Caenorhabditis elegans

2 known processes

pme-2 (CELE_E02H1.4)

Protein PME-2

pme-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 2992 0.835
embryo development GO:0009790 3052 0.458
aromatic compound biosynthetic process GO:0019438 192 0.287
post embryonic development GO:0009791 2152 0.286
rna biosynthetic process GO:0032774 169 0.236
post embryonic organ development GO:0048569 336 0.223
rna metabolic process GO:0016070 228 0.203
macromolecule biosynthetic process GO:0009059 250 0.199
organic cyclic compound biosynthetic process GO:1901362 195 0.194
cellular macromolecule biosynthetic process GO:0034645 247 0.188
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.163
nucleobase containing compound biosynthetic process GO:0034654 184 0.158
nucleic acid templated transcription GO:0097659 169 0.152
gene expression GO:0010467 412 0.151
transcription from rna polymerase ii promoter GO:0006366 149 0.149
organic substance biosynthetic process GO:1901576 323 0.141
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.140
cellular biosynthetic process GO:0044249 315 0.140
signaling GO:0023052 401 0.135
Mouse
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.135
transcription dna templated GO:0006351 168 0.135
multicellular organism reproduction GO:0032504 819 0.132
anatomical structure formation involved in morphogenesis GO:0048646 250 0.132
developmental process involved in reproduction GO:0003006 1165 0.126
muscle structure development GO:0061061 191 0.116
genitalia development GO:0048806 741 0.116
organelle assembly GO:0070925 214 0.114
cell development GO:0048468 696 0.113
molting cycle GO:0042303 281 0.110
establishment of localization GO:0051234 1171 0.110
locomotion GO:0040011 1634 0.108
organ development GO:0048513 1102 0.102
regulation of nematode larval development GO:0061062 260 0.101
determination of adult lifespan GO:0008340 812 0.099
regulation of rna biosynthetic process GO:2001141 165 0.098
regulation of developmental process GO:0050793 684 0.096
regulation of nucleocytoplasmic transport GO:0046822 3 0.096
regulation of biosynthetic process GO:0009889 189 0.095
organelle organization GO:0006996 783 0.095
macromolecular complex subunit organization GO:0043933 320 0.095
regulation of nitrogen compound metabolic process GO:0051171 222 0.095
regulation of nucleic acid templated transcription GO:1903506 165 0.091
cellular nitrogen compound biosynthetic process GO:0044271 192 0.091
regulation of transcription dna templated GO:0006355 164 0.088
multi organism reproductive process GO:0044703 867 0.087
regulation of gene expression GO:0010468 366 0.086
apoptotic process GO:0006915 478 0.085
Mouse
regulation of primary metabolic process GO:0080090 292 0.081
chromatin organization GO:0006325 32 0.081
regulation of metabolic process GO:0019222 478 0.081
protein complex assembly GO:0006461 186 0.080
vulval development GO:0040025 333 0.080
vesicle mediated transport GO:0016192 852 0.077
regulation of cytoplasmic transport GO:1903649 3 0.076
cytoskeleton organization GO:0007010 339 0.075
regulation of cellular metabolic process GO:0031323 305 0.074
cellular component assembly GO:0022607 293 0.074
germ cell development GO:0007281 351 0.071
macromolecule localization GO:0033036 771 0.071
nucleic acid metabolic process GO:0090304 299 0.068
Mouse
macromolecular complex assembly GO:0065003 193 0.067
protein complex subunit organization GO:0071822 280 0.067
mrna metabolic process GO:0016071 31 0.066
biosynthetic process GO:0009058 323 0.066
regulation of biological quality GO:0065008 741 0.066
reproductive structure development GO:0048608 850 0.064
multi organism behavior GO:0051705 389 0.063
sex differentiation GO:0007548 909 0.062
muscle cell differentiation GO:0042692 171 0.062
maintenance of location GO:0051235 580 0.061
multicellular organismal aging GO:0010259 812 0.060
receptor mediated endocytosis GO:0006898 715 0.060
protein complex biogenesis GO:0070271 186 0.059
regulation of macromolecule metabolic process GO:0060255 421 0.058
heterocycle biosynthetic process GO:0018130 187 0.058
gonad development GO:0008406 840 0.057
single organism reproductive process GO:0044702 1196 0.057
aging GO:0007568 812 0.056
hermaphrodite genitalia development GO:0040035 734 0.055
cellular component biogenesis GO:0044085 297 0.055
lipid storage GO:0019915 565 0.054
single organism localization GO:1902578 518 0.054
nucleobase containing compound metabolic process GO:0006139 406 0.053
Mouse
sexual reproduction GO:0019953 546 0.052
development of primary sexual characteristics GO:0045137 840 0.052
cellular localization GO:0051641 360 0.052
regulation of post embryonic development GO:0048580 260 0.051
reproductive system development GO:0061458 850 0.051
regulation of vulval development GO:0040028 248 0.050
striated muscle cell differentiation GO:0051146 158 0.050
cell proliferation GO:0008283 116 0.049
nucleus organization GO:0006997 38 0.049
lipid localization GO:0010876 573 0.049
chromatin assembly or disassembly GO:0006333 1 0.049
cellular component morphogenesis GO:0032989 318 0.048
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.048
regulation of localization GO:0032879 194 0.047
growth GO:0040007 562 0.047
programmed cell death GO:0012501 500 0.044
Mouse
chromatin modification GO:0016568 32 0.043
cell surface receptor signaling pathway GO:0007166 149 0.043
Mouse
embryonic morphogenesis GO:0048598 152 0.043
cellular component assembly involved in morphogenesis GO:0010927 183 0.043
single organism cellular localization GO:1902580 72 0.042
multicellular organismal reproductive process GO:0048609 815 0.042
organ morphogenesis GO:0009887 67 0.042
developmental growth GO:0048589 412 0.042
establishment or maintenance of cell polarity GO:0007163 63 0.041
multi multicellular organism process GO:0044706 390 0.040
positive regulation of metabolic process GO:0009893 187 0.040
positive regulation of chromosome segregation GO:0051984 1 0.039
posttranscriptional regulation of gene expression GO:0010608 166 0.039
ribosome biogenesis GO:0042254 4 0.039
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.039
positive regulation of cellular process GO:0048522 332 0.038
negative regulation of cellular process GO:0048523 239 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.038
macromolecule modification GO:0043412 218 0.037
regulation of macromolecule biosynthetic process GO:0010556 189 0.037
negative regulation of developmental process GO:0051093 227 0.037
oviposition GO:0018991 364 0.037
regulation of signaling GO:0023051 172 0.036
lipid metabolic process GO:0006629 77 0.036
cellular protein localization GO:0034613 75 0.034
chromatin remodeling GO:0006338 2 0.034
cell death GO:0008219 547 0.034
Mouse
response to heat GO:0009408 50 0.034
transport GO:0006810 1093 0.034
striated muscle cell development GO:0055002 157 0.033
protein phosphorylation GO:0006468 85 0.033
negative regulation of biological process GO:0048519 567 0.032
reproductive behavior GO:0019098 387 0.032
cellular protein metabolic process GO:0044267 279 0.032
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.032
muscle cell development GO:0055001 158 0.032
digestive tract development GO:0048565 122 0.032
endocytosis GO:0006897 819 0.032
ras protein signal transduction GO:0007265 31 0.032
positive regulation of intracellular transport GO:0032388 2 0.031
myofibril assembly GO:0030239 154 0.031
positive regulation of developmental process GO:0051094 408 0.031
response to abiotic stimulus GO:0009628 152 0.031
cellular macromolecule localization GO:0070727 75 0.030
regulation of protein import into nucleus GO:0042306 3 0.030
positive regulation of chromosome organization GO:2001252 2 0.030
cellular macromolecular complex assembly GO:0034622 184 0.029
protein modification process GO:0036211 207 0.029
localization of cell GO:0051674 313 0.029
negative regulation of signaling GO:0023057 61 0.029
positive regulation of multicellular organism growth GO:0040018 352 0.029
cellular response to endogenous stimulus GO:0071495 32 0.029
regulation of gene expression epigenetic GO:0040029 163 0.029
response to temperature stimulus GO:0009266 66 0.028
negative regulation of multicellular organismal process GO:0051241 236 0.028
regulation of signal transduction GO:0009966 135 0.028
regulation of multicellular organism growth GO:0040014 373 0.028
positive regulation of macromolecule metabolic process GO:0010604 149 0.027
cellular protein complex assembly GO:0043623 178 0.027
regulation of lipid metabolic process GO:0019216 4 0.027
single organism signaling GO:0044700 401 0.027
Mouse
single organism organelle organization GO:1902589 501 0.026
negative regulation of metabolic process GO:0009892 240 0.026
rna processing GO:0006396 34 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.026
canonical wnt signaling pathway GO:0060070 3 0.026
establishment of localization in cell GO:0051649 318 0.026
negative regulation of nematode larval development GO:0061064 208 0.026
gamete generation GO:0007276 461 0.026
striated muscle myosin thick filament assembly GO:0071688 138 0.025
multi organism reproductive behavior GO:0044705 387 0.025
er nucleus signaling pathway GO:0006984 66 0.025
digestive tract morphogenesis GO:0048546 76 0.025
multicellular organism growth GO:0035264 385 0.025
negative regulation of gene expression GO:0010629 217 0.024
myosin filament assembly GO:0031034 138 0.024
cellular response to chemical stimulus GO:0070887 129 0.024
multicellular organismal reproductive behavior GO:0033057 384 0.024
organic substance catabolic process GO:1901575 294 0.024
regulation of rna metabolic process GO:0051252 173 0.024
regulation of protein targeting GO:1903533 3 0.023
covalent chromatin modification GO:0016569 30 0.023
behavior GO:0007610 527 0.023
mitotic spindle organization GO:0007052 81 0.023
actin cytoskeleton organization GO:0030036 184 0.023
digestive system development GO:0055123 122 0.023
posttranscriptional gene silencing GO:0016441 143 0.022
actomyosin structure organization GO:0031032 154 0.022
intracellular signal transduction GO:0035556 96 0.022
rna interference GO:0016246 137 0.022
meiotic cell cycle GO:0051321 335 0.022
protein localization GO:0008104 205 0.021
positive regulation of gene expression GO:0010628 112 0.021
positive regulation of growth GO:0045927 369 0.021
oogenesis GO:0048477 229 0.021
phosphorylation GO:0016310 116 0.021
regulation of transport GO:0051049 91 0.021
meiotic chromosome segregation GO:0045132 139 0.021
single organism transport GO:0044765 447 0.021
oocyte differentiation GO:0009994 45 0.021
regulation of apoptotic signaling pathway GO:2001233 1 0.021
positive regulation of vulval development GO:0040026 52 0.021
tube morphogenesis GO:0035239 79 0.021
positive regulation of multicellular organismal process GO:0051240 417 0.020
regulation of multicellular organismal development GO:2000026 317 0.020
positive regulation of cellular biosynthetic process GO:0031328 109 0.020
regulation of cell communication GO:0010646 176 0.020
actin filament based process GO:0030029 191 0.020
myosin filament organization GO:0031033 138 0.020
dna metabolic process GO:0006259 74 0.020
Mouse
response to external stimulus GO:0009605 289 0.020
positive regulation of rna metabolic process GO:0051254 103 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.020
establishment of spindle localization GO:0051293 51 0.020
negative regulation of vulval development GO:0040027 206 0.019
death GO:0016265 547 0.019
Mouse
positive regulation of developmental growth GO:0048639 354 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.019
cell fate commitment GO:0045165 139 0.019
regulation of developmental growth GO:0048638 389 0.019
negative regulation of signal transduction GO:0009968 60 0.019
posttranscriptional gene silencing by rna GO:0035194 143 0.019
cell motility GO:0048870 313 0.018
cell cycle g2 m phase transition GO:0044839 1 0.018
negative regulation of macromolecule metabolic process GO:0010605 229 0.018
epithelial tube morphogenesis GO:0060562 1 0.018
cellular protein modification process GO:0006464 207 0.018
neuron projection morphogenesis GO:0048812 114 0.018
phosphorus metabolic process GO:0006793 232 0.017
phosphate containing compound metabolic process GO:0006796 232 0.017
negative regulation of response to stimulus GO:0048585 73 0.017
regulation of organelle organization GO:0033043 164 0.017
endoplasmic reticulum unfolded protein response GO:0030968 66 0.017
regulation of cell proliferation GO:0042127 105 0.017
protein localization to organelle GO:0033365 37 0.017
single organism biosynthetic process GO:0044711 91 0.016
gene silencing by rna GO:0031047 143 0.016
regulation of response to stimulus GO:0048583 243 0.016
head development GO:0060322 1 0.016
neurogenesis GO:0022008 236 0.016
regulation of growth GO:0040008 409 0.016
regulation of phosphorus metabolic process GO:0051174 81 0.016
positive regulation of cellular metabolic process GO:0031325 178 0.016
regulation of cellular biosynthetic process GO:0031326 189 0.016
peptidyl lysine acetylation GO:0018394 3 0.016
cell type specific apoptotic process GO:0097285 4 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.016
cell cell signaling GO:0007267 118 0.015
chromosome organization GO:0051276 104 0.015
regulation of molecular function GO:0065009 89 0.015
cell part morphogenesis GO:0032990 152 0.015
female gamete generation GO:0007292 254 0.015
meiotic nuclear division GO:0007126 300 0.015
small gtpase mediated signal transduction GO:0007264 32 0.015
positive regulation of rna biosynthetic process GO:1902680 102 0.015
regulation of multicellular organismal process GO:0051239 726 0.015
microtubule based process GO:0007017 182 0.015
histone modification GO:0016570 30 0.015
negative regulation of gene expression epigenetic GO:0045814 2 0.015
regulation of cellular localization GO:0060341 42 0.015
negative regulation of cell communication GO:0010648 61 0.014
regulation of catalytic activity GO:0050790 78 0.014
organic substance transport GO:0071702 113 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
nucleic acid phosphodiester bond hydrolysis GO:0090305 28 0.014
regulation of protein serine threonine kinase activity GO:0071900 18 0.014
negative regulation of rna metabolic process GO:0051253 53 0.013
spermatogenesis GO:0007283 41 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.013
chromosome organization involved in meiosis GO:0070192 25 0.013
regulation of protein localization GO:0032880 50 0.013
regulation of cellular component organization GO:0051128 248 0.013
cellular response to stress GO:0033554 162 0.013
Mouse
regulation of programmed cell death GO:0043067 50 0.013
internal peptidyl lysine acetylation GO:0018393 3 0.013
macromolecule catabolic process GO:0009057 202 0.013
negative regulation of neurogenesis GO:0050768 4 0.012
carboxylic acid metabolic process GO:0019752 34 0.012
negative regulation of post embryonic development GO:0048581 208 0.012
oxoacid metabolic process GO:0043436 47 0.012
negative regulation of apoptotic process GO:0043066 17 0.012
chromatin assembly GO:0031497 1 0.012
cell morphogenesis GO:0000902 163 0.012
organonitrogen compound metabolic process GO:1901564 151 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 34 0.012
secretion GO:0046903 147 0.012
pigmentation GO:0043473 2 0.012
positive regulation of post embryonic development GO:0048582 54 0.012
cytoplasmic transport GO:0016482 23 0.012
cellular catabolic process GO:0044248 199 0.012
system process GO:0003008 136 0.011
cellular nitrogen compound catabolic process GO:0044270 119 0.011
amine metabolic process GO:0009308 15 0.011
internal protein amino acid acetylation GO:0006475 3 0.011
intracellular transport GO:0046907 77 0.011
rrna processing GO:0006364 3 0.011
response to endoplasmic reticulum stress GO:0034976 71 0.011
organelle localization GO:0051640 127 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 2 0.011
positive regulation of protein transport GO:0051222 4 0.011
tube development GO:0035295 126 0.011
inductive cell migration GO:0040039 145 0.011
cellular amino acid metabolic process GO:0006520 15 0.011
membrane organization GO:0061024 135 0.011
cellular ketone metabolic process GO:0042180 14 0.011
regulation of microtubule based process GO:0032886 21 0.010
regulation of chromatin modification GO:1903308 2 0.010
intraspecies interaction between organisms GO:0051703 3 0.010
protein import GO:0017038 9 0.010
dna packaging GO:0006323 7 0.010
regulation of cytoskeleton organization GO:0051493 41 0.010
response to topologically incorrect protein GO:0035966 82 0.010
neuron development GO:0048666 199 0.010
cell cycle g1 s phase transition GO:0044843 2 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010

pme-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
disease of cellular proliferation DOID:14566 0 0.020
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.017