Danio rerio

0 known processes

psme2

proteasome activator subunit 2

(Aliases: unp309)

psme2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
immune system process GO:0002376 241 0.228
regulation of cellular metabolic process GO:0031323 320 0.140
small molecule metabolic process GO:0044281 77 0.138
cellular macromolecule metabolic process GO:0044260 391 0.133
amine metabolic process GO:0009308 2 0.123
regulation of cellular ketone metabolic process GO:0010565 7 0.113
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.105
regulation of macromolecule metabolic process GO:0060255 317 0.105
ubiquitin dependent protein catabolic process GO:0006511 3 0.099
response to external biotic stimulus GO:0043207 97 0.097
nitrogen compound metabolic process GO:0006807 319 0.096
nucleobase containing compound metabolic process GO:0006139 274 0.093
regulation of primary metabolic process GO:0080090 311 0.091
modification dependent macromolecule catabolic process GO:0043632 3 0.088
cellular protein catabolic process GO:0044257 4 0.085
organic cyclic compound metabolic process GO:1901360 301 0.083
positive regulation of cellular metabolic process GO:0031325 94 0.081
modification dependent protein catabolic process GO:0019941 3 0.081
response to drug GO:0042493 3 0.079
cellular nitrogen compound metabolic process GO:0034641 290 0.068
organonitrogen compound metabolic process GO:1901564 74 0.067
regulation of metabolic process GO:0019222 359 0.066
cellular amino acid metabolic process GO:0006520 7 0.062
heterocycle metabolic process GO:0046483 290 0.061
positive regulation of biological process GO:0048518 253 0.060
phosphorus metabolic process GO:0006793 109 0.055
protein metabolic process GO:0019538 183 0.055
oxoacid metabolic process GO:0043436 31 0.054
regulation of endopeptidase activity GO:0052548 23 0.054
protein import into nucleus GO:0006606 3 0.053
establishment of protein localization to organelle GO:0072594 4 0.052
carboxylic acid metabolic process GO:0019752 22 0.052
cellular amine metabolic process GO:0044106 2 0.051
single organism metabolic process GO:0044710 217 0.049
gtp metabolic process GO:0046039 4 0.049
positive regulation of catabolic process GO:0009896 4 0.049
i kappab kinase nf kappab signaling GO:0007249 4 0.048
cellular aromatic compound metabolic process GO:0006725 295 0.047
embryonic organ development GO:0048568 381 0.047
organic acid metabolic process GO:0006082 31 0.046
regulation of protein targeting GO:1903533 2 0.045
regulation of establishment of protein localization GO:0070201 4 0.045
guanosine containing compound metabolic process GO:1901068 4 0.044
positive regulation of cellular process GO:0048522 201 0.044
regulation of cellular amine metabolic process GO:0033238 0 0.044
biosynthetic process GO:0009058 294 0.044
regulation of nucleic acid templated transcription GO:1903506 213 0.043
cellular protein metabolic process GO:0044267 129 0.043
positive regulation of metabolic process GO:0009893 108 0.042
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.040
regulation of protein transport GO:0051223 3 0.040
defense response GO:0006952 47 0.039
cell projection morphogenesis GO:0048858 244 0.039
proteasomal protein catabolic process GO:0010498 2 0.038
nuclear transport GO:0051169 4 0.037
regulation of cellular amino acid metabolic process GO:0006521 0 0.037
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.036
protein targeting to nucleus GO:0044744 3 0.036
regulation of binding GO:0051098 3 0.035
immune response GO:0006955 28 0.035
gtp catabolic process GO:0006184 2 0.035
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.035
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
negative regulation of biological process GO:0048519 304 0.034
cellular component morphogenesis GO:0032989 336 0.034
single organism nuclear import GO:1902593 3 0.034
protein localization to nucleus GO:0034504 3 0.034
proteolysis GO:0006508 38 0.033
regulation of protein localization to nucleus GO:1900180 2 0.033
larval development GO:0002164 2 0.033
regulation of signal transduction GO:0009966 225 0.033
regulation of molecular function GO:0065009 70 0.032
negative regulation of protein transport GO:0051224 3 0.032
response to external stimulus GO:0009605 264 0.032
regulation of intracellular protein transport GO:0033157 3 0.031
rna metabolic process GO:0016070 219 0.031
positive regulation of molecular function GO:0044093 33 0.030
nucleocytoplasmic transport GO:0006913 4 0.030
positive regulation of macromolecule metabolic process GO:0010604 93 0.030
cell morphogenesis GO:0000902 289 0.030
response to chemical GO:0042221 320 0.030
nucleic acid metabolic process GO:0090304 244 0.029
regulation of nucleoside metabolic process GO:0009118 2 0.029
neuroblast proliferation GO:0007405 2 0.029
guanosine containing compound catabolic process GO:1901069 2 0.029
regulation of nucleocytoplasmic transport GO:0046822 2 0.028
maintenance of location GO:0051235 4 0.028
regulation of protein complex assembly GO:0043254 3 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.027
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.027
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.027
spindle assembly GO:0051225 2 0.026
multicellular organism growth GO:0035264 4 0.026
regulation of gtp catabolic process GO:0033124 2 0.026
positive regulation of hydrolase activity GO:0051345 13 0.026
regulation of multicellular organismal process GO:0051239 277 0.026
morphogenesis of an epithelium GO:0002009 333 0.026
response to other organism GO:0051707 97 0.026
protein import GO:0017038 3 0.026
regulation of protein import into nucleus GO:0042306 2 0.026
gene expression GO:0010467 252 0.025
meiotic chromosome segregation GO:0045132 3 0.025
viral process GO:0016032 1 0.025
regulation of protein ubiquitination GO:0031396 3 0.025
regulation of rna metabolic process GO:0051252 224 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.025
single organism organelle organization GO:1902589 199 0.025
positive regulation of nucleoside metabolic process GO:0045979 1 0.025
regulation of response to stimulus GO:0048583 269 0.024
positive regulation of secretion GO:0051047 1 0.024
hemopoiesis GO:0030097 183 0.024
regulation of cytoplasmic transport GO:1903649 4 0.024
cell projection organization GO:0030030 284 0.024
organic cyclic compound biosynthetic process GO:1901362 223 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.024
developmental growth GO:0048589 166 0.024
regulation of gtpase activity GO:0043087 2 0.024
macromolecule biosynthetic process GO:0009059 227 0.023
positive regulation of secretion by cell GO:1903532 1 0.023
stem cell proliferation GO:0072089 4 0.023
regulation of biological quality GO:0065008 263 0.023
macromolecular complex subunit organization GO:0043933 74 0.022
aging GO:0007568 2 0.022
multi organism process GO:0051704 134 0.022
regulation of protein catabolic process GO:0042176 1 0.022
regulation of developmental process GO:0050793 247 0.022
negative regulation of cytoplasmic transport GO:1903650 2 0.022
positive regulation of immune effector process GO:0002699 3 0.022
regulation of purine nucleotide catabolic process GO:0033121 2 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
innate immune response GO:0045087 13 0.022
phosphate containing compound metabolic process GO:0006796 108 0.021
regulation of protein metabolic process GO:0051246 56 0.021
positive regulation of nucleotide catabolic process GO:0030813 1 0.021
cellular protein modification process GO:0006464 100 0.021
leukocyte mediated cytotoxicity GO:0001909 1 0.021
meiotic nuclear division GO:0007126 4 0.021
cytokinesis GO:0000910 3 0.020
mitochondrion organization GO:0007005 4 0.020
positive regulation of gtpase activity GO:0043547 1 0.020
iron ion homeostasis GO:0055072 4 0.020
regulation of cellular protein metabolic process GO:0032268 52 0.020
nucleic acid templated transcription GO:0097659 181 0.020
transcription dna templated GO:0006351 181 0.020
intracellular signal transduction GO:0035556 85 0.020
cellular component assembly GO:0022607 170 0.020
regulation of muscle contraction GO:0006937 3 0.020
regulation of nucleotide catabolic process GO:0030811 2 0.020
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
defense response to bacterium GO:0042742 22 0.019
regulation of gene expression GO:0010468 265 0.019
positive regulation of transport GO:0051050 2 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.019
negative regulation of cellular process GO:0048523 283 0.019
embryonic cranial skeleton morphogenesis GO:0048701 90 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
interspecies interaction between organisms GO:0044419 4 0.019
positive regulation of cellular protein metabolic process GO:0032270 22 0.018
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.018
hematopoietic or lymphoid organ development GO:0048534 191 0.018
regulation of cell activation GO:0050865 1 0.018
response to biotic stimulus GO:0009607 97 0.018
negative regulation of nuclear division GO:0051784 3 0.018
positive regulation of gtp catabolic process GO:0033126 1 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.018
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.018
positive regulation of catalytic activity GO:0043085 25 0.018
regulation of cell shape GO:0008360 1 0.018
reactive oxygen species metabolic process GO:0072593 6 0.017
signal transduction GO:0007165 455 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.017
negative regulation of intracellular transport GO:0032387 3 0.017
regulation of signaling GO:0023051 235 0.017
carbohydrate derivative metabolic process GO:1901135 61 0.017
regulation of hydrolase activity GO:0051336 28 0.017
positive regulation of endopeptidase activity GO:0010950 10 0.017
single organism localization GO:1902578 225 0.017
regulation of peptidase activity GO:0052547 23 0.017
multi organism cellular process GO:0044764 2 0.017
regulation of proteolysis GO:0030162 24 0.017
embryonic neurocranium morphogenesis GO:0048702 15 0.017
organic substance biosynthetic process GO:1901576 289 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
positive regulation of cell cycle GO:0045787 3 0.016
peptide transport GO:0015833 1 0.016
neuron projection morphogenesis GO:0048812 161 0.016
transport GO:0006810 220 0.016
organelle organization GO:0006996 227 0.016
reactive oxygen species biosynthetic process GO:1903409 1 0.016
skeletal system development GO:0001501 181 0.016
homeostatic process GO:0042592 142 0.016
protein complex subunit organization GO:0071822 46 0.015
cellular biosynthetic process GO:0044249 286 0.015
establishment of localization GO:0051234 244 0.015
cell killing GO:0001906 2 0.015
response to organic substance GO:0010033 153 0.015
rna biosynthetic process GO:0032774 181 0.015
cellular component movement GO:0006928 335 0.015
macromolecule modification GO:0043412 111 0.015
regulation of response to cytokine stimulus GO:0060759 3 0.015
regulation of meiotic cell cycle GO:0051445 1 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
regulation of catalytic activity GO:0050790 55 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
regulation of cell killing GO:0031341 2 0.015
meiotic cell cycle process GO:1903046 3 0.015
cellular component biogenesis GO:0044085 178 0.015
cellular component disassembly GO:0022411 1 0.015
regulation of tube size GO:0035150 2 0.015
regulation of blood pressure GO:0008217 1 0.015
immune system development GO:0002520 191 0.014
protein complex localization GO:0031503 1 0.014
protein polyubiquitination GO:0000209 4 0.014
positive regulation of leukocyte mediated immunity GO:0002705 1 0.014
lipid storage GO:0019915 1 0.014
response to nutrient GO:0007584 3 0.014
nucleobase containing small molecule metabolic process GO:0055086 32 0.014
regulation of cytokine production GO:0001817 3 0.014
microtubule based process GO:0007017 60 0.014
positive regulation of protein metabolic process GO:0051247 23 0.014
response to bacterium GO:0009617 58 0.014
nuclear import GO:0051170 3 0.014
protein modification process GO:0036211 100 0.014
atp catabolic process GO:0006200 4 0.014
regulation of cell death GO:0010941 103 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
cilium morphogenesis GO:0060271 85 0.014
secondary metabolic process GO:0019748 3 0.014
endocrine process GO:0050886 2 0.013
cellular response to dsrna GO:0071359 1 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
embryonic skeletal system development GO:0048706 97 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
positive regulation of peptidase activity GO:0010952 10 0.013
growth GO:0040007 174 0.013
superoxide metabolic process GO:0006801 2 0.013
signal transduction in absence of ligand GO:0038034 1 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
regulation of phosphorus metabolic process GO:0051174 43 0.013
regulation of jak stat cascade GO:0046425 3 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
response to hexose GO:0009746 3 0.012
positive regulation of proteolysis GO:0045862 10 0.012
regulation of cell projection assembly GO:0060491 4 0.012
protein phosphorylation GO:0006468 47 0.012
tyrosine phosphorylation of stat protein GO:0007260 1 0.012
regulation of microtubule cytoskeleton organization GO:0070507 3 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
regulation of localization GO:0032879 104 0.012
response to endogenous stimulus GO:0009719 83 0.012
cellular ketone metabolic process GO:0042180 11 0.012
cilium organization GO:0044782 71 0.012
nuclear export GO:0051168 1 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
positive regulation of dna metabolic process GO:0051054 1 0.012
regulation of locomotion GO:0040012 55 0.012
vacuolar transport GO:0007034 2 0.012
regulation of blood vessel size GO:0050880 2 0.012
hormone secretion GO:0046879 2 0.012
immune effector process GO:0002252 23 0.012
regulation of chromosome segregation GO:0051983 1 0.012
microtubule polymerization or depolymerization GO:0031109 3 0.012
regulation of exocytosis GO:0017157 1 0.012
protein polymerization GO:0051258 4 0.011
muscle cell development GO:0055001 115 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
exocytosis GO:0006887 1 0.011
cellular response to nutrient levels GO:0031669 2 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
response to glucocorticoid GO:0051384 1 0.011
smooth muscle contraction GO:0006939 2 0.011
positive regulation of cell activation GO:0050867 1 0.011
regulation of reproductive process GO:2000241 4 0.011
melanin metabolic process GO:0006582 2 0.011
renal tubule morphogenesis GO:0061333 1 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
defense response to other organism GO:0098542 33 0.011
regulation of protein polymerization GO:0032271 2 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
response to stress GO:0006950 263 0.011
regulation of leukocyte mediated immunity GO:0002703 1 0.011
phosphorylation GO:0016310 69 0.011
positive regulation of exocytosis GO:0045921 1 0.011
adult behavior GO:0030534 2 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
leukocyte proliferation GO:0070661 1 0.011
response to vitamin GO:0033273 3 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
peptide metabolic process GO:0006518 1 0.011
regulation of cell communication GO:0010646 232 0.010
regulation of transcription dna templated GO:0006355 213 0.010
death GO:0016265 121 0.010
neuron development GO:0048666 262 0.010
cell morphogenesis involved in differentiation GO:0000904 195 0.010
cellular protein complex assembly GO:0043623 19 0.010
actin polymerization or depolymerization GO:0008154 2 0.010
mitotic cytokinesis GO:0000281 3 0.010
protein localization to plasma membrane GO:0072659 1 0.010
chordate embryonic development GO:0043009 271 0.010
negative regulation of defense response GO:0031348 2 0.010
regulation of transporter activity GO:0032409 2 0.010
positive regulation of ras gtpase activity GO:0032320 1 0.010
generation of neurons GO:0048699 385 0.010

psme2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.092
disease of anatomical entity DOID:7 0 0.092
primary immunodeficiency disease DOID:612 0 0.022
nervous system disease DOID:863 0 0.019
sensory system disease DOID:0050155 0 0.012