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Drosophila melanogaster

35 genes annotated in fly

Multi-species View

negative regulation of defense response

GO:0031348

Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of defense response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of defense response" (in gray)

Name	Description	Probability	Func Analog Organism
PGRP-LC	Peptidoglycan recognition protein LC	0.776	Fly
AttA	Attacin-A	0.451
cact	cactus	0.359
Rel	Relish	0.332	Mouse
PGRP-SD	CG7496 gene product from transcript CG7496-RA	0.286	Fly
tkv	thickveins	0.222	Fly
Mad	Mothers against dpp	0.214
PGRP-LB	Peptidoglycan recognition protein LB	0.202
dco	discs overgrown	0.190
fon	fondue	0.187
grass	Gram-positive Specific Serine protease	0.184
PGRP-SA	Peptidoglycan recognition protein SA	0.169	Fly
DptB	Diptericin B	0.163
LysB	Lysozyme B	0.153	Fly
rl	rolled	0.141
Mtk	Metchnikowin	0.135
CG18594	CG18594 gene product from transcript CG18594-RA	0.130
PGRP-LF	Peptidoglycan recognition protein LF	0.117	Fly
PGRP-SC1a	CG14746 gene product from transcript CG14746-RA	0.116
CG9014	CG9014 gene product from transcript CG9014-RA	0.116
CG6361	CG6361 gene product from transcript CG6361-RA	0.115
Sp7	Serine protease 7	0.114
CG42863	CG42863 gene product from transcript CG42863-RB	0.113
foxo	forkhead box, sub-group O	0.110
Irc	Immune-regulated catalase	0.109
PGRP-SC1b	CG8577 gene product from transcript CG8577-RA	0.107
LysD	Lysozyme D	0.105	Fly
LysE	Lysozyme E	0.099
AttC	Attacin-C	0.088
bcd	bicoid	0.088
Trx-2	thioredoxin-2	0.085
SPE	Spatzle-Processing Enzyme	0.083
LysC	Lysozyme C	0.079
Pi3K92E	CG4141 gene product from transcript CG4141-RB	0.072
CG15917	CG15917 gene product from transcript CG15917-RA	0.071
pirk	poor Imd response upon knock-in	0.064
NFAT	NFAT homolog	0.063
CG32185	CG32185 gene product from transcript CG32185-RA	0.060
fh	frataxin homolog	0.060
CG14864	CG14864 gene product from transcript CG14864-RB	0.050
Mpk2	CG5475 gene product from transcript CG5475-RB	0.049
Myo31DF	Myosin 31DF	0.049
Spn27A	Serpin 27A	0.047
upd3	unpaired 3	0.045	Fly
GNBP3	Gram-negative bacteria binding protein 3	0.044
Eip71CD	Ecdysone-induced protein 28/29kD	0.043
Glut1	Glucose transporter 1	0.043
Drs	Drosomycin	0.043
AGO1	Argonaute-1	0.039
nos	nanos	0.039
Pten	CG5671 gene product from transcript CG5671-RB	0.039
Lmpt	Limpet	0.039
caz	cabeza	0.039
CG17633	CG17633 gene product from transcript CG17633-RA	0.038
psh	persephone	0.038
CG5794	CG5794 gene product from transcript CG5794-RB	0.035
Atg9	Autophagy-specific gene 9	0.035
oys	oysgedart	0.035
eater	CG6124 gene product from transcript CG6124-RB	0.034
p38b	CG7393 gene product from transcript CG7393-RA	0.033
RagA	CG11968 gene product from transcript CG11968-RA	0.032
Nhe3	Na[+]/H[+] hydrogen exchanger 3	0.029
CSN8	COP9 complex homolog subunit 8	0.029
G9a	CG2995 gene product from transcript CG2995-RA	0.029
Spn77Ba	Serpin 77Ba	0.029
dl	dorsal	0.029
upd2	unpaired 2	0.028
CG12943	CG12943 gene product from transcript CG12943-RA	0.028
Stat92E	Signal-transducer and activator of transcription protein at 92E	0.028
PGRP-SC2	CG14745 gene product from transcript CG14745-RA	0.027
Rip11	Rab11 interacting protein	0.027
CG5325	CG5325 gene product from transcript CG5325-RB	0.027
alphaTry	alphaTrypsin	0.026
modSP	modular serine protease	0.026
imd	immune deficiency	0.026
Mmp1	Matrix metalloproteinase 1	0.026
skpA	CG16983 gene product from transcript CG16983-RD	0.025
daw	dawdle	0.025
CG18404	CG18404 gene product from transcript CG18404-RA	0.024
Tsp42Ef	Tetraspanin 42Ef	0.024
IM4	Immune induced molecule 4	0.024
Socs36E	Suppressor of cytokine signaling at 36E	0.024
CG5399	CG5399 gene product from transcript CG5399-RA	0.024
CG15065	CG15065 gene product from transcript CG15065-RA	0.024
IM18	Immune induced molecule 18	0.024
CG8709	CG8709 gene product from transcript CG8709-RK	0.024
phl	pole hole	0.023
CycE	Cyclin E	0.023
Adk2	Adenylate kinase-2	0.023
ash1	absent, small, or homeotic discs 1	0.022	Mouse
Lis-1	Lissencephaly-1	0.022
CG13422	CG13422 gene product from transcript CG13422-RA	0.022
CG6503	CG6503 gene product from transcript CG6503-RA	0.022
Sod2	Superoxide dismutase 2 (Mn)	0.022
CG13060	CG13060 gene product from transcript CG13060-RA	0.022
CG5346	CG5346 gene product from transcript CG5346-RA	0.022
Ser7	CG2045 gene product from transcript CG2045-RA	0.021
CG17107	CG17107 gene product from transcript CG17107-RA	0.021
CaMKII	Calcium/calmodulin-dependent protein kinase II	0.021
cv-c	crossveinless c	0.021
ird1	immune response deficient 1	0.021
coro	CG9446 gene product from transcript CG9446-RC	0.021
CG30031	CG30031 gene product from transcript CG30031-RA	0.020
krz	kurtz	0.020
jdp	CG2239 gene product from transcript CG2239-RB	0.020
hpo	hippo	0.020
bgcn	benign gonial cell neoplasm	0.019
wnd	wallenda	0.019
p53	CG33336 gene product from transcript CG33336-RB	0.019
Tk	Tachykinin	0.019
Spn1	Serine protease inhibitor 1	0.019	Rat
Thor	CG8846 gene product from transcript CG8846-RA	0.019
Rim	CG33547 gene product from transcript CG33547-RB	0.019
CG12974	CG12974 gene product from transcript CG12974-RA	0.019
CG9498	CG9498 gene product from transcript CG9498-RA	0.019
Nplp4	Neuropeptide-like precursor 4	0.019
Anxb11	Annexin B11	0.018
swa	swallow	0.018
LysP	Lysozyme P	0.018	Fly
Atg6	Autophagy-specific gene 6	0.018
pnt	pointed	0.018
betaTry	betaTrypsin	0.018
CecC	Cecropin C	0.018
Prx5037	Peroxiredoxin 5037	0.018
msopa	male-specific opa containing gene	0.018
Jafrac1	thioredoxin peroxidase 1	0.018
CG4847	CG4847 gene product from transcript CG4847-RA	0.017
CG4199	CG4199 gene product from transcript CG4199-RG	0.017
Surf1	Surfeit 1	0.017
SIFR	SIFamide receptor	0.017
dap	dacapo	0.017
hebe	CG1623 gene product from transcript CG1623-RD	0.017
cad	caudal	0.017
PGRP-SB1	CG9681 gene product from transcript CG9681-RA	0.017	Fly
Oatp33Eb	Organic anion transporting polypeptide 33Eb	0.017
tai	taiman	0.017
CG13641	CG13641 gene product from transcript CG13641-RA	0.017
whd	withered	0.017
dm	diminutive	0.017
CG18284	CG18284 gene product from transcript CG18284-RB	0.017
CG5835	CG5835 gene product from transcript CG5835-RA	0.017
sqz	squeeze	0.017
epsilonTry	epsilonTrypsin	0.016
Octbeta2R	CG33976 gene product from transcript CG33976-RA	0.016
Bace	beta-site APP-cleaving enzyme	0.016
Tsf1	Transferrin 1	0.016
Ack	CG14992 gene product from transcript CG14992-RA	0.016
REG	CG1591 gene product from transcript CG1591-RA	0.016
CG31739	CG31739 gene product from transcript CG31739-RA	0.016
CG13965	CG13965 gene product from transcript CG13965-RA	0.016
Smox	Smad on X	0.016
GNBP1	Gram-negative bacteria binding protein 1	0.016
Atg13	Autophagy-specific gene 13	0.016
Gadd45	CG11086 gene product from transcript CG11086-RA	0.016
Rbp6	RNA-binding protein 6	0.016
POSH	Plenty of SH3s	0.016
spirit	Serine Protease Immune Response Integrator	0.015
CG9005	CG9005 gene product from transcript CG9005-RB	0.015
dro5	drosomycin-5	0.015
Rpb10	CG13628 gene product from transcript CG13628-RA	0.015
CG5773	CG5773 gene product from transcript CG5773-RA	0.015
CG14823	CG14823 gene product from transcript CG14823-RD	0.015
Dro	Drosocin	0.015
CG13482	CG13482 gene product from transcript CG13482-RA	0.015
CG10472	CG10472 gene product from transcript CG10472-RA	0.015
CAH1	Carbonic anhydrase 1	0.015
Hsp67Ba	Heat shock gene 67Ba	0.015
neo	neyo	0.015
CG16713	CG16713 gene product from transcript CG16713-RA	0.015
CG11151	CG11151 gene product from transcript CG11151-RA	0.015
CG5890	CG5890 gene product from transcript CG5890-RB	0.015
sphinx1	CG32383 gene product from transcript CG32383-RB	0.015
Dpt	Diptericin	0.015
CG33138	CG33138 gene product from transcript CG33138-RA	0.015
CG3292	CG3292 gene product from transcript CG3292-RA	0.015
tam	tamas	0.015
CG10992	CG10992 gene product from transcript CG10992-RA	0.015
CG10912	CG10912 gene product from transcript CG10912-RA	0.015
Gem3	Gemin3	0.014
CG4734	CG4734 gene product from transcript CG4734-RA	0.014
Spn5	Serine protease inhibitor 5	0.014
debcl	death executioner Bcl-2 homologue	0.014
MP1	Melanization Protease 1	0.014
CG10650	CG10650 gene product from transcript CG10650-RA	0.014
Dip3	Dorsal interacting protein 3	0.014
Nrx-IV	Neurexin IV	0.014
pico	CG11940 gene product from transcript CG11940-RA	0.014
Spn28D	Serpin 28D	0.014
Cht11	CG3044 gene product from transcript CG3044-RA	0.014
pgant5	polypeptide GalNAc transferase 5	0.014
Jon65Aiii	Jonah 65Aiii	0.014
spz	spatzle	0.014
Alh	Alhambra	0.014
Sir2	CG5216 gene product from transcript CG5216-RA	0.014
CG11286	CG11286 gene product from transcript CG11286-RA	0.014
Hr39	Hormone receptor-like in 39	0.014
KCNQ	KCNQ potassium channel	0.014
l(1)G0289	lethal (1) G0289	0.014
fan	farinelli	0.014
Tsp42Ed	Tetraspanin 42Ed	0.014
CG6969	CG6969 gene product from transcript CG6969-RA	0.014
rnh1	ribonuclease H1	0.014
CG9796	CG9796 gene product from transcript CG9796-RA	0.014
Pvf1	PDGF- and VEGF-related factor 1	0.014
CSN4	COP9 complex homolog subunit 4	0.014
CG18480	CG18480 gene product from transcript CG18480-RA	0.014
stai	stathmin	0.014
Hsp27	Heat shock protein 27	0.014
IM10	Immune induced molecule 10	0.013
Egm	Enigma	0.013
scb	scab	0.013
Spn6	Serine protease inhibitor 6	0.013	Rat
stj	straightjacket	0.013
cv-2	crossveinless 2	0.013
Traf4	TNF-receptor-associated factor 4	0.013
CG13086	CG13086 gene product from transcript CG13086-RA	0.013
CG32066	CG32066 gene product from transcript CG32066-RC	0.013
CG5791	CG5791 gene product from transcript CG5791-RA	0.013
CG9782	CG9782 gene product from transcript CG9782-RA	0.013
Sema-1b	CG6446 gene product from transcript CG6446-RA	0.013
Mec2	CG7635 gene product from transcript CG7635-RA	0.013
Jon99Ciii	Jonah 99Ciii	0.013
dj-1beta	CG1349 gene product from transcript CG1349-RA	0.013
stck	steamer duck	0.013
pcs	parcas	0.013
CG30269	CG30269 gene product from transcript CG30269-RA	0.013
insc	inscuteable	0.013
yki	yorkie	0.013
CG15482	CG15482 gene product from transcript CG15482-RA	0.013
sm	smooth	0.013
CG1724	CG1724 gene product from transcript CG1724-RA	0.013
Nach	CG8178 gene product from transcript CG8178-RA	0.013
Tom70	Translocase of outer membrane 70	0.013
ird5	immune response deficient 5	0.013
CG12338	CG12338 gene product from transcript CG12338-RA	0.013
key	kenny	0.013
CG7567	CG7567 gene product from transcript CG7567-RA	0.013
ltd	lightoid	0.013
spag4	sperm-associated antigen 4	0.013
Unc-76	CG3981 gene product from transcript CG3981-RB	0.013
CG8369	CG8369 gene product from transcript CG8369-RA	0.013
CG13321	CG13321 gene product from transcript CG13321-RA	0.013
pdfr	PDF receptor	0.013
CG4036	CG4036 gene product from transcript CG4036-RC	0.013
kar	karmoisin	0.013
wal	walrus	0.013
RhoGAP15B	CG4937 gene product from transcript CG4937-RC	0.012
CG17754	CG17754 gene product from transcript CG17754-RC	0.012
CG15353	CG15353 gene product from transcript CG15353-RA	0.012
edl	ETS-domain lacking	0.012
Syt4	Synaptotagmin 4	0.012
Obp18a	Odorant-binding protein 18a	0.012
Six4	CG3871 gene product from transcript CG3871-RA	0.012
CG8531	CG8531 gene product from transcript CG8531-RA	0.012
dimm	dimmed	0.012
ns2	nucleostemin 2	0.012
pasha	partner of drosha	0.012
yps	ypsilon schachtel	0.012
CG18067	CG18067 gene product from transcript CG18067-RA	0.012
CG17097	CG17097 gene product from transcript CG17097-RB	0.012
CG9691	CG9691 gene product from transcript CG9691-RB	0.012
La	La autoantigen-like	0.012
jumu	jumeau	0.012
CG4577	CG4577 gene product from transcript CG4577-RA	0.012
thetaTry	thetaTrypsin	0.012
CG6543	CG6543 gene product from transcript CG6543-RA	0.012
Map205	Microtubule-associated protein 205	0.012
Hsp23	Heat shock protein 23	0.012
CG42630	CG42630 gene product from transcript CG42630-RA	0.012
rols	rolling pebbles	0.012
Gef64C	Guanine nucleotide exchange factor GEF64C	0.012
CG31619	CG31619 gene product from transcript CG31619-RC	0.012
CG13506	CG13506 gene product from transcript CG13506-RA	0.012
Iswi	Imitation SWI	0.012
Rb97D	Ribonuclear protein at 97D	0.012
Peritrophin-15a	CG17814 gene product from transcript CG17814-RA	0.012
hb	hunchback	0.012
CG14073	CG14073 gene product from transcript CG14073-RB	0.012
CG8586	CG8586 gene product from transcript CG8586-RA	0.012
CG11911	CG11911 gene product from transcript CG11911-RA	0.012
nmo	nemo	0.012
star1	allatostatin C receptor 1	0.012
CG13810	CG13810 gene product from transcript CG13810-RA	0.012
CG15347	CG15347 gene product from transcript CG15347-RA	0.012
Cyp18a1	Cytochrome P450-18a1	0.012
CG13068	CG13068 gene product from transcript CG13068-RA	0.012
mRpS30	mitochondrial ribosomal protein S30	0.011
CG9743	CG9743 gene product from transcript CG9743-RA	0.011
dgt5	dim gamma-tubulin 5	0.011
Actbeta	Activin-beta	0.011
ade3	adenosine 3	0.011
CG18557	CG18557 gene product from transcript CG18557-RA	0.011
Atg1	Autophagy-specific gene 1	0.011
CG6701	CG6701 gene product from transcript CG6701-RD	0.011
CG2789	CG2789 gene product from transcript CG2789-RA	0.011
retn	retained	0.011
drk	downstream of receptor kinase	0.011
tsr	twinstar	0.011
CG11347	CG11347 gene product from transcript CG11347-RE	0.011
glec	gliolectin	0.011
Ntl	Neurotransmitter transporter-like	0.011
eya	eyes absent	0.011
Clk	Clock	0.011
CG42613	CG42613 gene product from transcript CG42613-RC	0.011
m1	E(spl) region transcript m1	0.011
CG4080	CG4080 gene product from transcript CG4080-RA	0.011
CG9316	CG9316 gene product from transcript CG9316-RA	0.011
CG5335	CG5335 gene product from transcript CG5335-RA	0.011
unk	unkempt	0.011
CG34370	CG34370 gene product from transcript CG34370-RG	0.011
CG14300	CG14300 gene product from transcript CG14300-RA	0.011
CG7376	CG7376 gene product from transcript CG7376-RA	0.011
Mt2	Methyltransferase 2	0.011
CG13830	CG13830 gene product from transcript CG13830-RD	0.011
Eig71Ec	Ecdysone-induced gene 71Ec	0.011
CG14452	CG14452 gene product from transcript CG14452-RA	0.011
Syx17	Syntaxin 17	0.011
Pros54	Proteasome 54kD subunit	0.011
CG4461	CG4461 gene product from transcript CG4461-RA	0.011
Duox	Dual oxidase	0.011
CG9380	CG9380 gene product from transcript CG9380-RC	0.011
Acp63F	Accessory gland peptide 63F	0.011
koi	klaroid	0.011
Chrac-14	CG13399 gene product from transcript CG13399-RA	0.011
CG13323	CG13323 gene product from transcript CG13323-RA	0.011
Crag	Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein	0.011
CG14017	CG14017 gene product from transcript CG14017-RA	0.011
CG17145	CG17145 gene product from transcript CG17145-RA	0.011
SdhB	Succinate dehydrogenase B	0.011
Or2a	Odorant receptor 2a	0.011
trpm	CG34123 gene product from transcript CG34123-RG	0.011
CG1347	CG1347 gene product from transcript CG1347-RB	0.011
LamC	Lamin C	0.011
Acp32CD	Accessory gland-specific peptide 32CD	0.011
CG5953	CG5953 gene product from transcript CG5953-RA	0.011
Spn77Bb	Serpin 77Bb	0.011
egr	eiger	0.011
Jon99Ci	Jonah 99Ci	0.011
CBP	sarcoplasmic calcium-binding protein	0.011
Ag5r	Antigen 5-related	0.011
obst-A	obstructor-A	0.011
Sk1	Sphingosine kinase 1	0.011
ImpE2	Ecdysone-inducible gene E2	0.011
CG4757	CG4757 gene product from transcript CG4757-RA	0.011
Dcr-2	Dicer-2	0.011
CG14626	CG14626 gene product from transcript CG14626-RA	0.011
CG10543	CG10543 gene product from transcript CG10543-RA	0.011
CG14401	CG14401 gene product from transcript CG14401-RA	0.011
mmd	mind-meld	0.011
Kua	CG10723 gene product from transcript CG10723-RA	0.011
Nep4	Neprilysin 4	0.011
pigeon	CG10739 gene product from transcript CG10739-RB	0.010
poly	CG9829 gene product from transcript CG9829-RB	0.010
Krn	Keren	0.010
CG13040	CG13040 gene product from transcript CG13040-RA	0.010
CG16718	CG16718 gene product from transcript CG16718-RA	0.010
jet	jetlag	0.010
Arr2	Arrestin 2	0.010
CG4781	CG4781 gene product from transcript CG4781-RA	0.010
CG17329	CG17329 gene product from transcript CG17329-RA	0.010
bbg	big bang	0.010
CG7290	CG7290 gene product from transcript CG7290-RA	0.010
CG3884	CG3884 gene product from transcript CG3884-RA	0.010
CG9757	CG9757 gene product from transcript CG9757-RA	0.010
PIP5K59B	CG3682 gene product from transcript CG3682-RE	0.010
spz6	spatzle 6	0.010
hug	hugin	0.010
CG9733	CG9733 gene product from transcript CG9733-RA	0.010
mnb	minibrain	0.010
Mst57Dc	Male-specific RNA 57Dc	0.010
Aps	CG6391 gene product from transcript CG6391-RC	0.010
l(2)01810	lethal (2) 01810	0.010
CG13737	CG13737 gene product from transcript CG13737-RA	0.010
CG9717	CG9717 gene product from transcript CG9717-RA	0.010
alpha-Est9	alpha-Esterase-9	0.010
Aplip1	APP-like protein interacting protein 1	0.010
CG10803	CG10803 gene product from transcript CG10803-RA	0.010
S6kII	RPS6-protein kinase-II	0.010
Akt1	CG4006 gene product from transcript CG4006-RA	0.010
hfw	halfway	0.010
Tsp42Eq	Tetraspanin 42Eq	0.010
CG10337	CG10337 gene product from transcript CG10337-RA	0.010