Danio rerio

161 known processes

gli2a

GLI-Kruppel family member GLI2a

(Aliases: gli2,yot,fc85b05,wu:fc85b05)

gli2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.999
chordate embryonic development GO:0043009 271 0.998
embryonic organ development GO:0048568 381 0.998
digestive tract development GO:0048565 265 0.996
skeletal system development GO:0001501 181 0.996
Mouse
regulation of response to stimulus GO:0048583 269 0.994
Zebrafish Mouse
digestive system development GO:0055123 289 0.994
generation of neurons GO:0048699 385 0.994
chemotaxis GO:0006935 104 0.990
embryonic organ morphogenesis GO:0048562 274 0.989
neural tube development GO:0021915 62 0.988
retinal ganglion cell axon guidance GO:0031290 35 0.987
axon guidance GO:0007411 86 0.987
response to external stimulus GO:0009605 264 0.986
forebrain development GO:0030900 96 0.985
diencephalon development GO:0021536 58 0.984
neuron projection guidance GO:0097485 86 0.984
central nervous system neuron differentiation GO:0021953 74 0.984
axon development GO:0061564 166 0.982
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.978
regulation of signal transduction GO:0009966 225 0.977
Zebrafish Mouse
cell migration GO:0016477 237 0.971
Worm
endochondral bone morphogenesis GO:0060350 8 0.969
sensory organ development GO:0007423 393 0.967
Mouse Fly
cell differentiation in spinal cord GO:0021515 40 0.963
ear morphogenesis GO:0042471 64 0.960
Mouse
regulation of cell communication GO:0010646 232 0.958
Zebrafish Mouse
morphogenesis of an epithelium GO:0002009 333 0.958
Mouse
axonogenesis GO:0007409 152 0.955
brain development GO:0007420 293 0.955
neuron differentiation GO:0030182 353 0.954
regulation of primary metabolic process GO:0080090 311 0.947
Human Zebrafish Mouse Worm Fly
regulation of nervous system development GO:0051960 90 0.946
specification of symmetry GO:0009799 204 0.939
regulation of developmental process GO:0050793 247 0.939
spinal cord motor neuron differentiation GO:0021522 26 0.938
positive regulation of neural precursor cell proliferation GO:2000179 1 0.936
Mouse
response to chemical GO:0042221 320 0.936
regulation of cell differentiation GO:0045595 142 0.926
smoothened signaling pathway GO:0007224 30 0.919
cell migration involved in gastrulation GO:0042074 79 0.917
connective tissue development GO:0061448 99 0.915
Mouse
biosynthetic process GO:0009058 294 0.914
Human Zebrafish Mouse Worm Fly
cellular component movement GO:0006928 335 0.913
notochord development GO:0030903 54 0.908
Mouse
locomotion GO:0040011 313 0.906
cilium organization GO:0044782 71 0.906
cell morphogenesis GO:0000902 289 0.900
regulation of signaling GO:0023051 235 0.899
Zebrafish Mouse
neuron projection morphogenesis GO:0048812 161 0.898
enzyme linked receptor protein signaling pathway GO:0007167 106 0.896
cell cell signaling GO:0007267 52 0.895
Mouse
endothelial cell fate commitment GO:0060839 3 0.893
cellular component morphogenesis GO:0032989 336 0.888
regulation of neural precursor cell proliferation GO:2000177 3 0.887
Mouse
neuron projection development GO:0031175 180 0.886
localization of cell GO:0051674 244 0.883
Worm
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.877
organic cyclic compound metabolic process GO:1901360 301 0.876
Human Zebrafish Mouse Worm Fly
digestive tract morphogenesis GO:0048546 231 0.870
eye development GO:0001654 277 0.866
Fly
determination of heart left right asymmetry GO:0061371 117 0.865
cellular macromolecule metabolic process GO:0044260 391 0.865
Human Zebrafish Mouse Worm Fly
tube morphogenesis GO:0035239 349 0.864
ventral spinal cord development GO:0021517 35 0.863
skeletal muscle fiber development GO:0048741 35 0.863
regulation of neuron differentiation GO:0045664 56 0.858
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.853
inner ear development GO:0048839 126 0.847
Mouse
cell fate commitment GO:0045165 99 0.846
signal transduction GO:0007165 455 0.844
cell fate specification GO:0001708 68 0.844
cell motility GO:0048870 244 0.842
Worm
bone development GO:0060348 14 0.841
regulation of cell development GO:0060284 100 0.837
negative regulation of endothelial cell migration GO:0010596 1 0.834
somatic motor neuron differentiation GO:0021523 5 0.834
regulation of multicellular organismal development GO:2000026 223 0.831
motor neuron axon guidance GO:0008045 23 0.828
cartilage development GO:0051216 96 0.819
Mouse
bmp signaling pathway GO:0030509 52 0.819
ear development GO:0043583 127 0.818
Mouse
endocrine system development GO:0035270 65 0.812
vasculature development GO:0001944 278 0.808
bone morphogenesis GO:0060349 11 0.802
cell projection morphogenesis GO:0048858 244 0.794
somite development GO:0061053 96 0.790
heart development GO:0007507 313 0.788
Mouse Fly
epithelial cell differentiation GO:0030855 116 0.784
Human Fly
embryonic skeletal system morphogenesis GO:0048704 93 0.781
spinal cord development GO:0021510 46 0.781
cell surface receptor signaling pathway GO:0007166 325 0.778
blood vessel morphogenesis GO:0048514 216 0.775
adenohypophysis morphogenesis GO:0048855 4 0.772
regulation of neurogenesis GO:0050767 87 0.762
somitogenesis GO:0001756 87 0.756
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.755
muscle cell differentiation GO:0042692 139 0.751
regulation of metabolic process GO:0019222 359 0.740
heart looping GO:0001947 94 0.735
cell proliferation GO:0008283 80 0.729
Human Mouse
determination of left right symmetry GO:0007368 179 0.729
eye morphogenesis GO:0048592 144 0.716
Fly
somite specification GO:0001757 12 0.710
heart jogging GO:0003146 40 0.710
blood vessel development GO:0001568 246 0.701
regulation of macromolecule metabolic process GO:0060255 317 0.698
negative regulation of neurogenesis GO:0050768 20 0.694
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.688
Human Zebrafish Mouse Worm Fly
gastrulation GO:0007369 208 0.681
inner ear morphogenesis GO:0042472 63 0.680
Mouse
regulation of bmp signaling pathway GO:0030510 39 0.679
embryonic skeletal system development GO:0048706 97 0.676
embryonic heart tube morphogenesis GO:0003143 108 0.666
hematopoietic or lymphoid organ development GO:0048534 191 0.662
Mouse
angiogenesis GO:0001525 158 0.655
determination of bilateral symmetry GO:0009855 204 0.649
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.646
positive regulation of cellular biosynthetic process GO:0031328 68 0.642
Human Mouse Worm Fly
camera type eye morphogenesis GO:0048593 108 0.619
sensory organ morphogenesis GO:0090596 200 0.614
Mouse Fly
forebrain anterior posterior pattern specification GO:0021797 3 0.609
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.600
embryonic heart tube development GO:0035050 133 0.599
epidermal cell differentiation GO:0009913 36 0.599
Human
striated muscle cell development GO:0055002 108 0.599
patterning of blood vessels GO:0001569 15 0.598
rhombomere morphogenesis GO:0021593 17 0.592
forebrain neuron development GO:0021884 7 0.589
hindbrain development GO:0030902 91 0.588
Zebrafish Mouse
head development GO:0060322 303 0.584
cardiac atrium morphogenesis GO:0003209 2 0.581
positive regulation of cell cycle GO:0045787 3 0.581
Fly
neuron projection extension GO:1990138 45 0.579
muscle organ development GO:0007517 101 0.576
neuron development GO:0048666 262 0.576
vasculogenesis GO:0001570 41 0.574
negative regulation of epithelial cell migration GO:0010633 1 0.572
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.564
positive regulation of cellular process GO:0048522 201 0.563
Human Zebrafish Mouse Worm Fly
positive regulation of response to stimulus GO:0048584 80 0.557
Zebrafish
gland development GO:0048732 143 0.556
autonomic nervous system development GO:0048483 19 0.546
Zebrafish
commissural neuron axon guidance GO:0071679 3 0.543
hypochord development GO:0055016 3 0.539
ventral spinal cord interneuron specification GO:0021521 3 0.539
Zebrafish Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.536
negative regulation of biological process GO:0048519 304 0.535
Human Mouse Worm
myotube cell development GO:0014904 35 0.534
floor plate development GO:0033504 15 0.530
heart morphogenesis GO:0003007 156 0.529
Fly
neuron fate commitment GO:0048663 26 0.526
Zebrafish Mouse
positive regulation of transcription dna templated GO:0045893 57 0.518
Human Mouse Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.517
Human Zebrafish Mouse Worm Fly
proximal distal pattern formation GO:0009954 1 0.516
Mouse
cilium assembly GO:0042384 58 0.512
mesoderm development GO:0007498 88 0.511
facial nerve development GO:0021561 3 0.506
Zebrafish
ameboidal type cell migration GO:0001667 143 0.504
cell projection organization GO:0030030 284 0.504
cell part morphogenesis GO:0032990 246 0.504
stem cell development GO:0048864 82 0.503
embryonic cranial skeleton morphogenesis GO:0048701 90 0.501
positive regulation of cellular metabolic process GO:0031325 94 0.499
Human Mouse Worm Fly
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.498
abducens nucleus development GO:0021742 2 0.498
Zebrafish
camera type eye development GO:0043010 222 0.497
g1 s transition of mitotic cell cycle GO:0000082 1 0.496
Fly
skeletal system morphogenesis GO:0048705 102 0.495
epithelial cell development GO:0002064 42 0.490
aorta development GO:0035904 4 0.488
pituitary gland development GO:0021983 16 0.484
hypophysis morphogenesis GO:0048850 5 0.479
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.476
lymph vessel morphogenesis GO:0036303 25 0.472
patterning of lymph vessels GO:0060854 1 0.465
regulation of extent of cell growth GO:0061387 29 0.462
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.462
floor plate morphogenesis GO:0033505 12 0.460
embryonic camera type eye development GO:0031076 29 0.449
negative regulation of axon guidance GO:1902668 1 0.449
negative regulation of axonogenesis GO:0050771 7 0.448
appendage development GO:0048736 80 0.443
Mouse
adenohypophysis development GO:0021984 15 0.435
telencephalon development GO:0021537 14 0.433
cell fate specification involved in pattern specification GO:0060573 3 0.431
Zebrafish Mouse
positive regulation of signal transduction GO:0009967 56 0.425
Zebrafish
apoptotic process GO:0006915 116 0.419
Worm
taxis GO:0042330 109 0.415
diencephalon morphogenesis GO:0048852 5 0.414
positive regulation of biological process GO:0048518 253 0.406
Human Zebrafish Mouse Worm Fly
primary neural tube formation GO:0014020 1 0.406
regulation of multicellular organismal process GO:0051239 277 0.405
positive regulation of rna biosynthetic process GO:1902680 57 0.400
Human Mouse Worm Fly
positive regulation of rna metabolic process GO:0051254 59 0.398
Human Mouse Worm Fly
kidney development GO:0001822 92 0.397
regulation of stem cell proliferation GO:0072091 2 0.396
cellular nitrogen compound biosynthetic process GO:0044271 218 0.394
Human Zebrafish Mouse Worm Fly
pronephros development GO:0048793 69 0.387
regulation of oligodendrocyte differentiation GO:0048713 1 0.385
cell morphogenesis involved in differentiation GO:0000904 195 0.372
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.372
positive regulation of metabolic process GO:0009893 108 0.368
Human Mouse Worm Fly
muscle fiber development GO:0048747 52 0.365
macromolecule biosynthetic process GO:0009059 227 0.362
Human Zebrafish Mouse Worm Fly
organic substance biosynthetic process GO:1901576 289 0.362
Human Zebrafish Mouse Worm Fly
ventral spinal cord interneuron fate commitment GO:0060579 3 0.361
Zebrafish Mouse
blood vessel endothelial cell differentiation GO:0060837 2 0.358
positive regulation of muscle organ development GO:0048636 1 0.350
fin development GO:0033333 77 0.350
retinoic acid receptor signaling pathway GO:0048384 16 0.348
otolith morphogenesis GO:0032474 8 0.339
developmental growth involved in morphogenesis GO:0060560 86 0.332
multi organism process GO:0051704 134 0.331
Human Worm Fly
hair cell differentiation GO:0035315 32 0.325
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.320
dorsal ventral pattern formation GO:0009953 125 0.315
striated muscle tissue development GO:0014706 110 0.310
negative regulation of developmental process GO:0051093 65 0.308
Mouse
cellular biosynthetic process GO:0044249 286 0.304
Human Zebrafish Mouse Worm Fly
fin morphogenesis GO:0033334 53 0.302
rna biosynthetic process GO:0032774 181 0.300
Human Zebrafish Mouse Worm Fly
cellular response to chemical stimulus GO:0070887 157 0.300
Mouse
cranial nerve development GO:0021545 42 0.298
extracellular structure organization GO:0043062 27 0.297
lateral mesoderm development GO:0048368 23 0.297
positive regulation of notch signaling pathway GO:0045747 3 0.295
cellular component assembly involved in morphogenesis GO:0010927 107 0.294
cellular response to organic substance GO:0071310 105 0.291
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.289
tube closure GO:0060606 1 0.289
heterocycle metabolic process GO:0046483 290 0.286
Human Zebrafish Mouse Worm Fly
epithelial tube formation GO:0072175 19 0.285
cellular nitrogen compound metabolic process GO:0034641 290 0.282
Human Zebrafish Mouse Worm Fly
nucleic acid metabolic process GO:0090304 244 0.282
Human Zebrafish Mouse Worm Fly
positive regulation of neurogenesis GO:0050769 24 0.275
Mouse
regulation of smoothened signaling pathway GO:0008589 18 0.275
Zebrafish Mouse
neural precursor cell proliferation GO:0061351 20 0.271
spinal cord dorsal ventral patterning GO:0021513 5 0.268
Zebrafish Mouse
embryonic viscerocranium morphogenesis GO:0048703 52 0.268
positive regulation of signaling GO:0023056 56 0.265
Zebrafish
aorta morphogenesis GO:0035909 3 0.262
nephron development GO:0072006 31 0.261
organelle assembly GO:0070925 110 0.257
endodermal digestive tract morphogenesis GO:0061031 2 0.257
muscle cell migration GO:0014812 4 0.256
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.255
cilium morphogenesis GO:0060271 85 0.248
nitrogen compound metabolic process GO:0006807 319 0.246
Human Zebrafish Mouse Worm Fly
heterocycle biosynthetic process GO:0018130 215 0.241
Human Zebrafish Mouse Worm Fly
positive regulation of cell communication GO:0010647 56 0.239
Zebrafish
muscle cell development GO:0055001 115 0.239
nerve development GO:0021675 45 0.238
response to stress GO:0006950 263 0.237
lymphangiogenesis GO:0001946 25 0.237
regulation of embryonic development GO:0045995 47 0.235
heart valve morphogenesis GO:0003179 8 0.234
regulation of locomotion GO:0040012 55 0.230
axon extension GO:0048675 45 0.223
liver development GO:0001889 96 0.223
limb development GO:0060173 8 0.221
Mouse
inner ear receptor cell development GO:0060119 20 0.219
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.217
sensory system development GO:0048880 76 0.217
endodermal cell differentiation GO:0035987 19 0.217
response to organic substance GO:0010033 153 0.215
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.212
Human Mouse Worm Fly
positive regulation of mesodermal cell fate specification GO:0048337 1 0.211
compound eye development GO:0048749 2 0.211
neuronal stem cell maintenance GO:0097150 2 0.210
cellular response to prostaglandin stimulus GO:0071379 3 0.209
forebrain neuron differentiation GO:0021879 14 0.209
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.207
Human Mouse Worm Fly
cell proliferation in forebrain GO:0021846 3 0.207
rna metabolic process GO:0016070 219 0.204
Human Zebrafish Mouse Worm Fly
post embryonic organ development GO:0048569 4 0.201
inner ear receptor cell differentiation GO:0060113 29 0.199
regulation of stem cell differentiation GO:2000736 4 0.198
segment polarity determination GO:0007367 1 0.197
Fly
establishment of localization GO:0051234 244 0.195
Worm
positive regulation of nervous system development GO:0051962 25 0.195
Mouse
convergent extension involved in gastrulation GO:0060027 71 0.194
ventral spinal cord interneuron differentiation GO:0021514 12 0.194
Zebrafish Mouse
cerebellar cortex development GO:0021695 5 0.193
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.193
Human Zebrafish Mouse Worm Fly
cell cycle g1 s phase transition GO:0044843 1 0.192
Fly
regulation of establishment of protein localization GO:0070201 4 0.191
regulation of glial cell differentiation GO:0045685 4 0.191
preganglionic parasympathetic nervous system development GO:0021783 6 0.184
Zebrafish
developmental growth GO:0048589 166 0.182
Mouse
convergent extension GO:0060026 118 0.182
gene expression GO:0010467 252 0.181
regulation of canonical wnt signaling pathway GO:0060828 34 0.181
embryonic limb morphogenesis GO:0030326 2 0.179
Mouse
pons development GO:0021548 11 0.177
Zebrafish
appendage morphogenesis GO:0035107 56 0.176
Mouse
stem cell differentiation GO:0048863 117 0.176
morphogenesis of an epithelial sheet GO:0002011 49 0.172
embryonic pattern specification GO:0009880 44 0.171
Fly
regulation of biological quality GO:0065008 263 0.168
rhombomere development GO:0021546 19 0.167
radial glial cell differentiation GO:0060019 2 0.165
embryonic appendage morphogenesis GO:0035113 30 0.165
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.164
renal system development GO:0072001 94 0.164
negative regulation of signaling GO:0023057 96 0.163
pericardium morphogenesis GO:0003344 1 0.162
negative chemotaxis GO:0050919 1 0.158
epithelial tube morphogenesis GO:0060562 148 0.157
Mouse
epidermis development GO:0008544 48 0.157
Human Fly
formation of primary germ layer GO:0001704 62 0.156
regulation of muscle organ development GO:0048634 9 0.155
neurological system process GO:0050877 62 0.155
anterior posterior pattern specification GO:0009952 152 0.154
stem cell maintenance GO:0019827 4 0.153
negative regulation of locomotion GO:0040013 18 0.152
intracellular receptor signaling pathway GO:0030522 30 0.151
negative regulation of signal transduction GO:0009968 94 0.150
oligodendrocyte development GO:0014003 7 0.149
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.149
Human Mouse Worm Fly
negative regulation of axon extension GO:0030517 7 0.149
mesenchymal cell development GO:0014031 78 0.148
regulation of neuron projection development GO:0010975 40 0.146
mesenchymal cell differentiation GO:0048762 87 0.146
forebrain regionalization GO:0021871 4 0.146
negative regulation of multicellular organismal process GO:0051241 69 0.145
Mouse
somatic stem cell maintenance GO:0035019 1 0.145
response to endogenous stimulus GO:0009719 83 0.144
regulation of endodermal cell fate specification GO:0042663 15 0.143
left right pattern formation GO:0060972 19 0.143
tissue regeneration GO:0042246 74 0.142
negative regulation of gene expression GO:0010629 65 0.142
Human Mouse Worm
bmp signaling pathway involved in heart development GO:0061312 15 0.141
gliogenesis GO:0042063 45 0.141
single organism organelle organization GO:1902589 199 0.140
Worm
multi organism reproductive process GO:0044703 36 0.139
Worm Fly
positive regulation of biosynthetic process GO:0009891 68 0.138
Human Mouse Worm Fly
ventral midline development GO:0007418 13 0.138
negative regulation of neuron differentiation GO:0045665 10 0.137
skeletal muscle tissue development GO:0007519 67 0.137
segmentation GO:0035282 97 0.133
lateral line development GO:0048882 66 0.131
regulation of protein transport GO:0051223 3 0.130
brain morphogenesis GO:0048854 18 0.128
single organism localization GO:1902578 225 0.127
morphogenesis of embryonic epithelium GO:0016331 30 0.127
Mouse
neuron recognition GO:0008038 18 0.126
maintenance of location GO:0051235 4 0.126
regulation of axon extension GO:0030516 24 0.124
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.124
hepaticobiliary system development GO:0061008 98 0.123
astrocyte differentiation GO:0048708 1 0.123
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.122
germ cell migration GO:0008354 8 0.122
positive regulation of gene expression GO:0010628 71 0.121
Human Mouse Worm Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.120
Human Mouse Worm
embryonic digestive tract development GO:0048566 4 0.118
transcription from rna polymerase ii promoter GO:0006366 80 0.117
Human Mouse Worm Fly
skeletal muscle organ development GO:0060538 78 0.116
endodermal cell fate specification GO:0001714 17 0.116
forebrain dorsal ventral pattern formation GO:0021798 1 0.115
cellular component biogenesis GO:0044085 178 0.115
semicircular canal development GO:0060872 24 0.115
neuroblast proliferation GO:0007405 2 0.114
foregut morphogenesis GO:0007440 4 0.114
nucleobase containing compound metabolic process GO:0006139 274 0.113
Human Zebrafish Mouse Worm Fly
forebrain generation of neurons GO:0021872 14 0.113
pectoral fin development GO:0033339 50 0.112
otic vesicle development GO:0071599 42 0.112
basement membrane organization GO:0071711 5 0.112
anterior posterior axon guidance GO:0033564 5 0.111
mesoderm morphogenesis GO:0048332 51 0.111
optic nerve morphogenesis GO:0021631 6 0.109
positive regulation of gliogenesis GO:0014015 2 0.108
negative regulation of neuron projection development GO:0010977 9 0.108
regionalization GO:0003002 274 0.107
negative regulation of protein transport GO:0051224 3 0.105
angioblast cell migration GO:0035476 9 0.104
organelle organization GO:0006996 227 0.102
Worm
cell recognition GO:0008037 19 0.101
neural crest cell differentiation GO:0014033 72 0.100
rhombomere boundary formation GO:0021654 10 0.099
endothelium development GO:0003158 25 0.099
regulation of rna biosynthetic process GO:2001141 213 0.099
Human Zebrafish Mouse Worm Fly
response to lipid GO:0033993 60 0.098
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.098
regulation of inner ear receptor cell differentiation GO:2000980 1 0.097
regulation of synapse organization GO:0050807 3 0.097
negative regulation of stem cell differentiation GO:2000737 2 0.096
protein import GO:0017038 3 0.095
anatomical structure arrangement GO:0048532 2 0.094
regulation of skeletal muscle fiber development GO:0048742 2 0.093
tube formation GO:0035148 25 0.093
single organism transport GO:0044765 206 0.092
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.092
Human Mouse Worm Fly
single organism metabolic process GO:0044710 217 0.091
negative regulation of myeloid cell differentiation GO:0045638 1 0.089
nucleobase containing compound biosynthetic process GO:0034654 205 0.089
Human Zebrafish Mouse Worm Fly
mesodermal cell fate specification GO:0007501 12 0.089
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.087
regulation of skeletal muscle tissue development GO:0048641 4 0.086
protein import into nucleus GO:0006606 3 0.084
regulation of wnt signaling pathway GO:0030111 53 0.084
type b pancreatic cell development GO:0003323 4 0.084
cytoskeleton organization GO:0007010 96 0.084
Worm
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 1 0.083
cardiac ventricle development GO:0003231 9 0.083
positive regulation of developmental process GO:0051094 50 0.082
Mouse Fly
glandular epithelial cell differentiation GO:0002067 9 0.082
neural crest cell development GO:0014032 62 0.080
regulation of gene expression GO:0010468 265 0.080
negative regulation of response to stimulus GO:0048585 104 0.080
skin development GO:0043588 54 0.079
Human Fly
mechanoreceptor differentiation GO:0042490 37 0.079
regulation of axonogenesis GO:0050770 32 0.079
system process GO:0003008 185 0.079
muscle structure development GO:0061061 196 0.078
specification of organ identity GO:0010092 2 0.078
negative regulation of wnt signaling pathway GO:0030178 30 0.078
ectodermal placode morphogenesis GO:0071697 32 0.077
retina morphogenesis in camera type eye GO:0060042 79 0.076
reproductive process GO:0022414 40 0.076
Mouse Worm Fly
mesenchyme development GO:0060485 127 0.076
regulation of cellular biosynthetic process GO:0031326 245 0.075
Human Zebrafish Mouse Worm Fly
retina development in camera type eye GO:0060041 146 0.075
regulation of reproductive process GO:2000241 4 0.075
response to acid chemical GO:0001101 17 0.075
negative regulation of cell migration GO:0030336 17 0.075
glial cell differentiation GO:0010001 42 0.075
notochord cell differentiation GO:0060034 18 0.074
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.074
semicircular canal morphogenesis GO:0048752 18 0.073
lymph vessel development GO:0001945 27 0.073
exocrine system development GO:0035272 28 0.073
regulation of biosynthetic process GO:0009889 250 0.072
Human Zebrafish Mouse Worm Fly
positive regulation of skeletal muscle tissue development GO:0048643 1 0.071
regulation of organ growth GO:0046620 3 0.071
growth GO:0040007 174 0.071
Mouse
regulation of striated muscle tissue development GO:0016202 6 0.071
nucleic acid templated transcription GO:0097659 181 0.070
Human Zebrafish Mouse Worm Fly
regulation of collateral sprouting GO:0048670 7 0.070
positive regulation of cell adhesion GO:0045785 1 0.069
embryonic eye morphogenesis GO:0048048 30 0.069
morphogenesis of a branching epithelium GO:0061138 16 0.068
Mouse
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.068
glial cell migration GO:0008347 3 0.067
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.067
positive regulation of neuron apoptotic process GO:0043525 1 0.066
Worm
transcription dna templated GO:0006351 181 0.066
Human Zebrafish Mouse Worm Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.066
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.065
Human Zebrafish Mouse Worm Fly
regulation of cell matrix adhesion GO:0001952 1 0.065
regulation of cell proliferation GO:0042127 37 0.064
Mouse
single organism nuclear import GO:1902593 3 0.064
kidney epithelium development GO:0072073 23 0.063
germ line stem cell maintenance GO:0030718 2 0.063
embryonic pectoral fin morphogenesis GO:0035118 24 0.063
outflow tract morphogenesis GO:0003151 1 0.062
heart valve formation GO:0003188 4 0.062
epithelial to mesenchymal transition GO:0001837 21 0.062
regulation of cartilage development GO:0061035 7 0.061
Mouse
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.060
Human Mouse Worm
midbrain development GO:0030901 28 0.060
endodermal cell fate determination GO:0007493 2 0.060
nephron epithelium development GO:0072009 16 0.060
cranial nerve morphogenesis GO:0021602 15 0.059
rhombomere formation GO:0021594 12 0.059
branching morphogenesis of an epithelial tube GO:0048754 15 0.059
Mouse
cardiac atrium development GO:0003230 4 0.059
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.059
Fly
cell cell adhesion GO:0098609 6 0.059
gamete generation GO:0007276 33 0.058
Worm Fly
lateral inhibition GO:0046331 1 0.058
floor plate formation GO:0021508 12 0.058
regulation of vasculature development GO:1901342 33 0.057
regulation of protein import into nucleus GO:0042306 2 0.056
bmp signaling pathway involved in heart jogging GO:0003303 14 0.056
vagus nerve development GO:0021564 2 0.055
Zebrafish
ossification GO:0001503 23 0.055
Human Mouse
female gamete generation GO:0007292 14 0.055
Fly
neuroblast fate commitment GO:0014017 1 0.055
myotube differentiation GO:0014902 45 0.055
nephron epithelium morphogenesis GO:0072088 1 0.054
negative regulation of chemotaxis GO:0050922 4 0.054
regulation of apoptotic process GO:0042981 98 0.054
Worm
positive regulation of cell fate specification GO:0042660 1 0.054
muscle tissue development GO:0060537 110 0.054
regulation of meiotic cell cycle GO:0051445 1 0.053

gli2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
organ system cancer DOID:0050686 0 0.228
colon carcinoma DOID:1520 0 0.228
cancer DOID:162 0 0.228
colorectal cancer DOID:9256 0 0.228
disease of cellular proliferation DOID:14566 0 0.228
gastrointestinal system cancer DOID:3119 0 0.228
large intestine cancer DOID:5672 0 0.228
intestinal cancer DOID:10155 0 0.228
colon cancer DOID:219 0 0.228
disease of anatomical entity DOID:7 0 0.111
cardiovascular system disease DOID:1287 0 0.111