Rattus norvegicus

56 known processes

Traf6

Tnf receptor-associated factor 6

Traf6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna metabolic process GO:0016070 406 0.132
Human Zebrafish Mouse
regulation of nucleic acid templated transcription GO:1903506 380 0.090
Human Zebrafish Mouse
nucleic acid templated transcription GO:0097659 379 0.082
Human Zebrafish Mouse
protein phosphorylation GO:0006468 345 0.077
Human
regulation of rna metabolic process GO:0051252 391 0.068
Human Zebrafish Mouse
negative regulation of cell death GO:0060548 229 0.067
catabolic process GO:0009056 351 0.064
transcription dna templated GO:0006351 377 0.064
Human Zebrafish Mouse
regulation of phosphate metabolic process GO:0019220 349 0.062
Human
regulation of rna biosynthetic process GO:2001141 381 0.061
Human Zebrafish Mouse
negative regulation of programmed cell death GO:0043069 183 0.057
regulation of cellular protein metabolic process GO:0032268 267 0.056
Human
positive regulation of gene expression GO:0010628 244 0.052
Human Zebrafish
rna biosynthetic process GO:0032774 380 0.049
Human Zebrafish Mouse
regulation of intracellular signal transduction GO:1902531 218 0.048
Human Mouse
cellular amino acid metabolic process GO:0006520 107 0.048
negative regulation of gene expression GO:0010629 199 0.048
Human
neuron death GO:0070997 127 0.047
regulation of cell proliferation GO:0042127 359 0.047
negative regulation of macromolecule metabolic process GO:0010605 260 0.047
Human
regulation of protein metabolic process GO:0051246 289 0.046
Human Mouse
carboxylic acid metabolic process GO:0019752 289 0.046
regulation of programmed cell death GO:0043067 341 0.045
cell migration GO:0016477 197 0.045
regulation of signal transduction GO:0009966 318 0.045
Human Mouse
metal ion transport GO:0030001 289 0.044
carbohydrate derivative metabolic process GO:1901135 346 0.042
positive regulation of transport GO:0051050 245 0.041
nucleobase containing small molecule metabolic process GO:0055086 316 0.040
cellular catabolic process GO:0044248 295 0.040
macromolecular complex subunit organization GO:0043933 339 0.040
positive regulation of phosphate metabolic process GO:0045937 262 0.039
Human
regulation of phosphorus metabolic process GO:0051174 349 0.039
Human
positive regulation of cellular protein metabolic process GO:0032270 167 0.039
Human
apoptotic process GO:0006915 381 0.038
positive regulation of protein modification process GO:0031401 142 0.038
Human
neuron differentiation GO:0030182 368 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
Human Zebrafish
negative regulation of cellular metabolic process GO:0031324 281 0.037
Human
regulation of transcription dna templated GO:0006355 374 0.036
Human Zebrafish Mouse
positive regulation of phosphorylation GO:0042327 177 0.036
Human
regulation of cellular amine metabolic process GO:0033238 8 0.034
response to extracellular stimulus GO:0009991 380 0.034
programmed cell death GO:0012501 392 0.034
cation transport GO:0006812 382 0.034
cellular amine metabolic process GO:0044106 38 0.033
positive regulation of cell proliferation GO:0008284 249 0.033
peptidyl amino acid modification GO:0018193 126 0.032
amine metabolic process GO:0009308 38 0.032
negative regulation of apoptotic process GO:0043066 181 0.031
secretion GO:0046903 307 0.031
Mouse
organic acid metabolic process GO:0006082 292 0.031
macromolecular complex assembly GO:0065003 273 0.031
organic substance catabolic process GO:1901575 316 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
Human
response to nutrient levels GO:0031667 370 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.030
Human
regulation of cellular ketone metabolic process GO:0010565 27 0.030
cell projection organization GO:0030030 302 0.029
regulation of cellular catabolic process GO:0031329 101 0.029
neuron development GO:0048666 286 0.029
regulation of catabolic process GO:0009894 113 0.029
cellular ketone metabolic process GO:0042180 51 0.029
protein autophosphorylation GO:0046777 66 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.028
intracellular signal transduction GO:0035556 314 0.028
regulation of phosphorylation GO:0042325 248 0.028
Human
positive regulation of protein metabolic process GO:0051247 178 0.027
Human Mouse
aging GO:0007568 241 0.027
cell morphogenesis involved in differentiation GO:0000904 119 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.026
positive regulation of signaling GO:0023056 270 0.026
Human Mouse
central nervous system development GO:0007417 311 0.026
oxoacid metabolic process GO:0043436 290 0.026
regulation of protein modification process GO:0031399 194 0.026
Human
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
response to acid chemical GO:0001101 222 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.025
positive regulation of cell communication GO:0010647 271 0.025
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
Human Zebrafish
positive regulation of cell death GO:0010942 184 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
Human Zebrafish Mouse
cellular response to endogenous stimulus GO:0071495 377 0.025
ribonucleotide metabolic process GO:0009259 231 0.025
negative regulation of metabolic process GO:0009892 331 0.025
Human
response to nutrient GO:0007584 248 0.025
regulation of apoptotic process GO:0042981 335 0.025
single organism catabolic process GO:0044712 283 0.025
cell motility GO:0048870 202 0.025
small gtpase mediated signal transduction GO:0007264 36 0.025
organophosphate metabolic process GO:0019637 370 0.025
reproductive process GO:0022414 372 0.024
locomotion GO:0040011 237 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
Human
positive regulation of developmental process GO:0051094 283 0.024
Human
protein heterooligomerization GO:0051291 89 0.024
positive regulation of phosphorus metabolic process GO:0010562 262 0.024
Human
nucleotide metabolic process GO:0009117 279 0.023
protein transport GO:0015031 132 0.023
Mouse
purine nucleoside metabolic process GO:0042278 169 0.023
cellular response to oxygen containing compound GO:1901701 386 0.023
Human Mouse
organic cyclic compound catabolic process GO:1901361 175 0.023
positive regulation of molecular function GO:0044093 230 0.023
Human Mouse
positive regulation of response to stimulus GO:0048584 285 0.023
Human Mouse
cellular response to stress GO:0033554 269 0.023
regulation of neuron death GO:1901214 115 0.023
ras protein signal transduction GO:0007265 29 0.022
positive regulation of biosynthetic process GO:0009891 319 0.022
Human Zebrafish Mouse
protein localization GO:0008104 191 0.022
Mouse
single organism reproductive process GO:0044702 297 0.022
protein oligomerization GO:0051259 191 0.022
regulation of protein phosphorylation GO:0001932 183 0.022
Human
nucleoside metabolic process GO:0009116 179 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.022
ribonucleoside metabolic process GO:0009119 174 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
regulation of mapk cascade GO:0043408 116 0.021
Human
cell cell signaling GO:0007267 335 0.021
purine nucleotide metabolic process GO:0006163 229 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
Human
cellular response to organonitrogen compound GO:0071417 197 0.021
neuron projection development GO:0031175 273 0.021
localization of cell GO:0051674 202 0.021
regulation of cell differentiation GO:0045595 320 0.021
Human
signal transduction by phosphorylation GO:0023014 144 0.021
regulation of cellular localization GO:0060341 263 0.021
Mouse
oxidation reduction process GO:0055114 304 0.020
regulation of molecular function GO:0065009 398 0.020
Human Mouse
muscle system process GO:0003012 115 0.020
cellular response to external stimulus GO:0071496 118 0.020
heterocycle catabolic process GO:0046700 167 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
Human Zebrafish Mouse
multicellular organism reproduction GO:0032504 233 0.020
regulation of nervous system development GO:0051960 264 0.020
cellular response to cytokine stimulus GO:0071345 127 0.019
nucleobase containing compound catabolic process GO:0034655 152 0.019
cellular component biogenesis GO:0044085 368 0.019
regulation of catalytic activity GO:0050790 304 0.019
Human
macroautophagy GO:0016236 4 0.019
protein complex subunit organization GO:0071822 302 0.019
regulation of protein localization GO:0032880 81 0.019
Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
Human
response to mechanical stimulus GO:0009612 134 0.019
cardiovascular system development GO:0072358 134 0.019
response to glucose GO:0009749 136 0.019
regulation of cell projection organization GO:0031344 175 0.019
macromolecule catabolic process GO:0009057 58 0.019
negative regulation of rna metabolic process GO:0051253 123 0.019
Human
response to external biotic stimulus GO:0043207 221 0.018
Human Zebrafish Mouse
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
Human Zebrafish
cellular response to organic cyclic compound GO:0071407 202 0.018
protein complex assembly GO:0006461 263 0.018
response to growth factor GO:0070848 189 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
Human
response to estrogen GO:0043627 232 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
Human
transmembrane transport GO:0055085 412 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
Human
purine containing compound metabolic process GO:0072521 253 0.018
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
regulation of response to stress GO:0080134 126 0.018
Human
positive regulation of cell differentiation GO:0045597 217 0.018
Human
nitrogen compound transport GO:0071705 229 0.017
regulation of hydrolase activity GO:0051336 143 0.017
regulation of secretion GO:0051046 224 0.017
Mouse
purine ribonucleoside catabolic process GO:0046130 124 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.017
Human
anatomical structure morphogenesis GO:0009653 298 0.017
Mouse
single organism organelle organization GO:1902589 180 0.017
positive regulation of catabolic process GO:0009896 78 0.017
positive regulation of programmed cell death GO:0043068 157 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
response to carbohydrate GO:0009743 183 0.016
cellular component assembly GO:0022607 360 0.016
axon development GO:0061564 96 0.016
cell morphogenesis GO:0000902 142 0.016
dna metabolic process GO:0006259 96 0.016
proteolysis GO:0006508 175 0.016
blood circulation GO:0008015 183 0.016
response to cytokine GO:0034097 215 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
axis specification GO:0009798 4 0.016
aromatic compound catabolic process GO:0019439 168 0.016
cytoplasmic transport GO:0016482 115 0.016
protein complex biogenesis GO:0070271 263 0.016
cellular response to lipid GO:0071396 201 0.016
Human Mouse
organonitrogen compound biosynthetic process GO:1901566 167 0.016
chemosensory behavior GO:0007635 2 0.016
negative regulation of cellular biosynthetic process GO:0031327 161 0.016
Human
single organism intracellular transport GO:1902582 166 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
response to inorganic substance GO:0010035 377 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
cell projection morphogenesis GO:0048858 123 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
cell type specific apoptotic process GO:0097285 134 0.015
embryonic pattern specification GO:0009880 1 0.015
regulation of cellular component organization GO:0051128 368 0.015
carbohydrate derivative catabolic process GO:1901136 147 0.015
regulation of cell migration GO:0030334 128 0.015
response to glucocorticoid GO:0051384 223 0.015
divalent inorganic cation transport GO:0072511 134 0.015
ion transmembrane transport GO:0034220 365 0.015
secretion by cell GO:0032940 248 0.014
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
response to hexose GO:0009746 144 0.014
development of primary sexual characteristics GO:0045137 107 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
positive regulation of cell development GO:0010720 176 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
Human Zebrafish
reproductive structure development GO:0048608 128 0.014
neuron projection morphogenesis GO:0048812 122 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.014
regulation of cell development GO:0060284 263 0.014
positive regulation of signal transduction GO:0009967 175 0.014
Human Mouse
ion homeostasis GO:0050801 212 0.014
positive regulation of cellular catabolic process GO:0031331 71 0.014
response to metal ion GO:0010038 253 0.014
regulation of system process GO:0044057 208 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
cellular component morphogenesis GO:0032989 155 0.014
organelle organization GO:0006996 266 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
Human
anterior posterior pattern specification GO:0009952 1 0.013
b cell differentiation GO:0030183 2 0.013
positive regulation of ion transport GO:0043270 94 0.013
positive regulation of transcription dna templated GO:0045893 197 0.013
Human Zebrafish
regulation of membrane potential GO:0042391 110 0.013
positive regulation of nervous system development GO:0051962 178 0.013
purine ribonucleotide catabolic process GO:0009154 136 0.013
nucleotide catabolic process GO:0009166 139 0.013
multicellular organism growth GO:0035264 1 0.013
response to wounding GO:0009611 254 0.013
macromolecule localization GO:0033036 252 0.013
Mouse
muscle structure development GO:0061061 87 0.013
developmental process involved in reproduction GO:0003006 159 0.013
nucleoside phosphate catabolic process GO:1901292 140 0.013
circulatory system development GO:0072359 134 0.013
regeneration GO:0031099 163 0.013
taxis GO:0042330 67 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
homeostatic process GO:0042592 331 0.013
Mouse
muscle contraction GO:0006936 88 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
Human
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
cellular response to acid chemical GO:0071229 75 0.013
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
learning or memory GO:0007611 90 0.013
reactive nitrogen species metabolic process GO:2001057 1 0.013
response to radiation GO:0009314 137 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
Mouse
immune system process GO:0002376 204 0.012
Human Zebrafish Mouse
regulation of transferase activity GO:0051338 123 0.012
Human
vesicle mediated transport GO:0016192 181 0.012
epithelium development GO:0060429 96 0.012
Mouse
monovalent inorganic cation transport GO:0015672 172 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
negative regulation of transport GO:0051051 136 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.012
nucleoside catabolic process GO:0009164 126 0.012
regulation of proteasomal protein catabolic process GO:0061136 4 0.012
regulation of cellular response to stress GO:0080135 49 0.012
Human
positive regulation of cell projection organization GO:0031346 111 0.012
mechanoreceptor differentiation GO:0042490 2 0.012
intracellular transport GO:0046907 185 0.012
cellular homeostasis GO:0019725 252 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
Human
rhythmic process GO:0048511 156 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
Human
negative regulation of molecular function GO:0044092 133 0.012
cellular response to tumor necrosis factor GO:0071356 46 0.012
response to tumor necrosis factor GO:0034612 56 0.012
neurological system process GO:0050877 219 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
biological adhesion GO:0022610 110 0.012
signal release GO:0023061 145 0.012
single organism behavior GO:0044708 130 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
cell part morphogenesis GO:0032990 123 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.012
response to other organism GO:0051707 220 0.012
Human Zebrafish Mouse
cellular component movement GO:0006928 248 0.011
circulatory system process GO:0003013 183 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
Human
response to activity GO:0014823 73 0.011
vascular process in circulatory system GO:0003018 96 0.011
axonogenesis GO:0007409 71 0.011
regulation of growth GO:0040008 105 0.011
vasculature development GO:0001944 70 0.011
response to monosaccharide GO:0034284 159 0.011
regulation of canonical wnt signaling pathway GO:0060828 4 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
Human Zebrafish
cellular chemical homeostasis GO:0055082 247 0.011
response to temperature stimulus GO:0009266 94 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
embryonic axis specification GO:0000578 1 0.011
rho protein signal transduction GO:0007266 11 0.011
circadian rhythm GO:0007623 88 0.011
regulation of protein kinase activity GO:0045859 105 0.011
Human
regulation of anatomical structure size GO:0090066 135 0.011
regulation of metal ion transport GO:0010959 118 0.011
heart morphogenesis GO:0003007 3 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
positive regulation of nucleotide metabolic process GO:0045981 91 0.011
defense response GO:0006952 194 0.011
Zebrafish
growth GO:0040007 165 0.011
regulation of secretion by cell GO:1903530 208 0.011
Mouse
sodium ion transport GO:0006814 82 0.011
purine containing compound catabolic process GO:0072523 138 0.011
response to alkaloid GO:0043279 132 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
synaptic transmission GO:0007268 235 0.011
response to lipopolysaccharide GO:0032496 191 0.011
Human Mouse
organophosphate catabolic process GO:0046434 148 0.011
cell adhesion GO:0007155 110 0.011
chromosome segregation GO:0007059 2 0.011
anion transport GO:0006820 178 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
i kappab kinase nf kappab signaling GO:0007249 19 0.010
Human Mouse
cell growth GO:0016049 104 0.010
metal ion homeostasis GO:0055065 186 0.010
blood vessel morphogenesis GO:0048514 58 0.010
positive regulation of multicellular organismal process GO:0051240 387 0.010
Human Mouse
gliogenesis GO:0042063 93 0.010
brain development GO:0007420 247 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
olfactory behavior GO:0042048 2 0.010
response to toxic substance GO:0009636 133 0.010
behavior GO:0007610 205 0.010
regulation of neuron differentiation GO:0045664 208 0.010
regulation of hormone levels GO:0010817 187 0.010
hormone secretion GO:0046879 115 0.010
gastrulation GO:0007369 2 0.010
autonomic nervous system development GO:0048483 3 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.010
response to amino acid GO:0043200 75 0.010
regulation of neurogenesis GO:0050767 247 0.010
head development GO:0060322 247 0.010
response to decreased oxygen levels GO:0036293 237 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
neuron apoptotic process GO:0051402 88 0.010
chemical homeostasis GO:0048878 292 0.010
sensory perception of pain GO:0019233 73 0.010
regulation of cellular component movement GO:0051270 150 0.010

Traf6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
nervous system disease DOID:863 0 0.047
central nervous system disease DOID:331 0 0.020
musculoskeletal system disease DOID:17 0 0.017
bone disease DOID:0080001 0 0.017
connective tissue disease DOID:65 0 0.017
disease of metabolism DOID:0014667 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.014
cancer DOID:162 0 0.014