IMP

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Homo sapiens

29 genes annotated in human

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regulation of bone mineralization

GO:0030500

Any process that modulates the frequency, rate or extent of bone mineralization.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of bone mineralization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of bone mineralization" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.999	Human
CCL5	chemokine (C-C motif) ligand 5	0.997	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.994
SMAD2	SMAD family member 2	0.980
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.967
BMP2	bone morphogenetic protein 2	0.961
TGFB1	transforming growth factor, beta 1	0.928
FSTL1	follistatin-like 1	0.901
CCL22	chemokine (C-C motif) ligand 22	0.886	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.826
ENG	endoglin	0.813
FKBP1A	FK506 binding protein 1A, 12kDa	0.805
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.716
CXCL10	chemokine (C-X-C motif) ligand 10	0.689
TGFB3	transforming growth factor, beta 3	0.666
IFNG	interferon, gamma	0.651
RUNX1	runt-related transcription factor 1	0.636
CCR4	chemokine (C-C motif) receptor 4	0.630	Human
BMPR1B	bone morphogenetic protein receptor, type IB	0.625
CCR7	chemokine (C-C motif) receptor 7	0.612	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.560
CCL3	chemokine (C-C motif) ligand 3	0.558
IL2RB	interleukin 2 receptor, beta	0.554
SETD8	SET domain containing (lysine methyltransferase) 8	0.547
CCL4	chemokine (C-C motif) ligand 4	0.543	Human
GDF5	growth differentiation factor 5	0.467	Human
CCL2	chemokine (C-C motif) ligand 2	0.425	Human
SMAD7	SMAD family member 7	0.413
VCAN	versican	0.345
CCL8	chemokine (C-C motif) ligand 8	0.314	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.305
KDM2B	lysine (K)-specific demethylase 2B	0.267
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.256
CCL13	chemokine (C-C motif) ligand 13	0.248	Human
CXCR6	chemokine (C-X-C motif) receptor 6	0.236	Human
IRF4	interferon regulatory factor 4	0.232
CCL19	chemokine (C-C motif) ligand 19	0.224	Human
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.215
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.215
IL10	interleukin 10	0.214
CXCL13	chemokine (C-X-C motif) ligand 13	0.211
CCR2	chemokine (C-C motif) receptor 2	0.209	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.189
BMP4	bone morphogenetic protein 4	0.187
CCL7	chemokine (C-C motif) ligand 7	0.185	Human
CCL11	chemokine (C-C motif) ligand 11	0.183	Human
TM4SF1	transmembrane 4 L six family member 1	0.181
GATA2	GATA binding protein 2	0.174
SPRR2A	small proline-rich protein 2A	0.174
COL11A2	collagen, type XI, alpha 2	0.158
SMAD1	SMAD family member 1	0.156
CXCR3	chemokine (C-X-C motif) receptor 3	0.138	Human
PTPRA	protein tyrosine phosphatase, receptor type, A	0.130
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.124
SRCIN1	SRC kinase signaling inhibitor 1	0.122
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.121
DPP4	dipeptidyl-peptidase 4	0.119
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.111
NOG	noggin	0.106
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.105
PRKG1	protein kinase, cGMP-dependent, type I	0.105
ARRDC3	arrestin domain containing 3	0.103
RGS1	regulator of G-protein signaling 1	0.090
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.089
IL1B	interleukin 1, beta	0.086
CCR1	chemokine (C-C motif) receptor 1	0.086
CD40LG	CD40 ligand	0.083
IL6	interleukin 6 (interferon, beta 2)	0.082
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.081
IL8	interleukin 8	0.080
EP300	E1A binding protein p300	0.076
SLAMF7	SLAM family member 7	0.075
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.073
ACVR1	activin A receptor, type I	0.073
CXCR5	chemokine (C-X-C motif) receptor 5	0.069	Human
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.069
EPAS1	endothelial PAS domain protein 1	0.068
MATK	megakaryocyte-associated tyrosine kinase	0.067
CCR9	chemokine (C-C motif) receptor 9	0.065	Human
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.061
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.061
CXCL11	chemokine (C-X-C motif) ligand 11	0.061
KAT2B	K(lysine) acetyltransferase 2B	0.060
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.060
TGFBR1	transforming growth factor, beta receptor 1	0.059	Human
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.058
WNT2	wingless-type MMTV integration site family member 2	0.054	Human
ACVR2B	activin A receptor, type IIB	0.053
DNM1	dynamin 1	0.053
CCR8	chemokine (C-C motif) receptor 8	0.053	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.050	Human
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.048
NRP1	neuropilin 1	0.047
KCTD1	potassium channel tetramerisation domain containing 1	0.045
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.045
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.044
IL1F5	interleukin 1 family, member 5 (delta)	0.043
FOXF2	forkhead box F2	0.042
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.041
GDNF	glial cell derived neurotrophic factor	0.040
IL4	interleukin 4	0.039
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.039
IQGAP1	IQ motif containing GTPase activating protein 1	0.039
TLX1	T-cell leukemia homeobox 1	0.038
INHBA	inhibin, beta A	0.038
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.038
TGFBR3	transforming growth factor, beta receptor III	0.037
ALB	albumin	0.036
WNT1	wingless-type MMTV integration site family, member 1	0.036	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.036
SH3BP4	SH3-domain binding protein 4	0.035
APP	amyloid beta (A4) precursor protein	0.035
FGF18	fibroblast growth factor 18	0.034
SMAD9	SMAD family member 9	0.034
IL21R	interleukin 21 receptor	0.034
IDE	insulin-degrading enzyme	0.034
CXCL12	chemokine (C-X-C motif) ligand 12	0.034
HDAC9	histone deacetylase 9	0.034
CCR6	chemokine (C-C motif) receptor 6	0.033	Human
MEF2A	myocyte enhancer factor 2A	0.033
ESR1	estrogen receptor 1	0.033
EGLN3	egl nine homolog 3 (C. elegans)	0.033
MYOD1	myogenic differentiation 1	0.032
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.032
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.032
CXCR4	chemokine (C-X-C motif) receptor 4	0.031	Human
COL2A1	collagen, type II, alpha 1	0.030
IL6R	interleukin 6 receptor	0.030
TNF	tumor necrosis factor	0.030
SMAD6	SMAD family member 6	0.030
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.029
FGF8	fibroblast growth factor 8 (androgen-induced)	0.029
IL1A	interleukin 1, alpha	0.028
SNAPIN	SNAP-associated protein	0.028
SOX1	SRY (sex determining region Y)-box 1	0.028
HAND2	heart and neural crest derivatives expressed 2	0.028	Human
EBI3	Epstein-Barr virus induced 3	0.027
UBR4	ubiquitin protein ligase E3 component n-recognin 4	0.026
PLA2G2D	phospholipase A2, group IID	0.026
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.026
CCL1	chemokine (C-C motif) ligand 1	0.026	Human
CCL20	chemokine (C-C motif) ligand 20	0.026	Human
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.025
SLAMF1	signaling lymphocytic activation molecule family member 1	0.025
PDCD1	programmed cell death 1	0.025
CD86	CD86 molecule	0.025
EPHB2	EPH receptor B2	0.025
TCF12	transcription factor 12	0.025
PTEN	phosphatase and tensin homolog	0.024
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.024
SFRP1	secreted frizzled-related protein 1	0.024
NEUROG2	neurogenin 2	0.024	Human
IL18RAP	interleukin 18 receptor accessory protein	0.024
FGF3	fibroblast growth factor 3	0.023
IL13	interleukin 13	0.022
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.022
RUNX2	runt-related transcription factor 2	0.022
FZD7	frizzled homolog 7 (Drosophila)	0.022
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.022
TBX21	T-box 21	0.021
SHOX2	short stature homeobox 2	0.021
GABARAPL1	GABA(A) receptor-associated protein like 1	0.021
GAB2	GRB2-associated binding protein 2	0.020
CD80	CD80 molecule	0.020
IL7R	interleukin 7 receptor	0.020
LAG3	lymphocyte-activation gene 3	0.020
SELE	selectin E	0.020
CXCR2	chemokine (C-X-C motif) receptor 2	0.020	Human
WIF1	WNT inhibitory factor 1	0.019
IHH	Indian hedgehog	0.019
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.019
CCL21	chemokine (C-C motif) ligand 21	0.019
FPR3	formyl peptide receptor 3	0.019
FOXF1	forkhead box F1	0.019
SIX6	SIX homeobox 6	0.019
IL2RA	interleukin 2 receptor, alpha	0.019
MMP19	matrix metallopeptidase 19	0.018
INSR	insulin receptor	0.018
PITPNM3	PITPNM family member 3	0.018
EFS	embryonal Fyn-associated substrate	0.018
EVI2B	ecotropic viral integration site 2B	0.018
GAS1	growth arrest-specific 1	0.018
NELL1	NEL-like 1 (chicken)	0.018
ADAMDEC1	ADAM-like, decysin 1	0.018
IL11	interleukin 11	0.018
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.018
HTR4	5-hydroxytryptamine (serotonin) receptor 4	0.018
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.018
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	0.018
FOXB1	forkhead box B1	0.018
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.018
CLEC7A	C-type lectin domain family 7, member A	0.018
HOXC8	homeobox C8	0.017
SOD3	superoxide dismutase 3, extracellular	0.017
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.017
ALX4	ALX homeobox 4	0.017
LNX1	ligand of numb-protein X 1	0.017
PTK2	PTK2 protein tyrosine kinase 2	0.017
FGF4	fibroblast growth factor 4	0.017
CCR3	chemokine (C-C motif) receptor 3	0.017	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.017
NRP2	neuropilin 2	0.017
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.017
EGFL6	EGF-like-domain, multiple 6	0.017
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.017
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.016
DARC	Duffy blood group, chemokine receptor	0.016
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.016
EFNB3	ephrin-B3	0.016
CD83	CD83 molecule	0.016
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.016
TAL1	T-cell acute lymphocytic leukemia 1	0.016	Human
IL2RG	interleukin 2 receptor, gamma	0.016
LGALS2	lectin, galactoside-binding, soluble, 2	0.016
MUC1	mucin 1, cell surface associated	0.015
PHOX2A	paired-like homeobox 2a	0.015
MSC	musculin	0.015
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.015
IL1RN	interleukin 1 receptor antagonist	0.015
KLF1	Kruppel-like factor 1 (erythroid)	0.015
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.015
RUNX3	runt-related transcription factor 3	0.015
AHR	aryl hydrocarbon receptor	0.015
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	0.015
CSF1	colony stimulating factor 1 (macrophage)	0.015
SMAD4	SMAD family member 4	0.015
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.015
AQP5	aquaporin 5	0.015
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.014
RGS16	regulator of G-protein signaling 16	0.014
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.014
CXCL5	chemokine (C-X-C motif) ligand 5	0.014
ACVR1B	activin A receptor, type IB	0.014	Human
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.014
FEV	FEV (ETS oncogene family)	0.014
PRRX2	paired related homeobox 2	0.014
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.014
DUOX1	dual oxidase 1	0.014
WISP1	WNT1 inducible signaling pathway protein 1	0.014
ACTL8	actin-like 8	0.014
FGF10	fibroblast growth factor 10	0.014
C2	complement component 2	0.014
WISP2	WNT1 inducible signaling pathway protein 2	0.014
ADRB3	adrenergic, beta-3-, receptor	0.014
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.014
C11orf10	chromosome 11 open reading frame 10	0.014
DHH	desert hedgehog	0.013
USP15	ubiquitin specific peptidase 15	0.013
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.013
MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.013
DDR2	discoidin domain receptor tyrosine kinase 2	0.013
HIPK2	homeodomain interacting protein kinase 2	0.013
WNT7A	wingless-type MMTV integration site family, member 7A	0.013	Human
NKX3-2	NK3 homeobox 2	0.013
SELPLG	selectin P ligand	0.013
LAMA5	laminin, alpha 5	0.013
BMP8B	bone morphogenetic protein 8b	0.013	Human
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.013
IL9	interleukin 9	0.013
CH25H	cholesterol 25-hydroxylase	0.013
CCL17	chemokine (C-C motif) ligand 17	0.013	Human
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.013
POU4F3	POU class 4 homeobox 3	0.013
TG	thyroglobulin	0.013
PLEK	pleckstrin	0.013
EIF2D	eukaryotic translation initiation factor 2D	0.013
MAPK8	mitogen-activated protein kinase 8	0.013
DIO3	deiodinase, iodothyronine, type III	0.013
SOX11	SRY (sex determining region Y)-box 11	0.013
HMX1	H6 family homeobox 1	0.013
XCR1	chemokine (C motif) receptor 1	0.013	Human
FGF21	fibroblast growth factor 21	0.013
HIC1	hypermethylated in cancer 1	0.013
TCF4	transcription factor 4	0.013
PDX1	pancreatic and duodenal homeobox 1	0.012
PITX2	paired-like homeodomain 2	0.012
IL1R2	interleukin 1 receptor, type II	0.012
NPAS1	neuronal PAS domain protein 1	0.012
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.012
HAS2	hyaluronan synthase 2	0.012
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.012
VCAM1	vascular cell adhesion molecule 1	0.012
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	0.012
FZD10	frizzled homolog 10 (Drosophila)	0.012
ADAM15	ADAM metallopeptidase domain 15	0.012
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.012
AQP9	aquaporin 9	0.012
SSX4	synovial sarcoma, X breakpoint 4	0.012
PF4	platelet factor 4	0.012
OAF	OAF homolog (Drosophila)	0.012
HEMGN	hemogen	0.012
TRAF1	TNF receptor-associated factor 1	0.011
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.011
CDCP1	CUB domain containing protein 1	0.011
TGFB2	transforming growth factor, beta 2	0.011	Human
SCRT1	scratch homolog 1, zinc finger protein (Drosophila)	0.011
DLX4	distal-less homeobox 4	0.011
HDAC4	histone deacetylase 4	0.011
CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
PRPH	peripherin	0.011
ARRB1	arrestin, beta 1	0.011
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
CD160	CD160 molecule	0.011
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
GSC2	goosecoid homeobox 2	0.011
CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.011	Human
VSX1	visual system homeobox 1	0.011
NEUROG1	neurogenin 1	0.011	Human
TCF21	transcription factor 21	0.011
POU4F2	POU class 4 homeobox 2	0.011
LY96	lymphocyte antigen 96	0.011
CD48	CD48 molecule	0.011
SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
HOXD11	homeobox D11	0.011
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.011
VAX1	ventral anterior homeobox 1	0.011
INHBB	inhibin, beta B	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.011
FBLN1	fibulin 1	0.011
ITGB8	integrin, beta 8	0.011
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.011
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.011
FOXD3	forkhead box D3	0.011
SLURP1	secreted LY6/PLAUR domain containing 1	0.011
HES2	hairy and enhancer of split 2 (Drosophila)	0.011
HOXD13	homeobox D13	0.010
ICOSLG	inducible T-cell co-stimulator ligand	0.010
KREMEN2	kringle containing transmembrane protein 2	0.010
TBC1D10A	TBC1 domain family, member 10A	0.010
GJD2	gap junction protein, delta 2, 36kDa	0.010
TSHB	thyroid stimulating hormone, beta	0.010
BMP6	bone morphogenetic protein 6	0.010
ACAN	aggrecan	0.010