Rattus norvegicus

67 known processes

Impdh2

IMP (inosine monophosphate) dehydrogenase 2

(Aliases: MGC72938)

Impdh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of programmed cell death GO:0043067 341 0.428
regulation of apoptotic process GO:0042981 335 0.419
programmed cell death GO:0012501 392 0.412
reproductive process GO:0022414 372 0.292
translation GO:0006412 35 0.276
macromolecular complex subunit organization GO:0043933 339 0.261
spindle organization GO:0007051 2 0.243
sperm egg recognition GO:0035036 1 0.229
cell cycle GO:0007049 101 0.228
carboxylic acid metabolic process GO:0019752 289 0.206
apoptotic process GO:0006915 381 0.202
regulation of intracellular signal transduction GO:1902531 218 0.197
response to peptide hormone GO:0043434 278 0.192
cell cycle process GO:0022402 57 0.188
positive regulation of molecular function GO:0044093 230 0.179
monosaccharide metabolic process GO:0005996 61 0.179
regulation of catalytic activity GO:0050790 304 0.175
single organism reproductive process GO:0044702 297 0.170
mitotic spindle organization GO:0007052 2 0.155
response to inorganic substance GO:0010035 377 0.154
protein complex subunit organization GO:0071822 302 0.154
cardiovascular system development GO:0072358 134 0.140
regulation of molecular function GO:0065009 398 0.138
positive regulation of response to stimulus GO:0048584 285 0.132
regulation of cell proliferation GO:0042127 359 0.126
tissue development GO:0009888 252 0.125
aromatic compound catabolic process GO:0019439 168 0.124
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.121
negative regulation of cellular metabolic process GO:0031324 281 0.119
intracellular signal transduction GO:0035556 314 0.117
multi organism reproductive process GO:0044703 262 0.117
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.116
activation of cysteine type endopeptidase activity GO:0097202 4 0.116
positive regulation of catalytic activity GO:0043085 184 0.105
cellular response to endogenous stimulus GO:0071495 377 0.103
carbohydrate metabolic process GO:0005975 130 0.099
negative regulation of cell death GO:0060548 229 0.099
regulation of hydrolase activity GO:0051336 143 0.099
positive regulation of cell proliferation GO:0008284 249 0.098
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.096
organelle organization GO:0006996 266 0.094
positive regulation of signal transduction GO:0009967 175 0.091
positive regulation of cell death GO:0010942 184 0.090
single organism biosynthetic process GO:0044711 342 0.089
negative regulation of cell differentiation GO:0045596 99 0.087
positive regulation of programmed cell death GO:0043068 157 0.086
reproduction GO:0000003 245 0.085
negative regulation of macromolecule metabolic process GO:0010605 260 0.081
cellular nitrogen compound catabolic process GO:0044270 163 0.080
toxin transport GO:1901998 3 0.080
polysaccharide metabolic process GO:0005976 25 0.078
negative regulation of gene expression GO:0010629 199 0.077
protein processing GO:0016485 68 0.077
single fertilization GO:0007338 3 0.077
regulation of neuron death GO:1901214 115 0.076
binding of sperm to zona pellucida GO:0007339 1 0.075
regulation of phosphorylation GO:0042325 248 0.073
rna metabolic process GO:0016070 406 0.073
positive regulation of hydrolase activity GO:0051345 86 0.071
negative regulation of programmed cell death GO:0043069 183 0.070
cellular response to oxygen containing compound GO:1901701 386 0.069
sexual reproduction GO:0019953 148 0.069
positive regulation of apoptotic process GO:0043065 154 0.069
regulation of response to stress GO:0080134 126 0.069
amine metabolic process GO:0009308 38 0.068
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.068
positive regulation of cellular biosynthetic process GO:0031328 295 0.067
protein complex biogenesis GO:0070271 263 0.065
positive regulation of signaling GO:0023056 270 0.064
regulation of cell differentiation GO:0045595 320 0.064
negative regulation of metabolic process GO:0009892 331 0.063
regulation of cell motility GO:2000145 131 0.063
organic acid metabolic process GO:0006082 292 0.062
neuron death GO:0070997 127 0.062
macromolecular complex assembly GO:0065003 273 0.062
nucleobase containing small molecule metabolic process GO:0055086 316 0.061
regulation of membrane potential GO:0042391 110 0.061
positive regulation of protein metabolic process GO:0051247 178 0.060
regulation of phosphate metabolic process GO:0019220 349 0.060
nitrogen compound transport GO:0071705 229 0.059
response to carbohydrate GO:0009743 183 0.058
negative regulation of apoptotic process GO:0043066 181 0.057
regulation of signal transduction GO:0009966 318 0.057
regulation of multicellular organismal development GO:2000026 376 0.054
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.054
circulatory system development GO:0072359 134 0.054
oxoacid metabolic process GO:0043436 290 0.054
response to hypoxia GO:0001666 231 0.052
cellular amine metabolic process GO:0044106 38 0.052
negative regulation of rna metabolic process GO:0051253 123 0.052
cellular response to hormone stimulus GO:0032870 247 0.052
protein complex assembly GO:0006461 263 0.051
response to oxygen levels GO:0070482 265 0.051
glycosyl compound metabolic process GO:1901657 182 0.051
response to nutrient levels GO:0031667 370 0.051
positive regulation of cell migration GO:0030335 96 0.051
organic substance catabolic process GO:1901575 316 0.050
fertilization GO:0009566 3 0.049
single organism carbohydrate metabolic process GO:0044723 118 0.049
positive regulation of intracellular signal transduction GO:1902533 138 0.049
cellular carbohydrate metabolic process GO:0044262 72 0.049
cellular component biogenesis GO:0044085 368 0.049
nucleoside phosphate metabolic process GO:0006753 283 0.048
positive regulation of gene expression GO:0010628 244 0.048
protein maturation GO:0051604 68 0.048
positive regulation of nucleic acid templated transcription GO:1903508 197 0.047
glucose metabolic process GO:0006006 52 0.047
regulation of nucleoside metabolic process GO:0009118 66 0.047
positive regulation of cell communication GO:0010647 271 0.046
multicellular organism reproduction GO:0032504 233 0.044
nucleic acid templated transcription GO:0097659 379 0.044
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.044
regulation of protein metabolic process GO:0051246 289 0.043
cellular amino acid metabolic process GO:0006520 107 0.041
regulation of apoptotic signaling pathway GO:2001233 13 0.041
cell type specific apoptotic process GO:0097285 134 0.041
response to decreased oxygen levels GO:0036293 237 0.041
nucleotide metabolic process GO:0009117 279 0.040
hexose metabolic process GO:0019318 58 0.040
chromosome segregation GO:0007059 2 0.040
generation of precursor metabolites and energy GO:0006091 62 0.040
neuron projection development GO:0031175 273 0.040
regulation of transcription dna templated GO:0006355 374 0.040
cell projection organization GO:0030030 302 0.039
regulation of cellular ketone metabolic process GO:0010565 27 0.039
cellular ketone metabolic process GO:0042180 51 0.038
single organism organelle organization GO:1902589 180 0.038
mitotic cell cycle GO:0000278 49 0.037
protein oligomerization GO:0051259 191 0.036
gastrulation GO:0007369 2 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
developmental process involved in reproduction GO:0003006 159 0.036
positive regulation of transcription dna templated GO:0045893 197 0.035
organophosphate metabolic process GO:0019637 370 0.035
regulation of cell cycle GO:0051726 73 0.035
regulation of cellular amine metabolic process GO:0033238 8 0.035
negative regulation of neuron death GO:1901215 69 0.034
response to cytokine GO:0034097 215 0.034
protein localization GO:0008104 191 0.034
transcription dna templated GO:0006351 377 0.034
mrna processing GO:0006397 14 0.033
positive regulation of rna biosynthetic process GO:1902680 197 0.033
regulation of anatomical structure morphogenesis GO:0022603 141 0.033
heterocycle catabolic process GO:0046700 167 0.033
cellular response to cytokine stimulus GO:0071345 127 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.032
anatomical structure morphogenesis GO:0009653 298 0.032
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.031
cell recognition GO:0008037 11 0.031
axonogenesis GO:0007409 71 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.031
response to extracellular stimulus GO:0009991 380 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.030
organonitrogen compound biosynthetic process GO:1901566 167 0.030
developmental growth involved in morphogenesis GO:0060560 33 0.029
positive regulation of nucleotide metabolic process GO:0045981 91 0.029
localization of cell GO:0051674 202 0.029
energy derivation by oxidation of organic compounds GO:0015980 46 0.029
cell cell recognition GO:0009988 1 0.029
regulation of camp metabolic process GO:0030814 43 0.028
neurological system process GO:0050877 219 0.028
gamete generation GO:0007276 124 0.028
regulation of phagocytosis GO:0050764 13 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
response to glucose GO:0009749 136 0.028
motor neuron axon guidance GO:0008045 1 0.028
ribonucleotide metabolic process GO:0009259 231 0.028
positive regulation of phosphate metabolic process GO:0045937 262 0.027
sensory organ development GO:0007423 74 0.027
single organism membrane organization GO:0044802 74 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
cellular response to insulin stimulus GO:0032869 81 0.027
positive regulation of protein phosphorylation GO:0001934 135 0.027
membrane organization GO:0061024 94 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.027
ribose phosphate metabolic process GO:0019693 235 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
negative regulation of signal transduction GO:0009968 83 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of cellular catabolic process GO:0031329 101 0.026
neuron differentiation GO:0030182 368 0.026
negative regulation of transport GO:0051051 136 0.026
cellular homeostasis GO:0019725 252 0.025
regulation of cell development GO:0060284 263 0.025
homeostatic process GO:0042592 331 0.025
regulation of cellular localization GO:0060341 263 0.025
positive regulation of developmental process GO:0051094 283 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
positive regulation of catabolic process GO:0009896 78 0.024
regulation of homeostatic process GO:0032844 101 0.024
g protein coupled receptor signaling pathway GO:0007186 242 0.024
regulation of nucleotide metabolic process GO:0006140 117 0.024
peptidyl amino acid modification GO:0018193 126 0.024
epithelium development GO:0060429 96 0.024
cellular response to peptide GO:1901653 133 0.024
multicellular organismal reproductive process GO:0048609 233 0.023
regulation of cellular component organization GO:0051128 368 0.023
tube development GO:0035295 89 0.023
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
regulation of purine nucleotide metabolic process GO:1900542 115 0.023
cell motility GO:0048870 202 0.023
regulation of establishment of protein localization GO:0070201 69 0.023
locomotion GO:0040011 237 0.023
axon development GO:0061564 96 0.023
behavior GO:0007610 205 0.023
nucleoside metabolic process GO:0009116 179 0.022
transcription from rna polymerase ii promoter GO:0006366 252 0.022
blood vessel morphogenesis GO:0048514 58 0.022
regulation of carbohydrate metabolic process GO:0006109 41 0.022
protein homooligomerization GO:0051260 91 0.022
regulation of proteolysis GO:0030162 66 0.021
polar body extrusion after meiotic divisions GO:0040038 1 0.021
regulation of cellular protein metabolic process GO:0032268 267 0.021
posttranscriptional regulation of gene expression GO:0010608 37 0.021
response to nutrient GO:0007584 248 0.021
camp catabolic process GO:0006198 13 0.021
neuron development GO:0048666 286 0.020
purine containing compound metabolic process GO:0072521 253 0.020
regulation of protein localization GO:0032880 81 0.020
translational initiation GO:0006413 8 0.020
mitotic cell cycle process GO:1903047 35 0.020
anion transmembrane transport GO:0098656 77 0.019
embryo development GO:0009790 49 0.019
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
secretion GO:0046903 307 0.019
cellular component movement GO:0006928 248 0.019
neuron projection extension GO:1990138 26 0.018
nucleocytoplasmic transport GO:0006913 48 0.018
cellular component assembly GO:0022607 360 0.018
intracellular transport GO:0046907 185 0.018
regulation of metanephros development GO:0072215 4 0.018
positive regulation of multicellular organismal process GO:0051240 387 0.018
purine ribonucleoside metabolic process GO:0046128 168 0.018
positive regulation of protein modification process GO:0031401 142 0.018
regulation of embryonic development GO:0045995 2 0.018
rhythmic process GO:0048511 156 0.018
microtubule cytoskeleton organization GO:0000226 25 0.018
cellular response to external stimulus GO:0071496 118 0.017
protein localization to membrane GO:0072657 36 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
negative regulation of developmental process GO:0051093 125 0.017
catabolic process GO:0009056 351 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
ossification GO:0001503 70 0.017
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.017
regulation of transferase activity GO:0051338 123 0.016
cellular chemical homeostasis GO:0055082 247 0.016
response to peptide GO:1901652 292 0.016
regulation of kinase activity GO:0043549 117 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
tissue morphogenesis GO:0048729 22 0.016
glycogen metabolic process GO:0005977 23 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
jak stat cascade GO:0007259 26 0.016
nuclear transport GO:0051169 49 0.016
regulation of endopeptidase activity GO:0052548 51 0.016
chromatin remodeling GO:0006338 3 0.016
response to monosaccharide GO:0034284 159 0.016
regulation of cellular response to stress GO:0080135 49 0.016
vasculature development GO:0001944 70 0.015
protein transport GO:0015031 132 0.015
regulation of organ morphogenesis GO:2000027 22 0.015
cytoplasmic transport GO:0016482 115 0.015
regulation of rna metabolic process GO:0051252 391 0.015
aging GO:0007568 241 0.015
apoptotic signaling pathway GO:0097190 27 0.015
negative regulation of transcription dna templated GO:0045892 116 0.015
regulation of peptidase activity GO:0052547 55 0.015
cell projection morphogenesis GO:0048858 123 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
digestive system development GO:0055123 41 0.015
regulation of catabolic process GO:0009894 113 0.015
organonitrogen compound catabolic process GO:1901565 179 0.014
regulation of cysteine type endopeptidase activity GO:2000116 32 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
regeneration GO:0031099 163 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
carbohydrate homeostasis GO:0033500 75 0.014
gtp catabolic process GO:0006184 71 0.014
chemical homeostasis GO:0048878 292 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
negative regulation of signaling GO:0023057 157 0.014
regulation of locomotion GO:0040012 148 0.013
positive regulation of gtpase activity GO:0043547 47 0.013
sex differentiation GO:0007548 113 0.013
cytoskeleton organization GO:0007010 111 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
camp metabolic process GO:0046058 63 0.013
growth GO:0040007 165 0.013
response to insulin GO:0032868 133 0.013
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 3 0.013
positive regulation of transport GO:0051050 245 0.013
cell growth GO:0016049 104 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
female gamete generation GO:0007292 25 0.013
digestive tract development GO:0048565 39 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
regulation of generation of precursor metabolites and energy GO:0043467 18 0.013
cellular protein localization GO:0034613 122 0.013
immune system process GO:0002376 204 0.012
regulation of response to wounding GO:1903034 69 0.012
positive regulation of nucleoside metabolic process GO:0045979 55 0.012
cellular response to lipid GO:0071396 201 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
immune response GO:0006955 104 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
chemotaxis GO:0006935 66 0.012
multi multicellular organism process GO:0044706 138 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
negative regulation of oxidative stress induced neuron death GO:1903204 2 0.012
response to wounding GO:0009611 254 0.012
regulation of cell migration GO:0030334 128 0.012
anion transport GO:0006820 178 0.012
cyclic nucleotide catabolic process GO:0009214 13 0.012
negative regulation of catalytic activity GO:0043086 103 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
regulation of mrna 3 end processing GO:0031440 1 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
cell migration GO:0016477 197 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
macromolecule localization GO:0033036 252 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
lymphocyte chemotaxis GO:0048247 3 0.011
glycogen biosynthetic process GO:0005978 15 0.011
organelle fission GO:0048285 25 0.011
negative regulation of multicellular organismal process GO:0051241 203 0.011
response to growth factor GO:0070848 189 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
establishment of protein localization GO:0045184 141 0.011
taxis GO:0042330 67 0.011
rna localization GO:0006403 4 0.011
energy reserve metabolic process GO:0006112 25 0.011
reproductive system development GO:0061458 128 0.011
microtubule based process GO:0007017 36 0.011
regulation of oxidative stress induced neuron death GO:1903203 2 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
protein localization to organelle GO:0033365 57 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
peptidyl tyrosine phosphorylation GO:0018108 72 0.010
brain development GO:0007420 247 0.010
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.010
cellular polysaccharide biosynthetic process GO:0033692 15 0.010
gland development GO:0048732 155 0.010
positive regulation of gtp catabolic process GO:0033126 48 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
ion transmembrane transport GO:0034220 365 0.010
chromatin assembly or disassembly GO:0006333 1 0.010
carbohydrate biosynthetic process GO:0016051 42 0.010

Impdh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
cancer DOID:162 0 0.016