Saccharomyces cerevisiae

47 known processes

CHL1 (YPL008W)

Chl1p

(Aliases: MCM12,LPA9,CTF1)

CHL1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
sister chromatid cohesion GO:0007062 49 0.887
dna replication initiation GO:0006270 48 0.867
chromatin silencing GO:0006342 147 0.720
negative regulation of gene expression GO:0010629 312 0.688
sister chromatid segregation GO:0000819 93 0.642
chromosome segregation GO:0007059 159 0.574
negative regulation of cellular metabolic process GO:0031324 407 0.552
mitotic sister chromatid cohesion GO:0007064 38 0.544
negative regulation of macromolecule metabolic process GO:0010605 375 0.535
dna dependent dna replication GO:0006261 115 0.508
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.498
negative regulation of rna biosynthetic process GO:1902679 260 0.490
gene silencing GO:0016458 151 0.469
mitotic cell cycle process GO:1903047 294 0.449
negative regulation of rna metabolic process GO:0051253 262 0.380
negative regulation of transcription dna templated GO:0045892 258 0.370
regulation of gene expression epigenetic GO:0040029 147 0.366
mitotic cell cycle GO:0000278 306 0.345
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.342
negative regulation of cell cycle process GO:0010948 86 0.306
negative regulation of cellular biosynthetic process GO:0031327 312 0.304
negative regulation of nucleic acid templated transcription GO:1903507 260 0.301
negative regulation of gene expression epigenetic GO:0045814 147 0.252
mitotic nuclear division GO:0007067 131 0.252
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.240
dna conformation change GO:0071103 98 0.233
mitotic sister chromatid segregation GO:0000070 85 0.218
regulation of mitosis GO:0007088 65 0.204
dna replication GO:0006260 147 0.196
mitotic cell cycle checkpoint GO:0007093 56 0.191
negative regulation of biosynthetic process GO:0009890 312 0.183
regulation of cell cycle GO:0051726 195 0.166
negative regulation of nuclear division GO:0051784 62 0.158
cellular protein catabolic process GO:0044257 213 0.142
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.141
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.139
cell cycle checkpoint GO:0000075 82 0.138
nuclear division GO:0000280 263 0.131
macromolecule catabolic process GO:0009057 383 0.131
chromatin silencing at telomere GO:0006348 84 0.128
cell division GO:0051301 205 0.126
organelle fission GO:0048285 272 0.122
proteasomal protein catabolic process GO:0010498 141 0.118
regulation of cell cycle process GO:0010564 150 0.116
single organism catabolic process GO:0044712 619 0.113
Human
negative regulation of organelle organization GO:0010639 103 0.111
establishment of sister chromatid cohesion GO:0034085 17 0.105
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 137 0.101
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.101
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.100
cellular macromolecule catabolic process GO:0044265 363 0.098
cell cycle phase transition GO:0044770 144 0.095
negative regulation of catabolic process GO:0009895 43 0.095
modification dependent protein catabolic process GO:0019941 181 0.092
proteolysis GO:0006508 268 0.092
negative regulation of cellular catabolic process GO:0031330 43 0.089
cellular protein complex assembly GO:0043623 209 0.082
negative regulation of mitotic cell cycle GO:0045930 63 0.081
chromatin silencing at silent mating type cassette GO:0030466 53 0.081
cell cycle g2 m phase transition GO:0044839 39 0.080
negative regulation of cell cycle GO:0045786 91 0.079
nucleotide catabolic process GO:0009166 330 0.076
Human
dna repair GO:0006281 236 0.075
negative regulation of mitosis GO:0045839 39 0.074
cellular response to dna damage stimulus GO:0006974 287 0.074
purine ribonucleotide metabolic process GO:0009150 372 0.072
Human
nucleoside metabolic process GO:0009116 394 0.072
Human
regulation of cellular protein metabolic process GO:0032268 232 0.072
double strand break repair GO:0006302 105 0.071
regulation of dna dependent dna replication initiation GO:0030174 21 0.069
protein complex assembly GO:0006461 302 0.065
regulation of cell division GO:0051302 113 0.064
regulation of mitotic cell cycle phase transition GO:1901990 68 0.064
developmental process GO:0032502 261 0.063
negative regulation of cellular component organization GO:0051129 109 0.062
recombinational repair GO:0000725 64 0.061
regulation of mitotic cell cycle GO:0007346 107 0.060
negative regulation of cell division GO:0051782 66 0.059
response to chemical GO:0042221 390 0.059
protein localization to organelle GO:0033365 337 0.059
carbohydrate derivative metabolic process GO:1901135 549 0.059
Human
organelle localization GO:0051640 128 0.058
regulation of chromatin silencing GO:0031935 39 0.058
mitotic cell cycle phase transition GO:0044772 141 0.056
negative regulation of transcription from rna polymerase ii promoter GO:0000122 137 0.056
regulation of organelle organization GO:0033043 243 0.056
organophosphate catabolic process GO:0046434 338 0.056
Human
cell aging GO:0007569 70 0.055
regulation of proteasomal protein catabolic process GO:0061136 34 0.054
cytokinesis GO:0000910 92 0.054
purine ribonucleoside catabolic process GO:0046130 330 0.053
Human
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 27 0.052
regulation of cell cycle phase transition GO:1901987 70 0.052
positive regulation of cellular biosynthetic process GO:0031328 336 0.051
positive regulation of catalytic activity GO:0043085 178 0.051
protein dna complex assembly GO:0065004 105 0.051
negative regulation of chromosome organization GO:2001251 39 0.050
ubiquitin dependent protein catabolic process GO:0006511 181 0.050
nucleoside triphosphate catabolic process GO:0009143 329 0.049
Human
negative regulation of cell cycle phase transition GO:1901988 59 0.049
double strand break repair via homologous recombination GO:0000724 54 0.048
ribonucleoside triphosphate metabolic process GO:0009199 356 0.048
Human
purine ribonucleoside metabolic process GO:0046128 380 0.046
Human
chromatin modification GO:0016568 200 0.046
establishment of mitotic sister chromatid cohesion GO:0034087 15 0.045
regulation of molecular function GO:0065009 320 0.045
spindle checkpoint GO:0031577 35 0.044
negative regulation of protein metabolic process GO:0051248 85 0.043
regulation of cellular component biogenesis GO:0044087 112 0.042
dna packaging GO:0006323 55 0.042
meiotic cell cycle GO:0051321 272 0.041
ribonucleoside metabolic process GO:0009119 389 0.041
Human
regulation of protein processing GO:0070613 34 0.041
regulation of hydrolase activity GO:0051336 133 0.040
modification dependent macromolecule catabolic process GO:0043632 203 0.040
protein dna complex subunit organization GO:0071824 153 0.039
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.039
cell wall organization or biogenesis GO:0071554 190 0.038
regulation of mitotic metaphase anaphase transition GO:0030071 27 0.037
regulation of cellular catabolic process GO:0031329 195 0.037
positive regulation of molecular function GO:0044093 185 0.036
regulation of phosphorus metabolic process GO:0051174 230 0.036
regulation of catalytic activity GO:0050790 307 0.035
establishment of protein localization GO:0045184 367 0.035
ribose phosphate metabolic process GO:0019693 384 0.035
Human
regulation of gene silencing GO:0060968 41 0.035
protein complex biogenesis GO:0070271 314 0.035
negative regulation of mitotic sister chromatid separation GO:2000816 23 0.035
nucleoside triphosphate metabolic process GO:0009141 364 0.035
Human
single organism reproductive process GO:0044702 159 0.034
ribonucleoside catabolic process GO:0042454 332 0.034
Human
protein catabolic process GO:0030163 221 0.034
glycosyl compound catabolic process GO:1901658 335 0.034
Human
protein processing GO:0016485 64 0.034
carbohydrate derivative catabolic process GO:1901136 339 0.034
Human
vesicle mediated transport GO:0016192 335 0.034
organonitrogen compound catabolic process GO:1901565 404 0.033
Human
purine containing compound catabolic process GO:0072523 332 0.033
Human
negative regulation of proteolysis GO:0045861 33 0.032
cellular nitrogen compound catabolic process GO:0044270 494 0.032
Human
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.031
protein maturation GO:0051604 76 0.031
positive regulation of biosynthetic process GO:0009891 336 0.031
cell cycle dna replication GO:0044786 36 0.031
phosphorylation GO:0016310 291 0.030
purine nucleoside triphosphate metabolic process GO:0009144 356 0.030
Human
purine ribonucleotide catabolic process GO:0009154 327 0.030
Human
spindle assembly checkpoint GO:0071173 23 0.029
glycosyl compound metabolic process GO:1901657 398 0.029
Human
negative regulation of proteasomal protein catabolic process GO:1901799 25 0.029
growth GO:0040007 157 0.029
regulation of chromosome organization GO:0033044 66 0.028
filamentous growth of a population of unicellular organisms GO:0044182 109 0.028
regulation of phosphate metabolic process GO:0019220 230 0.027
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 23 0.027
regulation of chromatin silencing at telomere GO:0031938 27 0.027
regulation of cellular component organization GO:0051128 334 0.027
attachment of spindle microtubules to kinetochore GO:0008608 25 0.027
dna recombination GO:0006310 172 0.026
regulation of dna metabolic process GO:0051052 100 0.026
replicative cell aging GO:0001302 46 0.025
cell development GO:0048468 107 0.025
negative regulation of mitotic metaphase anaphase transition GO:0045841 23 0.025
establishment of protein localization to organelle GO:0072594 278 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.025
Human
purine nucleotide metabolic process GO:0006163 376 0.024
Human
lipid metabolic process GO:0006629 269 0.024
cell communication GO:0007154 345 0.024
protein complex disassembly GO:0043241 70 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.024
regulation of nucleotide catabolic process GO:0030811 106 0.024
ribonucleotide catabolic process GO:0009261 327 0.024
Human
nuclear dna replication GO:0033260 27 0.024
regulation of catabolic process GO:0009894 199 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.023
Human
maintenance of location in cell GO:0051651 58 0.023
response to inorganic substance GO:0010035 47 0.023
negative regulation of protein processing GO:0010955 33 0.023
cellular component disassembly GO:0022411 86 0.023
positive regulation of macromolecule metabolic process GO:0010604 394 0.022
dephosphorylation GO:0016311 127 0.022
regulation of protein catabolic process GO:0042176 40 0.022
single organism cellular localization GO:1902580 375 0.022
ribonucleoside triphosphate catabolic process GO:0009203 327 0.022
Human
purine nucleoside metabolic process GO:0042278 380 0.021
Human
maintenance of location GO:0051235 66 0.021
dna integrity checkpoint GO:0031570 41 0.021
cellular response to chemical stimulus GO:0070887 315 0.021
regulation of mitotic sister chromatid separation GO:0010965 29 0.020
protein localization to chromosome GO:0034502 28 0.020
single organism developmental process GO:0044767 258 0.020
organelle assembly GO:0070925 118 0.020
purine containing compound metabolic process GO:0072521 400 0.020
Human
regulation of cellular protein catabolic process GO:1903362 36 0.020
regulation of nuclear division GO:0051783 103 0.019
organic acid metabolic process GO:0006082 352 0.019
regulation of protein phosphorylation GO:0001932 75 0.019
maintenance of protein location GO:0045185 53 0.019
regulation of dna replication GO:0006275 51 0.019
reproductive process in single celled organism GO:0022413 145 0.019
positive regulation of cell cycle process GO:0090068 31 0.019
reproduction of a single celled organism GO:0032505 191 0.019
regulation of purine nucleotide catabolic process GO:0033121 106 0.019
organophosphate metabolic process GO:0019637 597 0.018
Human
protein targeting GO:0006605 272 0.018
carbohydrate metabolic process GO:0005975 252 0.018
nucleoside catabolic process GO:0009164 335 0.018
Human
mitotic spindle assembly checkpoint GO:0007094 23 0.018
maintenance of protein location in cell GO:0032507 50 0.018
negative regulation of phosphate metabolic process GO:0045936 49 0.018
dna damage checkpoint GO:0000077 29 0.017
regulation of biological quality GO:0065008 391 0.017
positive regulation of programmed cell death GO:0043068 3 0.017
purine nucleoside catabolic process GO:0006152 330 0.017
Human
negative regulation of response to stimulus GO:0048585 40 0.017
purine nucleoside triphosphate catabolic process GO:0009146 329 0.017
Human
response to external stimulus GO:0009605 158 0.017
nucleoside phosphate catabolic process GO:1901292 331 0.017
Human
cell differentiation GO:0030154 161 0.017
peptidyl amino acid modification GO:0018193 116 0.017
response to organic substance GO:0010033 182 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 30 0.016
telomere organization GO:0032200 75 0.016
glycerolipid metabolic process GO:0046486 108 0.016
regulation of proteolysis GO:0030162 44 0.016
regulation of nucleotide metabolic process GO:0006140 110 0.016
regulation of purine nucleotide metabolic process GO:1900542 109 0.015
negative regulation of cellular protein catabolic process GO:1903363 27 0.015
response to abiotic stimulus GO:0009628 159 0.015
intracellular protein transport GO:0006886 319 0.015
growth of unicellular organism as a thread of attached cells GO:0070783 105 0.015
ribonucleotide metabolic process GO:0009259 377 0.015
Human
endosomal transport GO:0016197 86 0.015
mitotic chromosome condensation GO:0007076 11 0.015
cytoskeleton organization GO:0007010 230 0.015
response to oxygen containing compound GO:1901700 61 0.015
mitotic dna integrity checkpoint GO:0044774 18 0.015
covalent chromatin modification GO:0016569 119 0.015
regulation of response to stimulus GO:0048583 157 0.015
regulation of dna dependent dna replication GO:0090329 37 0.015
regulation of phosphorylation GO:0042325 86 0.014
internal protein amino acid acetylation GO:0006475 52 0.014
purine nucleotide catabolic process GO:0006195 328 0.014
Human
cell cycle g1 s phase transition GO:0044843 64 0.014
negative regulation of protein catabolic process GO:0042177 27 0.014
dna geometric change GO:0032392 43 0.014
protein phosphorylation GO:0006468 197 0.014
positive regulation of cellular catabolic process GO:0031331 128 0.014
peptidyl lysine modification GO:0018205 77 0.014
g2 m transition of mitotic cell cycle GO:0000086 38 0.014
positive regulation of gene expression GO:0010628 321 0.013
regulation of chromosome segregation GO:0051983 44 0.013
attachment of mitotic spindle microtubules to kinetochore GO:0051315 9 0.013
response to organic cyclic compound GO:0014070 1 0.013
response to calcium ion GO:0051592 1 0.013
positive regulation of cell cycle GO:0045787 32 0.013
positive regulation of organelle organization GO:0010638 85 0.013
nucleoside monophosphate catabolic process GO:0009125 224 0.013
Human
double strand break repair via break induced replication GO:0000727 25 0.013
cellular response to nutrient levels GO:0031669 144 0.013
positive regulation of phosphate metabolic process GO:0045937 147 0.013
anatomical structure formation involved in morphogenesis GO:0048646 136 0.013
sister chromatid biorientation GO:0031134 8 0.013
response to temperature stimulus GO:0009266 74 0.013
monocarboxylic acid metabolic process GO:0032787 122 0.012
cytoskeleton dependent cytokinesis GO:0061640 65 0.012
cellular amine metabolic process GO:0044106 51 0.012
nucleobase containing compound catabolic process GO:0034655 479 0.012
Human
aging GO:0007568 71 0.012
meiotic cell cycle process GO:1903046 229 0.012
response to metal ion GO:0010038 24 0.012
meiotic chromosome segregation GO:0045132 31 0.012
purine nucleoside monophosphate metabolic process GO:0009126 262 0.012
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 36 0.012
methylation GO:0032259 101 0.012
negative regulation of mitotic sister chromatid segregation GO:0033048 24 0.012
single organism carbohydrate metabolic process GO:0044723 237 0.012
regulation of dna templated transcription in response to stress GO:0043620 51 0.012
reproductive process GO:0022414 248 0.012
nucleotide metabolic process GO:0009117 453 0.011
Human
atp catabolic process GO:0006200 224 0.011
Human
heterocycle catabolic process GO:0046700 494 0.011
Human
negative regulation of chromosome segregation GO:0051985 25 0.011
peptidyl lysine acetylation GO:0018394 52 0.011
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.011
regulation of protein maturation GO:1903317 34 0.011
cytokinetic process GO:0032506 78 0.011
gtp catabolic process GO:0006184 107 0.011
cellular carbohydrate metabolic process GO:0044262 135 0.011
microtubule cytoskeleton organization involved in mitosis GO:1902850 13 0.011
cellular amino acid metabolic process GO:0006520 225 0.011
negative regulation of protein maturation GO:1903318 33 0.011
establishment of organelle localization GO:0051656 96 0.010
homeostatic process GO:0042592 227 0.010
cell death GO:0008219 30 0.010
mitotic spindle checkpoint GO:0071174 34 0.010

CHL1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org