IMP

Process View

Homo sapiens

5 genes annotated in human

negative regulation of chemokine mediated signaling pathway

Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of chemokine mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of chemokine mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
IL8	interleukin 8	0.993
CXCL9	chemokine (C-X-C motif) ligand 9	0.973
IL1B	interleukin 1, beta	0.972
CCL4	chemokine (C-C motif) ligand 4	0.968	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.955
CXCL10	chemokine (C-X-C motif) ligand 10	0.904
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.880
IL6	interleukin 6 (interferon, beta 2)	0.858
CXCL3	chemokine (C-X-C motif) ligand 3	0.851
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.843	Human
CCL2	chemokine (C-C motif) ligand 2	0.711	Human
CCL8	chemokine (C-C motif) ligand 8	0.692	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.602
ICAM1	intercellular adhesion molecule 1	0.532
IDE	insulin-degrading enzyme	0.522
CCL20	chemokine (C-C motif) ligand 20	0.313	Human
GNLY	granulysin	0.293
CCL5	chemokine (C-C motif) ligand 5	0.268
CCL13	chemokine (C-C motif) ligand 13	0.263	Human
DPP4	dipeptidyl-peptidase 4	0.238
CCR1	chemokine (C-C motif) receptor 1	0.220
CCR7	chemokine (C-C motif) receptor 7	0.216
TRAF1	TNF receptor-associated factor 1	0.190
CCL3	chemokine (C-C motif) ligand 3	0.190	Human
IFNG	interferon, gamma	0.183
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.139
IL2RB	interleukin 2 receptor, beta	0.132
CXCL13	chemokine (C-X-C motif) ligand 13	0.131
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.124
VCAM1	vascular cell adhesion molecule 1	0.122
CCL19	chemokine (C-C motif) ligand 19	0.119	Human
CCL11	chemokine (C-C motif) ligand 11	0.117	Human
CD83	CD83 molecule	0.117
CPE	carboxypeptidase E	0.110
CXCL5	chemokine (C-X-C motif) ligand 5	0.110
RGS1	regulator of G-protein signaling 1	0.103
CCL7	chemokine (C-C motif) ligand 7	0.098	Human
IL10	interleukin 10	0.091
CCL22	chemokine (C-C motif) ligand 22	0.075
SELE	selectin E	0.067
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.058
IL7R	interleukin 7 receptor	0.057
BCL2A1	BCL2-related protein A1	0.052
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.049
TNF	tumor necrosis factor	0.047
UBD	ubiquitin D	0.042
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.041
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.039
DARC	Duffy blood group, chemokine receptor	0.037
IL1RN	interleukin 1 receptor antagonist	0.033
CD163	CD163 molecule	0.033
CH25H	cholesterol 25-hydroxylase	0.032
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.032
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.029
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.029
SRGN	serglycin	0.029
CD69	CD69 molecule	0.026
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.026
IL18RAP	interleukin 18 receptor accessory protein	0.025
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.025
IL2RG	interleukin 2 receptor, gamma	0.023
SLAMF7	SLAM family member 7	0.022
SOD2	superoxide dismutase 2, mitochondrial	0.022
CCR4	chemokine (C-C motif) receptor 4	0.022
STAT4	signal transducer and activator of transcription 4	0.021
IL10RA	interleukin 10 receptor, alpha	0.020
IDO1	indoleamine 2,3-dioxygenase 1	0.019
CXCR6	chemokine (C-X-C motif) receptor 6	0.019
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.018
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.018
FPR3	formyl peptide receptor 3	0.018
CCL21	chemokine (C-C motif) ligand 21	0.016
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.016
NKG7	natural killer cell group 7 sequence	0.016
DPT	dermatopontin	0.014
ARRB1	arrestin, beta 1	0.014
INHBA	inhibin, beta A	0.013
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.013
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.013
IL32	interleukin 32	0.013
IL18R1	interleukin 18 receptor 1	0.012
GZMK	granzyme K (granzyme 3; tryptase II)	0.012
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.012
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.012
IL2RA	interleukin 2 receptor, alpha	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
ADAMDEC1	ADAM-like, decysin 1	0.011
XCL2	chemokine (C motif) ligand 2	0.011
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.010
SLAMF8	SLAM family member 8	0.010