Saccharomyces cerevisiae

123 known processes

LHS1 (YKL073W)

Lhs1p

(Aliases: SSI1,CER1)

LHS1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transmembrane transport GO:0055085 349 0.835
protein localization to endoplasmic reticulum GO:0070972 47 0.650
protein targeting GO:0006605 272 0.526
protein targeting to er GO:0045047 39 0.497
signal transduction GO:0007165 208 0.489
Mouse
single organism cellular localization GO:1902580 375 0.303
protein modification by small protein conjugation or removal GO:0070647 172 0.288
Mouse
signaling GO:0023052 208 0.280
Mouse
ubiquitin dependent protein catabolic process GO:0006511 181 0.279
Yeast
response to chemical GO:0042221 390 0.266
protein modification by small protein conjugation GO:0032446 144 0.256
Mouse
establishment of protein localization to organelle GO:0072594 278 0.253
proteasomal protein catabolic process GO:0010498 141 0.240
Yeast
establishment of protein localization to endoplasmic reticulum GO:0072599 40 0.237
sexual reproduction GO:0019953 216 0.219
Yeast
single organism membrane organization GO:0044802 275 0.216
er associated ubiquitin dependent protein catabolic process GO:0030433 46 0.208
Yeast
intracellular protein transport GO:0006886 319 0.206
multi organism cellular process GO:0044764 120 0.197
Yeast
protein folding GO:0006457 94 0.196
establishment of organelle localization GO:0051656 96 0.192
cell communication GO:0007154 345 0.190
Human Mouse
conjugation GO:0000746 107 0.187
Yeast
single organism signaling GO:0044700 208 0.184
Mouse
modification dependent macromolecule catabolic process GO:0043632 203 0.180
Yeast
modification dependent protein catabolic process GO:0019941 181 0.175
Yeast
protein transport GO:0015031 345 0.167
response to organic substance GO:0010033 182 0.164
multi organism process GO:0051704 233 0.164
Yeast
carbohydrate derivative metabolic process GO:1901135 549 0.164
multi organism reproductive process GO:0044703 216 0.161
Yeast
protein ubiquitination GO:0016567 118 0.160
Mouse
regulation of map kinase activity GO:0043405 12 0.159
regulation of molecular function GO:0065009 320 0.159
negative regulation of signal transduction GO:0009968 30 0.156
Mouse
establishment of protein localization GO:0045184 367 0.151
response to topologically incorrect protein GO:0035966 38 0.146
organelle localization GO:0051640 128 0.139
cell wall organization or biogenesis GO:0071554 190 0.137
protein folding in endoplasmic reticulum GO:0034975 13 0.137
regulation of cell communication GO:0010646 124 0.122
Mouse
peptidyl amino acid modification GO:0018193 116 0.122
regulation of cellular component biogenesis GO:0044087 112 0.121
negative regulation of cell communication GO:0010648 33 0.120
Mouse
regulation of protein serine threonine kinase activity GO:0071900 41 0.119
protein localization to membrane GO:0072657 102 0.115
regulation of protein kinase activity GO:0045859 67 0.113
Mouse
cellular macromolecule catabolic process GO:0044265 363 0.112
Yeast Mouse
protein targeting to membrane GO:0006612 52 0.112
membrane organization GO:0061024 276 0.111
regulation of response to stimulus GO:0048583 157 0.111
Mouse
regulation of localization GO:0032879 127 0.110
Human
conjugation with cellular fusion GO:0000747 106 0.108
Yeast
signal transduction by phosphorylation GO:0023014 31 0.107
regulation of biological quality GO:0065008 391 0.107
Human
vesicle organization GO:0016050 68 0.104
regulation of transferase activity GO:0051338 83 0.103
Mouse
regulation of cellular response to stress GO:0080135 50 0.103
establishment of protein localization to membrane GO:0090150 99 0.101
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 137 0.100
Yeast
regulation of catalytic activity GO:0050790 307 0.099
negative regulation of intracellular signal transduction GO:1902532 27 0.098
protein localization to organelle GO:0033365 337 0.094
microtubule based process GO:0007017 117 0.092
Fly
vesicle mediated transport GO:0016192 335 0.090
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.090
reproductive process GO:0022414 248 0.089
Yeast
negative regulation of response to stimulus GO:0048585 40 0.089
Mouse
heterocycle catabolic process GO:0046700 494 0.088
cellular lipid metabolic process GO:0044255 229 0.088
mitotic cell cycle GO:0000278 306 0.087
carbohydrate derivative biosynthetic process GO:1901137 181 0.087
negative regulation of molecular function GO:0044092 68 0.086
nitrogen compound transport GO:0071705 212 0.086
regulation of mapk cascade GO:0043408 22 0.082
negative regulation of macromolecule metabolic process GO:0010605 375 0.080
Fly
membrane lipid metabolic process GO:0006643 67 0.080
organic anion transport GO:0015711 114 0.077
cellular response to dna damage stimulus GO:0006974 287 0.077
negative regulation of kinase activity GO:0033673 24 0.074
ribonucleoside triphosphate catabolic process GO:0009203 327 0.073
mapk cascade GO:0000165 30 0.072
membrane lipid biosynthetic process GO:0046467 54 0.072
purine ribonucleoside catabolic process GO:0046130 330 0.070
negative regulation of map kinase activity GO:0043407 9 0.069
regulation of cellular component organization GO:0051128 334 0.069
regulation of protein modification process GO:0031399 110 0.068
Mouse
intracellular signal transduction GO:0035556 112 0.068
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.068
purine ribonucleotide catabolic process GO:0009154 327 0.066
cellular protein complex assembly GO:0043623 209 0.066
purine nucleoside metabolic process GO:0042278 380 0.065
ribonucleoside catabolic process GO:0042454 332 0.065
protein import into mitochondrial matrix GO:0030150 20 0.065
regulation of phosphate metabolic process GO:0019220 230 0.064
Mouse
negative regulation of protein phosphorylation GO:0001933 24 0.062
protein phosphorylation GO:0006468 197 0.061
Mouse
regulation of kinase activity GO:0043549 71 0.061
Mouse
cellular nitrogen compound catabolic process GO:0044270 494 0.060
protein complex assembly GO:0006461 302 0.059
positive regulation of phosphorus metabolic process GO:0010562 147 0.059
Mouse
single organism catabolic process GO:0044712 619 0.059
organic cyclic compound catabolic process GO:1901361 499 0.058
negative regulation of transferase activity GO:0051348 31 0.057
regulation of phosphorus metabolic process GO:0051174 230 0.057
Mouse
regulation of transport GO:0051049 85 0.056
establishment of protein localization to mitochondrion GO:0072655 63 0.055
lipid metabolic process GO:0006629 269 0.055
negative regulation of cellular metabolic process GO:0031324 407 0.055
cytoskeleton organization GO:0007010 230 0.054
Fly
nucleus organization GO:0006997 62 0.053
Yeast
regulation of signal transduction GO:0009966 114 0.053
Mouse
positive regulation of phosphate metabolic process GO:0045937 147 0.051
Mouse
negative regulation of cellular component organization GO:0051129 109 0.051
negative regulation of nucleic acid templated transcription GO:1903507 260 0.050
meiotic nuclear division GO:0007126 163 0.049
nucleoside phosphate catabolic process GO:1901292 331 0.049
gpi anchor metabolic process GO:0006505 28 0.048
ribonucleoside triphosphate metabolic process GO:0009199 356 0.048
cell surface receptor signaling pathway GO:0007166 38 0.048
Mouse
regulation of response to stress GO:0080134 57 0.048
glycerolipid metabolic process GO:0046486 108 0.048
positive regulation of macromolecule metabolic process GO:0010604 394 0.048
Mouse
aromatic compound catabolic process GO:0019439 491 0.045
single organism developmental process GO:0044767 258 0.045
Human Mouse
negative regulation of protein metabolic process GO:0051248 85 0.044
nucleoside triphosphate catabolic process GO:0009143 329 0.044
negative regulation of mapk cascade GO:0043409 11 0.044
ribose phosphate metabolic process GO:0019693 384 0.044
regulation of membrane lipid distribution GO:0097035 14 0.043
cotranslational protein targeting to membrane GO:0006613 15 0.043
Yeast
negative regulation of catalytic activity GO:0043086 60 0.042
positive regulation of cell death GO:0010942 3 0.042
spindle organization GO:0007051 37 0.042
negative regulation of signaling GO:0023057 30 0.041
Mouse
mitotic cell cycle process GO:1903047 294 0.041
cellular protein catabolic process GO:0044257 213 0.041
Yeast Mouse
cellular response to chemical stimulus GO:0070887 315 0.041
Mouse Rat
purine nucleotide metabolic process GO:0006163 376 0.041
localization within membrane GO:0051668 29 0.040
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.040
regulation of signaling GO:0023051 119 0.040
Mouse
ribosome biogenesis GO:0042254 335 0.039
cell wall biogenesis GO:0042546 93 0.039
negative regulation of biosynthetic process GO:0009890 312 0.039
protein glycosylation GO:0006486 57 0.038
organophosphate metabolic process GO:0019637 597 0.038
purine nucleoside catabolic process GO:0006152 330 0.038
regulation of protein ubiquitination GO:0031396 20 0.038
Mouse
ncrna processing GO:0034470 330 0.038
ion transport GO:0006811 274 0.037
cellular response to organic substance GO:0071310 159 0.037
Mouse
regulation of protein metabolic process GO:0051246 237 0.037
Mouse
nucleoside metabolic process GO:0009116 394 0.036
negative regulation of cellular biosynthetic process GO:0031327 312 0.036
regulation of gene expression epigenetic GO:0040029 147 0.036
Fly
nucleocytoplasmic transport GO:0006913 163 0.035
cellular response to pheromone GO:0071444 88 0.035
maintenance of location in cell GO:0051651 58 0.035
Human
developmental process GO:0032502 261 0.035
Human Mouse
macromolecular complex disassembly GO:0032984 80 0.034
karyogamy GO:0000741 17 0.034
Yeast
nucleoside triphosphate metabolic process GO:0009141 364 0.034
negative regulation of rna metabolic process GO:0051253 262 0.033
gtp catabolic process GO:0006184 107 0.033
proteolysis GO:0006508 268 0.033
Yeast Mouse
sporulation GO:0043934 132 0.033
organic hydroxy compound metabolic process GO:1901615 125 0.033
regulation of purine nucleotide metabolic process GO:1900542 109 0.031
purine containing compound catabolic process GO:0072523 332 0.031
ribonucleotide catabolic process GO:0009261 327 0.031
organophosphate catabolic process GO:0046434 338 0.031
phosphatidylinositol biosynthetic process GO:0006661 39 0.031
protein catabolic process GO:0030163 221 0.031
Yeast Mouse
gpi anchor biosynthetic process GO:0006506 26 0.031
nucleoside catabolic process GO:0009164 335 0.030
regulation of cellular protein metabolic process GO:0032268 232 0.030
Mouse
regulation of hydrolase activity GO:0051336 133 0.030
Mouse
nucleobase containing compound catabolic process GO:0034655 479 0.030
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.030
positive regulation of kinase activity GO:0033674 24 0.030
Mouse
intracellular protein transmembrane import GO:0044743 67 0.030
glycosyl compound metabolic process GO:1901657 398 0.030
fungal type cell wall organization GO:0031505 145 0.030
positive regulation of phosphorylation GO:0042327 33 0.030
Mouse
rrna processing GO:0006364 227 0.030
rrna metabolic process GO:0016072 244 0.029
purine ribonucleotide metabolic process GO:0009150 372 0.029
regulation of protein modification by small protein conjugation or removal GO:1903320 29 0.029
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.029
negative regulation of phosphorus metabolic process GO:0010563 49 0.029
guanosine containing compound catabolic process GO:1901069 109 0.029
protein complex biogenesis GO:0070271 314 0.029
ribonucleoside metabolic process GO:0009119 389 0.028
regulation of organelle organization GO:0033043 243 0.028
response to temperature stimulus GO:0009266 74 0.028
nuclear export GO:0051168 124 0.028
negative regulation of protein serine threonine kinase activity GO:0071901 18 0.028
regulation of nucleoside metabolic process GO:0009118 106 0.028
ribonucleoprotein complex subunit organization GO:0071826 152 0.027
gene silencing GO:0016458 151 0.027
Fly
external encapsulating structure organization GO:0045229 146 0.027
glycerolipid biosynthetic process GO:0045017 71 0.027
positive regulation of apoptotic process GO:0043065 3 0.026
glycerophospholipid metabolic process GO:0006650 98 0.026
alcohol metabolic process GO:0006066 112 0.026
regulation of intracellular signal transduction GO:1902531 78 0.026
guanosine containing compound metabolic process GO:1901068 111 0.025
membrane budding GO:0006900 22 0.024
response to external stimulus GO:0009605 158 0.024
Human
glycerophospholipid biosynthetic process GO:0046474 68 0.024
carbohydrate derivative transport GO:1901264 27 0.024
negative regulation of rna biosynthetic process GO:1902679 260 0.024
regulation of nucleotide metabolic process GO:0006140 110 0.024
purine nucleotide catabolic process GO:0006195 328 0.023
nucleoside phosphate metabolic process GO:0006753 458 0.023
ribonucleoprotein complex assembly GO:0022618 143 0.023
purine nucleoside triphosphate catabolic process GO:0009146 329 0.023
negative regulation of phosphate metabolic process GO:0045936 49 0.023
microtubule cytoskeleton organization GO:0000226 109 0.023
Fly
protein sumoylation GO:0016925 17 0.022
generation of precursor metabolites and energy GO:0006091 147 0.022
glycoprotein metabolic process GO:0009100 62 0.022
g protein coupled receptor signaling pathway GO:0007186 37 0.022
positive regulation of hydrolase activity GO:0051345 112 0.021
Mouse
response to organic cyclic compound GO:0014070 1 0.021
homeostatic process GO:0042592 227 0.021
endomembrane system organization GO:0010256 74 0.020
nuclear transport GO:0051169 165 0.020
negative regulation of gene expression epigenetic GO:0045814 147 0.020
purine ribonucleoside metabolic process GO:0046128 380 0.020
positive regulation of protein metabolic process GO:0051247 93 0.020
Mouse
stress activated protein kinase signaling cascade GO:0031098 4 0.020
glycosyl compound catabolic process GO:1901658 335 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.020
Yeast Mouse
nucleobase containing small molecule metabolic process GO:0055086 491 0.020
detection of stimulus GO:0051606 4 0.020
liposaccharide metabolic process GO:1903509 31 0.020
purine nucleoside triphosphate metabolic process GO:0009144 356 0.020
positive regulation of programmed cell death GO:0043068 3 0.019
positive regulation of protein phosphorylation GO:0001934 28 0.019
Mouse
anion transport GO:0006820 145 0.019
rna localization GO:0006403 112 0.019
response to pheromone involved in conjugation with cellular fusion GO:0000749 74 0.019
aging GO:0007568 71 0.019
sexual sporulation GO:0034293 113 0.019
organelle inheritance GO:0048308 51 0.019
protein transmembrane transport GO:0071806 82 0.019
apoptotic process GO:0006915 30 0.018
Human
cellular protein complex disassembly GO:0043624 42 0.018
anatomical structure morphogenesis GO:0009653 160 0.018
Mouse
response to unfolded protein GO:0006986 29 0.018
regulation of multi organism process GO:0043900 20 0.018
lipoprotein metabolic process GO:0042157 40 0.018
regulation of cellular localization GO:0060341 50 0.018
phosphorylation GO:0016310 291 0.017
Mouse
negative regulation of transcription dna templated GO:0045892 258 0.017
chemical homeostasis GO:0048878 137 0.017
gtp metabolic process GO:0046039 107 0.017
cellular response to topologically incorrect protein GO:0035967 32 0.017
Mouse
cation transmembrane transport GO:0098655 135 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.017
Mouse
karyogamy involved in conjugation with cellular fusion GO:0000742 15 0.017
Yeast
golgi vesicle transport GO:0048193 188 0.017
lipid transport GO:0006869 58 0.017
regulation of nucleotide catabolic process GO:0030811 106 0.017
phospholipid biosynthetic process GO:0008654 89 0.017
organophosphate ester transport GO:0015748 45 0.017
nucleotide metabolic process GO:0009117 453 0.017
inorganic ion transmembrane transport GO:0098660 109 0.017
ribonucleotide metabolic process GO:0009259 377 0.017
regulation of dna templated transcription in response to stress GO:0043620 51 0.017
regulation of metal ion transport GO:0010959 2 0.016
positive regulation of secretion by cell GO:1903532 2 0.016
protein lipidation GO:0006497 40 0.016
nucleotide catabolic process GO:0009166 330 0.016
er nucleus signaling pathway GO:0006984 23 0.016
Mouse
atp metabolic process GO:0046034 251 0.016
cellular cation homeostasis GO:0030003 100 0.016
ribonucleoside monophosphate catabolic process GO:0009158 224 0.016
stress activated mapk cascade GO:0051403 4 0.015
energy derivation by oxidation of organic compounds GO:0015980 125 0.015
cellular component disassembly GO:0022411 86 0.015
response to endoplasmic reticulum stress GO:0034976 23 0.015
Mouse Rat
aerobic respiration GO:0009060 55 0.015
regulation of intracellular transport GO:0032386 26 0.014
endoplasmic reticulum unfolded protein response GO:0030968 23 0.014
Mouse
regulation of chromatin organization GO:1902275 23 0.014
cellular chemical homeostasis GO:0055082 123 0.014
protein complex disassembly GO:0043241 70 0.014
negative regulation of phosphorylation GO:0042326 28 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 97 0.014
cellular response to unfolded protein GO:0034620 23 0.014
Mouse
organelle assembly GO:0070925 118 0.014
positive regulation of nucleotide metabolic process GO:0045981 101 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.013
Mouse
mitochondrion organization GO:0007005 261 0.013
purine containing compound metabolic process GO:0072521 400 0.013
establishment of vesicle localization GO:0051650 9 0.013
potassium ion transport GO:0006813 17 0.013
steroid metabolic process GO:0008202 47 0.013
positive regulation of transport GO:0051050 32 0.013
glycoprotein biosynthetic process GO:0009101 61 0.013
programmed cell death GO:0012501 30 0.013
Human
cellular homeostasis GO:0019725 138 0.013
positive regulation of molecular function GO:0044093 185 0.013
Mouse
positive regulation of nucleoside metabolic process GO:0045979 97 0.013
positive regulation of intracellular transport GO:0032388 4 0.013
positive regulation of protein modification process GO:0031401 49 0.013
Mouse
maintenance of protein location in cell GO:0032507 50 0.012
Human
endoplasmic reticulum organization GO:0007029 30 0.012
regulation of purine nucleotide catabolic process GO:0033121 106 0.012
posttranslational protein targeting to membrane GO:0006620 17 0.012
signal transduction involved in conjugation with cellular fusion GO:0032005 31 0.012
pheromone dependent signal transduction involved in conjugation with cellular fusion GO:0000750 31 0.012
organonitrogen compound catabolic process GO:1901565 404 0.012
negative regulation of gene expression GO:0010629 312 0.012
Fly
organophosphate biosynthetic process GO:0090407 182 0.012
chromatin silencing GO:0006342 147 0.012
organic acid metabolic process GO:0006082 352 0.012
response to pheromone GO:0019236 92 0.012
positive regulation of organelle organization GO:0010638 85 0.012
protein refolding GO:0042026 16 0.011
dephosphorylation GO:0016311 127 0.011
nuclear division GO:0000280 263 0.011
nucleoside monophosphate catabolic process GO:0009125 224 0.011
fungal type cell wall assembly GO:0071940 53 0.011
regulation of phosphorylation GO:0042325 86 0.011
Mouse
cell development GO:0048468 107 0.011
sphingolipid biosynthetic process GO:0030148 29 0.011
regulation of gtpase activity GO:0043087 84 0.011
meiotic cell cycle GO:0051321 272 0.011
copii coated vesicle budding GO:0090114 12 0.011
regulation of reproductive process GO:2000241 24 0.011
alpha amino acid metabolic process GO:1901605 124 0.011
response to calcium ion GO:0051592 1 0.011
sporulation resulting in formation of a cellular spore GO:0030435 129 0.011
positive regulation of protein kinase activity GO:0045860 22 0.011
Mouse
mitochondrial transport GO:0006839 76 0.011
protein localization to mitochondrion GO:0070585 63 0.011
rna splicing GO:0008380 131 0.011
response to extracellular stimulus GO:0009991 156 0.011
Human
regulation of establishment of protein localization GO:0070201 17 0.011
ion homeostasis GO:0050801 118 0.011
regulation of stress activated mapk cascade GO:0032872 4 0.010
positive regulation of cellular component organization GO:0051130 116 0.010
positive regulation of cytoplasmic transport GO:1903651 4 0.010
inorganic cation transmembrane transport GO:0098662 98 0.010
regulation of protein transport GO:0051223 17 0.010
ascospore wall biogenesis GO:0070591 52 0.010
gene silencing by rna GO:0031047 3 0.010
Fly
posttranscriptional regulation of gene expression GO:0010608 115 0.010
Fly
cellular metabolic compound salvage GO:0043094 20 0.010
cellular ion homeostasis GO:0006873 112 0.010
fungal type cell wall biogenesis GO:0009272 80 0.010

LHS1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012