Rattus norvegicus

19 known processes

Alx1

ALX homeobox 1

(Aliases: Cart1,CART1X)

Alx1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of nucleic acid templated transcription GO:1903507 117 0.240
Human
negative regulation of rna metabolic process GO:0051253 123 0.213
Human
negative regulation of biosynthetic process GO:0009890 168 0.212
Human
regulation of multicellular organismal development GO:2000026 376 0.181
negative regulation of macromolecule metabolic process GO:0010605 260 0.174
Human
cation transport GO:0006812 382 0.157
negative regulation of metabolic process GO:0009892 331 0.155
Human
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.154
Human
positive regulation of multicellular organismal process GO:0051240 387 0.154
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.144
Human
negative regulation of cellular metabolic process GO:0031324 281 0.129
Human
negative regulation of transcription dna templated GO:0045892 116 0.126
Human
anterior posterior pattern specification GO:0009952 1 0.114
Mouse
negative regulation of cellular biosynthetic process GO:0031327 161 0.112
Human
nitrogen compound transport GO:0071705 229 0.109
cell projection organization GO:0030030 302 0.108
circulatory system development GO:0072359 134 0.105
regulation of transcription dna templated GO:0006355 374 0.101
negative regulation of gene expression GO:0010629 199 0.096
Human
negative regulation of rna biosynthetic process GO:1902679 118 0.094
Human
rna biosynthetic process GO:0032774 380 0.092
Human Mouse
organic anion transport GO:0015711 132 0.089
cell cell signaling GO:0007267 335 0.088
regulation of molecular function GO:0065009 398 0.087
response to metal ion GO:0010038 253 0.085
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.085
Human
cardiac chamber development GO:0003205 1 0.080
regulation of neurogenesis GO:0050767 247 0.080
gland development GO:0048732 155 0.078
nucleic acid templated transcription GO:0097659 379 0.078
Human Mouse
organelle organization GO:0006996 266 0.076
regulation of rna biosynthetic process GO:2001141 381 0.075
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.074
Human
cation homeostasis GO:0055080 195 0.073
regulation of cell development GO:0060284 263 0.065
enzyme linked receptor protein signaling pathway GO:0007167 116 0.064
cellular amino acid metabolic process GO:0006520 107 0.058
cellular ion homeostasis GO:0006873 184 0.058
cardiac ventricle development GO:0003231 1 0.057
heart morphogenesis GO:0003007 3 0.057
protein complex biogenesis GO:0070271 263 0.056
response to nutrient levels GO:0031667 370 0.056
regulation of cellular component organization GO:0051128 368 0.055
cellular response to endogenous stimulus GO:0071495 377 0.055
anatomical structure morphogenesis GO:0009653 298 0.054
Mouse
muscle tissue development GO:0060537 58 0.053
cellular component biogenesis GO:0044085 368 0.053
rna metabolic process GO:0016070 406 0.053
Human Mouse
chemical homeostasis GO:0048878 292 0.052
intracellular signal transduction GO:0035556 314 0.051
negative regulation of response to stimulus GO:0048585 155 0.050
growth GO:0040007 165 0.050
cell morphogenesis GO:0000902 142 0.049
single organism biosynthetic process GO:0044711 342 0.049
inflammatory response GO:0006954 150 0.049
positive regulation of cell differentiation GO:0045597 217 0.047
positive regulation of gene expression GO:0010628 244 0.047
Human Mouse
muscle structure development GO:0061061 87 0.046
cellular cation homeostasis GO:0030003 180 0.046
regulation of cell differentiation GO:0045595 320 0.045
heart development GO:0007507 72 0.045
central nervous system development GO:0007417 311 0.045
homeostatic process GO:0042592 331 0.045
regulation of ion transport GO:0043269 245 0.045
cellular catabolic process GO:0044248 295 0.044
cardiovascular system development GO:0072358 134 0.044
organic acid transport GO:0015849 116 0.044
reproductive process GO:0022414 372 0.043
Worm
carbohydrate derivative metabolic process GO:1901135 346 0.043
cellular component morphogenesis GO:0032989 155 0.043
macromolecular complex subunit organization GO:0043933 339 0.043
positive regulation of cell development GO:0010720 176 0.041
circulatory system process GO:0003013 183 0.041
cardiac muscle tissue morphogenesis GO:0055008 1 0.041
positive regulation of neurogenesis GO:0050769 165 0.041
cellular response to growth factor stimulus GO:0071363 162 0.040
cellular component assembly GO:0022607 360 0.040
cell morphogenesis involved in differentiation GO:0000904 119 0.040
response to estradiol GO:0032355 164 0.039
response to external biotic stimulus GO:0043207 221 0.039
regulation of cell proliferation GO:0042127 359 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.038
Human Mouse
regulation of rna metabolic process GO:0051252 391 0.036
tissue development GO:0009888 252 0.036
Mouse
regulation of nervous system development GO:0051960 264 0.036
response to lipopolysaccharide GO:0032496 191 0.036
apoptotic process GO:0006915 381 0.035
programmed cell death GO:0012501 392 0.034
regulation of organelle organization GO:0033043 80 0.034
cytoskeleton organization GO:0007010 111 0.034
development of primary sexual characteristics GO:0045137 107 0.034
response to decreased oxygen levels GO:0036293 237 0.033
membrane lipid catabolic process GO:0046466 1 0.033
multi organism reproductive process GO:0044703 262 0.032
Worm
secretion by cell GO:0032940 248 0.032
secretion GO:0046903 307 0.032
vasculature development GO:0001944 70 0.032
transcription from rna polymerase ii promoter GO:0006366 252 0.031
Human Mouse
reproduction GO:0000003 245 0.030
Worm
single organism catabolic process GO:0044712 283 0.030
regulation of nucleic acid templated transcription GO:1903506 380 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
muscle organ morphogenesis GO:0048644 1 0.030
macromolecular complex assembly GO:0065003 273 0.029
positive regulation of cell proliferation GO:0008284 249 0.029
calcium ion homeostasis GO:0055074 162 0.029
positive regulation of programmed cell death GO:0043068 157 0.029
regulation of system process GO:0044057 208 0.028
embryonic skeletal system development GO:0048706 3 0.028
Mouse
regulation of secretion GO:0051046 224 0.028
neuron projection development GO:0031175 273 0.028
neurological system process GO:0050877 219 0.028
positive regulation of protein metabolic process GO:0051247 178 0.028
response to acid chemical GO:0001101 222 0.027
mesonephric epithelium development GO:0072163 14 0.027
response to extracellular stimulus GO:0009991 380 0.027
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.027
positive regulation of response to stimulus GO:0048584 285 0.027
response to hypoxia GO:0001666 231 0.027
head development GO:0060322 247 0.026
axis specification GO:0009798 4 0.026
embryonic skeletal system morphogenesis GO:0048704 3 0.026
Mouse
regulation of muscle system process GO:0090257 79 0.025
response to oxygen levels GO:0070482 265 0.025
organic acid metabolic process GO:0006082 292 0.025
developmental growth GO:0048589 100 0.025
regulation of neuron projection development GO:0010975 161 0.025
regulation of membrane potential GO:0042391 110 0.025
glial cell differentiation GO:0010001 65 0.025
single organism organelle organization GO:1902589 180 0.024
cell adhesion GO:0007155 110 0.024
peptide hormone secretion GO:0030072 84 0.024
positive regulation of signaling GO:0023056 270 0.024
positive regulation of apoptotic process GO:0043065 154 0.024
carboxylic acid transport GO:0046942 115 0.024
endocrine system development GO:0035270 30 0.024
organic substance catabolic process GO:1901575 316 0.024
positive regulation of ion transport GO:0043270 94 0.024
positive regulation of developmental process GO:0051094 283 0.023
regulation of protein metabolic process GO:0051246 289 0.023
positive regulation of protein modification process GO:0031401 142 0.023
cellular lipid metabolic process GO:0044255 208 0.023
response to wounding GO:0009611 254 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
Worm
brain development GO:0007420 247 0.022
nephric duct development GO:0072176 1 0.022
cellular amine metabolic process GO:0044106 38 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
oxoacid metabolic process GO:0043436 290 0.022
sensory perception GO:0007600 101 0.022
neuron differentiation GO:0030182 368 0.022
neuron development GO:0048666 286 0.022
muscle system process GO:0003012 115 0.022
ion homeostasis GO:0050801 212 0.022
cellular chemical homeostasis GO:0055082 247 0.022
locomotion GO:0040011 237 0.022
Worm
cytosolic calcium ion homeostasis GO:0051480 140 0.021
positive regulation of transport GO:0051050 245 0.021
glycosyl compound metabolic process GO:1901657 182 0.021
muscle tissue morphogenesis GO:0060415 1 0.021
cell part morphogenesis GO:0032990 123 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
regulation of cell projection organization GO:0031344 175 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
Human Mouse
monovalent inorganic cation transport GO:0015672 172 0.020
chromosome segregation GO:0007059 2 0.020
carbohydrate derivative biosynthetic process GO:1901137 124 0.020
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.020
cellular homeostasis GO:0019725 252 0.020
positive regulation of nervous system development GO:0051962 178 0.020
urogenital system development GO:0001655 78 0.020
mitotic sister chromatid separation GO:0051306 1 0.020
amine metabolic process GO:0009308 38 0.020
muscle organ development GO:0007517 50 0.020
metal ion transport GO:0030001 289 0.020
regulation of neuron differentiation GO:0045664 208 0.020
axonogenesis GO:0007409 71 0.020
behavior GO:0007610 205 0.020
Worm
ribose phosphate metabolic process GO:0019693 235 0.020
positive regulation of neuron projection development GO:0010976 99 0.020
sulfur compound biosynthetic process GO:0044272 19 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
transmission of nerve impulse GO:0019226 42 0.019
developmental process involved in reproduction GO:0003006 159 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
Human Mouse
response to inorganic substance GO:0010035 377 0.019
cellular response to stress GO:0033554 269 0.019
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
peptide secretion GO:0002790 86 0.019
multicellular organism reproduction GO:0032504 233 0.019
Worm
divalent inorganic cation transport GO:0072511 134 0.019
cellular divalent inorganic cation homeostasis GO:0072503 162 0.019
cardiac muscle tissue development GO:0048738 26 0.019
metal ion homeostasis GO:0055065 186 0.019
protein oligomerization GO:0051259 191 0.019
response to estrogen GO:0043627 232 0.018
sulfur compound metabolic process GO:0006790 70 0.018
nucleoside metabolic process GO:0009116 179 0.018
negative regulation of innate immune response GO:0045824 4 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
negative regulation of cell communication GO:0010648 158 0.018
response to peptide hormone GO:0043434 278 0.018
protein phosphorylation GO:0006468 345 0.018
mesonephros development GO:0001823 14 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
Mouse
response to amino acid GO:0043200 75 0.017
tube development GO:0035295 89 0.017
Mouse
regulation of protein phosphorylation GO:0001932 183 0.017
embryonic pattern specification GO:0009880 1 0.017
regulation of growth GO:0040008 105 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
muscle cell differentiation GO:0042692 52 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.017
Human
chemosensory behavior GO:0007635 2 0.017
cellular ketone metabolic process GO:0042180 51 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
purine ribonucleotide biosynthetic process GO:0009152 81 0.017
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 1 0.017
organophosphate metabolic process GO:0019637 370 0.017
lipid metabolic process GO:0006629 283 0.017
nucleoside monophosphate metabolic process GO:0009123 93 0.016
regulation of catalytic activity GO:0050790 304 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
Human Mouse
ureteric bud development GO:0001657 14 0.016
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.016
regulation of transporter activity GO:0032409 50 0.016
gamete generation GO:0007276 124 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
neural crest cell development GO:0014032 2 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
transcription dna templated GO:0006351 377 0.016
Human Mouse
inorganic ion transmembrane transport GO:0098660 229 0.016
wound healing GO:0042060 122 0.016
respiratory system development GO:0060541 45 0.016
response to herbicide GO:0009635 16 0.016
positive regulation of secretion GO:0051047 140 0.015
regulation of chromosome segregation GO:0051983 1 0.015
sister chromatid segregation GO:0000819 1 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
parturition GO:0007567 10 0.015
hormone secretion GO:0046879 115 0.015
ion transmembrane transport GO:0034220 365 0.015
cell migration GO:0016477 197 0.015
Worm
regulation of homeostatic process GO:0032844 101 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.015
aromatic compound catabolic process GO:0019439 168 0.015
cellular response to hormone stimulus GO:0032870 247 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
protein complex subunit organization GO:0071822 302 0.015
actin filament based process GO:0030029 86 0.014
regulation of signal transduction GO:0009966 318 0.014
glomerulus development GO:0032835 10 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
Human Mouse
purine containing compound metabolic process GO:0072521 253 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
proteolysis GO:0006508 175 0.014
motor neuron axon guidance GO:0008045 1 0.014
protein complex assembly GO:0006461 263 0.014
carboxylic acid metabolic process GO:0019752 289 0.014
immune system development GO:0002520 41 0.014
dendrite development GO:0016358 72 0.014
embryonic axis specification GO:0000578 1 0.013
olfactory behavior GO:0042048 2 0.013
ossification GO:0001503 70 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
cell motility GO:0048870 202 0.013
Worm
s shaped body morphogenesis GO:0072050 2 0.013
neuromuscular synaptic transmission GO:0007274 2 0.013
positive regulation of cell death GO:0010942 184 0.013
epithelial cell proliferation GO:0050673 54 0.013
response to ketone GO:1901654 182 0.013
oxidation reduction process GO:0055114 304 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
cytoplasmic transport GO:0016482 115 0.013
response to bacterium GO:0009617 200 0.013
organ growth GO:0035265 24 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
macromolecule localization GO:0033036 252 0.013
response to growth factor GO:0070848 189 0.012
response to acetate GO:0010034 3 0.012
anion transport GO:0006820 178 0.012
lipid transport GO:0006869 61 0.012
negative regulation of molecular function GO:0044092 133 0.012
defense response GO:0006952 194 0.012
bmp signaling pathway GO:0030509 4 0.012
response to glucose GO:0009749 136 0.012
embryonic limb morphogenesis GO:0030326 4 0.012
Mouse
sensory organ development GO:0007423 74 0.012
regulation of transmembrane transporter activity GO:0022898 49 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
negative regulation of cell development GO:0010721 82 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
cell proliferation involved in metanephros development GO:0072203 2 0.012
embryonic cranial skeleton morphogenesis GO:0048701 2 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
neural crest cell migration GO:0001755 1 0.012
response to lithium ion GO:0010226 28 0.012
positive regulation of molecular function GO:0044093 230 0.012
regulation of cytokine production GO:0001817 56 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
Human Mouse
neuron projection morphogenesis GO:0048812 122 0.012
positive regulation of transmembrane transport GO:0034764 25 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.012
regulation of exit from mitosis GO:0007096 1 0.012
catabolic process GO:0009056 351 0.012
tongue morphogenesis GO:0043587 3 0.012
response to glucocorticoid GO:0051384 223 0.012
regulation of mitotic sister chromatid separation GO:0010965 1 0.011
neural crest cell differentiation GO:0014033 2 0.011
grooming behavior GO:0007625 4 0.011
cellular response to acid chemical GO:0071229 75 0.011
regulation of stem cell differentiation GO:2000736 2 0.011
glycosyl compound catabolic process GO:1901658 126 0.011
camera type eye morphogenesis GO:0048593 2 0.011
neuronal action potential GO:0019228 35 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of fatty acid beta oxidation GO:0032000 4 0.011
locomotor rhythm GO:0045475 1 0.011
jak stat cascade GO:0007259 26 0.011
metaphase anaphase transition of cell cycle GO:0044784 1 0.011
regulation of metanephros development GO:0072215 4 0.011
nucleotide metabolic process GO:0009117 279 0.011
organ regeneration GO:0031100 101 0.011
positive regulation of peptide hormone secretion GO:0090277 50 0.011
metanephric part of ureteric bud development GO:0035502 1 0.011
response to nutrient GO:0007584 248 0.011
regulation of cell motility GO:2000145 131 0.011
Worm
cytokine production GO:0001816 61 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
epithelium development GO:0060429 96 0.011
Mouse
limbic system development GO:0021761 38 0.011
heart contraction GO:0060047 57 0.011
ras protein signal transduction GO:0007265 29 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
eye morphogenesis GO:0048592 4 0.011
response to alkaloid GO:0043279 132 0.011
cellular response to organic cyclic compound GO:0071407 202 0.011
mesonephric tubule development GO:0072164 14 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
small gtpase mediated signal transduction GO:0007264 36 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
Human Mouse
actin cytoskeleton organization GO:0030036 73 0.010
cardiocyte differentiation GO:0035051 22 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
regulation of catabolic process GO:0009894 113 0.010
cell type specific apoptotic process GO:0097285 134 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
nucleoside catabolic process GO:0009164 126 0.010
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
negative regulation of viral process GO:0048525 4 0.010
regulation of cytoskeleton organization GO:0051493 49 0.010
lipid localization GO:0010876 62 0.010
hepaticobiliary system development GO:0061008 90 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
kidney development GO:0001822 67 0.010
multi multicellular organism process GO:0044706 138 0.010
Worm
purine nucleoside catabolic process GO:0006152 124 0.010
response to cytokine GO:0034097 215 0.010
regulation of immune system process GO:0002682 123 0.010
cation transmembrane transport GO:0098655 263 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
cell cycle GO:0007049 101 0.010
response to peptide GO:1901652 292 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
ovulation cycle process GO:0022602 50 0.010
glomerular mesangial cell proliferation GO:0072110 4 0.010
negative regulation of cell differentiation GO:0045596 99 0.010

Alx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.052
disease of anatomical entity DOID:7 0 0.052
connective tissue disease DOID:65 0 0.025
bone disease DOID:0080001 0 0.025
nervous system disease DOID:863 0 0.023
bone development disease DOID:0080006 0 0.014
muscular disease DOID:0080000 0 0.010
myopathy DOID:423 0 0.010
muscle tissue disease DOID:66 0 0.010