Danio rerio

0 known processes

hsd17b12b

hydroxysteroid (17-beta) dehydrogenase 12b

(Aliases: zgc:73289,fb68b12,wu:fb68b12)

hsd17b12b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biological quality GO:0065008 263 0.372
Zebrafish Worm
larval development GO:0002164 2 0.310
Worm
androgen metabolic process GO:0008209 2 0.294
Zebrafish Worm
female sex differentiation GO:0046660 4 0.212
Worm
dicarboxylic acid metabolic process GO:0043648 1 0.183
aging GO:0007568 2 0.167
Worm
embryonic organ morphogenesis GO:0048562 274 0.162
membrane lipid biosynthetic process GO:0046467 2 0.158
Yeast
signal transduction GO:0007165 455 0.153
regulation of response to stimulus GO:0048583 269 0.140
organic substance biosynthetic process GO:1901576 289 0.129
Yeast Zebrafish Worm
cell death GO:0008219 121 0.127
embryonic organ development GO:0048568 381 0.122
regulation of signaling GO:0023051 235 0.114
single organism metabolic process GO:0044710 217 0.112
Yeast Zebrafish Worm
androgen biosynthetic process GO:0006702 1 0.111
Zebrafish
positive regulation of cytokine production GO:0001819 2 0.108
programmed cell death GO:0012501 119 0.107
cellular biosynthetic process GO:0044249 286 0.104
Yeast Zebrafish Worm
very long chain fatty acid biosynthetic process GO:0042761 4 0.104
Yeast
very long chain fatty acid metabolic process GO:0000038 4 0.096
Yeast
regulation of signal transduction GO:0009966 225 0.095
single organism biosynthetic process GO:0044711 71 0.095
Yeast Zebrafish Worm
organelle organization GO:0006996 227 0.094
death GO:0016265 121 0.092
hormone metabolic process GO:0042445 19 0.083
Zebrafish Worm
fatty acid elongation GO:0030497 1 0.079
Yeast
regulation of multicellular organismal process GO:0051239 277 0.076
organic cyclic compound biosynthetic process GO:1901362 223 0.075
Zebrafish Worm
locomotion GO:0040011 313 0.075
Worm
cellular response to nutrient levels GO:0031669 2 0.074
central nervous system development GO:0007417 387 0.070
cellular component movement GO:0006928 335 0.069
positive regulation of biological process GO:0048518 253 0.068
Mouse
lipid storage GO:0019915 1 0.067
hormone biosynthetic process GO:0042446 3 0.065
Zebrafish
long chain fatty acid biosynthetic process GO:0042759 1 0.064
Worm
brain development GO:0007420 293 0.064
single organism localization GO:1902578 225 0.063
lipid biosynthetic process GO:0008610 22 0.061
Yeast Zebrafish Worm
angiogenesis GO:0001525 158 0.060
neuron development GO:0048666 262 0.060
response to organic substance GO:0010033 153 0.059
organonitrogen compound metabolic process GO:1901564 74 0.059
Yeast
negative regulation of biological process GO:0048519 304 0.059
stem cell maintenance GO:0019827 4 0.059
regulation of cytokine production GO:0001817 3 0.059
transmembrane transport GO:0055085 120 0.058
specification of symmetry GO:0009799 204 0.057
regulation of muscle contraction GO:0006937 3 0.057
regulation of tube size GO:0035150 2 0.057
apoptotic process GO:0006915 116 0.056
cellular response to external stimulus GO:0071496 2 0.053
atp catabolic process GO:0006200 4 0.053
mesenchyme development GO:0060485 127 0.053
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.053
regulation of dna templated transcription in response to stress GO:0043620 0 0.053
zinc ion homeostasis GO:0055069 1 0.052
regulation of cell death GO:0010941 103 0.051
regulation of multicellular organismal development GO:2000026 223 0.051
mechanosensory lateral line system development GO:0048881 49 0.051
ion homeostasis GO:0050801 41 0.051
regulation of blood pressure GO:0008217 1 0.051
regulation of multicellular organism growth GO:0040014 4 0.050
regulation of programmed cell death GO:0043067 101 0.050
oxidation reduction process GO:0055114 41 0.050
Yeast Zebrafish Worm
liver development GO:0001889 96 0.050
biosynthetic process GO:0009058 294 0.049
Yeast Zebrafish Worm
ribonucleoside monophosphate catabolic process GO:0009158 4 0.049
alpha amino acid metabolic process GO:1901605 3 0.048
neuromast development GO:0048884 46 0.047
gastrulation GO:0007369 208 0.047
carboxylic acid biosynthetic process GO:0046394 12 0.046
Yeast Worm
determination of bilateral symmetry GO:0009855 204 0.045
organic acid biosynthetic process GO:0016053 12 0.045
Yeast Worm
homeostatic process GO:0042592 142 0.045
positive regulation of cellular process GO:0048522 201 0.044
Mouse
inner ear development GO:0048839 126 0.043
cellular response to organic substance GO:0071310 105 0.043
stem cell differentiation GO:0048863 117 0.043
maintenance of location GO:0051235 4 0.043
cellular response to chemical stimulus GO:0070887 157 0.042
cellular response to starvation GO:0009267 1 0.042
neuron differentiation GO:0030182 353 0.042
regulation of reproductive process GO:2000241 4 0.042
negative regulation of cellular process GO:0048523 283 0.041
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.041
actomyosin structure organization GO:0031032 53 0.041
regulation of cell communication GO:0010646 232 0.041
multicellular organismal response to stress GO:0033555 2 0.041
Zebrafish
cellular response to extracellular stimulus GO:0031668 2 0.040
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.040
regulation of nucleic acid templated transcription GO:1903506 213 0.040
stem cell development GO:0048864 82 0.039
metal ion homeostasis GO:0055065 26 0.039
cellular modified amino acid metabolic process GO:0006575 3 0.038
sensory organ development GO:0007423 393 0.038
macromolecule localization GO:0033036 54 0.038
smooth muscle contraction GO:0006939 2 0.037
hepaticobiliary system development GO:0061008 98 0.037
positive regulation of stress activated mapk cascade GO:0032874 3 0.037
cell death in response to oxidative stress GO:0036473 2 0.036
oxoacid metabolic process GO:0043436 31 0.036
Yeast Worm
generation of neurons GO:0048699 385 0.036
mesenchymal cell differentiation GO:0048762 87 0.036
regulation of rna biosynthetic process GO:2001141 213 0.036
establishment of localization GO:0051234 244 0.035
synaptic vesicle localization GO:0097479 1 0.035
reactive oxygen species biosynthetic process GO:1903409 1 0.035
nik nf kappab signaling GO:0038061 1 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.035
single organism organelle organization GO:1902589 199 0.034
estrogen metabolic process GO:0008210 2 0.034
Worm
monocarboxylic acid biosynthetic process GO:0072330 12 0.034
Yeast Worm
response to stress GO:0006950 263 0.034
Zebrafish
ovulation cycle process GO:0022602 2 0.033
regulation of protein catabolic process GO:0042176 1 0.033
protein metabolic process GO:0019538 183 0.033
positive regulation of cell cycle GO:0045787 3 0.032
cellular amide metabolic process GO:0043603 4 0.032
ovulation cycle GO:0042698 2 0.032
nucleobase containing compound metabolic process GO:0006139 274 0.032
fatty acid biosynthetic process GO:0006633 4 0.032
Yeast Worm
immune system process GO:0002376 241 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.031
purine nucleoside monophosphate catabolic process GO:0009128 4 0.031
negative regulation of catabolic process GO:0009895 3 0.031
small molecule catabolic process GO:0044282 3 0.031
regulation of protein ubiquitination GO:0031396 3 0.031
response to topologically incorrect protein GO:0035966 2 0.030
cellular response to topologically incorrect protein GO:0035967 2 0.030
cellular component morphogenesis GO:0032989 336 0.030
germ line stem cell maintenance GO:0030718 2 0.030
response to lipid GO:0033993 60 0.030
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
macromolecule biosynthetic process GO:0009059 227 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.030
regulation of reactive oxygen species metabolic process GO:2000377 2 0.029
regulation of developmental process GO:0050793 247 0.029
nucleobase containing compound biosynthetic process GO:0034654 205 0.029
muscle cell development GO:0055001 115 0.028
regulation of apoptotic process GO:0042981 98 0.028
regionalization GO:0003002 274 0.028
steroid biosynthetic process GO:0006694 5 0.028
Zebrafish Worm
cell part morphogenesis GO:0032990 246 0.028
multicellular organism growth GO:0035264 4 0.028
response to glucocorticoid GO:0051384 1 0.027
heterocycle biosynthetic process GO:0018130 215 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.027
regulation of cell activation GO:0050865 1 0.026
chordate embryonic development GO:0043009 271 0.026
zymogen activation GO:0031638 3 0.026
small molecule biosynthetic process GO:0044283 16 0.026
Yeast Worm
regulation of oxidative stress induced cell death GO:1903201 2 0.026
response to carbohydrate GO:0009743 3 0.026
cell motility GO:0048870 244 0.025
iron ion homeostasis GO:0055072 4 0.025
cellular response to unfolded protein GO:0034620 2 0.025
cell aging GO:0007569 2 0.025
negative regulation of developmental process GO:0051093 65 0.025
cellular protein catabolic process GO:0044257 4 0.025
organic cyclic compound metabolic process GO:1901360 301 0.025
Zebrafish Worm
regulation of stem cell differentiation GO:2000736 4 0.025
regulation of response to nutrient levels GO:0032107 1 0.025
carboxylic acid metabolic process GO:0019752 22 0.024
Yeast Worm
lateral line development GO:0048882 66 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
female gonad development GO:0008585 4 0.024
response to nutrient GO:0007584 3 0.024
regulation of rac protein signal transduction GO:0035020 1 0.024
response to fatty acid GO:0070542 5 0.023
determination of left right symmetry GO:0007368 179 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
cell migration GO:0016477 237 0.023
lipid metabolic process GO:0006629 52 0.023
Yeast Zebrafish Worm
development of primary female sexual characteristics GO:0046545 4 0.023
regulation of hormone metabolic process GO:0032350 6 0.022
Worm
cellular amino acid metabolic process GO:0006520 7 0.022
transport GO:0006810 220 0.022
multi organism process GO:0051704 134 0.022
embryonic cranial skeleton morphogenesis GO:0048701 90 0.022
determination of heart left right asymmetry GO:0061371 117 0.022
establishment of localization in cell GO:0051649 77 0.022
synaptic vesicle transport GO:0048489 1 0.022
embryonic skeletal system development GO:0048706 97 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
small molecule metabolic process GO:0044281 77 0.021
Yeast Worm
cellular protein metabolic process GO:0044267 129 0.021
cellular component biogenesis GO:0044085 178 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
negative regulation of apoptotic process GO:0043066 55 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
hydrogen peroxide metabolic process GO:0042743 2 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
skeletal system development GO:0001501 181 0.020
response to chemical GO:0042221 320 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
ion transport GO:0006811 114 0.020
sensory system development GO:0048880 76 0.020
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.020
single organism transport GO:0044765 206 0.019
lateral line system development GO:0048925 76 0.019
response to corticosteroid GO:0031960 1 0.019
cell type specific apoptotic process GO:0097285 22 0.019
negative regulation of reproductive process GO:2000242 3 0.019
establishment of synaptic vesicle localization GO:0097480 1 0.019
response to external stimulus GO:0009605 264 0.019
blood vessel morphogenesis GO:0048514 216 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
protein secretion GO:0009306 1 0.019
mitochondrion organization GO:0007005 4 0.019
muscle contraction GO:0006936 18 0.019
er nucleus signaling pathway GO:0006984 2 0.019
regulation of protein complex assembly GO:0043254 3 0.019
developmental growth GO:0048589 166 0.018
positive regulation of neuron death GO:1901216 1 0.018
peptidyl serine phosphorylation GO:0018105 1 0.018
nucleic acid metabolic process GO:0090304 244 0.018
regulation of response to oxidative stress GO:1902882 2 0.018
regulation of anatomical structure morphogenesis GO:0022603 130 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.018
embryo development ending in birth or egg hatching GO:0009792 271 0.018
Worm
regulation of anatomical structure size GO:0090066 33 0.018
cellular response to lipid GO:0071396 39 0.018
endosomal transport GO:0016197 2 0.018
mitochondrial transport GO:0006839 2 0.018
heterocycle metabolic process GO:0046483 290 0.018
endoplasmic reticulum unfolded protein response GO:0030968 2 0.018
forebrain cell migration GO:0021885 1 0.018
alcohol biosynthetic process GO:0046165 2 0.018
regulation of cellular protein catabolic process GO:1903362 1 0.018
regulation of jak stat cascade GO:0046425 3 0.018
regulation of primary metabolic process GO:0080090 311 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.018
heart morphogenesis GO:0003007 156 0.017
embryonic heart tube morphogenesis GO:0003143 108 0.017
regulation of biosynthetic process GO:0009889 250 0.017
calcium ion import GO:0070509 4 0.017
negative regulation of signal transduction GO:0009968 94 0.017
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.017
protein complex biogenesis GO:0070271 30 0.017
calcium ion transport into cytosol GO:0060402 3 0.016
regulation of localization GO:0032879 104 0.016
nitric oxide biosynthetic process GO:0006809 2 0.016
gene expression GO:0010467 252 0.016
blood circulation GO:0008015 87 0.016
embryonic skeletal system morphogenesis GO:0048704 93 0.016
negative regulation of cell communication GO:0010648 96 0.016
heart looping GO:0001947 94 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.016
response to endogenous stimulus GO:0009719 83 0.016
macroautophagy GO:0016236 1 0.016
regulation of metabolic process GO:0019222 359 0.016
Worm
cellular response to oxygen radical GO:0071450 2 0.016
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.016
system process GO:0003008 185 0.016
localization of cell GO:0051674 244 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
axon development GO:0061564 166 0.016
intracellular transport GO:0046907 32 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
growth GO:0040007 174 0.015
protein complex assembly GO:0006461 30 0.015
sensory perception of chemical stimulus GO:0007606 3 0.015
regulation of rna metabolic process GO:0051252 224 0.015
negative regulation of cellular catabolic process GO:0031330 3 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
oocyte maturation GO:0001556 4 0.015
b cell activation GO:0042113 2 0.015
compound eye development GO:0048749 2 0.015
neuron death GO:0070997 21 0.015
single organism intracellular transport GO:1902582 25 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
Yeast
head development GO:0060322 303 0.015
protein homooligomerization GO:0051260 3 0.015
regulation of autophagy GO:0010506 3 0.015
tyrosine phosphorylation of stat protein GO:0007260 1 0.015
ear development GO:0043583 127 0.015
photoreceptor cell outer segment organization GO:0035845 9 0.015
regulation of systemic arterial blood pressure GO:0003073 1 0.015
germ line stem cell division GO:0042078 1 0.014
positive regulation of immune effector process GO:0002699 3 0.014
carbohydrate homeostasis GO:0033500 1 0.014
forebrain development GO:0030900 96 0.014
response to alkaloid GO:0043279 2 0.014
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.014
cell morphogenesis GO:0000902 289 0.014
organic substance transport GO:0071702 58 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
neural crest cell differentiation GO:0014033 72 0.014
nucleoside monophosphate catabolic process GO:0009125 4 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
rna metabolic process GO:0016070 219 0.014
regulation of cellular response to oxidative stress GO:1900407 2 0.014
organic acid metabolic process GO:0006082 31 0.014
Yeast Worm
synaptic target recognition GO:0008039 1 0.013
energy reserve metabolic process GO:0006112 2 0.013
regulation of inflammatory response GO:0050727 2 0.013
cell projection morphogenesis GO:0048858 244 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
protein import GO:0017038 3 0.013
cellular component assembly GO:0022607 170 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
developmental growth involved in morphogenesis GO:0060560 86 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
epithelial to mesenchymal transition GO:0001837 21 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
positive regulation of programmed cell death GO:0043068 29 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.013
positive regulation of rna biosynthetic process GO:1902680 57 0.013
embryonic viscerocranium morphogenesis GO:0048703 52 0.013
response to drug GO:0042493 3 0.013
embryonic heart tube development GO:0035050 133 0.013
neurotransmitter secretion GO:0007269 2 0.013
regulation of locomotion GO:0040012 55 0.013
myeloid cell homeostasis GO:0002262 56 0.012
cellular transition metal ion homeostasis GO:0046916 3 0.012
positive regulation of cell division GO:0051781 2 0.012
protein modification process GO:0036211 100 0.012
inner ear receptor cell differentiation GO:0060113 29 0.012
response to monosaccharide GO:0034284 3 0.012
protein stabilization GO:0050821 2 0.012
negative regulation of cell death GO:0060548 60 0.012
nitric oxide metabolic process GO:0046209 2 0.012
digestive tract morphogenesis GO:0048546 231 0.012
cation homeostasis GO:0055080 33 0.012
long chain fatty acid metabolic process GO:0001676 1 0.012
Worm
regulation of protein transport GO:0051223 3 0.012
ovarian follicle development GO:0001541 2 0.012
cell migration involved in gastrulation GO:0042074 79 0.012
negative regulation of translation GO:0017148 1 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
hematopoietic stem cell differentiation GO:0060218 20 0.012
chemical homeostasis GO:0048878 49 0.012
neuron apoptotic process GO:0051402 20 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
photoreceptor cell differentiation GO:0046530 55 0.012
regulation of cellular component movement GO:0051270 55 0.012
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
peripheral nervous system development GO:0007422 55 0.011
nucleic acid templated transcription GO:0097659 181 0.011
positive regulation of response to stimulus GO:0048584 80 0.011
skeletal system morphogenesis GO:0048705 102 0.011
photoreceptor cell development GO:0042461 40 0.011
cytoskeleton organization GO:0007010 96 0.011
gland development GO:0048732 143 0.011
intracellular signal transduction GO:0035556 85 0.011
regulation of wnt signaling pathway GO:0030111 53 0.011
apoptotic signaling pathway GO:0097190 23 0.011
negative regulation of nuclear division GO:0051784 3 0.011
epithelial cell development GO:0002064 42 0.011
regulation of binding GO:0051098 3 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
pigmentation GO:0043473 85 0.011
mesoderm development GO:0007498 88 0.011
muscle cell differentiation GO:0042692 139 0.011
regulation of cell differentiation GO:0045595 142 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
blood vessel development GO:0001568 246 0.011
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.011
negative regulation of multi organism process GO:0043901 3 0.011
macromolecular complex assembly GO:0065003 35 0.011
neuron projection morphogenesis GO:0048812 161 0.011
lipid oxidation GO:0034440 1 0.011
response to abiotic stimulus GO:0009628 122 0.011
negative regulation of signaling GO:0023057 96 0.011
response to unfolded protein GO:0006986 2 0.010
transcription dna templated GO:0006351 181 0.010
divalent inorganic cation homeostasis GO:0072507 22 0.010
positive regulation of metabolic process GO:0009893 108 0.010
positive regulation of transport GO:0051050 2 0.010
response to uv GO:0009411 3 0.010
negative regulation of kinase activity GO:0033673 4 0.010
connective tissue development GO:0061448 99 0.010
regulation of nitrogen compound metabolic process GO:0051171 251 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
Mouse
gamete generation GO:0007276 33 0.010
immune system development GO:0002520 191 0.010
calcium mediated signaling GO:0019722 2 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
carboxylic acid catabolic process GO:0046395 3 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010
reproductive process GO:0022414 40 0.010
Worm

hsd17b12b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.136
nervous system disease DOID:863 0 0.085
motor neuron disease DOID:231 0 0.043
central nervous system disease DOID:331 0 0.043
neurodegenerative disease DOID:1289 0 0.043
amyotrophic lateral sclerosis DOID:332 0 0.043
disease of metabolism DOID:0014667 0 0.033
inherited metabolic disorder DOID:655 0 0.033
disease of cellular proliferation DOID:14566 0 0.015
cancer DOID:162 0 0.015
sensory system disease DOID:0050155 0 0.013