Rattus norvegicus

27 known processes

Slc6a5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5

(Aliases: GLYT2)

Slc6a5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid transport GO:0046942 115 0.231
reproductive structure development GO:0048608 128 0.217
cation transport GO:0006812 382 0.216
regulation of cell proliferation GO:0042127 359 0.185
Rat
regulation of ion transport GO:0043269 245 0.165
Rat
tissue development GO:0009888 252 0.158
regulation of secretion GO:0051046 224 0.154
Rat
reproductive process GO:0022414 372 0.145
Rat
cation transmembrane transport GO:0098655 263 0.145
cell cell signaling GO:0007267 335 0.143
Human Rat
transmembrane transport GO:0055085 412 0.136
single organism reproductive process GO:0044702 297 0.130
Rat
reproductive system development GO:0061458 128 0.118
organic anion transport GO:0015711 132 0.116
response to inorganic substance GO:0010035 377 0.115
Rat
reproduction GO:0000003 245 0.113
Rat
anion transport GO:0006820 178 0.109
intracellular signal transduction GO:0035556 314 0.106
ion transmembrane transport GO:0034220 365 0.103
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.095
response to carbohydrate GO:0009743 183 0.092
Rat
response to estrogen GO:0043627 232 0.092
Rat
female pregnancy GO:0007565 122 0.085
response to metal ion GO:0010038 253 0.083
Rat
response to peptide hormone GO:0043434 278 0.083
inorganic ion transmembrane transport GO:0098660 229 0.083
Human Rat
cellular chemical homeostasis GO:0055082 247 0.082
Rat
locomotion GO:0040011 237 0.080
cellular response to hormone stimulus GO:0032870 247 0.078
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.077
negative regulation of cellular biosynthetic process GO:0031327 161 0.076
response to extracellular stimulus GO:0009991 380 0.076
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.076
sensory perception GO:0007600 101 0.075
multicellular organismal reproductive process GO:0048609 233 0.074
Rat
organic acid transport GO:0015849 116 0.073
organonitrogen compound biosynthetic process GO:1901566 167 0.072
brain development GO:0007420 247 0.071
Rat
regulation of programmed cell death GO:0043067 341 0.071
apoptotic process GO:0006915 381 0.070
monovalent inorganic cation transport GO:0015672 172 0.070
Human Rat
regulation of hormone levels GO:0010817 187 0.070
negative regulation of biosynthetic process GO:0009890 168 0.069
response to hydrogen peroxide GO:0042542 89 0.067
limb morphogenesis GO:0035108 4 0.066
developmental process involved in reproduction GO:0003006 159 0.063
inorganic cation transmembrane transport GO:0098662 202 0.062
Human Rat
skeletal system development GO:0001501 41 0.059
programmed cell death GO:0012501 392 0.058
ovulation cycle GO:0042698 67 0.058
positive regulation of cellular biosynthetic process GO:0031328 295 0.057
regulation of membrane potential GO:0042391 110 0.057
neurological system process GO:0050877 219 0.057
Rat
positive regulation of developmental process GO:0051094 283 0.055
homeostatic process GO:0042592 331 0.055
Rat
response to nutrient levels GO:0031667 370 0.055
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.055
regulation of blood circulation GO:1903522 110 0.055
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.054
response to monosaccharide GO:0034284 159 0.054
cellular homeostasis GO:0019725 252 0.054
Rat
cellular response to endogenous stimulus GO:0071495 377 0.053
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.052
Rat
response to external biotic stimulus GO:0043207 221 0.051
negative regulation of cell proliferation GO:0008285 119 0.051
Rat
response to glucocorticoid GO:0051384 223 0.050
multi organism reproductive process GO:0044703 262 0.049
Rat
response to estradiol GO:0032355 164 0.048
Rat
cell projection organization GO:0030030 302 0.046
anatomical structure morphogenesis GO:0009653 298 0.045
neuron development GO:0048666 286 0.045
regulation of apoptotic process GO:0042981 335 0.045
regulation of phosphorus metabolic process GO:0051174 349 0.045
cellular response to stress GO:0033554 269 0.044
Rat
negative regulation of cellular metabolic process GO:0031324 281 0.044
response to peptide GO:1901652 292 0.043
lipid metabolic process GO:0006629 283 0.043
negative regulation of signaling GO:0023057 157 0.043
Rat
single organism biosynthetic process GO:0044711 342 0.043
response to acid chemical GO:0001101 222 0.042
Rat
cardiovascular system development GO:0072358 134 0.042
regulation of phosphate metabolic process GO:0019220 349 0.040
positive regulation of biosynthetic process GO:0009891 319 0.040
response to starvation GO:0042594 59 0.039
chemical homeostasis GO:0048878 292 0.039
Rat
response to corticosteroid GO:0031960 235 0.039
cyclic nucleotide biosynthetic process GO:0009190 63 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.039
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.039
cellular metal ion homeostasis GO:0006875 172 0.038
regulation of phosphorylation GO:0042325 248 0.038
nitrogen compound transport GO:0071705 229 0.038
response to decreased oxygen levels GO:0036293 237 0.038
Rat
neuron projection development GO:0031175 273 0.038
positive regulation of signaling GO:0023056 270 0.038
sexual reproduction GO:0019953 148 0.037
Rat
gonad development GO:0008406 104 0.037
regulation of mapk cascade GO:0043408 116 0.037
cellular response to organic cyclic compound GO:0071407 202 0.037
Rat
bone development GO:0060348 25 0.037
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.037
multicellular organism reproduction GO:0032504 233 0.037
Rat
behavior GO:0007610 205 0.036
Rat
positive regulation of phosphate metabolic process GO:0045937 262 0.036
cgmp biosynthetic process GO:0006182 15 0.036
cellular response to lipid GO:0071396 201 0.035
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.035
regulation of rna metabolic process GO:0051252 391 0.035
cellular divalent inorganic cation homeostasis GO:0072503 162 0.035
response to growth factor GO:0070848 189 0.034
positive regulation of synaptic plasticity GO:0031915 3 0.034
ribose phosphate biosynthetic process GO:0046390 87 0.034
divalent inorganic cation homeostasis GO:0072507 165 0.034
response to nutrient GO:0007584 248 0.034
Rat
purine containing compound biosynthetic process GO:0072522 85 0.033
metal ion transport GO:0030001 289 0.033
Human Rat
organophosphate biosynthetic process GO:0090407 143 0.033
cellular ion homeostasis GO:0006873 184 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.032
calcium ion homeostasis GO:0055074 162 0.032
purine ribonucleotide metabolic process GO:0009150 227 0.032
regulation of system process GO:0044057 208 0.032
development of primary female sexual characteristics GO:0046545 56 0.031
development of primary sexual characteristics GO:0045137 107 0.031
cyclic nucleotide metabolic process GO:0009187 80 0.031
positive regulation of nucleic acid templated transcription GO:1903508 197 0.031
response to hexose GO:0009746 144 0.031
sensory organ development GO:0007423 74 0.031
negative regulation of metabolic process GO:0009892 331 0.031
regulation of rna biosynthetic process GO:2001141 381 0.030
cell communication involved in cardiac conduction GO:0086065 2 0.030
response to biotic stimulus GO:0009607 226 0.030
positive regulation of cell communication GO:0010647 271 0.030
positive regulation of transcription dna templated GO:0045893 197 0.029
regeneration GO:0031099 163 0.029
appendage morphogenesis GO:0035107 4 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
Rat
positive regulation of rna biosynthetic process GO:1902680 197 0.028
regulation of nucleotide biosynthetic process GO:0030808 47 0.028
lipid transport GO:0006869 61 0.028
sex differentiation GO:0007548 113 0.028
action potential GO:0001508 54 0.027
potassium ion transport GO:0006813 97 0.027
single organism behavior GO:0044708 130 0.027
Rat
heart morphogenesis GO:0003007 3 0.027
monocarboxylic acid transport GO:0015718 52 0.027
Rat
cellular component movement GO:0006928 248 0.027
positive regulation of programmed cell death GO:0043068 157 0.027
negative regulation of nucleic acid templated transcription GO:1903507 117 0.027
transcription dna templated GO:0006351 377 0.027
regulation of catalytic activity GO:0050790 304 0.026
nucleotide biosynthetic process GO:0009165 98 0.026
regulation of protein metabolic process GO:0051246 289 0.026
regulation of cellular localization GO:0060341 263 0.026
catecholamine metabolic process GO:0006584 19 0.025
regulation of erk1 and erk2 cascade GO:0070372 41 0.025
response to glucose GO:0009749 136 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
response to oxidative stress GO:0006979 186 0.025
organophosphate metabolic process GO:0019637 370 0.025
fear response GO:0042596 9 0.024
vesicle mediated transport GO:0016192 181 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
negative regulation of programmed cell death GO:0043069 183 0.024
regulation of signal transduction GO:0009966 318 0.024
response to retinoic acid GO:0032526 63 0.024
Rat
regulation of secretion by cell GO:1903530 208 0.024
purine ribonucleotide biosynthetic process GO:0009152 81 0.024
negative regulation of apoptotic process GO:0043066 181 0.024
response to cytokine GO:0034097 215 0.023
response to light stimulus GO:0009416 52 0.023
ensheathment of neurons GO:0007272 40 0.023
cellular response to growth factor stimulus GO:0071363 162 0.023
response to radiation GO:0009314 137 0.023
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.023
head development GO:0060322 247 0.023
Rat
epithelium development GO:0060429 96 0.022
protein oligomerization GO:0051259 191 0.022
Rat
regulation of camp biosynthetic process GO:0030817 38 0.022
steroid metabolic process GO:0008202 73 0.022
adult locomotory behavior GO:0008344 4 0.022
regulation of dna metabolic process GO:0051052 60 0.022
carbohydrate derivative biosynthetic process GO:1901137 124 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
embryonic appendage morphogenesis GO:0035113 4 0.022
neuron differentiation GO:0030182 368 0.022
Rat
positive regulation of catalytic activity GO:0043085 184 0.021
cellular component assembly GO:0022607 360 0.021
Rat
negative regulation of rna biosynthetic process GO:1902679 118 0.021
monocarboxylic acid metabolic process GO:0032787 152 0.021
nucleotide metabolic process GO:0009117 279 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
single organism organelle organization GO:1902589 180 0.021
neuropeptide signaling pathway GO:0007218 29 0.021
calcium ion transmembrane transport GO:0070588 70 0.021
regulation of locomotion GO:0040012 148 0.020
positive regulation of molecular function GO:0044093 230 0.020
negative regulation of rna metabolic process GO:0051253 123 0.020
epithelial cell proliferation GO:0050673 54 0.020
male sex differentiation GO:0046661 64 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
regulation of organelle organization GO:0033043 80 0.020
embryonic limb morphogenesis GO:0030326 4 0.020
regulation of transmembrane transport GO:0034762 122 0.019
negative regulation of cell death GO:0060548 229 0.019
cellular cation homeostasis GO:0030003 180 0.019
dna metabolic process GO:0006259 96 0.019
negative regulation of transcription dna templated GO:0045892 116 0.019
cellular lipid metabolic process GO:0044255 208 0.019
catabolic process GO:0009056 351 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
proteolysis GO:0006508 175 0.019
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
cellular component morphogenesis GO:0032989 155 0.018
positive regulation of kinase activity GO:0033674 77 0.018
g protein coupled receptor internalization GO:0002031 3 0.018
regulation of nervous system development GO:0051960 264 0.018
Rat
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.018
regulation of smooth muscle cell proliferation GO:0048660 75 0.018
kidney development GO:0001822 67 0.018
receptor metabolic process GO:0043112 18 0.018
lipid localization GO:0010876 62 0.018
maintenance of location GO:0051235 17 0.018
male gonad development GO:0008584 59 0.018
secretion GO:0046903 307 0.018
Rat
rna metabolic process GO:0016070 406 0.018
regulation of nucleic acid templated transcription GO:1903506 380 0.017
ion homeostasis GO:0050801 212 0.017
regulation of blood pressure GO:0008217 83 0.017
regulation of intracellular signal transduction GO:1902531 218 0.017
multicellular organismal response to stress GO:0033555 25 0.017
female sex differentiation GO:0046660 59 0.017
metal ion homeostasis GO:0055065 186 0.017
signal release GO:0023061 145 0.017
cellular response to extracellular stimulus GO:0031668 73 0.017
neuronal action potential GO:0019228 35 0.017
spermatogenesis GO:0007283 99 0.017
response to oxygen levels GO:0070482 265 0.017
Rat
positive regulation of hepatocyte differentiation GO:0070368 2 0.017
cellular calcium ion homeostasis GO:0006874 160 0.017
muscle system process GO:0003012 115 0.017
connective tissue development GO:0061448 33 0.016
response to wounding GO:0009611 254 0.016
response to ethanol GO:0045471 162 0.016
Rat
eye development GO:0001654 50 0.016
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.016
response to calcium ion GO:0051592 59 0.016
Rat
small molecule biosynthetic process GO:0044283 124 0.016
response to purine containing compound GO:0014074 126 0.016
Rat
positive regulation of cell death GO:0010942 184 0.016
cyclic purine nucleotide metabolic process GO:0052652 62 0.016
response to reactive oxygen species GO:0000302 120 0.016
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.016
female gonad development GO:0008585 53 0.016
response to fluid shear stress GO:0034405 16 0.016
negative regulation of signal transduction GO:0009968 83 0.016
negative regulation of cell communication GO:0010648 158 0.016
Rat
purine containing compound metabolic process GO:0072521 253 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.015
positive regulation of mapk cascade GO:0043410 92 0.015
regulation of cellular component organization GO:0051128 368 0.015
cellular response to nutrient levels GO:0031669 60 0.015
response to hypoxia GO:0001666 231 0.015
Rat
negative regulation of transport GO:0051051 136 0.015
cellular catabolic process GO:0044248 295 0.015
myelination GO:0042552 39 0.015
response to testosterone GO:0033574 55 0.015
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 2 0.015
positive regulation of hormone secretion GO:0046887 65 0.015
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.015
cytosolic calcium ion homeostasis GO:0051480 140 0.015
aging GO:0007568 241 0.014
Rat
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.014
regulation of cell migration GO:0030334 128 0.014
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.014
ossification GO:0001503 70 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
rhythmic process GO:0048511 156 0.014
Rat
purine nucleotide biosynthetic process GO:0006164 83 0.014
positive regulation of peptide hormone secretion GO:0090277 50 0.014
regulation of hormone secretion GO:0046883 106 0.014
positive regulation of multicellular organismal process GO:0051240 387 0.014
positive regulation of signal transduction GO:0009967 175 0.014
macromolecular complex assembly GO:0065003 273 0.014
Rat
cellular response to corticosteroid stimulus GO:0071384 69 0.014
heart contraction GO:0060047 57 0.014
mapk cascade GO:0000165 140 0.014
camp metabolic process GO:0046058 63 0.014
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
one carbon compound transport GO:0019755 5 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
protein complex biogenesis GO:0070271 263 0.013
Rat
small gtpase mediated signal transduction GO:0007264 36 0.013
reactive oxygen species metabolic process GO:0072593 37 0.013
calcium ion transport GO:0006816 131 0.013
gamete generation GO:0007276 124 0.013
striated muscle contraction GO:0006941 44 0.013
positive regulation of gene expression GO:0010628 244 0.013
regulation of multicellular organismal development GO:2000026 376 0.013
Rat
axon ensheathment GO:0008366 40 0.013
alcohol metabolic process GO:0006066 77 0.013
regulation of epithelial cell proliferation GO:0050678 49 0.013
protein complex subunit organization GO:0071822 302 0.013
Rat
response to insulin GO:0032868 133 0.013
positive regulation of action potential GO:0045760 8 0.013
cellular response to vitamin e GO:0071306 3 0.012
alternative mrna splicing via spliceosome GO:0000380 4 0.012
hormone transport GO:0009914 121 0.012
intestinal absorption GO:0050892 3 0.012
cardiac muscle cell contraction GO:0086003 10 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
response to ketone GO:1901654 182 0.012
muscle cell proliferation GO:0033002 84 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
secretion by cell GO:0032940 248 0.012
response to ammonium ion GO:0060359 71 0.012
Rat
mesoderm development GO:0007498 2 0.012
potassium ion transmembrane transport GO:0071805 71 0.012
cation homeostasis GO:0055080 195 0.012
negative regulation of cell cycle phase transition GO:1901988 4 0.012
hormone secretion GO:0046879 115 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
response to vitamin GO:0033273 131 0.012
lipid biosynthetic process GO:0008610 128 0.012
positive regulation of peptide secretion GO:0002793 52 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
Rat
receptor internalization GO:0031623 14 0.012
cellular amine metabolic process GO:0044106 38 0.012
receptor mediated endocytosis GO:0006898 42 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
development of primary male sexual characteristics GO:0046546 59 0.011
heart process GO:0003015 57 0.011
regulation of transcription dna templated GO:0006355 374 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
glucose homeostasis GO:0042593 75 0.011
cell morphogenesis GO:0000902 142 0.011
cellular response to oxygen levels GO:0071453 60 0.011
brown fat cell proliferation GO:0070342 2 0.011
central nervous system development GO:0007417 311 0.011
Rat
regulation of nucleotide metabolic process GO:0006140 117 0.011
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.011
sodium ion transmembrane transport GO:0035725 67 0.011
Human Rat
cellular response to starvation GO:0009267 27 0.011
detection of visible light GO:0009584 3 0.011
neuron apoptotic process GO:0051402 88 0.011
organic acid metabolic process GO:0006082 292 0.011
enzyme linked receptor protein signaling pathway GO:0007167 116 0.011
regulation of cell cycle GO:0051726 73 0.011
hindlimb morphogenesis GO:0035137 2 0.011
cellular response to hexose stimulus GO:0071331 65 0.011
amine metabolic process GO:0009308 38 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
sensory perception of pain GO:0019233 73 0.011
divalent inorganic cation transport GO:0072511 134 0.011
nucleic acid templated transcription GO:0097659 379 0.011
transmission of nerve impulse GO:0019226 42 0.011
dendrite morphogenesis GO:0048813 43 0.010
regulation of peptide secretion GO:0002791 82 0.010
synaptic transmission GO:0007268 235 0.010
Human Rat
male gamete generation GO:0048232 99 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
sodium ion transport GO:0006814 82 0.010
Human Rat
regulation of cellular protein metabolic process GO:0032268 267 0.010
response to nicotine GO:0035094 51 0.010
Rat
negative regulation of secretion GO:0051048 82 0.010
circulatory system development GO:0072359 134 0.010

Slc6a5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.025
disease of anatomical entity DOID:7 0 0.025
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024
bone disease DOID:0080001 0 0.011
disease of metabolism DOID:0014667 0 0.011
cardiovascular system disease DOID:1287 0 0.010