Rattus norvegicus

145 known processes

Ddit3

DNA-damage inducible transcript 3

(Aliases: CHOP,CHOP-10,Gadd153,MGC124604,Chop10)

Ddit3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of macromolecule metabolic process GO:0010605 260 0.128
programmed cell death GO:0012501 392 0.121
negative regulation of cell death GO:0060548 229 0.111
nucleic acid templated transcription GO:0097659 379 0.105
transcription dna templated GO:0006351 377 0.085
regulation of rna metabolic process GO:0051252 391 0.084
regulation of cellular protein metabolic process GO:0032268 267 0.083
rna biosynthetic process GO:0032774 380 0.076
cellular response to stress GO:0033554 269 0.075
regulation of protein metabolic process GO:0051246 289 0.071
negative regulation of apoptotic process GO:0043066 181 0.063
regulation of apoptotic process GO:0042981 335 0.061
regulation of rna biosynthetic process GO:2001141 381 0.060
regulation of cell differentiation GO:0045595 320 0.060
Mouse
regulation of nucleic acid templated transcription GO:1903506 380 0.059
regulation of phosphorus metabolic process GO:0051174 349 0.059
negative regulation of metabolic process GO:0009892 331 0.058
negative regulation of response to stimulus GO:0048585 155 0.057
Mouse
regulation of molecular function GO:0065009 398 0.057
negative regulation of gene expression GO:0010629 199 0.057
catabolic process GO:0009056 351 0.056
Human
protein refolding GO:0042026 3 0.055
nucleobase containing small molecule metabolic process GO:0055086 316 0.055
apoptotic process GO:0006915 381 0.053
negative regulation of cellular metabolic process GO:0031324 281 0.052
intracellular signal transduction GO:0035556 314 0.052
Human Mouse
regulation of catalytic activity GO:0050790 304 0.052
response to inorganic substance GO:0010035 377 0.048
regulation of cellular component organization GO:0051128 368 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
response to external biotic stimulus GO:0043207 221 0.046
cellular catabolic process GO:0044248 295 0.046
Human
protein phosphorylation GO:0006468 345 0.045
intracellular transport GO:0046907 185 0.045
Mouse
positive regulation of cellular biosynthetic process GO:0031328 295 0.044
regulation of cell proliferation GO:0042127 359 0.044
nucleoside phosphate metabolic process GO:0006753 283 0.043
organic acid metabolic process GO:0006082 292 0.043
negative regulation of programmed cell death GO:0043069 183 0.042
response to extracellular stimulus GO:0009991 380 0.041
transmembrane transport GO:0055085 412 0.041
response to hypoxia GO:0001666 231 0.041
defense response GO:0006952 194 0.040
rna metabolic process GO:0016070 406 0.040
organophosphate metabolic process GO:0019637 370 0.040
carboxylic acid metabolic process GO:0019752 289 0.040
response to decreased oxygen levels GO:0036293 237 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.038
negative regulation of transport GO:0051051 136 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
g protein coupled receptor signaling pathway GO:0007186 242 0.037
transcription from rna polymerase ii promoter GO:0006366 252 0.037
negative regulation of multicellular organismal process GO:0051241 203 0.036
Human Mouse
homeostatic process GO:0042592 331 0.036
Human Mouse
neuron death GO:0070997 127 0.036
Mouse
response to oxygen levels GO:0070482 265 0.036
cellular amino acid metabolic process GO:0006520 107 0.035
cation transport GO:0006812 382 0.035
Mouse
oxidation reduction process GO:0055114 304 0.034
regulation of cellular localization GO:0060341 263 0.034
oxoacid metabolic process GO:0043436 290 0.034
nucleotide metabolic process GO:0009117 279 0.034
secretion by cell GO:0032940 248 0.033
regulation of hydrolase activity GO:0051336 143 0.033
positive regulation of multicellular organismal process GO:0051240 387 0.033
Human
macromolecule localization GO:0033036 252 0.033
negative regulation of cellular protein metabolic process GO:0032269 106 0.032
negative regulation of cell communication GO:0010648 158 0.032
Mouse
regulation of nervous system development GO:0051960 264 0.031
positive regulation of response to stimulus GO:0048584 285 0.031
neuron projection development GO:0031175 273 0.031
neuron differentiation GO:0030182 368 0.031
positive regulation of molecular function GO:0044093 230 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
negative regulation of nucleic acid templated transcription GO:1903507 117 0.031
organic substance catabolic process GO:1901575 316 0.030
Human
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.030
organelle organization GO:0006996 266 0.030
response to other organism GO:0051707 220 0.030
purine ribonucleotide metabolic process GO:0009150 227 0.030
regulation of purine nucleotide metabolic process GO:1900542 115 0.030
ribonucleotide metabolic process GO:0009259 231 0.029
metal ion homeostasis GO:0055065 186 0.029
Mouse
single organism biosynthetic process GO:0044711 342 0.029
central nervous system development GO:0007417 311 0.028
cellular component movement GO:0006928 248 0.028
regulation of nucleotide metabolic process GO:0006140 117 0.028
circulatory system process GO:0003013 183 0.028
regulation of cell development GO:0060284 263 0.028
Mouse
neuron development GO:0048666 286 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
single organism catabolic process GO:0044712 283 0.027
secretion GO:0046903 307 0.027
regulation of ion transport GO:0043269 245 0.027
negative regulation of developmental process GO:0051093 125 0.027
Human Mouse
regulation of transcription dna templated GO:0006355 374 0.027
protein localization GO:0008104 191 0.026
response to nutrient levels GO:0031667 370 0.026
negative regulation of transcription dna templated GO:0045892 116 0.026
cellular amine metabolic process GO:0044106 38 0.026
brain development GO:0007420 247 0.025
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
cellular component biogenesis GO:0044085 368 0.025
cellular response to topologically incorrect protein GO:0035967 3 0.025
Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.025
regulation of phosphorylation GO:0042325 248 0.024
response to biotic stimulus GO:0009607 226 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
purine nucleoside triphosphate metabolic process GO:0009144 141 0.024
amine metabolic process GO:0009308 38 0.024
cell projection organization GO:0030030 302 0.024
purine containing compound metabolic process GO:0072521 253 0.024
monovalent inorganic cation transport GO:0015672 172 0.024
regulation of neuron differentiation GO:0045664 208 0.024
purine ribonucleotide catabolic process GO:0009154 136 0.024
cellular protein localization GO:0034613 122 0.023
regulation of protein modification process GO:0031399 194 0.023
positive regulation of biosynthetic process GO:0009891 319 0.023
negative regulation of rna metabolic process GO:0051253 123 0.023
positive regulation of apoptotic process GO:0043065 154 0.023
regulation of signal transduction GO:0009966 318 0.023
Mouse
cellular homeostasis GO:0019725 252 0.023
Human Mouse
single organism intracellular transport GO:1902582 166 0.023
Mouse
negative regulation of molecular function GO:0044092 133 0.023
ribose phosphate metabolic process GO:0019693 235 0.022
purine nucleotide metabolic process GO:0006163 229 0.022
nucleoside metabolic process GO:0009116 179 0.022
anatomical structure morphogenesis GO:0009653 298 0.022
glycosyl compound metabolic process GO:1901657 182 0.022
cellular cation homeostasis GO:0030003 180 0.022
Mouse
regulation of response to stress GO:0080134 126 0.021
negative regulation of biosynthetic process GO:0009890 168 0.021
regulation of neurogenesis GO:0050767 247 0.021
regulation of secretion GO:0051046 224 0.021
negative regulation of phosphorus metabolic process GO:0010563 80 0.021
nitrogen compound transport GO:0071705 229 0.021
regulation of multicellular organismal development GO:2000026 376 0.021
Human Mouse
positive regulation of transcription dna templated GO:0045893 197 0.021
ion homeostasis GO:0050801 212 0.021
Mouse
organonitrogen compound biosynthetic process GO:1901566 167 0.021
response to estrogen GO:0043627 232 0.021
head development GO:0060322 247 0.021
regulation of system process GO:0044057 208 0.021
regulation of neuron death GO:1901214 115 0.020
Mouse
negative regulation of protein metabolic process GO:0051248 114 0.020
macromolecular complex subunit organization GO:0043933 339 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
behavior GO:0007610 205 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
response to wounding GO:0009611 254 0.020
proteolysis GO:0006508 175 0.020
Human
negative regulation of rna biosynthetic process GO:1902679 118 0.020
regulation of cellular ketone metabolic process GO:0010565 27 0.020
axis specification GO:0009798 4 0.019
Mouse
multicellular organism reproduction GO:0032504 233 0.019
positive regulation of transport GO:0051050 245 0.019
cell type specific apoptotic process GO:0097285 134 0.019
Mouse
tissue development GO:0009888 252 0.019
Mouse
cytoplasmic transport GO:0016482 115 0.019
Mouse
cellular response to endogenous stimulus GO:0071495 377 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
regulation of programmed cell death GO:0043067 341 0.019
multi organism reproductive process GO:0044703 262 0.019
heterocycle catabolic process GO:0046700 167 0.019
positive regulation of nervous system development GO:0051962 178 0.019
cellular response to growth factor stimulus GO:0071363 162 0.019
chemical homeostasis GO:0048878 292 0.018
Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.018
response to growth factor GO:0070848 189 0.018
response to molecule of bacterial origin GO:0002237 194 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
organophosphate catabolic process GO:0046434 148 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
Mouse
cellular response to organic cyclic compound GO:0071407 202 0.018
regulation of cell projection organization GO:0031344 175 0.018
regeneration GO:0031099 163 0.018
single organism cellular localization GO:1902580 102 0.018
regulation of immune system process GO:0002682 123 0.018
response to lipopolysaccharide GO:0032496 191 0.018
regulation of membrane potential GO:0042391 110 0.018
regulation of metal ion transport GO:0010959 118 0.018
reproductive process GO:0022414 372 0.017
positive regulation of protein modification process GO:0031401 142 0.017
cell cell signaling GO:0007267 335 0.017
establishment of protein localization GO:0045184 141 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
response to peptide GO:1901652 292 0.017
response to hydrogen peroxide GO:0042542 89 0.017
inorganic cation transmembrane transport GO:0098662 202 0.017
heart morphogenesis GO:0003007 3 0.017
small gtpase mediated signal transduction GO:0007264 36 0.017
neurological system process GO:0050877 219 0.017
reactive oxygen species metabolic process GO:0072593 37 0.017
regulation of neuron projection development GO:0010975 161 0.017
mapk cascade GO:0000165 140 0.017
cellular ketone metabolic process GO:0042180 51 0.017
aging GO:0007568 241 0.017
regulation of secretion by cell GO:1903530 208 0.017
signal transduction by phosphorylation GO:0023014 144 0.017
positive regulation of neurogenesis GO:0050769 165 0.017
nucleoside phosphate catabolic process GO:1901292 140 0.017
positive regulation of cellular component organization GO:0051130 200 0.016
regulation of cellular catabolic process GO:0031329 101 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
response to metal ion GO:0010038 253 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.016
amide transport GO:0042886 105 0.016
purine ribonucleoside metabolic process GO:0046128 168 0.016
response to cytokine GO:0034097 215 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
response to acid chemical GO:0001101 222 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
cellular response to oxidative stress GO:0034599 76 0.016
ras protein signal transduction GO:0007265 29 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
regulation of protein phosphorylation GO:0001932 183 0.016
response to bacterium GO:0009617 200 0.016
response to estradiol GO:0032355 164 0.016
positive regulation of rna metabolic process GO:0051254 203 0.016
positive regulation of cell development GO:0010720 176 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
localization of cell GO:0051674 202 0.016
reproduction GO:0000003 245 0.015
locomotion GO:0040011 237 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
cation transmembrane transport GO:0098655 263 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
Mouse
dna metabolic process GO:0006259 96 0.015
cellular component morphogenesis GO:0032989 155 0.015
positive regulation of cell death GO:0010942 184 0.015
negative regulation of phosphate metabolic process GO:0045936 80 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
cell morphogenesis GO:0000902 142 0.015
regulation of catabolic process GO:0009894 113 0.015
organic anion transport GO:0015711 132 0.015
positive regulation of developmental process GO:0051094 283 0.015
protein transport GO:0015031 132 0.015
purine nucleotide biosynthetic process GO:0006164 83 0.015
cellular macromolecule localization GO:0070727 122 0.015
maintenance of location GO:0051235 17 0.015
Mouse
cellular component assembly GO:0022607 360 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
cell projection morphogenesis GO:0048858 123 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
purine ribonucleoside catabolic process GO:0046130 124 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
cation homeostasis GO:0055080 195 0.015
Mouse
potassium ion transport GO:0006813 97 0.015
negative regulation of neuron death GO:1901215 69 0.015
regulation of transferase activity GO:0051338 123 0.015
cell migration GO:0016477 197 0.014
blood circulation GO:0008015 183 0.014
response to ketone GO:1901654 182 0.014
purine nucleoside triphosphate catabolic process GO:0009146 122 0.014
nucleotide catabolic process GO:0009166 139 0.014
immune response GO:0006955 104 0.014
regulation of mapk cascade GO:0043408 116 0.014
ion transmembrane transport GO:0034220 365 0.014
single organism organelle organization GO:1902589 180 0.014
axon development GO:0061564 96 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
organic acid transport GO:0015849 116 0.014
carboxylic acid transport GO:0046942 115 0.013
cellular lipid metabolic process GO:0044255 208 0.013
generation of precursor metabolites and energy GO:0006091 62 0.013
negative regulation of ion transport GO:0043271 51 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
gastrulation GO:0007369 2 0.013
regulation of homeostatic process GO:0032844 101 0.013
Mouse
protein complex subunit organization GO:0071822 302 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
regulation of kinase activity GO:0043549 117 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
single organism reproductive process GO:0044702 297 0.013
purine containing compound catabolic process GO:0072523 138 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
negative regulation of signal transduction GO:0009968 83 0.013
Mouse
regulation of anatomical structure size GO:0090066 135 0.013
cell part morphogenesis GO:0032990 123 0.013
cellular calcium ion homeostasis GO:0006874 160 0.012
Mouse
immune system process GO:0002376 204 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
response to reactive oxygen species GO:0000302 120 0.012
response to radiation GO:0009314 137 0.012
aromatic compound catabolic process GO:0019439 168 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.012
anion transport GO:0006820 178 0.012
regulation of hormone levels GO:0010817 187 0.012
renal system development GO:0072001 67 0.012
positive regulation of protein phosphorylation GO:0001934 135 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of immune system process GO:0002684 90 0.012
cell cycle GO:0007049 101 0.012
metal ion transport GO:0030001 289 0.012
Mouse
membrane organization GO:0061024 94 0.012
regulation of cell growth GO:0001558 85 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
calcium ion transport GO:0006816 131 0.012
Mouse
purine nucleotide catabolic process GO:0006195 136 0.012
regulation of protein processing GO:0070613 50 0.012
response to nutrient GO:0007584 248 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
negative regulation of signaling GO:0023057 157 0.011
Mouse
multicellular organism growth GO:0035264 1 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
peptide transport GO:0015833 97 0.011
nucleoside phosphate biosynthetic process GO:1901293 102 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
nucleoside catabolic process GO:0009164 126 0.011
cellular response to lipid GO:0071396 201 0.011
regulation of proteasomal protein catabolic process GO:0061136 4 0.011
microtubule organizing center organization GO:0031023 1 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
regulation of protein maturation GO:1903317 50 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
response to toxic substance GO:0009636 133 0.011
regulation of protein kinase activity GO:0045859 105 0.011
kidney development GO:0001822 67 0.011
purine containing compound biosynthetic process GO:0072522 85 0.011
cellular response to biotic stimulus GO:0071216 59 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
positive regulation of gene expression GO:0010628 244 0.011
vesicle mediated transport GO:0016192 181 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
positive regulation of signaling GO:0023056 270 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
cold acclimation GO:0009631 1 0.011
positive regulation of response to external stimulus GO:0032103 51 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
growth GO:0040007 165 0.011
positive regulation of catabolic process GO:0009896 78 0.011
defense response to gram negative bacterium GO:0050829 3 0.010
nucleotide biosynthetic process GO:0009165 98 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.010
protein complex assembly GO:0006461 263 0.010
myosin filament assembly GO:0031034 1 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
purine nucleoside monophosphate metabolic process GO:0009126 84 0.010
response to carbohydrate GO:0009743 183 0.010
amino acid transport GO:0006865 70 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
Mouse
regulation of cellular response to stress GO:0080135 49 0.010
synaptic transmission GO:0007268 235 0.010
protein localization to membrane GO:0072657 36 0.010
embryonic pattern specification GO:0009880 1 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
nucleoside triphosphate metabolic process GO:0009141 144 0.010
regulation of blood circulation GO:1903522 110 0.010
response to ethanol GO:0045471 162 0.010
regulation of defense response GO:0031347 68 0.010
cell motility GO:0048870 202 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.010
cellular response to external stimulus GO:0071496 118 0.010
positive regulation of cellular catabolic process GO:0031331 71 0.010

Ddit3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.017
disease of anatomical entity DOID:7 0 0.017
disease of metabolism DOID:0014667 0 0.010
musculoskeletal system disease DOID:17 0 0.010