical wnt signaling pathway GO:0060070 130 0.959
embryonic heart tube morphogenesis GO:0003143 51 0.955
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.953
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.951
negative regulation of cardiac chamber morphogenesis GO:1901220 2 0.947
wnt signaling pathway GO:0016055 188 0.941
cardiac right atrium morphogenesis GO:0003213 3 0.932
genitalia morphogenesis GO:0035112 11 0.930
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.917
stem cell development GO:0048864 219 0.916
Human Mouse
morphogenesis of a polarized epithelium GO:0001738 37 0.909
neural tube patterning GO:0021532 43 0.900
regulation of wnt signaling pathway GO:0030111 123 0.893
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.875
regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000148 1 0.865
lung induction GO:0060492 3 0.865
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000151 1 0.860
positive regulation of wnt signaling pathway GO:0030177 45 0.860
Human
gastrulation GO:0007369 116 0.858
cardiac chamber development GO:0003205 108 0.857
primary neural tube formation GO:0014020 95 0.841
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.841
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.840
trachea cartilage morphogenesis GO:0060535 4 0.835
digestive system development GO:0055123 200 0.824
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.814
skeletal system development GO:0001501 356 0.811
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 2 0.796
embryonic skeletal system development GO:0048706 120 0.795
single organismal cell cell adhesion GO:0016337 131 0.788
branching morphogenesis of an epithelial tube GO:0048754 159 0.776
forebrain neuroblast division GO:0021873 9 0.768
digestive tract development GO:0048565 190 0.767
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.760
neural tube formation GO:0001841 108 0.756
heart field specification GO:0003128 6 0.753
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.753
segmentation GO:0035282 93 0.749
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.745
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.741
somite development GO:0061053 81 0.737
regulation of cardiac chamber morphogenesis GO:1901219 2 0.736
negative regulation of protein modification process GO:0031400 163 0.734
Human
stem cell differentiation GO:0048863 268 0.731
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.730
embryonic skeletal joint development GO:0072498 13 0.726
stem cell proliferation GO:0072089 117 0.717
epithelial tube morphogenesis GO:0060562 303 0.716
negative regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000160 1 0.715
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.714
regulation of endodermal cell fate specification GO:0042663 2 0.710
negative regulation of phosphorus metabolic process GO:0010563 184 0.708
Human
morphogenesis of embryonic epithelium GO:0016331 159 0.702
neural tube closure GO:0001843 90 0.701
negative regulation of cell proliferation GO:0008285 296 0.701
rostrocaudal neural tube patterning GO:0021903 12 0.699
chondrocyte differentiation GO:0002062 72 0.698
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.685
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.680
cardiac septum morphogenesis GO:0060411 46 0.675
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.670
muscle tissue development GO:0060537 308 0.666
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.659
osteoblast development GO:0002076 17 0.658
Mouse
negative regulation of cell fate specification GO:0009996 4 0.655
hindbrain development GO:0030902 128 0.653
cell adhesion GO:0007155 329 0.650
neural plate development GO:0001840 12 0.647
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000162 1 0.645
post anal tail morphogenesis GO:0036342 23 0.644
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.643
cerebral cortex development GO:0021987 86 0.643
mesenchyme development GO:0060485 152 0.638
neuroblast division GO:0055057 10 0.630
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.630
Mouse
ventricular septum morphogenesis GO:0060412 27 0.624
regulation of wnt signaling pathway planar cell polarity pathway GO:2000095 10 0.624
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.614
establishment of planar polarity involved in neural tube closure GO:0090177 15 0.613
neuron projection guidance GO:0097485 141 0.610
convergent extension GO:0060026 14 0.601
morphogenesis of a branching structure GO:0001763 203 0.600
hypermethylation of cpg island GO:0044027 3 0.598
cellular macromolecule catabolic process GO:0044265 206 0.598
Mouse
dna metabolic process GO:0006259 303 0.593
determination of left right symmetry GO:0007368 80 0.592
cardiac muscle tissue morphogenesis GO:0055008 44 0.591
negative regulation of neuron differentiation GO:0045665 101 0.583
Mouse
cell migration involved in gastrulation GO:0042074 13 0.582
forebrain generation of neurons GO:0021872 63 0.579
respiratory tube development GO:0030323 167 0.574
embryonic appendage morphogenesis GO:0035113 126 0.574
respiratory system development GO:0060541 190 0.573
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.572
epithelial to mesenchymal transition GO:0001837 47 0.571
Human
foregut regionalization GO:0060423 3 0.569
cardiac ventricle development GO:0003231 83 0.569
muscle system process GO:0003012 141 0.569
somite specification GO:0001757 4 0.567
regulation of canonical wnt signaling pathway GO:0060828 82 0.566
Human
cardiac endothelial cell differentiation GO:0003348 4 0.561
appendage morphogenesis GO:0035107 149 0.560
regulation of planar cell polarity pathway involved in heart morphogenesis GO:2000159 1 0.559
mesenchymal cell differentiation GO:0048762 107 0.558
renal system development GO:0072001 225 0.552
Mouse
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.552
odontogenesis GO:0042476 78 0.552
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.547
Mouse
blood circulation GO:0008015 195 0.546
regulation of neuron differentiation GO:0045664 281 0.545
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.535
regulation of mesenchymal cell proliferation GO:0010464 37 0.532
sensory organ morphogenesis GO:0090596 242 0.531
regulation of fat cell differentiation GO:0045598 81 0.530
embryonic camera type eye development GO:0031076 36 0.528
chondrocyte development GO:0002063 24 0.524
digestive tract morphogenesis GO:0048546 147 0.524
cellular amine metabolic process GO:0044106 44 0.524
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.523
mammary gland epithelium development GO:0061180 65 0.523
establishment of tissue polarity GO:0007164 28 0.522
metanephric mesenchyme morphogenesis GO:0072133 4 0.520
urogenital system development GO:0001655 261 0.514
Mouse
cellular amino acid metabolic process GO:0006520 103 0.513
embryonic digit morphogenesis GO:0042733 56 0.511
mesenchymal cell proliferation GO:0010463 44 0.507
forebrain development GO:0030900 302 0.504
stem cell maintenance GO:0019827 130 0.503
Mouse
cardiac muscle tissue development GO:0048738 130 0.502
positive regulation of branching involved in lung morphogenesis GO:0061047 4 0.501
renal vesicle induction GO:0072034 3 0.501
negative regulation of planar cell polarity pathway involved in neural tube closure GO:2000168 1 0.500
negative regulation of hormone biosynthetic process GO:0032353 4 0.498
hindlimb morphogenesis GO:0035137 42 0.497
cell migration in hindbrain GO:0021535 16 0.496
purine containing compound catabolic process GO:0072523 213 0.495
pallium development GO:0021543 120 0.492
regulation of heart morphogenesis GO:2000826 22 0.487
negative regulation of protein phosphorylation GO:0001933 126 0.486
Human
polarity specification of proximal distal axis GO:0010085 2 0.485
regulation of cellular amino acid metabolic process GO:0006521 5 0.484
telencephalon development GO:0021537 186 0.481
axial mesodermal cell fate commitment GO:0048322 1 0.481
regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:2000161 1 0.480
axis elongation GO:0003401 30 0.478
cardiac left ventricle morphogenesis GO:0003214 9 0.477
regulation of cellular protein catabolic process GO:1903362 61 0.476
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 0.474
telencephalon cell migration GO:0022029 55 0.472
cell proliferation in hindbrain GO:0021534 10 0.471
Mouse
renal inner medulla development GO:0072053 3 0.471
endocardial cushion formation GO:0003272 13 0.464
endoderm formation GO:0001706 20 0.463
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 6 0.459
determination of heart left right asymmetry GO:0061371 48 0.457
regulation of phospholipase activity GO:0010517 9 0.456
Mouse
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.449
Mouse
cellular ketone metabolic process GO:0042180 84 0.446
regulation of cellular amine metabolic process GO:0033238 20 0.444
mesodermal cell migration GO:0008078 4 0.439
negative regulation of cell development GO:0010721 169 0.438
Mouse
lung development GO:0030324 164 0.437
negative regulation of cell projection organization GO:0031345 56 0.437
Mouse
ear development GO:0043583 200 0.437
regulation of cardiac muscle tissue development GO:0055024 31 0.437
regulation of mapk cascade GO:0043408 248 0.434
Mouse
axon guidance GO:0007411 141 0.431
central nervous system morphogenesis GO:0021551 2 0.430
establishment of planar polarity of embryonic epithelium GO:0042249 16 0.428
embryonic limb morphogenesis GO:0030326 126 0.424
sinoatrial node cell differentiation GO:0060921 3 0.422
positive regulation of proteolysis GO:0045862 85 0.417
Mouse
heart morphogenesis GO:0003007 178 0.415
embryonic skeletal system morphogenesis GO:0048704 91 0.412
hindbrain radial glia guided cell migration GO:0021932 12 0.408
hexose metabolic process GO:0019318 98 0.395
midbrain hindbrain boundary development GO:0030917 9 0.392
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.390
multicellular organismal homeostasis GO:0048871 164 0.390
mesoderm development GO:0007498 100 0.388
negative regulation of neuron projection development GO:0010977 50 0.380
Mouse
regulation of establishment of planar polarity GO:0090175 28 0.379
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 0.375
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.374
Mouse
cardiac cell fate specification GO:0060912 2 0.373
mesenchymal cell development GO:0014031 93 0.372
Human
pericardium morphogenesis GO:0003344 5 0.372
negative regulation of wnt signaling pathway GO:0030178 73 0.370
cardiac chamber morphogenesis GO:0003206 93 0.369
aorta morphogenesis GO:0035909 22 0.369
Mouse
carbohydrate metabolic process GO:0005975 230 0.368
negative regulation of cardiac muscle tissue development GO:0055026 8 0.367
positive regulation of hh target transcription factor activity GO:0007228 3 0.365
central nervous system vasculogenesis GO:0022009 3 0.364
ossification GO:0001503 216 0.364
negative regulation of cholesterol transport GO:0032375 4 0.363
Mouse
ventricular zone neuroblast division GO:0021847 3 0.361
cerebellum development GO:0021549 77 0.360
neural crest cell differentiation GO:0014033 54 0.359
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.357
nephric duct formation GO:0072179 4 0.356
regulation of muscle tissue development GO:1901861 97 0.355
cell fate specification GO:0001708 72 0.354
regulation of planar cell polarity pathway involved in neural tube closure GO:2000167 1 0.354
epithelial tube formation GO:0072175 130 0.353
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.353
Mouse
skeletal system morphogenesis GO:0048705 203 0.352
peptidyl amino acid modification GO:0018193 336 0.352
Mouse
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.352
positive regulation of ossification GO:0045778 47 0.351
cartilage development GO:0051216 140 0.346
organic hydroxy compound metabolic process GO:1901615 203 0.344
Mouse
endoderm development GO:0007492 45 0.344
regulation of endodermal cell differentiation GO:1903224 2 0.344
establishment of endothelial blood brain barrier GO:0014045 3 0.342
embryonic skeletal joint morphogenesis GO:0060272 11 0.342
canonical wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development GO:0061310 1 0.341
regulation of proteolysis GO:0030162 164 0.341
Mouse
ear morphogenesis GO:0042471 118 0.337
regulation of protein serine threonine kinase activity GO:0071900 157 0.336
Human Mouse
regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:2000150 1 0.335
limb morphogenesis GO:0035108 149 0.335
lung field specification GO:0060424 3 0.335
negative regulation of cellular amine metabolic process GO:0033239 1 0.333
positive regulation of nuclear division GO:0051785 27 0.333
neuroblast differentiation GO:0014016 2 0.332
mammary gland formation GO:0060592 9 0.331
mesenchymal cell apoptotic process involved in nephron morphogenesis GO:1901145 4 0.331
negative regulation of sterol transport GO:0032372 4 0.331
Mouse
positive regulation of cellular protein catabolic process GO:1903364 34 0.329
Mouse
camera type eye development GO:0043010 266 0.329
negative regulation of nfat protein import into nucleus GO:0051534 3 0.328
purine ribonucleotide metabolic process GO:0009150 290 0.326
organic cyclic compound catabolic process GO:1901361 295 0.326
spermatogenesis GO:0007283 284 0.326
cellular nitrogen compound catabolic process GO:0044270 280 0.324
organ growth GO:0035265 117 0.320
embryonic genitalia morphogenesis GO:0030538 4 0.318
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.316
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.314
morphogenesis of an epithelial sheet GO:0002011 27 0.314
ectodermal placode formation GO:0060788 16 0.311
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.310
axial mesoderm formation GO:0048320 3 0.306
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.305
amine metabolic process GO:0009308 45 0.302
purine nucleotide metabolic process GO:0006163 302 0.301
germ line stem cell division GO:0042078 2 0.299
negative regulation of protein metabolic process GO:0051248 282 0.299
Human
regulation of peptidyl threonine phosphorylation GO:0010799 12 0.295
developmental growth involved in morphogenesis GO:0060560 138 0.294
regulation of organelle organization GO:0033043 289 0.292
Mouse
regulation of cardiac chamber formation GO:1901210 1 0.292
atrioventricular bundle cell differentiation GO:0003167 1 0.291
negative regulation of molecular function GO:0044092 258 0.291
Human
embryonic epithelial tube formation GO:0001838 130 0.285
vagus nerve morphogenesis GO:0021644 2 0.284
regulation of neuron maturation GO:0014041 5 0.283
ectodermal placode development GO:0071696 16 0.280
engulfment of apoptotic cell GO:0043652 3 0.280
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.279
cerebellar granule cell precursor proliferation GO:0021930 10 0.279
Mouse
chemotaxis GO:0006935 247 0.278
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.278
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 12 0.277
semicircular canal development GO:0060872 9 0.276
formation of primary germ layer GO:0001704 77 0.275
regulation of mitotic cell cycle GO:0007346 126 0.274
endodermal cell differentiation GO:0035987 14 0.274
regulation of cell cycle process GO:0010564 160 0.273
limb development GO:0060173 166 0.273
regulation of smoothened signaling pathway GO:0008589 58 0.271
glial cell differentiation GO:0010001 131 0.270
negative regulation of alcohol biosynthetic process GO:1902931 4 0.269
retina vasculature development in camera type eye GO:0061298 17 0.268
Mouse
regulation of cardioblast differentiation GO:0051890 3 0.264
regulation of phospholipase a2 activity GO:0032429 3 0.263
Mouse
regulation of cell migration GO:0030334 219 0.258
Mouse
mesonephric epithelium development GO:0072163 94 0.256
striated muscle tissue development GO:0014706 293 0.255
cellular response to extracellular stimulus GO:0031668 81 0.255
ventricular septum development GO:0003281 42 0.255
renal outer medulla development GO:0072054 2 0.254
morphogenesis of an epithelial bud GO:0060572 18 0.251
negative regulation of osteoblast differentiation GO:0045668 30 0.251
cerebellar granule cell differentiation GO:0021707 9 0.251
metencephalon development GO:0022037 89 0.250
metanephric loop of henle development GO:0072236 4 0.250
regulation of purine nucleotide metabolic process GO:1900542 169 0.248
neural crest cell migration GO:0001755 32 0.248
epithelial cell morphogenesis GO:0003382 41 0.248
regulation of cellular component biogenesis GO:0044087 181 0.246
receptor mediated endocytosis of low density lipoprotein particle involved in cholesterol transport GO:0090118 1 0.244
mesoderm morphogenesis GO:0048332 64 0.243
meiotic cell cycle GO:0051321 122 0.243
regulation of tongue muscle cell differentiation GO:2001035 2 0.242
positive regulation of gtp catabolic process GO:0033126 85 0.242
dorsal ventral neural tube patterning GO:0021904 28 0.240
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.239
lateral line system development GO:0048925 1 0.238
response to extracellular stimulus GO:0009991 127 0.237
negative regulation of epidermis development GO:0045683 9 0.237
anatomical structure regression GO:0060033 9 0.237
Mouse
regulation of osteoblast proliferation GO:0033688 15 0.236
Mouse
bone morphogenesis GO:0060349 78 0.236
synaptic growth at neuromuscular junction GO:0051124 6 0.234
Mouse
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.234
artery development GO:0060840 53 0.233
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.233
Mouse
regulation of cardiac cell fate specification GO:2000043 1 0.232
notochord formation GO:0014028 5 0.232
anterior commissure morphogenesis GO:0021960 6 0.232
bone development GO:0060348 120 0.231
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.230
hair follicle development GO:0001942 85 0.230
Mouse
negative regulation of jun kinase activity GO:0043508 9 0.230
purine nucleoside triphosphate metabolic process GO:0009144 226 0.230
spinal cord motor neuron differentiation GO:0021522 35 0.230
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.230
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.229
negative regulation of prostatic bud formation GO:0060686 4 0.229
regulation of presynaptic membrane organization GO:1901629 3 0.229
Mouse
cell growth involved in cardiac muscle cell development GO:0061049 3 0.226
negative regulation of bmp signaling pathway GO:0030514 35 0.226
response to organic cyclic compound GO:0014070 198 0.226
neuron maturation GO:0042551 29 0.225
specification of organ identity GO:0010092 30 0.224
regulation of ras protein signal transduction GO:0046578 114 0.224
negative regulation of lipid metabolic process GO:0045833 30 0.224
forebrain cell migration GO:0021885 58 0.224
central nervous system neuron differentiation GO:0021953 162 0.223
tooth mineralization GO:0034505 9 0.223
external genitalia morphogenesis GO:0035261 1 0.222
monosaccharide metabolic process GO:0005996 106 0.221
modification dependent macromolecule catabolic process GO:0043632 133 0.220
Mouse
floor plate morphogenesis GO:0033505 3 0.220
axonogenesis GO:0007409 274 0.220
Mouse
regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000165 1 0.220
muscle contraction GO:0006936 101 0.219
regulation of heart induction GO:0090381 2 0.219
midbrain hindbrain boundary maturation GO:0021732 1 0.219
ameboidal type cell migration GO:0001667 128 0.218
middle ear morphogenesis GO:0042474 23 0.217
regulation of rho gtpase activity GO:0032319 58 0.217
forebrain radial glial cell differentiation GO:0021861 4 0.216
glycosyl compound metabolic process GO:1901657 246 0.215
physiological cardiac muscle hypertrophy GO:0003301 3 0.215
mitotic cell cycle process GO:1903047 159 0.214
pituitary gland development GO:0021983 38 0.214
neural plate morphogenesis GO:0001839 9 0.213
regulation of nucleotide metabolic process GO:0006140 169 0.213
regulation of purine nucleotide catabolic process GO:0033121 122 0.213
anatomical structure homeostasis GO:0060249 145 0.213
circulatory system process GO:0003013 197 0.213
cytoplasmic transport GO:0016482 234 0.212
Mouse Fly
habituation GO:0046959 3 0.211
jnk cascade GO:0007254 72 0.210
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 0.210
brain morphogenesis GO:0048854 32 0.209
small gtpase mediated signal transduction GO:0007264 97 0.207
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.206
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.205
Human
regulation of stem cell proliferation GO:0072091 78 0.205
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072040 4 0.204
kidney mesenchyme morphogenesis GO:0072131 4 0.203
sulfur compound biosynthetic process GO:0044272 37 0.202
positive regulation of canonical wnt signaling pathway GO:0090263 29 0.202
Human
heart induction GO:0003129 2 0.201
schwann cell proliferation GO:0014010 2 0.201
heterocycle catabolic process GO:0046700 280 0.199
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.198
Mouse
inner ear morphogenesis GO:0042472 101 0.198
positive regulation of binding GO:0051099 49 0.197
Mouse
carbohydrate homeostasis GO:0033500 128 0.196
Mouse
notch signaling pathway GO:0007219 71 0.195
regulation of ras gtpase activity GO:0032318 88 0.195
nucleoside catabolic process GO:0009164 206 0.195
cell proliferation in forebrain GO:0021846 30 0.195
vagus nerve development GO:0021564 3 0.194
negative regulation of phosphorylation GO:0042326 166 0.194
Human
forelimb morphogenesis GO:0035136 40 0.193
negative regulation of cardiac muscle cell differentiation GO:2000726 2 0.193
positive regulation of cellular catabolic process GO:0031331 148 0.193
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.193
Mouse
skeletal muscle organ development GO:0060538 163 0.192
positive regulation of cell death GO:0010942 224 0.192
purine nucleoside metabolic process GO:0042278 241 0.192
regulation of heart looping GO:1901207 1 0.191
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.191
establishment of protein localization to organelle GO:0072594 118 0.190
Mouse Fly
trachea formation GO:0060440 3 0.190
face morphogenesis GO:0060325 29 0.189
positive regulation of smoothened signaling pathway GO:0045880 23 0.188
regulation of cell cycle GO:0051726 281 0.188
Human
cerebellum morphogenesis GO:0021587 42 0.187
nucleoside metabolic process GO:0009116 246 0.185
apoptotic process in bone marrow GO:0071839 1 0.184
positive regulation of cell division GO:0051781 31 0.182
establishment of planar polarity GO:0001736 28 0.182
pulmonary valve formation GO:0003193 1 0.181
embryonic eye morphogenesis GO:0048048 29 0.181
cell fate commitment GO:0045165 210 0.181
microtubule based process GO:0007017 236 0.181
kidney morphogenesis GO:0060993 83 0.180
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.178
response to retinoic acid GO:0032526 56 0.177
protein localization to membrane GO:0072657 108 0.176
Mouse
regulation of hydrolase activity GO:0051336 246 0.176
Mouse
regulation of mesenchymal cell proliferation involved in ureter development GO:0072199 3 0.176
regulation of lipase activity GO:0060191 15 0.175
Mouse
embryonic heart tube development GO:0035050 65 0.174
cell surface receptor signaling pathway involved in heart development GO:0061311 15 0.173
limbic system development GO:0021761 72 0.173
regulation of kinase activity GO:0043549 249 0.172
Human Mouse
embryonic hindlimb morphogenesis GO:0035116 32 0.172
negative regulation of striated muscle cell differentiation GO:0051154 14 0.172
cerebral cortex neuron differentiation GO:0021895 19 0.171
regulation of cell proliferation involved in outflow tract morphogenesis GO:1901963 2 0.171
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.171
regulation of osteoblast differentiation GO:0045667 67 0.171
cardiac left ventricle formation GO:0003218 1 0.171
nucleotide metabolic process GO:0009117 332 0.171
response to fibroblast growth factor GO:0071774 47 0.170
neural crest cell migration involved in autonomic nervous system development GO:1901166 5 0.170
exocrine system development GO:0035272 45 0.169
macromolecule catabolic process GO:0009057 281 0.167
Mouse
regulation of ketone biosynthetic process GO:0010566 2 0.166
inner medullary collecting duct development GO:0072061 2 0.165
purine containing compound metabolic process GO:0072521 311 0.165
mesonephric duct morphogenesis GO:0072180 4 0.164
regulation of striated muscle cell differentiation GO:0051153 81 0.163
organelle localization GO:0051640 179 0.163
regulation of stem cell differentiation GO:2000736 50 0.163
single organism cell adhesion GO:0098602 156 0.163
gtp catabolic process GO:0006184 143 0.163
negative regulation of cardiac chamber formation GO:1901211 1 0.162
mesonephric tubule development GO:0072164 94 0.162
odontogenesis of dentin containing tooth GO:0042475 66 0.162
positive regulation of nervous system development GO:0051962 221 0.162
Mouse
regulation of intracellular protein transport GO:0033157 82 0.161
establishment of organelle localization GO:0051656 122 0.161
lateral inhibition GO:0046331 1 0.159
blastocyst development GO:0001824 80 0.159
positive regulation of cell cycle GO:0045787 92 0.159
Human
protein ubiquitination GO:0016567 171 0.159
Mouse
regulation of cellular catabolic process GO:0031329 242 0.159
Mouse
response to growth factor GO:0070848 198 0.158
regulation of bmp signaling pathway GO:0030510 60 0.158
cell differentiation in hindbrain GO:0021533 24 0.156
cerebellar granular layer development GO:0021681 13 0.156
regulation of nucleotide catabolic process GO:0030811 122 0.156
histone acetylation GO:0016573 41 0.155
endodermal cell fate determination GO:0007493 2 0.155
regulation of neuron projection development GO:0010975 169 0.154
Mouse
synapse organization GO:0050808 125 0.153
Mouse
visceral motor neuron differentiation GO:0021524 3 0.153
regulation of platelet derived growth factor receptor beta signaling pathway GO:2000586 2 0.153
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.153
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.153
regulation of mesodermal cell fate specification GO:0042661 5 0.152
hindbrain morphogenesis GO:0021575 46 0.151
mammary gland bud morphogenesis GO:0060648 4 0.151
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.150
protein localization to organelle GO:0033365 185 0.150
Mouse Fly
ribonucleotide metabolic process GO:0009259 291 0.150
branching involved in ureteric bud morphogenesis GO:0001658 56 0.149
positive regulation of heart growth GO:0060421 18 0.149
midgut development GO:0007494 4 0.148
inner ear receptor cell differentiation GO:0060113 61 0.147
trachea gland development GO:0061153 3 0.147
microtubule cytoskeleton organization GO:0000226 157 0.146
protein catabolic process GO:0030163 221 0.146
Mouse
positive regulation of apoptotic process GO:0043065 217 0.146

Lrp6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.740
musculoskeletal system disease DOID:17 0 0.740
connective tissue disease DOID:65 0 0.740
bone disease DOID:0080001 0 0.450
sensory system disease DOID:0050155 0 0.392
nervous system disease DOID:863 0 0.392
eye and adnexa disease DOID:1492 0 0.150
eye disease DOID:5614 0 0.150