Danio rerio

0 known processes

LOC100150090

sphingosine kinase 2-like

LOC100150090 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell motility GO:0048870 244 0.196
lipid homeostasis GO:0055088 3 0.143
regulation of multicellular organism growth GO:0040014 4 0.134
locomotion GO:0040011 313 0.129
homeostatic process GO:0042592 142 0.113
maintenance of location GO:0051235 4 0.100
tube morphogenesis GO:0035239 349 0.086
immune system process GO:0002376 241 0.085
macromolecule biosynthetic process GO:0009059 227 0.077
multicellular organism growth GO:0035264 4 0.074
skeletal system development GO:0001501 181 0.074
localization of cell GO:0051674 244 0.067
cell migration GO:0016477 237 0.065
blood vessel development GO:0001568 246 0.060
cellular component movement GO:0006928 335 0.058
digestive system development GO:0055123 289 0.058
signal transduction GO:0007165 455 0.058
ameboidal type cell migration GO:0001667 143 0.058
estrogen metabolic process GO:0008210 2 0.058
female sex differentiation GO:0046660 4 0.057
cell surface receptor signaling pathway GO:0007166 325 0.057
regulation of transcription dna templated GO:0006355 213 0.052
regulation of response to stimulus GO:0048583 269 0.048
embryonic organ development GO:0048568 381 0.047
i kappab kinase nf kappab signaling GO:0007249 4 0.047
regulation of metabolic process GO:0019222 359 0.047
organic acid metabolic process GO:0006082 31 0.045
negative regulation of protein phosphorylation GO:0001933 4 0.044
regulation of multicellular organismal process GO:0051239 277 0.043
blood vessel morphogenesis GO:0048514 216 0.041
head development GO:0060322 303 0.040
positive regulation of gtp catabolic process GO:0033126 1 0.040
positive regulation of catabolic process GO:0009896 4 0.039
regulation of signal transduction GO:0009966 225 0.038
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.036
regulation of gene expression GO:0010468 265 0.036
regulation of biological quality GO:0065008 263 0.036
organic substance biosynthetic process GO:1901576 289 0.036
angiogenesis GO:0001525 158 0.035
lipid storage GO:0019915 1 0.035
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
determination of left right symmetry GO:0007368 179 0.034
small molecule metabolic process GO:0044281 77 0.034
nucleocytoplasmic transport GO:0006913 4 0.033
embryonic organ morphogenesis GO:0048562 274 0.033
regulation of cell communication GO:0010646 232 0.033
positive regulation of transport GO:0051050 2 0.032
urogenital system development GO:0001655 97 0.032
gene expression GO:0010467 252 0.031
fatty acid biosynthetic process GO:0006633 4 0.031
androgen metabolic process GO:0008209 2 0.031
hemopoiesis GO:0030097 183 0.031
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.031
regulation of primary metabolic process GO:0080090 311 0.030
cellular response to biotic stimulus GO:0071216 3 0.030
regulation of cellular metabolic process GO:0031323 320 0.030
positive regulation of glucose transport GO:0010828 1 0.030
long chain fatty acid metabolic process GO:0001676 1 0.030
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.029
organic cyclic compound biosynthetic process GO:1901362 223 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.029
chordate embryonic development GO:0043009 271 0.029
regulation of protein transport GO:0051223 3 0.028
system process GO:0003008 185 0.028
digestive tract morphogenesis GO:0048546 231 0.028
single organism nuclear import GO:1902593 3 0.028
multi organism process GO:0051704 134 0.028
embryonic skeletal system development GO:0048706 97 0.028
adult behavior GO:0030534 2 0.028
embryonic skeletal system morphogenesis GO:0048704 93 0.028
cellular response to xenobiotic stimulus GO:0071466 35 0.028
regulation of signaling GO:0023051 235 0.027
protein localization to nucleus GO:0034504 3 0.027
amine metabolic process GO:0009308 2 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
developmental growth GO:0048589 166 0.027
skeletal system morphogenesis GO:0048705 102 0.027
centrosome cycle GO:0007098 1 0.027
nuclear migration GO:0007097 3 0.026
lipid metabolic process GO:0006629 52 0.026
positive regulation of chromatin modification GO:1903310 1 0.026
homeostasis of number of cells GO:0048872 62 0.026
embryo development ending in birth or egg hatching GO:0009792 271 0.026
negative regulation of protein kinase activity GO:0006469 4 0.026
negative regulation of cellular process GO:0048523 283 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
rna localization GO:0006403 4 0.025
regulation of tube size GO:0035150 2 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
development of primary female sexual characteristics GO:0046545 4 0.025
response to external stimulus GO:0009605 264 0.025
mitochondrion organization GO:0007005 4 0.025
epithelial cell differentiation GO:0030855 116 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.025
regulation of metal ion transport GO:0010959 4 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
response to stress GO:0006950 263 0.024
aging GO:0007568 2 0.024
neuron development GO:0048666 262 0.024
response to alkaloid GO:0043279 2 0.024
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.024
vasculature development GO:0001944 278 0.024
regulation of reproductive process GO:2000241 4 0.023
cell aging GO:0007569 2 0.023
protein import GO:0017038 3 0.023
biosynthetic process GO:0009058 294 0.023
phosphate containing compound metabolic process GO:0006796 108 0.023
positive regulation of nucleotide catabolic process GO:0030813 1 0.023
gastrulation GO:0007369 208 0.023
proteolysis GO:0006508 38 0.023
cellular response to external stimulus GO:0071496 2 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.022
nitrogen compound metabolic process GO:0006807 319 0.022
regulation of cell activation GO:0050865 1 0.022
triglyceride homeostasis GO:0070328 2 0.022
regulation of fatty acid metabolic process GO:0019217 1 0.022
regulation of ph GO:0006885 3 0.022
regulation of synaptic plasticity GO:0048167 1 0.022
cellular ketone metabolic process GO:0042180 11 0.022
taxis GO:0042330 109 0.021
single organism organelle organization GO:1902589 199 0.021
immune system development GO:0002520 191 0.021
rna biosynthetic process GO:0032774 181 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
positive regulation of dna metabolic process GO:0051054 1 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
apoptotic process GO:0006915 116 0.021
brain development GO:0007420 293 0.021
regulation of protein binding GO:0043393 3 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
oxoacid metabolic process GO:0043436 31 0.020
cation transmembrane transport GO:0098655 65 0.020
nuclear import GO:0051170 3 0.020
establishment of synaptic vesicle localization GO:0097480 1 0.020
meiotic cell cycle process GO:1903046 3 0.020
regulation of nucleotide catabolic process GO:0030811 2 0.020
protein targeting to nucleus GO:0044744 3 0.020
intracellular signal transduction GO:0035556 85 0.020
single organism metabolic process GO:0044710 217 0.020
neuron differentiation GO:0030182 353 0.020
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.020
reproduction GO:0000003 40 0.019
regulation of binding GO:0051098 3 0.019
regulation of cytokine production GO:0001817 3 0.019
protein import into nucleus GO:0006606 3 0.019
regulation of developmental growth GO:0048638 38 0.019
gtp metabolic process GO:0046039 4 0.019
organelle organization GO:0006996 227 0.019
dicarboxylic acid metabolic process GO:0043648 1 0.019
regulation of protein complex assembly GO:0043254 3 0.019
sensory organ development GO:0007423 393 0.019
cellular response to hormone stimulus GO:0032870 39 0.018
cellular nitrogen compound metabolic process GO:0034641 290 0.018
nuclear transport GO:0051169 4 0.018
positive regulation of metabolic process GO:0009893 108 0.018
positive regulation of defense response GO:0031349 9 0.018
sodium ion transmembrane transport GO:0035725 21 0.018
mesenchyme development GO:0060485 127 0.018
heterocycle biosynthetic process GO:0018130 215 0.018
epithelial tube morphogenesis GO:0060562 148 0.018
iron ion homeostasis GO:0055072 4 0.018
negative regulation of response to cytokine stimulus GO:0060761 2 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
single organism biosynthetic process GO:0044711 71 0.018
toxin transport GO:1901998 2 0.018
peptide metabolic process GO:0006518 1 0.018
ion transmembrane transport GO:0034220 91 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
response to hexose GO:0009746 3 0.017
inorganic anion transport GO:0015698 25 0.017
regulation of organ growth GO:0046620 3 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
regulation of transporter activity GO:0032409 2 0.017
ovulation cycle GO:0042698 2 0.017
regulation of behavior GO:0050795 24 0.017
hormone metabolic process GO:0042445 19 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
cellular ion homeostasis GO:0006873 17 0.017
zymogen activation GO:0031638 3 0.017
response to bacterium GO:0009617 58 0.017
compound eye development GO:0048749 2 0.017
female gonad development GO:0008585 4 0.017
cognition GO:0050890 1 0.017
negative regulation of protein transport GO:0051224 3 0.017
death GO:0016265 121 0.016
endocrine process GO:0050886 2 0.016
digestive tract development GO:0048565 265 0.016
regulation of gtpase activity GO:0043087 2 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
regulation of response to cytokine stimulus GO:0060759 3 0.016
multi organism reproductive process GO:0044703 36 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
odontogenesis of dentin containing tooth GO:0042475 1 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
peptide transport GO:0015833 1 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
centrosome organization GO:0051297 1 0.016
cellular amine metabolic process GO:0044106 2 0.016
regulation of molecular function GO:0065009 70 0.016
negative regulation of programmed cell death GO:0043069 58 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
atp catabolic process GO:0006200 4 0.016
cellular hormone metabolic process GO:0034754 19 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
protein polyubiquitination GO:0000209 4 0.015
negative regulation of biological process GO:0048519 304 0.015
regulation of dendrite development GO:0050773 3 0.015
generation of neurons GO:0048699 385 0.015
cellular response to nutrient levels GO:0031669 2 0.015
heart development GO:0007507 313 0.015
cell morphogenesis GO:0000902 289 0.015
regulation of protein catabolic process GO:0042176 1 0.015
larval development GO:0002164 2 0.015
response to chemical GO:0042221 320 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
chemotaxis GO:0006935 104 0.015
regulation of lipid transport GO:0032368 4 0.015
inorganic ion transmembrane transport GO:0098660 57 0.015
ear development GO:0043583 127 0.015
negative regulation of kinase activity GO:0033673 4 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
positive regulation of cell communication GO:0010647 56 0.014
cation homeostasis GO:0055080 33 0.014
positive regulation of catalytic activity GO:0043085 25 0.014
regulation of synapse organization GO:0050807 3 0.014
endosomal transport GO:0016197 2 0.014
phagocytosis GO:0006909 3 0.014
negative regulation of cell death GO:0060548 60 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
rna transport GO:0050658 2 0.014
apoptotic signaling pathway GO:0097190 23 0.014
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.014
p38mapk cascade GO:0038066 1 0.014
endocrine hormone secretion GO:0060986 2 0.014
cellular protein metabolic process GO:0044267 129 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
regulation of sodium ion transport GO:0002028 2 0.014
transport GO:0006810 220 0.014
renal system development GO:0072001 94 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
regulation of circadian rhythm GO:0042752 4 0.013
central nervous system development GO:0007417 387 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.013
regulation of cytokine mediated signaling pathway GO:0001959 3 0.013
negative regulation of cytokine production GO:0001818 1 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
regulation of protein targeting GO:1903533 2 0.013
sequestering of calcium ion GO:0051208 3 0.013
negative regulation of map kinase activity GO:0043407 2 0.013
modulation by virus of host morphology or physiology GO:0019048 1 0.013
positive regulation of signal transduction GO:0009967 56 0.013
amide biosynthetic process GO:0043604 1 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
cellular component morphogenesis GO:0032989 336 0.013
determination of bilateral symmetry GO:0009855 204 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
protein localization to plasma membrane GO:0072659 1 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
stem cell proliferation GO:0072089 4 0.013
modification dependent protein catabolic process GO:0019941 3 0.013
positive regulation of jnk cascade GO:0046330 3 0.013
positive regulation of cell cycle GO:0045787 3 0.013
positive regulation of lipid metabolic process GO:0045834 1 0.013
positive regulation of blood circulation GO:1903524 2 0.013
macromolecule localization GO:0033036 54 0.012
eye development GO:0001654 277 0.012
regulation of response to oxidative stress GO:1902882 2 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
hormone secretion GO:0046879 2 0.012
nitric oxide biosynthetic process GO:0006809 2 0.012
cellular biosynthetic process GO:0044249 286 0.012
leukocyte homeostasis GO:0001776 2 0.012
regulation of developmental process GO:0050793 247 0.012
chemosensory behavior GO:0007635 1 0.012
transmembrane transport GO:0055085 120 0.012
rna metabolic process GO:0016070 219 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
interaction with host GO:0051701 4 0.012
cellular transition metal ion homeostasis GO:0046916 3 0.012
transcription dna templated GO:0006351 181 0.012
response to monosaccharide GO:0034284 3 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
inorganic cation transmembrane transport GO:0098662 50 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
monocarboxylic acid catabolic process GO:0072329 3 0.012
cellular modified amino acid metabolic process GO:0006575 3 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
cellular protein catabolic process GO:0044257 4 0.012
regulation of heart growth GO:0060420 2 0.012
response to uv GO:0009411 3 0.012
mesenchymal cell development GO:0014031 78 0.012
cellular component disassembly GO:0022411 1 0.012
meiosis i GO:0007127 1 0.012
regulation of endocrine process GO:0044060 2 0.012
establishment of rna localization GO:0051236 3 0.012
response to carbohydrate GO:0009743 3 0.012
small molecule catabolic process GO:0044282 3 0.012
ovulation cycle process GO:0022602 2 0.012
organic acid biosynthetic process GO:0016053 12 0.012
sensory perception of chemical stimulus GO:0007606 3 0.012
hormone transport GO:0009914 2 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
peptidyl serine modification GO:0018209 2 0.012
vasculogenesis GO:0001570 41 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
neural crest cell differentiation GO:0014033 72 0.011
cellular response to starvation GO:0009267 1 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.011
regulation of inflammatory response GO:0050727 2 0.011
kidney development GO:0001822 92 0.011
dna biosynthetic process GO:0071897 3 0.011
positive regulation of histone modification GO:0031058 1 0.011
negative regulation of defense response GO:0031348 2 0.011
membrane lipid biosynthetic process GO:0046467 2 0.011
inner ear development GO:0048839 126 0.011
response to external biotic stimulus GO:0043207 97 0.011
negative regulation of intracellular signal transduction GO:1902532 22 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
response to ketone GO:1901654 1 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
regionalization GO:0003002 274 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
regulation of rna metabolic process GO:0051252 224 0.011
toll like receptor signaling pathway GO:0002224 4 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
intracellular mrna localization GO:0008298 1 0.011
response to drug GO:0042493 3 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
bicarbonate transport GO:0015701 4 0.011
positive regulation of neuron death GO:1901216 1 0.011
regulation of catalytic activity GO:0050790 55 0.011
synaptic vesicle localization GO:0097479 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.011
regulation of blood vessel size GO:0050880 2 0.011
apoptotic process involved in development GO:1902742 2 0.011
fertilization GO:0009566 3 0.011
neutrophil migration GO:1990266 10 0.011
negative regulation of signal transduction GO:0009968 94 0.011
b cell activation GO:0042113 2 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
cartilage development GO:0051216 96 0.011
pericardium morphogenesis GO:0003344 1 0.011
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.011
appendage development GO:0048736 80 0.011
embryonic heart tube development GO:0035050 133 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
antimicrobial humoral response GO:0019730 2 0.010
response to nutrient GO:0007584 3 0.010
lymphocyte proliferation GO:0046651 1 0.010
regulation of synapse assembly GO:0051963 3 0.010
gtp catabolic process GO:0006184 2 0.010
regulation of dna templated transcription in response to stress GO:0043620 0 0.010
nitric oxide metabolic process GO:0046209 2 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.010
cell migration involved in gastrulation GO:0042074 79 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
stem cell maintenance GO:0019827 4 0.010
negative regulation of protein import into nucleus GO:0042308 2 0.010
heart looping GO:0001947 94 0.010
phosphorus metabolic process GO:0006793 109 0.010
meiotic nuclear division GO:0007126 4 0.010
sensory perception of smell GO:0007608 2 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
retina development in camera type eye GO:0060041 146 0.010
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 3 0.010
positive regulation of glucose import GO:0046326 1 0.010
acylglycerol homeostasis GO:0055090 2 0.010
neuron projection morphogenesis GO:0048812 161 0.010
negative regulation of mapk cascade GO:0043409 4 0.010
regulation of protein ubiquitination GO:0031396 3 0.010
glucose import GO:0046323 2 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
regulation of jak stat cascade GO:0046425 3 0.010
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.010

LOC100150090 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.069
nervous system disease DOID:863 0 0.032
immune system disease DOID:2914 0 0.020
inherited metabolic disorder DOID:655 0 0.014
disease of metabolism DOID:0014667 0 0.014
eye disease DOID:5614 0 0.011
eye and adnexa disease DOID:1492 0 0.011
sensory system disease DOID:0050155 0 0.011
retinal disease DOID:5679 0 0.010