Danio rerio

218 known processes

tp53

tumor protein p53

(Aliases: zgc:111919,brp53,fb40d06,wu:fb40d06,drp53,p53)

tp53 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gene expression GO:0010467 252 0.999
regulation of cellular metabolic process GO:0031323 320 0.998
embryonic organ development GO:0048568 381 0.997
Zebrafish Mouse
regionalization GO:0003002 274 0.997
Mouse
positive regulation of transcription dna templated GO:0045893 57 0.994
nucleic acid metabolic process GO:0090304 244 0.993
regulation of gene expression GO:0010468 265 0.986
embryonic organ morphogenesis GO:0048562 274 0.985
Zebrafish
positive regulation of metabolic process GO:0009893 108 0.985
embryo development ending in birth or egg hatching GO:0009792 271 0.984
Zebrafish Mouse Worm
positive regulation of cellular metabolic process GO:0031325 94 0.984
cellular macromolecule metabolic process GO:0044260 391 0.983
rna metabolic process GO:0016070 219 0.982
cell proliferation GO:0008283 80 0.979
Human Mouse Fly
regulation of primary metabolic process GO:0080090 311 0.978
cellular macromolecule biosynthetic process GO:0034645 224 0.977
stem cell differentiation GO:0048863 117 0.973
Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.973
positive regulation of cellular biosynthetic process GO:0031328 68 0.972
morphogenesis of an epithelium GO:0002009 333 0.972
neural tube patterning GO:0021532 33 0.971
positive regulation of macromolecule metabolic process GO:0010604 93 0.968
embryonic cranial skeleton morphogenesis GO:0048701 90 0.968
Zebrafish
response to biotic stimulus GO:0009607 97 0.967
Human
immune system development GO:0002520 191 0.967
nitrogen compound metabolic process GO:0006807 319 0.964
positive regulation of cellular process GO:0048522 201 0.962
cell death GO:0008219 121 0.961
nucleobase containing compound metabolic process GO:0006139 274 0.957
response to other organism GO:0051707 97 0.956
regulation of cell proliferation GO:0042127 37 0.956
Human Mouse Fly
gland development GO:0048732 143 0.955
regulation of biosynthetic process GO:0009889 250 0.953
hematopoietic or lymphoid organ development GO:0048534 191 0.951
programmed cell death GO:0012501 119 0.949
tube morphogenesis GO:0035239 349 0.946
Mouse
central nervous system development GO:0007417 387 0.945
Zebrafish Mouse
head development GO:0060322 303 0.944
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.943
digestive system development GO:0055123 289 0.943
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.940
generation of neurons GO:0048699 385 0.939
Mouse Fly
negative regulation of gene expression GO:0010629 65 0.937
Human Zebrafish Mouse
stem cell development GO:0048864 82 0.931
positive regulation of nucleic acid templated transcription GO:1903508 57 0.929
digestive tract development GO:0048565 265 0.927
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.924
neuron development GO:0048666 262 0.923
blood vessel development GO:0001568 246 0.920
regulation of metabolic process GO:0019222 359 0.920
camera type eye morphogenesis GO:0048593 108 0.914
positive regulation of cell cycle GO:0045787 3 0.911
blood vessel morphogenesis GO:0048514 216 0.910
gamete generation GO:0007276 33 0.910
regulation of signal transduction GO:0009966 225 0.910
Human Mouse Fly
hepaticobiliary system development GO:0061008 98 0.907
larval development GO:0002164 2 0.903
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.902
regulation of cellular biosynthetic process GO:0031326 245 0.900
chordate embryonic development GO:0043009 271 0.898
Zebrafish Mouse
response to external stimulus GO:0009605 264 0.895
Human Mouse Worm Fly
regulation of multicellular organismal process GO:0051239 277 0.893
vasculature development GO:0001944 278 0.892
macromolecule biosynthetic process GO:0009059 227 0.880
liver development GO:0001889 96 0.877
anterior posterior pattern specification GO:0009952 152 0.875
Mouse
skeletal system development GO:0001501 181 0.868
Zebrafish
cellular component morphogenesis GO:0032989 336 0.867
brain development GO:0007420 293 0.865
Mouse
glial cell differentiation GO:0010001 42 0.865
eye development GO:0001654 277 0.864
neuron differentiation GO:0030182 353 0.863
Fly
digestive tract morphogenesis GO:0048546 231 0.862
Mouse
heart looping GO:0001947 94 0.862
sensory organ morphogenesis GO:0090596 200 0.861
protein modification process GO:0036211 100 0.856
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.856
embryonic heart tube morphogenesis GO:0003143 108 0.853
pancreas development GO:0031016 84 0.851
embryonic heart tube development GO:0035050 133 0.848
localization of cell GO:0051674 244 0.845
positive regulation of biological process GO:0048518 253 0.845
regulation of multicellular organismal development GO:2000026 223 0.842
positive regulation of rna biosynthetic process GO:1902680 57 0.841
nucleic acid templated transcription GO:0097659 181 0.840
determination of heart left right asymmetry GO:0061371 117 0.835
biosynthetic process GO:0009058 294 0.832
heart development GO:0007507 313 0.831
immune system process GO:0002376 241 0.830
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.830
negative regulation of developmental process GO:0051093 65 0.828
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.823
Human Mouse
oligodendrocyte differentiation GO:0048709 23 0.822
maintenance of location GO:0051235 4 0.816
cell surface receptor signaling pathway GO:0007166 325 0.815
Mouse Fly
regulation of epithelial cell proliferation GO:0050678 3 0.813
tissue homeostasis GO:0001894 25 0.813
regulation of developmental process GO:0050793 247 0.809
cell motility GO:0048870 244 0.804
odontogenesis of dentin containing tooth GO:0042475 1 0.790
tissue remodeling GO:0048771 4 0.790
Mouse
response to external biotic stimulus GO:0043207 97 0.788
angiogenesis GO:0001525 158 0.786
hindbrain development GO:0030902 91 0.783
Mouse
somitogenesis GO:0001756 87 0.778
Mouse
wnt signaling pathway GO:0016055 80 0.778
embryonic pattern specification GO:0009880 44 0.770
single organism transport GO:0044765 206 0.770
Mouse Fly
regulation of biological quality GO:0065008 263 0.768
negative regulation of biological process GO:0048519 304 0.766
positive regulation of biosynthetic process GO:0009891 68 0.759
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.748
Fly
organic substance biosynthetic process GO:1901576 289 0.746
positive regulation of cellular component biogenesis GO:0044089 3 0.743
Human
mesenchymal cell differentiation GO:0048762 87 0.741
female gamete generation GO:0007292 14 0.740
Fly
stem cell maintenance GO:0019827 4 0.730
regulation of response to stimulus GO:0048583 269 0.718
Human Mouse Fly
defense response to bacterium GO:0042742 22 0.717
rna biosynthetic process GO:0032774 181 0.716
regulation of stem cell proliferation GO:0072091 2 0.715
Mouse
regulation of nervous system development GO:0051960 90 0.713
Mouse Fly
cellular component biogenesis GO:0044085 178 0.713
Human
reproduction GO:0000003 40 0.709
locomotion GO:0040011 313 0.702
intracellular transport GO:0046907 32 0.695
Mouse Fly
ectodermal placode development GO:0071696 37 0.686
regulation of rna biosynthetic process GO:2001141 213 0.681
cytokinesis GO:0000910 3 0.668
heterocycle metabolic process GO:0046483 290 0.666
cellular nitrogen compound metabolic process GO:0034641 290 0.665
hemopoiesis GO:0030097 183 0.664
forebrain development GO:0030900 96 0.663
epithelial tube morphogenesis GO:0060562 148 0.659
cellular biosynthetic process GO:0044249 286 0.658
apoptotic process GO:0006915 116 0.654
positive regulation of rna metabolic process GO:0051254 59 0.653
sensory organ development GO:0007423 393 0.653
embryonic skeletal system morphogenesis GO:0048704 93 0.644
Zebrafish
homeostatic process GO:0042592 142 0.637
regulation of neurogenesis GO:0050767 87 0.633
Mouse Fly
transcription dna templated GO:0006351 181 0.632
germ cell development GO:0007281 22 0.624
Fly
protein import GO:0017038 3 0.623
Mouse Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.621
regulation of cell death GO:0010941 103 0.617
camera type eye development GO:0043010 222 0.615
cellular amide metabolic process GO:0043603 4 0.605
chemical homeostasis GO:0048878 49 0.600
diencephalon development GO:0021536 58 0.599
cellular response to chemical stimulus GO:0070887 157 0.598
cell morphogenesis GO:0000902 289 0.595
eye morphogenesis GO:0048592 144 0.581
heart morphogenesis GO:0003007 156 0.574
mitotic cell cycle process GO:1903047 48 0.572
Human Mouse
cell fate commitment GO:0045165 99 0.570
Mouse
determination of left right symmetry GO:0007368 179 0.567
endocardium development GO:0003157 9 0.564
regulation of neuron differentiation GO:0045664 56 0.563
Fly
regulation of cell cycle GO:0051726 52 0.558
regulation of cell development GO:0060284 100 0.552
Mouse Fly
exocrine pancreas development GO:0031017 28 0.551
negative regulation of metabolic process GO:0009892 86 0.549
Human Zebrafish Mouse Fly
mesenchyme development GO:0060485 127 0.542
regulation of protein ubiquitination GO:0031396 3 0.536
epithelial cell development GO:0002064 42 0.530
regulation of rna metabolic process GO:0051252 224 0.527
neural crest cell development GO:0014032 62 0.527
regulation of nitrogen compound metabolic process GO:0051171 251 0.523
negative regulation of cellular process GO:0048523 283 0.522
cell projection morphogenesis GO:0048858 244 0.520
specification of symmetry GO:0009799 204 0.519
neuron projection morphogenesis GO:0048812 161 0.510
endodermal digestive tract morphogenesis GO:0061031 2 0.504
g1 s transition of mitotic cell cycle GO:0000082 1 0.502
Human Mouse
regulation of oligodendrocyte differentiation GO:0048713 1 0.498
lymphocyte differentiation GO:0030098 9 0.495
Mouse
macromolecule modification GO:0043412 111 0.492
Mouse
cellular macromolecular complex assembly GO:0034622 24 0.488
cellular component assembly GO:0022607 170 0.487
Human
cell part morphogenesis GO:0032990 246 0.484
embryonic skeletal system development GO:0048706 97 0.477
Zebrafish
viral process GO:0016032 1 0.477
positive regulation of gene expression GO:0010628 71 0.470
cell cycle process GO:0022402 53 0.469
neuron projection development GO:0031175 180 0.469
regulation of programmed cell death GO:0043067 101 0.460
gliogenesis GO:0042063 45 0.457
ameboidal type cell migration GO:0001667 143 0.457
multi organism process GO:0051704 134 0.457
cell morphogenesis involved in differentiation GO:0000904 195 0.456
negative regulation of protein phosphorylation GO:0001933 4 0.450
response to bacterium GO:0009617 58 0.446
transcription from rna polymerase ii promoter GO:0006366 80 0.445
Human Mouse Fly
cellular protein modification process GO:0006464 100 0.444
Mouse
positive regulation of cell death GO:0010942 29 0.441
response to stress GO:0006950 263 0.438
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.436
embryonic digestive tract morphogenesis GO:0048557 3 0.434
regulation of cell differentiation GO:0045595 142 0.432
Mouse Fly
nuclear import GO:0051170 3 0.420
Mouse Fly
positive regulation of catabolic process GO:0009896 4 0.420
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.419
Human Mouse Fly
negative regulation of transcription dna templated GO:0045892 45 0.415
Human Zebrafish Mouse
cellular response to endogenous stimulus GO:0071495 68 0.415
Mouse
cell cycle GO:0007049 93 0.414
mesenchymal cell development GO:0014031 78 0.413
establishment of protein localization to organelle GO:0072594 4 0.413
Mouse Fly
positive regulation of cell differentiation GO:0045597 30 0.409
cell migration GO:0016477 237 0.408
oogenesis GO:0048477 14 0.406
Fly
germ line stem cell division GO:0042078 1 0.400
cell cycle g1 s phase transition GO:0044843 1 0.396
Human Mouse
photoreceptor cell differentiation GO:0046530 55 0.394
Fly
axonogenesis GO:0007409 152 0.391
regulation of signaling GO:0023051 235 0.390
Human Mouse Fly
single organism nuclear import GO:1902593 3 0.385
Mouse Fly
convergent extension GO:0060026 118 0.385
embryonic limb morphogenesis GO:0030326 2 0.384
cellular nitrogen compound biosynthetic process GO:0044271 218 0.379
single organism intracellular transport GO:1902582 25 0.377
Mouse Fly
peripheral nervous system development GO:0007422 55 0.372
protein complex biogenesis GO:0070271 30 0.371
Human
negative regulation of biosynthetic process GO:0009890 55 0.370
Human Zebrafish Mouse
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.369
Human Zebrafish Mouse
autonomic nervous system development GO:0048483 19 0.365
regulation of anatomical structure morphogenesis GO:0022603 130 0.361
regulation of transcription dna templated GO:0006355 213 0.359
muscle structure development GO:0061061 196 0.357
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.354
response to growth factor GO:0070848 39 0.353
Mouse
cytoplasmic transport GO:0016482 11 0.352
Mouse Fly
dorsal ventral neural tube patterning GO:0021904 1 0.351
response to endogenous stimulus GO:0009719 83 0.349
Mouse
leukocyte differentiation GO:0002521 25 0.342
Mouse
organelle organization GO:0006996 227 0.337
Human Mouse Worm Fly
single organism localization GO:1902578 225 0.336
Mouse Fly
cell division GO:0051301 20 0.336
regulation of protein catabolic process GO:0042176 1 0.331
negative regulation of cell cycle GO:0045786 14 0.328
cellular ketone metabolic process GO:0042180 11 0.327
regulation of macromolecule biosynthetic process GO:0010556 225 0.327
embryonic digestive tract development GO:0048566 4 0.326
regulation of multicellular organism growth GO:0040014 4 0.324
Fly
glial cell development GO:0021782 20 0.323
negative regulation of cell death GO:0060548 60 0.319
Human Mouse
lateral inhibition GO:0046331 1 0.313
astrocyte differentiation GO:0048708 1 0.312
negative regulation of epithelial cell proliferation GO:0050680 1 0.312
protein import into nucleus GO:0006606 3 0.306
Mouse Fly
death GO:0016265 121 0.305
ventral spinal cord interneuron specification GO:0021521 3 0.305
renal system development GO:0072001 94 0.302
skeletal system morphogenesis GO:0048705 102 0.302
Zebrafish
oligodendrocyte development GO:0014003 7 0.302
spermatogenesis GO:0007283 7 0.301
gastrulation GO:0007369 208 0.293
Mouse
endocardium morphogenesis GO:0003160 4 0.292
endocrine system development GO:0035270 65 0.289
segment polarity determination GO:0007367 1 0.288
response to oxidative stress GO:0006979 11 0.287
Human Mouse Worm
transport GO:0006810 220 0.285
Mouse Fly
reproductive process GO:0022414 40 0.285
endoderm development GO:0007492 49 0.282
determination of bilateral symmetry GO:0009855 204 0.279
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.279
developmental process involved in reproduction GO:0003006 27 0.274
Fly
somite development GO:0061053 96 0.259
Mouse
positive regulation of muscle cell differentiation GO:0051149 1 0.258
response to organic substance GO:0010033 153 0.256
regulation of cytoplasmic transport GO:1903649 4 0.249
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.249
Human Zebrafish Mouse
protein localization GO:0008104 40 0.248
Human Mouse Fly
negative regulation of cell differentiation GO:0045596 46 0.248
Mouse Fly
negative regulation of apoptotic process GO:0043066 55 0.248
Human Mouse
neural tube development GO:0021915 62 0.233
protein metabolic process GO:0019538 183 0.233
single organism biosynthetic process GO:0044711 71 0.232
regulation of apoptotic process GO:0042981 98 0.230
morphogenesis of a branching epithelium GO:0061138 16 0.230
neural crest cell differentiation GO:0014033 72 0.229
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.227
Human Zebrafish Mouse
modification of morphology or physiology of other organism GO:0035821 4 0.223
positive regulation of cellular protein metabolic process GO:0032270 22 0.223
b cell activation GO:0042113 2 0.222
Mouse
mitotic cell cycle GO:0000278 64 0.221
Human Mouse
regulation of eye photoreceptor cell development GO:0042478 2 0.221
cellular response to starvation GO:0009267 1 0.221
Human Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.221
protein targeting to nucleus GO:0044744 3 0.221
Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.219
lipid storage GO:0019915 1 0.218
regulation of protein binding GO:0043393 3 0.217
cell substrate adhesion GO:0031589 4 0.213
retina development in camera type eye GO:0060041 146 0.211
foregut morphogenesis GO:0007440 4 0.210
meiotic cell cycle process GO:1903046 3 0.209
Worm Fly
regulation of proteolysis GO:0030162 24 0.207
aorta development GO:0035904 4 0.205
retinoic acid biosynthetic process GO:0002138 6 0.204
negative regulation of neurogenesis GO:0050768 20 0.203
Mouse Fly
cellular carbohydrate metabolic process GO:0044262 4 0.199
macromolecular complex subunit organization GO:0043933 74 0.199
Human Mouse
meiotic nuclear division GO:0007126 4 0.198
Worm Fly
cell cell adhesion involved in mesendodermal cell migration GO:0003370 1 0.193
somite specification GO:0001757 12 0.193
organic cyclic compound biosynthetic process GO:1901362 223 0.191
urogenital system development GO:0001655 97 0.190
taste bud formation GO:0061195 3 0.187
positive regulation of chromatin modification GO:1903310 1 0.182
Mouse
appendage development GO:0048736 80 0.182
epithelial cell differentiation GO:0030855 116 0.182
negative regulation of programmed cell death GO:0043069 58 0.181
Human Mouse
cellular protein metabolic process GO:0044267 129 0.176
nuclear pore organization GO:0006999 2 0.175
extracellular matrix constituent secretion GO:0070278 3 0.174
heterocycle biosynthetic process GO:0018130 215 0.174
cardiac atrium morphogenesis GO:0003209 2 0.173
rostrocaudal neural tube patterning GO:0021903 29 0.172
aorta morphogenesis GO:0035909 3 0.171
cellular catabolic process GO:0044248 27 0.167
Mouse Fly
canonical wnt signaling pathway GO:0060070 48 0.167
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.165
negative regulation of cellular catabolic process GO:0031330 3 0.165
Mouse
retinoic acid metabolic process GO:0042573 9 0.161
positive regulation of protein complex assembly GO:0031334 2 0.161
Human
neural crest cell migration GO:0001755 42 0.161
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.158
intestinal epithelial cell differentiation GO:0060575 3 0.157
spindle assembly involved in female meiosis GO:0007056 1 0.157
negative regulation of proteolysis GO:0045861 10 0.154
Mouse
striated muscle tissue development GO:0014706 110 0.154
embryonic viscerocranium morphogenesis GO:0048703 52 0.153
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.151
negative regulation of cell proliferation GO:0008285 8 0.150
Human Mouse
regulation of neural precursor cell proliferation GO:2000177 3 0.148
Mouse
multi organism cellular process GO:0044764 2 0.147
stem cell proliferation GO:0072089 4 0.145
Mouse Fly
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.144
glucose homeostasis GO:0042593 1 0.144
response to glucose GO:0009749 3 0.143
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.142
positive regulation of developmental process GO:0051094 50 0.142
Mouse Fly
maturation of ssu rrna GO:0030490 1 0.141
phosphorus metabolic process GO:0006793 109 0.140
Mouse Fly
proteasomal protein catabolic process GO:0010498 2 0.139
organic cyclic compound metabolic process GO:1901360 301 0.137
positive regulation of signal transduction GO:0009967 56 0.137
Human Fly
muscle cell migration GO:0014812 4 0.137
cell growth GO:0016049 57 0.136
Human
defense response to other organism GO:0098542 33 0.134
cell activation GO:0001775 16 0.133
Mouse
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.133
cell fate determination GO:0001709 7 0.131
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.131
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.131
ribosomal small subunit biogenesis GO:0042274 2 0.131
negative regulation of macromolecule metabolic process GO:0010605 76 0.130
Human Zebrafish Mouse
response to wounding GO:0009611 116 0.130
Fly
melanocyte differentiation GO:0030318 26 0.129
regulation of phosphorus metabolic process GO:0051174 43 0.129
Mouse Fly
homeostasis of number of cells within a tissue GO:0048873 4 0.128
exocrine system development GO:0035272 28 0.128
pigmentation GO:0043473 85 0.127
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.127
iron ion transport GO:0006826 4 0.127
meiotic spindle organization GO:0000212 1 0.125
developmental maturation GO:0021700 34 0.124
positive regulation of cell proliferation GO:0008284 15 0.124
neuroblast fate commitment GO:0014017 1 0.124
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.124
connective tissue development GO:0061448 99 0.122
embryonic camera type eye development GO:0031076 29 0.121
homeostasis of number of cells GO:0048872 62 0.119
axon development GO:0061564 166 0.119
positive regulation of chromosome organization GO:2001252 1 0.118
Mouse
response to fungus GO:0009620 25 0.117
regulation of organ growth GO:0046620 3 0.117
Fly
somatic stem cell maintenance GO:0035019 1 0.117
endodermal cell fate determination GO:0007493 2 0.116
cell migration involved in heart development GO:0060973 22 0.116
regulation of cellular protein metabolic process GO:0032268 52 0.116
cellular response to external stimulus GO:0071496 2 0.115
Human Mouse Fly
carbohydrate homeostasis GO:0033500 1 0.115
neural precursor cell proliferation GO:0061351 20 0.115
Mouse Fly
protein destabilization GO:0031648 1 0.113
appendage morphogenesis GO:0035107 56 0.112
growth GO:0040007 174 0.112
Human Mouse Fly
ventral spinal cord interneuron fate commitment GO:0060579 3 0.112
pigment cell differentiation GO:0050931 38 0.111
axis elongation involved in somitogenesis GO:0090245 2 0.111
regulation of apoptotic signaling pathway GO:2001233 12 0.111
Human Mouse
macromolecular complex assembly GO:0065003 35 0.111
Human
regulation of production of molecular mediator of immune response GO:0002700 1 0.110
endocardial cushion formation GO:0003272 2 0.110
negative regulation of protein kinase activity GO:0006469 4 0.109
regulation of wnt signaling pathway GO:0030111 53 0.108
organonitrogen compound biosynthetic process GO:1901566 47 0.108
protein secretion GO:0009306 1 0.107
autophagy GO:0006914 4 0.107
Mouse Fly
branching morphogenesis of an epithelial tube GO:0048754 15 0.106
response to abiotic stimulus GO:0009628 122 0.106
anatomical structure homeostasis GO:0060249 36 0.105
segmentation GO:0035282 97 0.105
Mouse
nuclear transport GO:0051169 4 0.104
Mouse Fly
positive regulation of cellular catabolic process GO:0031331 3 0.104
Fly
regulation of establishment of protein localization GO:0070201 4 0.104
Fly
organelle assembly GO:0070925 110 0.104
vagus nerve development GO:0021564 2 0.104
oxoacid metabolic process GO:0043436 31 0.103
positive regulation of transport GO:0051050 2 0.103
regulation of cardiac muscle contraction GO:0055117 2 0.102
negative regulation of cellular biosynthetic process GO:0031327 55 0.100
Human Zebrafish Mouse
negative regulation of mitotic cell cycle GO:0045930 11 0.100
Human Mouse
single organism metabolic process GO:0044710 217 0.100
Human Mouse Fly
isoprenoid biosynthetic process GO:0008299 7 0.100
negative regulation of signal transduction GO:0009968 94 0.099
Mouse
protein complex subunit organization GO:0071822 46 0.099
Human
negative regulation of cellular protein metabolic process GO:0032269 16 0.099
Mouse
carboxylic acid metabolic process GO:0019752 22 0.098
blood vessel endothelial cell differentiation GO:0060837 2 0.098
regulation of binding GO:0051098 3 0.098
cellular protein catabolic process GO:0044257 4 0.096
negative regulation of multicellular organismal process GO:0051241 69 0.096
specification of organ identity GO:0010092 2 0.095
stem cell fate commitment GO:0048865 1 0.094
cellular response to lipid GO:0071396 39 0.094
arterial endothelial cell differentiation GO:0060842 2 0.093
cardiac atrium development GO:0003230 4 0.093
interspecies interaction between organisms GO:0044419 4 0.090
biological adhesion GO:0022610 40 0.089
fin morphogenesis GO:0033334 53 0.088
metal ion transport GO:0030001 58 0.088
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.087
signal transduction GO:0007165 455 0.087
cellular component movement GO:0006928 335 0.087
axial mesoderm formation GO:0048320 4 0.087
cardiac endothelial cell differentiation GO:0003348 5 0.086
spindle assembly involved in meiosis GO:0090306 1 0.085
positive regulation of dna metabolic process GO:0051054 1 0.085
commissural neuron axon guidance GO:0071679 3 0.084
regulation of cellular component organization GO:0051128 86 0.083
Human Mouse
organic acid metabolic process GO:0006082 31 0.083
cell migration involved in mesendoderm migration GO:0090134 2 0.082
neuroblast proliferation GO:0007405 2 0.082
Mouse Fly
regulation of cell communication GO:0010646 232 0.082
Human Mouse Fly
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 1 0.081
positive regulation of multi organism process GO:0043902 3 0.081
regulation of glial cell differentiation GO:0045685 4 0.081
tongue morphogenesis GO:0043587 3 0.080
cell fate specification GO:0001708 68 0.080
signal transduction by p53 class mediator GO:0072331 13 0.078
muscle organ development GO:0007517 101 0.077
endothelial cell fate commitment GO:0060839 3 0.077
nerve development GO:0021675 45 0.077
positive regulation of epithelial cell proliferation GO:0050679 1 0.077
dorsal ventral pattern formation GO:0009953 125 0.076
single organism reproductive process GO:0044702 40 0.075
regulation of protein metabolic process GO:0051246 56 0.075
positive regulation of neuron death GO:1901216 1 0.075
regulation of protein transport GO:0051223 3 0.075
Fly
nephron epithelium morphogenesis GO:0072088 1 0.075
protein processing GO:0016485 12 0.075
Mouse Fly
hormone metabolic process GO:0042445 19 0.074
cellular localization GO:0051641 97 0.074
Human Mouse Fly
post embryonic development GO:0009791 7 0.073
Worm
negative regulation of protein maturation GO:1903318 10 0.073
Mouse
regulation of cellular ketone metabolic process GO:0010565 7 0.072
response to radiation GO:0009314 51 0.072
negative regulation of rna metabolic process GO:0051253 48 0.072
Human Zebrafish Mouse
cartilage development GO:0051216 96 0.072
establishment of localization GO:0051234 244 0.071
Mouse Fly
regulation of protein modification process GO:0031399 29 0.070
Mouse
epithelial cell proliferation GO:0050673 17 0.070
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.069
Mouse
positive regulation of nervous system development GO:0051962 25 0.069
regulation of cell substrate adhesion GO:0010810 1 0.069
intracellular receptor signaling pathway GO:0030522 30 0.069
embryonic appendage morphogenesis GO:0035113 30 0.069
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.069
Human Mouse Fly
spinal cord dorsal ventral patterning GO:0021513 5 0.068
regulation of molecular function GO:0065009 70 0.068
regulation of dna catabolic process GO:1903624 1 0.067
protein modification by small protein conjugation or removal GO:0070647 14 0.067
positive regulation of neurogenesis GO:0050769 24 0.067
system process GO:0003008 185 0.067
neuroepithelial cell differentiation GO:0060563 26 0.066
negative regulation of nucleic acid templated transcription GO:1903507 45 0.065
Human Zebrafish Mouse
positive regulation of neuron apoptotic process GO:0043525 1 0.065
vasculogenesis GO:0001570 41 0.065
maintenance of gastrointestinal epithelium GO:0030277 7 0.065
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.064
cellular amine metabolic process GO:0044106 2 0.063

tp53 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.137
disease of anatomical entity DOID:7 0 0.137
hematopoietic system disease DOID:74 0 0.137
cancer DOID:162 0 0.108
Human
disease of cellular proliferation DOID:14566 0 0.108
Human
organ system cancer DOID:0050686 0 0.069
Human