Saccharomyces cerevisiae

105 known processes

MLH1 (YMR167W)

Mlh1p

(Aliases: PMS2)

MLH1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
meiosis i GO:0007127 92 0.997
meiotic cell cycle process GO:1903046 229 0.994
dna recombination GO:0006310 172 0.989
dna repair GO:0006281 236 0.983
meiotic nuclear division GO:0007126 163 0.981
nuclear division GO:0000280 263 0.956
cellular response to dna damage stimulus GO:0006974 287 0.941
reciprocal meiotic recombination GO:0007131 54 0.937
organelle fission GO:0048285 272 0.914
meiotic cell cycle GO:0051321 272 0.769
reciprocal dna recombination GO:0035825 54 0.426
macromolecule catabolic process GO:0009057 383 0.375
Mouse
cellular macromolecule catabolic process GO:0044265 363 0.314
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.297
Mouse
negative regulation of cellular metabolic process GO:0031324 407 0.256
Mouse
developmental process involved in reproduction GO:0003006 159 0.246
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.241
Mouse
mismatch repair GO:0006298 14 0.236
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.218
mitotic recombination GO:0006312 55 0.193
Mouse
reproductive process in single celled organism GO:0022413 145 0.184
cell fate commitment GO:0045165 32 0.178
dna catabolic process GO:0006308 42 0.174
regulation of dna metabolic process GO:0051052 100 0.172
Mouse
heterocycle catabolic process GO:0046700 494 0.163
aromatic compound catabolic process GO:0019439 491 0.162
organic cyclic compound catabolic process GO:1901361 499 0.149
nucleobase containing compound catabolic process GO:0034655 479 0.145
meiotic mismatch repair GO:0000710 9 0.143
single organism developmental process GO:0044767 258 0.142
Mouse
protein complex biogenesis GO:0070271 314 0.133
Mouse
chromosome segregation GO:0007059 159 0.124
Zebrafish Mouse
mating type determination GO:0007531 32 0.122
reproduction of a single celled organism GO:0032505 191 0.113
organic acid metabolic process GO:0006082 352 0.112
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.111
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.106
cellular nitrogen compound catabolic process GO:0044270 494 0.102
cytoskeleton organization GO:0007010 230 0.094
Mouse
positive regulation of macromolecule metabolic process GO:0010604 394 0.092
regulation of cell cycle GO:0051726 195 0.092
response to chemical GO:0042221 390 0.089
non recombinational repair GO:0000726 33 0.088
Mouse
mitotic cell cycle process GO:1903047 294 0.085
chromosome organization involved in meiosis GO:0070192 32 0.084
Zebrafish Mouse
mitotic cell cycle GO:0000278 306 0.084
positive regulation of rna biosynthetic process GO:1902680 286 0.083
cellular developmental process GO:0048869 191 0.082
Mouse
gene silencing GO:0016458 151 0.080
single organism catabolic process GO:0044712 619 0.076
developmental process GO:0032502 261 0.074
Mouse
regulation of biological quality GO:0065008 391 0.071
homeostatic process GO:0042592 227 0.068
mitotic cell cycle phase transition GO:0044772 141 0.068
positive regulation of transcription dna templated GO:0045893 286 0.068
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.066
mating type switching GO:0007533 28 0.064
regulation of mitotic cell cycle phase transition GO:1901990 68 0.060
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.060
regulation of protein metabolic process GO:0051246 237 0.059
negative regulation of cellular biosynthetic process GO:0031327 312 0.059
negative regulation of biosynthetic process GO:0009890 312 0.057
positive regulation of gene expression GO:0010628 321 0.055
single organism reproductive process GO:0044702 159 0.054
Zebrafish Mouse
ribonucleoside metabolic process GO:0009119 389 0.054
negative regulation of gene expression GO:0010629 312 0.052
chromatin organization GO:0006325 242 0.051
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.051
carbohydrate derivative metabolic process GO:1901135 549 0.049
nucleoside phosphate metabolic process GO:0006753 458 0.049
regulation of cellular component organization GO:0051128 334 0.048
protein catabolic process GO:0030163 221 0.048
protein complex assembly GO:0006461 302 0.047
Mouse
cell differentiation GO:0030154 161 0.047
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 286 0.047
negative regulation of transcription dna templated GO:0045892 258 0.045
lipid metabolic process GO:0006629 269 0.045
regulation of molecular function GO:0065009 320 0.045
negative regulation of macromolecule metabolic process GO:0010605 375 0.045
Mouse
nucleobase containing small molecule metabolic process GO:0055086 491 0.045
regulation of nuclear division GO:0051783 103 0.045
gene conversion GO:0035822 14 0.044
anatomical structure morphogenesis GO:0009653 160 0.044
reproductive process GO:0022414 248 0.043
Zebrafish Mouse
anion transport GO:0006820 145 0.043
regulation of dna recombination GO:0000018 24 0.043
Mouse
negative regulation of rna metabolic process GO:0051253 262 0.043
double strand break repair GO:0006302 105 0.043
Mouse
chemical homeostasis GO:0048878 137 0.042
mitotic nuclear division GO:0007067 131 0.041
organonitrogen compound biosynthetic process GO:1901566 314 0.040
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.040
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.037
cellular lipid metabolic process GO:0044255 229 0.037
positive regulation of biosynthetic process GO:0009891 336 0.037
cell cycle phase transition GO:0044770 144 0.037
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.036
cellular protein complex assembly GO:0043623 209 0.036
Mouse
regulation of response to stimulus GO:0048583 157 0.036
microtubule cytoskeleton organization GO:0000226 109 0.035
Mouse
regulation of gene expression epigenetic GO:0040029 147 0.035
mitochondrion organization GO:0007005 261 0.035
meiotic chromosome segregation GO:0045132 31 0.035
Zebrafish Mouse
microtubule based process GO:0007017 117 0.034
Mouse
organic anion transport GO:0015711 114 0.034
negative regulation of dna metabolic process GO:0051053 36 0.033
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 260 0.033
nucleobase containing compound transport GO:0015931 124 0.033
regulation of mitotic cell cycle GO:0007346 107 0.033
response to abiotic stimulus GO:0009628 159 0.032
mitochondrial genome maintenance GO:0000002 40 0.031
purine ribonucleoside metabolic process GO:0046128 380 0.031
regulation of organelle organization GO:0033043 243 0.030
positive regulation of rna metabolic process GO:0051254 294 0.030
filamentous growth GO:0030447 124 0.030
sporulation GO:0043934 132 0.030
regulation of catabolic process GO:0009894 199 0.030
negative regulation of cell cycle phase transition GO:1901988 59 0.030
cell communication GO:0007154 345 0.030
Mouse
positive regulation of cellular biosynthetic process GO:0031328 336 0.030
modification dependent macromolecule catabolic process GO:0043632 203 0.029
sex determination GO:0007530 32 0.028
regulation of cellular catabolic process GO:0031329 195 0.028
regulation of cell cycle phase transition GO:1901987 70 0.027
organelle assembly GO:0070925 118 0.026
Mouse
ribose phosphate metabolic process GO:0019693 384 0.026
organophosphate metabolic process GO:0019637 597 0.026
nucleoside catabolic process GO:0009164 335 0.026
mitotic cell cycle checkpoint GO:0007093 56 0.026
glycosyl compound catabolic process GO:1901658 335 0.026
chromatin modification GO:0016568 200 0.026
regulation of signaling GO:0023051 119 0.025
rna localization GO:0006403 112 0.025
protein modification by small protein conjugation or removal GO:0070647 172 0.025
nucleotide excision repair GO:0006289 50 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 137 0.025
purine nucleoside monophosphate metabolic process GO:0009126 262 0.025
fatty acid metabolic process GO:0006631 51 0.025
cell aging GO:0007569 70 0.024
phosphorylation GO:0016310 291 0.024
regulation of response to stress GO:0080134 57 0.024
response to external stimulus GO:0009605 158 0.023
positive regulation of hydrolase activity GO:0051345 112 0.023
response to nutrient levels GO:0031667 150 0.023
cellular response to chemical stimulus GO:0070887 315 0.023
energy derivation by oxidation of organic compounds GO:0015980 125 0.023
positive regulation of molecular function GO:0044093 185 0.023
protein import GO:0017038 122 0.023
single organism cellular localization GO:1902580 375 0.022
lipid biosynthetic process GO:0008610 170 0.022
nitrogen compound transport GO:0071705 212 0.022
rna catabolic process GO:0006401 118 0.022
Mouse
ribonucleoside catabolic process GO:0042454 332 0.021
chromatin silencing GO:0006342 147 0.021
regulation of cellular protein metabolic process GO:0032268 232 0.021
purine ribonucleotide catabolic process GO:0009154 327 0.021
carboxylic acid biosynthetic process GO:0046394 152 0.021
oxoacid metabolic process GO:0043436 351 0.021
oxidation reduction process GO:0055114 353 0.021
double strand break repair via single strand annealing GO:0045002 7 0.020
removal of nonhomologous ends GO:0000735 6 0.020
nuclear transport GO:0051169 165 0.020
g1 s transition of mitotic cell cycle GO:0000082 64 0.020
regulation of localization GO:0032879 127 0.020
cell development GO:0048468 107 0.020
Mouse
chromatin silencing at silent mating type cassette GO:0030466 53 0.020
regulation of translation GO:0006417 89 0.020
mrna metabolic process GO:0016071 269 0.019
Mouse
cellular response to abiotic stimulus GO:0071214 62 0.019
apoptotic process GO:0006915 30 0.019
Mouse
regulation of meiosis GO:0040020 42 0.019
ribonucleoside triphosphate catabolic process GO:0009203 327 0.019
nucleotide metabolic process GO:0009117 453 0.019
maintenance of location in cell GO:0051651 58 0.019
cellular response to organic substance GO:0071310 159 0.019
cellular ion homeostasis GO:0006873 112 0.019
carboxylic acid metabolic process GO:0019752 338 0.019
negative regulation of rna biosynthetic process GO:1902679 260 0.018
negative regulation of cellular protein metabolic process GO:0032269 85 0.018
sexual reproduction GO:0019953 216 0.018
Zebrafish Mouse
ion homeostasis GO:0050801 118 0.018
histone modification GO:0016570 119 0.018
regulation of cell cycle process GO:0010564 150 0.018
glycosyl compound metabolic process GO:1901657 398 0.017
protein transport GO:0015031 345 0.017
sister chromatid segregation GO:0000819 93 0.017
synapsis GO:0007129 19 0.017
Zebrafish Mouse
regulation of hydrolase activity GO:0051336 133 0.017
organelle localization GO:0051640 128 0.017
Zebrafish Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.016
purine nucleoside catabolic process GO:0006152 330 0.016
cell division GO:0051301 205 0.016
signaling GO:0023052 208 0.016
Mouse
organonitrogen compound catabolic process GO:1901565 404 0.016
dna conformation change GO:0071103 98 0.016
aging GO:0007568 71 0.016
positive regulation of cellular catabolic process GO:0031331 128 0.016
negative regulation of gene expression epigenetic GO:0045814 147 0.016
programmed cell death GO:0012501 30 0.015
Mouse
positive regulation of cell cycle GO:0045787 32 0.015
purine nucleoside monophosphate catabolic process GO:0009128 224 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 137 0.015
purine ribonucleotide metabolic process GO:0009150 372 0.015
response to organic cyclic compound GO:0014070 1 0.015
purine containing compound metabolic process GO:0072521 400 0.015
double strand break repair via synthesis dependent strand annealing GO:0045003 12 0.014
cellular response to external stimulus GO:0071496 150 0.014
positive regulation of catalytic activity GO:0043085 178 0.014
mitotic dna integrity checkpoint GO:0044774 18 0.014
purine containing compound catabolic process GO:0072523 332 0.014
regulation of dna replication GO:0006275 51 0.014
cellular response to oxidative stress GO:0034599 94 0.014
gene conversion at mating type locus GO:0007534 11 0.014
response to drug GO:0042493 41 0.014
regulation of transport GO:0051049 85 0.014
nucleoside phosphate catabolic process GO:1901292 331 0.014
growth GO:0040007 157 0.014
ribonucleoside triphosphate metabolic process GO:0009199 356 0.013
anatomical structure development GO:0048856 160 0.013
Mouse
amine metabolic process GO:0009308 51 0.013
intracellular signal transduction GO:0035556 112 0.013
Mouse
sexual sporulation resulting in formation of a cellular spore GO:0043935 113 0.013
membrane organization GO:0061024 276 0.013
cellular homeostasis GO:0019725 138 0.013
nucleoside monophosphate catabolic process GO:0009125 224 0.013
proteolysis GO:0006508 268 0.013
double strand break repair via homologous recombination GO:0000724 54 0.013
nucleoside metabolic process GO:0009116 394 0.013
death GO:0016265 30 0.013
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 329 0.013
actin cytoskeleton organization GO:0030036 100 0.013
cellular respiration GO:0045333 82 0.013
proteasomal protein catabolic process GO:0010498 141 0.013
mitotic sister chromatid segregation GO:0000070 85 0.013
regulation of response to external stimulus GO:0032101 20 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.012
establishment of protein localization to mitochondrion GO:0072655 63 0.012
multi organism process GO:0051704 233 0.012
Zebrafish Mouse
positive regulation of protein metabolic process GO:0051247 93 0.012
dna packaging GO:0006323 55 0.012
mrna export from nucleus GO:0006406 60 0.012
cellular chemical homeostasis GO:0055082 123 0.012
ribonucleoside monophosphate catabolic process GO:0009158 224 0.012
response to extracellular stimulus GO:0009991 156 0.012
mitochondrion localization GO:0051646 29 0.012
positive regulation of cell cycle process GO:0090068 31 0.012
translation GO:0006412 230 0.012
cell growth GO:0016049 89 0.012
pseudohyphal growth GO:0007124 75 0.012
ribonucleoside monophosphate metabolic process GO:0009161 265 0.012
organic acid catabolic process GO:0016054 71 0.012
regulation of growth GO:0040008 50 0.012
mitotic cytokinesis GO:0000281 58 0.012
single organism signaling GO:0044700 208 0.012
Mouse
nucleoside triphosphate metabolic process GO:0009141 364 0.012
protein dna complex subunit organization GO:0071824 153 0.012
regulation of cell division GO:0051302 113 0.011
response to oxidative stress GO:0006979 99 0.011
ribonucleotide catabolic process GO:0009261 327 0.011
positive regulation of catabolic process GO:0009896 135 0.011
rna splicing GO:0008380 131 0.011
cellular amine metabolic process GO:0044106 51 0.011
regulation of catalytic activity GO:0050790 307 0.011
single organism membrane organization GO:0044802 275 0.011
filamentous growth of a population of unicellular organisms GO:0044182 109 0.011
regulation of protein localization GO:0032880 62 0.011
protein ubiquitination GO:0016567 118 0.011
posttranscriptional regulation of gene expression GO:0010608 115 0.011
establishment of protein localization to membrane GO:0090150 99 0.011
regulation of phosphorus metabolic process GO:0051174 230 0.011
negative regulation of mitotic cell cycle GO:0045930 63 0.011
macromolecular complex disassembly GO:0032984 80 0.011
carbohydrate derivative catabolic process GO:1901136 339 0.011
small molecule biosynthetic process GO:0044283 258 0.011
regulation of signal transduction GO:0009966 114 0.011
negative regulation of cellular component organization GO:0051129 109 0.011
protein modification by small protein conjugation GO:0032446 144 0.010
maintenance of protein location GO:0045185 53 0.010
response to uv GO:0009411 4 0.010
response to oxygen containing compound GO:1901700 61 0.010
aerobic respiration GO:0009060 55 0.010
nucleotide catabolic process GO:0009166 330 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.010
regulation of response to nutrient levels GO:0032107 20 0.010
nucleic acid transport GO:0050657 94 0.010
cellular component disassembly GO:0022411 86 0.010
purine nucleoside metabolic process GO:0042278 380 0.010

MLH1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org