Saccharomyces cerevisiae

112 known processes

SIR2 (YDL042C)

Sir2p

(Aliases: MAR1)

SIR2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of gene expression epigenetic GO:0040029 147 0.999
chromatin silencing GO:0006342 147 0.998
gene silencing GO:0016458 151 0.997
negative regulation of transcription dna templated GO:0045892 258 0.997
negative regulation of rna metabolic process GO:0051253 262 0.995
negative regulation of gene expression epigenetic GO:0045814 147 0.993
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.993
negative regulation of rna biosynthetic process GO:1902679 260 0.989
negative regulation of macromolecule metabolic process GO:0010605 375 0.989
negative regulation of nucleic acid templated transcription GO:1903507 260 0.989
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.987
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.982
negative regulation of gene expression GO:0010629 312 0.980
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.980
chromatin modification GO:0016568 200 0.978
negative regulation of biosynthetic process GO:0009890 312 0.977
negative regulation of cellular metabolic process GO:0031324 407 0.977
chromatin organization GO:0006325 242 0.926
double strand break repair GO:0006302 105 0.887
negative regulation of cellular biosynthetic process GO:0031327 312 0.857
cellular response to dna damage stimulus GO:0006974 287 0.771
dna conformation change GO:0071103 98 0.729
dna packaging GO:0006323 55 0.723
cell aging GO:0007569 70 0.695
aging GO:0007568 71 0.681
chromatin silencing at telomere GO:0006348 84 0.591
replicative cell aging GO:0001302 46 0.554
dna repair GO:0006281 236 0.499
regulation of chromatin silencing GO:0031935 39 0.381
chromatin silencing at silent mating type cassette GO:0030466 53 0.372
cellular response to chemical stimulus GO:0070887 315 0.361
nucleobase containing compound catabolic process GO:0034655 479 0.314
single organism developmental process GO:0044767 258 0.292
covalent chromatin modification GO:0016569 119 0.271
signaling GO:0023052 208 0.270
regulation of cell division GO:0051302 113 0.231
dna replication initiation GO:0006270 48 0.228
response to chemical GO:0042221 390 0.223
response to organic substance GO:0010033 182 0.223
heterocycle catabolic process GO:0046700 494 0.221
dna recombination GO:0006310 172 0.209
recombinational repair GO:0000725 64 0.209
histone modification GO:0016570 119 0.202
meiotic cell cycle process GO:1903046 229 0.199
negative regulation of gene silencing GO:0060969 27 0.175
response to oxidative stress GO:0006979 99 0.160
mitotic cell cycle process GO:1903047 294 0.151
cellular nitrogen compound catabolic process GO:0044270 494 0.147
developmental process GO:0032502 261 0.145
macromolecule catabolic process GO:0009057 383 0.142
regulation of cellular component organization GO:0051128 334 0.140
multi organism process GO:0051704 233 0.130
dna replication GO:0006260 147 0.129
nuclear division GO:0000280 263 0.126
aromatic compound catabolic process GO:0019439 491 0.124
cellular amino acid metabolic process GO:0006520 225 0.121
regulation of biological quality GO:0065008 391 0.121
cell communication GO:0007154 345 0.118
negative regulation of chromatin silencing GO:0031936 25 0.117
cellular response to oxidative stress GO:0034599 94 0.117
regulation of vesicle mediated transport GO:0060627 39 0.116
organic cyclic compound catabolic process GO:1901361 499 0.114
regulation of dna metabolic process GO:0051052 100 0.112
carboxylic acid metabolic process GO:0019752 338 0.112
Yeast
nucleus organization GO:0006997 62 0.111
regulation of dna dependent dna replication initiation GO:0030174 21 0.103
single organism catabolic process GO:0044712 619 0.101
protein localization to organelle GO:0033365 337 0.101
chromatin assembly GO:0031497 35 0.098
organelle fission GO:0048285 272 0.094
chromatin silencing at rdna GO:0000183 32 0.089
regulation of transport GO:0051049 85 0.081
regulation of cell cycle process GO:0010564 150 0.078
homeostatic process GO:0042592 227 0.077
non recombinational repair GO:0000726 33 0.075
positive regulation of biosynthetic process GO:0009891 336 0.074
phosphorylation GO:0016310 291 0.068
cellular developmental process GO:0048869 191 0.068
regulation of localization GO:0032879 127 0.067
glycosyl compound metabolic process GO:1901657 398 0.067
double strand break repair via homologous recombination GO:0000724 54 0.067
cellular response to organic substance GO:0071310 159 0.065
anatomical structure homeostasis GO:0060249 74 0.063
regulation of cell communication GO:0010646 124 0.061
rrna transcription GO:0009303 31 0.059
response to nutrient levels GO:0031667 150 0.057
regulation of organelle organization GO:0033043 243 0.057
regulation of dna replication GO:0006275 51 0.055
cellular lipid metabolic process GO:0044255 229 0.054
Yeast
negative regulation of dna metabolic process GO:0051053 36 0.053
cell surface receptor signaling pathway GO:0007166 38 0.053
negative regulation of transcription from rna polymerase ii promoter GO:0000122 137 0.050
cellular response to heat GO:0034605 53 0.050
mitotic cell cycle GO:0000278 306 0.050
reproductive process GO:0022414 248 0.049
chromatin assembly or disassembly GO:0006333 60 0.048
establishment or maintenance of cell polarity GO:0007163 96 0.048
cell cycle phase transition GO:0044770 144 0.048
regulation of gene silencing GO:0060968 41 0.048
single organism signaling GO:0044700 208 0.047
organic acid metabolic process GO:0006082 352 0.047
Yeast
dna damage checkpoint GO:0000077 29 0.045
signal transduction GO:0007165 208 0.044
sexual reproduction GO:0019953 216 0.042
negative regulation of cell division GO:0051782 66 0.042
dna dependent dna replication GO:0006261 115 0.041
meiotic nuclear division GO:0007126 163 0.041
multi organism reproductive process GO:0044703 216 0.040
single organism reproductive process GO:0044702 159 0.040
negative regulation of cell communication GO:0010648 33 0.039
positive regulation of macromolecule metabolic process GO:0010604 394 0.038
lipid localization GO:0010876 60 0.038
nucleoside catabolic process GO:0009164 335 0.038
response to heat GO:0009408 69 0.038
proteolysis GO:0006508 268 0.037
response to oxygen containing compound GO:1901700 61 0.037
small molecule catabolic process GO:0044282 88 0.036
cell differentiation GO:0030154 161 0.036
organonitrogen compound catabolic process GO:1901565 404 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.035
positive regulation of gene expression epigenetic GO:0045815 25 0.035
growth GO:0040007 157 0.034
multi organism cellular process GO:0044764 120 0.034
macromolecule methylation GO:0043414 85 0.034
negative regulation of organelle organization GO:0010639 103 0.034
cellular chemical homeostasis GO:0055082 123 0.032
regulation of transcription by chromatin organization GO:0034401 19 0.032
protein modification by small protein conjugation or removal GO:0070647 172 0.031
nucleotide metabolic process GO:0009117 453 0.031
protein localization to chromosome GO:0034502 28 0.029
mitotic cell cycle phase transition GO:0044772 141 0.029
nucleoside metabolic process GO:0009116 394 0.029
autophagy GO:0006914 106 0.029
regulation of catabolic process GO:0009894 199 0.028
purine containing compound metabolic process GO:0072521 400 0.028
cellular response to starvation GO:0009267 90 0.028
organophosphate metabolic process GO:0019637 597 0.027
carbohydrate derivative metabolic process GO:1901135 549 0.027
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.027
mrna metabolic process GO:0016071 269 0.026
chromatin remodeling GO:0006338 80 0.025
chromosome condensation GO:0030261 19 0.024
cellular response to extracellular stimulus GO:0031668 150 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.023
rdna condensation GO:0070550 9 0.022
oxoacid metabolic process GO:0043436 351 0.022
Yeast
nucleobase containing small molecule metabolic process GO:0055086 491 0.022
nuclear transcribed mrna catabolic process GO:0000956 89 0.022
sex determination GO:0007530 32 0.022
glycosyl compound catabolic process GO:1901658 335 0.022
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.022
dna templated transcription termination GO:0006353 42 0.021
dephosphorylation GO:0016311 127 0.021
g1 s transition of mitotic cell cycle GO:0000082 64 0.021
cellular response to external stimulus GO:0071496 150 0.021
negative regulation of cellular component organization GO:0051129 109 0.021
reproduction of a single celled organism GO:0032505 191 0.020
response to organic cyclic compound GO:0014070 1 0.020
protein phosphorylation GO:0006468 197 0.020
double strand break repair via nonhomologous end joining GO:0006303 27 0.019
negative regulation of cell cycle process GO:0010948 86 0.018
regulation of response to stress GO:0080134 57 0.018
protein ubiquitination GO:0016567 118 0.018
negative regulation of mitotic cell cycle GO:0045930 63 0.018
organophosphate catabolic process GO:0046434 338 0.018
purine containing compound catabolic process GO:0072523 332 0.018
regulation of multi organism process GO:0043900 20 0.017
single organism cellular localization GO:1902580 375 0.017
response to uv GO:0009411 4 0.017
regulation of cellular response to stress GO:0080135 50 0.017
response to external stimulus GO:0009605 158 0.017
response to abiotic stimulus GO:0009628 159 0.016
regulation of cell growth GO:0001558 29 0.016
conjugation GO:0000746 107 0.016
telomere maintenance via telomerase GO:0007004 21 0.016
lipid metabolic process GO:0006629 269 0.016
Yeast
cell division GO:0051301 205 0.016
cellular ketone metabolic process GO:0042180 63 0.016
carbohydrate derivative catabolic process GO:1901136 339 0.015
cellular protein catabolic process GO:0044257 213 0.015
snrna processing GO:0016180 17 0.015
telomere organization GO:0032200 75 0.015
regulation of cell cycle phase transition GO:1901987 70 0.015
regulation of catalytic activity GO:0050790 307 0.015
cellular amino acid catabolic process GO:0009063 48 0.015
cell fate commitment GO:0045165 32 0.015
ribose phosphate metabolic process GO:0019693 384 0.014
regulation of dna dependent dna replication GO:0090329 37 0.014
mating type switching GO:0007533 28 0.014
conjugation with cellular fusion GO:0000747 106 0.014
meiotic cell cycle GO:0051321 272 0.014
trna metabolic process GO:0006399 151 0.014
response to inorganic substance GO:0010035 47 0.013
establishment of cell polarity GO:0030010 64 0.013
carbohydrate metabolic process GO:0005975 252 0.013
positive regulation of cellular biosynthetic process GO:0031328 336 0.013
negative regulation of cell cycle phase transition GO:1901988 59 0.013
peptidyl lysine modification GO:0018205 77 0.013
regulation of mitotic cell cycle phase transition GO:1901990 68 0.012
protein dna complex subunit organization GO:0071824 153 0.012
ribonucleotide metabolic process GO:0009259 377 0.012
positive regulation of catabolic process GO:0009896 135 0.012
negative regulation of cell cycle GO:0045786 91 0.012
mrna catabolic process GO:0006402 93 0.012
mating type determination GO:0007531 32 0.012
regulation of response to stimulus GO:0048583 157 0.012
regulation of meiotic cell cycle GO:0051445 43 0.012
peptidyl lysine acetylation GO:0018394 52 0.011
regulation of chromatin silencing at telomere GO:0031938 27 0.011
protein complex assembly GO:0006461 302 0.011
positive regulation of rna metabolic process GO:0051254 294 0.011
rna catabolic process GO:0006401 118 0.011
regulation of signal transduction GO:0009966 114 0.011
response to temperature stimulus GO:0009266 74 0.011
dna catabolic process GO:0006308 42 0.011
regulation of cellular ketone metabolic process GO:0010565 42 0.011
regulation of protein metabolic process GO:0051246 237 0.011
positive regulation of dna metabolic process GO:0051054 26 0.011
regulation of molecular function GO:0065009 320 0.010
telomere maintenance via telomere lengthening GO:0010833 22 0.010
peptidyl amino acid modification GO:0018193 116 0.010
double strand break repair via break induced replication GO:0000727 25 0.010
cellular ion homeostasis GO:0006873 112 0.010
positive regulation of nucleic acid templated transcription GO:1903508 286 0.010
internal protein amino acid acetylation GO:0006475 52 0.010
transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery GO:0000972 19 0.010
response to endogenous stimulus GO:0009719 26 0.010

SIR2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015