Danio rerio

20 known processes

appa

amyloid beta (A4) precursor protein a

(Aliases: wu:fj34d10,app,wu:fk65e12,zgc:85740)

appa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 271 0.918
larval development GO:0002164 2 0.747
Worm
negative regulation of biological process GO:0048519 304 0.694
Human Mouse Fly
cell surface receptor signaling pathway GO:0007166 325 0.624
Mouse
regulation of multicellular organism growth GO:0040014 4 0.603
Mouse Worm
cognition GO:0050890 1 0.574
Mouse Fly
response to stress GO:0006950 263 0.531
Mouse Fly
negative regulation of cell communication GO:0010648 96 0.479
cellular component morphogenesis GO:0032989 336 0.445
Zebrafish Mouse Fly
negative regulation of cellular process GO:0048523 283 0.440
Human Mouse Fly
signal transduction GO:0007165 455 0.430
Mouse
positive regulation of signal transduction GO:0009967 56 0.397
forebrain development GO:0030900 96 0.396
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.393
Human Mouse
multi organism process GO:0051704 134 0.383
Mouse
multicellular organism growth GO:0035264 4 0.373
Mouse Worm
single organism localization GO:1902578 225 0.357
Mouse
digestive tract morphogenesis GO:0048546 231 0.351
stem cell maintenance GO:0019827 4 0.348
establishment of protein localization to organelle GO:0072594 4 0.321
neuron development GO:0048666 262 0.317
Zebrafish Mouse Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.312
Mouse
cellular protein modification process GO:0006464 100 0.308
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.305
Mouse
regulation of cell communication GO:0010646 232 0.305
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.304
Human Mouse
aging GO:0007568 2 0.298
regulation of cellular metabolic process GO:0031323 320 0.291
Human Mouse
negative regulation of protein transport GO:0051224 3 0.283
rna metabolic process GO:0016070 219 0.281
Mouse
regulation of signaling GO:0023051 235 0.278
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.277
Mouse
gene expression GO:0010467 252 0.275
Human Mouse
brain development GO:0007420 293 0.272
Mouse
growth GO:0040007 174 0.265
Mouse Worm
central nervous system development GO:0007417 387 0.262
phagocytosis GO:0006909 3 0.261
nitrogen compound metabolic process GO:0006807 319 0.257
Mouse
neuromuscular process controlling balance GO:0050885 3 0.252
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.241
Zebrafish Mouse
regulation of transcription dna templated GO:0006355 213 0.240
Mouse
positive regulation of cellular process GO:0048522 201 0.235
Mouse
homeostatic process GO:0042592 142 0.229
Mouse
rna polyadenylation GO:0043631 2 0.218
Mouse
positive regulation of biological process GO:0048518 253 0.216
Mouse Worm
regulation of receptor activity GO:0010469 2 0.206
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.198
Mouse
regulation of developmental process GO:0050793 247 0.198
Mouse Worm
locomotion GO:0040011 313 0.197
Mouse Worm
biosynthetic process GO:0009058 294 0.194
Mouse
sexual reproduction GO:0019953 36 0.193
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.187
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.184
Mouse
organic substance biosynthetic process GO:1901576 289 0.184
Mouse
convergent extension GO:0060026 118 0.183
regulation of biological quality GO:0065008 263 0.181
Mouse
phosphorus metabolic process GO:0006793 109 0.179
Mouse
head development GO:0060322 303 0.179
Mouse
regulation of metabolic process GO:0019222 359 0.177
Human Mouse
protein modification process GO:0036211 100 0.176
Mouse
hemopoiesis GO:0030097 183 0.175
cell morphogenesis involved in differentiation GO:0000904 195 0.174
Zebrafish Mouse
cellular protein metabolic process GO:0044267 129 0.172
Human Mouse
response to chemical GO:0042221 320 0.172
Mouse
generation of neurons GO:0048699 385 0.170
Zebrafish Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.167
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.167
Mouse
peripheral nervous system development GO:0007422 55 0.165
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.162
establishment of localization GO:0051234 244 0.156
Mouse
regulation of primary metabolic process GO:0080090 311 0.156
Human Mouse
cell death GO:0008219 121 0.154
Human Mouse Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.153
Mouse
cellular ketone metabolic process GO:0042180 11 0.149
sensory system development GO:0048880 76 0.149
regulation of signal transduction GO:0009966 225 0.149
Mouse
transcription dna templated GO:0006351 181 0.148
Mouse
protein localization to nucleus GO:0034504 3 0.146
meiotic nuclear division GO:0007126 4 0.144
regulation of nitrogen compound metabolic process GO:0051171 251 0.143
Mouse
axon development GO:0061564 166 0.142
Zebrafish Mouse
regulation of binding GO:0051098 3 0.133
Mouse
female gonad development GO:0008585 4 0.131
small molecule metabolic process GO:0044281 77 0.131
Mouse
gastrulation GO:0007369 208 0.129
protein targeting to nucleus GO:0044744 3 0.127
protein metabolic process GO:0019538 183 0.127
Human Mouse
response to other organism GO:0051707 97 0.126
neuron projection development GO:0031175 180 0.126
Zebrafish Mouse Fly
heterocycle metabolic process GO:0046483 290 0.125
Mouse
midbrain development GO:0030901 28 0.123
developmental growth GO:0048589 166 0.122
Mouse Worm
regulation of multicellular organismal development GO:2000026 223 0.121
Mouse
cellular transition metal ion homeostasis GO:0046916 3 0.120
Mouse
protein import into nucleus GO:0006606 3 0.120
cell motility GO:0048870 244 0.119
positive regulation of response to stimulus GO:0048584 80 0.119
regulation of cellular response to growth factor stimulus GO:0090287 35 0.116
cellular aromatic compound metabolic process GO:0006725 295 0.112
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.112
hematopoietic or lymphoid organ development GO:0048534 191 0.111
cellular carbohydrate metabolic process GO:0044262 4 0.109
regulation of establishment of protein localization GO:0070201 4 0.109
rna biosynthetic process GO:0032774 181 0.106
Mouse
regulation of phosphorylation GO:0042325 26 0.104
Mouse
regulation of intracellular protein transport GO:0033157 3 0.103
organic acid metabolic process GO:0006082 31 0.102
response to wounding GO:0009611 116 0.101
Fly
regulation of rna metabolic process GO:0051252 224 0.101
Mouse
protein complex localization GO:0031503 1 0.101
regulation of response to stimulus GO:0048583 269 0.100
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.099
Mouse
cellular component biogenesis GO:0044085 178 0.098
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.098
Mouse
amine metabolic process GO:0009308 2 0.097
epithelial cell differentiation GO:0030855 116 0.097
regulation of protein binding GO:0043393 3 0.097
Mouse
negative regulation of signaling GO:0023057 96 0.093
single organism nuclear import GO:1902593 3 0.092
positive regulation of nucleic acid templated transcription GO:1903508 57 0.092
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 106 0.092
Mouse
digestive tract development GO:0048565 265 0.090
single organism transport GO:0044765 206 0.089
Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.088
response to biotic stimulus GO:0009607 97 0.087
digestive system development GO:0055123 289 0.086
cellular response to stress GO:0033554 62 0.086
sensory organ development GO:0007423 393 0.085
regulation of biosynthetic process GO:0009889 250 0.085
Mouse
positive regulation of transcription dna templated GO:0045893 57 0.084
Mouse
regulation of phosphorus metabolic process GO:0051174 43 0.084
Mouse
regulation of protein transport GO:0051223 3 0.084
blood vessel development GO:0001568 246 0.084
axonogenesis GO:0007409 152 0.084
Zebrafish Mouse
negative regulation of cell migration GO:0030336 17 0.083
cell migration GO:0016477 237 0.083
cell projection organization GO:0030030 284 0.082
Zebrafish Mouse Fly
blood vessel morphogenesis GO:0048514 216 0.082
cell morphogenesis GO:0000902 289 0.081
Zebrafish Mouse Fly
cell cell adhesion involved in gastrulation GO:0070586 4 0.081
neuron projection morphogenesis GO:0048812 161 0.080
Zebrafish Mouse Fly
lateral line system development GO:0048925 76 0.080
macromolecule modification GO:0043412 111 0.079
Mouse
ion transport GO:0006811 114 0.079
transport GO:0006810 220 0.079
Mouse
modification dependent protein catabolic process GO:0019941 3 0.079
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.078
negative regulation of wnt signaling pathway GO:0030178 30 0.078
response to axon injury GO:0048678 14 0.078
Fly
negative regulation of signal transduction GO:0009968 94 0.077
stem cell development GO:0048864 82 0.077
neuron differentiation GO:0030182 353 0.076
Zebrafish Mouse Fly
regulation of reproductive process GO:2000241 4 0.076
organic cyclic compound metabolic process GO:1901360 301 0.074
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.074
Mouse
cellular amine metabolic process GO:0044106 2 0.073
cellular response to nutrient levels GO:0031669 2 0.072
cell part morphogenesis GO:0032990 246 0.072
Zebrafish Mouse Fly
nucleic acid metabolic process GO:0090304 244 0.072
Mouse
wnt signaling pathway GO:0016055 80 0.071
transition metal ion homeostasis GO:0055076 5 0.069
Mouse
guanosine containing compound catabolic process GO:1901069 2 0.068
mitotic cell cycle GO:0000278 64 0.067
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.066
regulation of molecular function GO:0065009 70 0.066
Human Mouse
positive regulation of neuron apoptotic process GO:0043525 1 0.066
internal protein amino acid acetylation GO:0006475 2 0.065
regulation of circadian rhythm GO:0042752 4 0.064
nuclear transport GO:0051169 4 0.064
cellular homeostasis GO:0019725 26 0.064
Mouse
regulation of cell migration GO:0030334 40 0.063
cellular response to endogenous stimulus GO:0071495 68 0.063
development of primary female sexual characteristics GO:0046545 4 0.062
organonitrogen compound metabolic process GO:1901564 74 0.062
tube morphogenesis GO:0035239 349 0.062
embryonic skeletal system morphogenesis GO:0048704 93 0.062
nuclear import GO:0051170 3 0.062
hepaticobiliary system development GO:0061008 98 0.062
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.061
Mouse
multi organism cellular process GO:0044764 2 0.061
eye development GO:0001654 277 0.061
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.060
negative regulation of secretion GO:0051048 2 0.059
organonitrogen compound biosynthetic process GO:1901566 47 0.059
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.059
cellular cation homeostasis GO:0030003 17 0.058
Mouse
negative regulation of macromolecule metabolic process GO:0010605 76 0.058
Human
negative regulation of cellular metabolic process GO:0031324 77 0.058
Human
regulation of nucleoside metabolic process GO:0009118 2 0.057
single organism metabolic process GO:0044710 217 0.056
Mouse
somatic muscle development GO:0007525 4 0.056
pyruvate metabolic process GO:0006090 1 0.056
immune system process GO:0002376 241 0.056
positive regulation of neuron death GO:1901216 1 0.055
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.055
cardiac cell fate commitment GO:0060911 1 0.054
regulation of phosphate metabolic process GO:0019220 43 0.053
Mouse
fertilization GO:0009566 3 0.053
negative regulation of multicellular organismal process GO:0051241 69 0.053
Mouse
regulation of protein targeting GO:1903533 2 0.053
nucleocytoplasmic transport GO:0006913 4 0.053
regulation of epithelial cell proliferation GO:0050678 3 0.052
gtp catabolic process GO:0006184 2 0.052
viral process GO:0016032 1 0.052
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.052
embryonic organ morphogenesis GO:0048562 274 0.051
ras protein signal transduction GO:0007265 7 0.051
response to external stimulus GO:0009605 264 0.051
Mouse
cellular response to extracellular stimulus GO:0031668 2 0.051
regulation of locomotion GO:0040012 55 0.050
mrna metabolic process GO:0016071 20 0.050
Mouse
regulation of programmed cell death GO:0043067 101 0.050
stem cell proliferation GO:0072089 4 0.050
regulation of cell shape GO:0008360 1 0.049
positive regulation of ras protein signal transduction GO:0046579 1 0.049
vasculature development GO:0001944 278 0.049
positive regulation of cell death GO:0010942 29 0.049
guanosine containing compound metabolic process GO:1901068 4 0.049
regulation of axonogenesis GO:0050770 32 0.048
anatomical structure homeostasis GO:0060249 36 0.048
female sex differentiation GO:0046660 4 0.048
protein acylation GO:0043543 3 0.048
peptidyl lysine acetylation GO:0018394 2 0.048
positive regulation of cell adhesion GO:0045785 1 0.047
cellular component movement GO:0006928 335 0.047
Mouse
regulation of response to cytokine stimulus GO:0060759 3 0.047
chemosensory behavior GO:0007635 1 0.047
neuron recognition GO:0008038 18 0.047
Mouse
reproductive process GO:0022414 40 0.046
Mouse
regulation of heart growth GO:0060420 2 0.045
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 6 0.045
negative regulation of locomotion GO:0040013 18 0.045
synaptic vesicle localization GO:0097479 1 0.045
post embryonic organ morphogenesis GO:0048563 1 0.045
gtp metabolic process GO:0046039 4 0.045
morphogenesis of an epithelium GO:0002009 333 0.044
regulation of nucleotide catabolic process GO:0030811 2 0.044
modulation by virus of host morphology or physiology GO:0019048 1 0.043
meiotic cell cycle process GO:1903046 3 0.043
ameboidal type cell migration GO:0001667 143 0.042
desmosome assembly GO:0002159 2 0.042
regulation of gene expression GO:0010468 265 0.042
Human Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.042
Mouse
regulation of photoreceptor cell differentiation GO:0046532 2 0.041
regulation of rac protein signal transduction GO:0035020 1 0.041
cellular response to starvation GO:0009267 1 0.041
regulation of gtp catabolic process GO:0033124 2 0.041
regulation of cell motility GO:2000145 46 0.041
response to endogenous stimulus GO:0009719 83 0.041
osteoclast differentiation GO:0030316 1 0.041
negative regulation of cell motility GO:2000146 17 0.041
cellular amino acid metabolic process GO:0006520 7 0.040
glucose homeostasis GO:0042593 1 0.040
positive regulation of rna biosynthetic process GO:1902680 57 0.040
Mouse
negative regulation of response to stimulus GO:0048585 104 0.040
cell cycle GO:0007049 93 0.040
Mouse
somatic stem cell maintenance GO:0035019 1 0.040
maintenance of location GO:0051235 4 0.039
gamete generation GO:0007276 33 0.039
cellular biosynthetic process GO:0044249 286 0.039
Mouse
developmental pigmentation GO:0048066 48 0.039
behavior GO:0007610 74 0.039
Mouse Fly
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.038
protein dephosphorylation GO:0006470 3 0.038
negative regulation of protein phosphorylation GO:0001933 4 0.038
negative chemotaxis GO:0050919 1 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.037
Mouse
response to oxidative stress GO:0006979 11 0.037
Mouse
organelle organization GO:0006996 227 0.037
neuronal stem cell maintenance GO:0097150 2 0.037
regulation of hydrolase activity GO:0051336 28 0.037
Human
positive regulation of signaling GO:0023056 56 0.036
tissue homeostasis GO:0001894 25 0.036
nuclear division GO:0000280 23 0.036
regulation of neuronal synaptic plasticity GO:0048168 1 0.035
macromolecule biosynthetic process GO:0009059 227 0.035
Mouse
multicellular organismal homeostasis GO:0048871 29 0.035
gastrulation with mouth forming second GO:0001702 44 0.035
heterocycle biosynthetic process GO:0018130 215 0.035
Mouse
oxoacid metabolic process GO:0043436 31 0.035
posterior lateral line neuromast deposition GO:0048922 5 0.035
heart development GO:0007507 313 0.035
regulation of localization GO:0032879 104 0.034
positive regulation of apoptotic signaling pathway GO:2001235 1 0.034
lipid storage GO:0019915 1 0.034
single organism reproductive process GO:0044702 40 0.034
muscle cell migration GO:0014812 4 0.034
phosphate containing compound metabolic process GO:0006796 108 0.034
Mouse
regulation of cell death GO:0010941 103 0.034
Fly
peptide transport GO:0015833 1 0.034
collateral sprouting in absence of injury GO:0048669 4 0.034
Mouse
rna processing GO:0006396 25 0.034
Mouse
embryonic skeletal system development GO:0048706 97 0.034
regulation of response to nutrient levels GO:0032107 1 0.034
protein secretion GO:0009306 1 0.033
actin cytoskeleton organization GO:0030036 63 0.033
liver development GO:0001889 96 0.033
primary neural tube formation GO:0014020 1 0.032
synaptic growth at neuromuscular junction GO:0051124 2 0.032
Mouse
i kappab kinase nf kappab signaling GO:0007249 4 0.031
regulation of cytokine production GO:0001817 3 0.031
defense response GO:0006952 47 0.031
gland development GO:0048732 143 0.031
mesenchymal cell proliferation GO:0010463 1 0.031
regulation of carbohydrate metabolic process GO:0006109 4 0.031
death GO:0016265 121 0.031
Human Mouse Fly
lateral line development GO:0048882 66 0.031
myotome development GO:0061055 1 0.030
single organism behavior GO:0044708 24 0.030
Mouse Fly
regulation of protein localization to nucleus GO:1900180 2 0.030
chemotaxis GO:0006935 104 0.030
Mouse
phosphorylation GO:0016310 69 0.030
Mouse
synaptic target recognition GO:0008039 1 0.030
regulation of cytoplasmic transport GO:1903649 4 0.030
stem cell differentiation GO:0048863 117 0.030
reproduction GO:0000003 40 0.030
Mouse Worm
regulation of protein import into nucleus GO:0042306 2 0.030
response to hormone GO:0009725 48 0.030
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.030
negative regulation of gene expression GO:0010629 65 0.030
Human
cellular metal ion homeostasis GO:0006875 16 0.030
Mouse
ovarian follicle development GO:0001541 2 0.030
nucleobase containing compound metabolic process GO:0006139 274 0.030
Mouse
negative regulation of protein kinase activity GO:0006469 4 0.030
negative regulation of intracellular protein transport GO:0090317 3 0.030
response to fibroblast growth factor GO:0071774 22 0.030
regionalization GO:0003002 274 0.029
ion homeostasis GO:0050801 41 0.029
Mouse
posterior lateral line system development GO:0048915 46 0.029
erk1 and erk2 cascade GO:0070371 4 0.029
embryonic skeletal joint development GO:0072498 3 0.029
regulation of synaptic plasticity GO:0048167 1 0.029
body morphogenesis GO:0010171 16 0.029
Worm
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.029
embryonic organ development GO:0048568 381 0.028
modification dependent macromolecule catabolic process GO:0043632 3 0.028
nephron tubule morphogenesis GO:0072078 1 0.028
nucleic acid templated transcription GO:0097659 181 0.028
Mouse
localization of cell GO:0051674 244 0.028
keratinocyte differentiation GO:0030216 0 0.028
meiotic chromosome segregation GO:0045132 3 0.028
response to external biotic stimulus GO:0043207 97 0.028
rna localization GO:0006403 4 0.027
regulation of protein phosphorylation GO:0001932 18 0.027
Mouse
response to organic substance GO:0010033 153 0.027
cellular component assembly GO:0022607 170 0.027
Mouse
organic substance transport GO:0071702 58 0.027
internal peptidyl lysine acetylation GO:0018393 2 0.027
asymmetric protein localization GO:0008105 6 0.027
regulation of myelination GO:0031641 1 0.027
regulation of intracellular signal transduction GO:1902531 57 0.027
mitochondrion organization GO:0007005 4 0.027
cellular protein localization GO:0034613 20 0.026
protein import GO:0017038 3 0.026
positive regulation of cell cycle GO:0045787 3 0.026
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.026
regulation of reactive oxygen species metabolic process GO:2000377 2 0.025
hemoglobin biosynthetic process GO:0042541 8 0.025
regulation of carbohydrate biosynthetic process GO:0043255 1 0.025
female gamete generation GO:0007292 14 0.025
regulation of growth GO:0040008 42 0.025
Mouse Worm
regulation of metal ion transport GO:0010959 4 0.025
single organism cellular localization GO:1902580 46 0.025
establishment of localization in cell GO:0051649 77 0.025
Mouse
modification of morphology or physiology of other organism GO:0035821 4 0.024
determination of ventral identity GO:0048264 21 0.024
insulin like growth factor receptor signaling pathway GO:0048009 4 0.024
positive regulation of rac protein signal transduction GO:0035022 1 0.024
system process GO:0003008 185 0.024
Mouse Fly
protein stabilization GO:0050821 2 0.024
negative regulation of intracellular transport GO:0032387 3 0.024
homeostasis of number of cells GO:0048872 62 0.024
cytoplasm organization GO:0007028 4 0.024
negative regulation of defense response GO:0031348 2 0.024
meiosis i GO:0007127 1 0.023
glycoprotein metabolic process GO:0009100 23 0.023
peripheral nervous system neuron differentiation GO:0048934 28 0.023
regulation of erythrocyte differentiation GO:0045646 2 0.023
regulation of inflammatory response GO:0050727 2 0.023
cellular response to external stimulus GO:0071496 2 0.023
regulation of erk1 and erk2 cascade GO:0070372 4 0.023
centrosome localization GO:0051642 1 0.023
regulation of gtpase activity GO:0043087 2 0.023
response to oxygen containing compound GO:1901700 55 0.023
autophagy GO:0006914 4 0.023
innervation GO:0060384 3 0.023
neuroblast differentiation GO:0014016 1 0.023
regulation of cell development GO:0060284 100 0.023
Mouse
negative regulation of metabolic process GO:0009892 86 0.023
Human
mrna polyadenylation GO:0006378 2 0.023
Mouse
regulation of purine nucleotide catabolic process GO:0033121 2 0.022
macromolecular complex subunit organization GO:0043933 74 0.022
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.022
axon cargo transport GO:0008088 2 0.022
Mouse
negative regulation of mapk cascade GO:0043409 4 0.022
entrainment of circadian clock GO:0009649 2 0.022
regulation of response to oxidative stress GO:1902882 2 0.022
pronuclear migration GO:0035046 1 0.022
carbohydrate derivative metabolic process GO:1901135 61 0.022
germ cell migration GO:0008354 8 0.022
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.022
positive regulation of epithelial cell proliferation GO:0050679 1 0.021
mechanosensory lateral line system development GO:0048881 49 0.021
regulation of embryonic development GO:0045995 47 0.021
regulation of bmp signaling pathway GO:0030510 39 0.021
ovulation cycle process GO:0022602 2 0.021
multicellular organism reproduction GO:0032504 35 0.021
cellular catabolic process GO:0044248 27 0.021
determination of heart left right asymmetry GO:0061371 117 0.021
multicellular organismal reproductive process GO:0048609 35 0.021
negative regulation of secretion by cell GO:1903531 2 0.021
regulation of cellular ketone metabolic process GO:0010565 7 0.021
cell substrate adhesion GO:0031589 4 0.021
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.020
small gtpase mediated signal transduction GO:0007264 8 0.020
programmed cell death GO:0012501 119 0.020
Human Mouse
single organism organelle organization GO:1902589 199 0.020
skeletal system morphogenesis GO:0048705 102 0.020
multi organism reproductive process GO:0044703 36 0.020
Mouse
cellular ion homeostasis GO:0006873 17 0.020
Mouse
ectodermal cell fate specification GO:0001715 2 0.020
activation of immune response GO:0002253 9 0.020
glutamate receptor signaling pathway GO:0007215 1 0.020
Mouse
metal ion homeostasis GO:0055065 26 0.020
Mouse
negative regulation of neuron death GO:1901215 8 0.020
Fly
positive regulation of multicellular organismal process GO:0051240 52 0.019
Worm
regulation of oocyte development GO:0060281 3 0.019
positive regulation of nucleoside metabolic process GO:0045979 1 0.019
long chain fatty acid transport GO:0015909 1 0.019
regulation of rho protein signal transduction GO:0035023 2 0.019
chordate embryonic development GO:0043009 271 0.019
response to growth factor GO:0070848 39 0.019
carbohydrate derivative biosynthetic process GO:1901137 43 0.019
phagocytosis engulfment GO:0006911 1 0.019
pigmentation GO:0043473 85 0.019
negative regulation of kinase activity GO:0033673 4 0.019
negative regulation of cell differentiation GO:0045596 46 0.019
Mouse
chemical homeostasis GO:0048878 49 0.019
Mouse
positive regulation of multi organism process GO:0043902 3 0.019
regeneration GO:0031099 91 0.018
regulation of cellular component movement GO:0051270 55 0.018
interspecies interaction between organisms GO:0044419 4 0.018
regulation of cell substrate adhesion GO:0010810 1 0.018
neuroblast proliferation GO:0007405 2 0.018
locomotory behavior GO:0007626 34 0.018
Mouse
neuron neuron synaptic transmission GO:0007270 1 0.018
vesicle mediated transport GO:0016192 22 0.018
Mouse
cell death in response to oxidative stress GO:0036473 2 0.018
apoptotic signaling pathway GO:0097190 23 0.018
regulation of cell maturation GO:1903429 1 0.018
angiogenesis GO:0001525 158 0.018
macromolecule localization GO:0033036 54 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
regulation of response to stress GO:0080134 36 0.018
mesenchyme development GO:0060485 127 0.018
lipid metabolic process GO:0006629 52 0.018
Mouse
microtubule based movement GO:0007018 33 0.018
Mouse
negative regulation of protein import into nucleus GO:0042308 2 0.017
mesenchymal cell differentiation GO:0048762 87 0.017
regulation of apoptotic process GO:0042981 98 0.017
synaptic vesicle transport GO:0048489 1 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.017
type i interferon production GO:0032606 2 0.017
photoreceptor cell development GO:0042461 40 0.017
leukocyte homeostasis GO:0001776 2 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
Mouse
negative regulation of dna replication GO:0008156 2 0.017
axon guidance GO:0007411 86 0.017
Mouse
smooth muscle tissue development GO:0048745 1 0.017
cell junction maintenance GO:0034331 2 0.017
response to virus GO:0009615 21 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
positive regulation of gene expression GO:0010628 71 0.017
Mouse
cellular localization GO:0051641 97 0.017
Mouse
regulation of cellular response to oxidative stress GO:1900407 2 0.017
exocytosis GO:0006887 1 0.017
negative regulation of cytoplasmic transport GO:1903650 2 0.016
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.016
cellular response to growth factor stimulus GO:0071363 39 0.016
neuron death GO:0070997 21 0.016
Human Mouse Fly
negative regulation of protein kinase b signaling GO:0051898 2 0.016
regulation of protein kinase activity GO:0045859 15 0.016
Mouse
endomembrane system organization GO:0010256 13 0.016

appa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.044
disease of cellular proliferation DOID:14566 0 0.044
disease of anatomical entity DOID:7 0 0.029
Human
congenital nervous system abnormality DOID:2490 0 0.025
physical disorder DOID:0080015 0 0.025
cardiovascular system disease DOID:1287 0 0.025
neurodegenerative disease DOID:1289 0 0.021
Human
nervous system disease DOID:863 0 0.021
Human
central nervous system disease DOID:331 0 0.021
Human
organ system cancer DOID:0050686 0 0.018
tauopathy DOID:680 0 0.017
Human
gastrointestinal system cancer DOID:3119 0 0.017