IMP

Process View

Homo sapiens

20 genes annotated in human

regulated secretory pathway

A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulated secretory pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulated secretory pathway" (in gray)

Name	Description	Probability	Func Analog Organism
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.572
CCR5	chemokine (C-C motif) receptor 5	0.488
EGFR	epidermal growth factor receptor	0.294
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.282
PLCG1	phospholipase C, gamma 1	0.221
BLNK	B-cell linker	0.211
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.206
LAT	linker for activation of T cells	0.203
GRB2	growth factor receptor-bound protein 2	0.186
GBA	glucosidase, beta, acid	0.185
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.164	Human
SYK	spleen tyrosine kinase	0.155	Mouse Rat
CCL4	chemokine (C-C motif) ligand 4	0.150	Human
SNAP23	synaptosomal-associated protein, 23kDa	0.146
UBASH3B	ubiquitin associated and SH3 domain containing B	0.123
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.120
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.116
C19orf50	chromosome 19 open reading frame 50	0.111
VEGFA	vascular endothelial growth factor A	0.089
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.085
EEA1	early endosome antigen 1	0.084
PPL	periplakin	0.081
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.071
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.062
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.057
GAB1	GRB2-associated binding protein 1	0.056
CCL5	chemokine (C-C motif) ligand 5	0.056	Human
IL2RG	interleukin 2 receptor, gamma	0.056
RAB14	RAB14, member RAS oncogene family	0.053
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.048
CCL2	chemokine (C-C motif) ligand 2	0.045	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.044
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.044
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.042
CCR7	chemokine (C-C motif) receptor 7	0.042
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.042
CXCL9	chemokine (C-X-C motif) ligand 9	0.041
VAV1	vav 1 guanine nucleotide exchange factor	0.041
TFF1	trefoil factor 1	0.038
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.038	Human
CCR1	chemokine (C-C motif) receptor 1	0.036
ZNF746	zinc finger protein 746	0.036
SLA	Src-like-adaptor	0.035
BTK	Bruton agammaglobulinemia tyrosine kinase	0.035	Rat
DPP4	dipeptidyl-peptidase 4	0.034
CXCL10	chemokine (C-X-C motif) ligand 10	0.034
COPB2	coatomer protein complex, subunit beta 2 (beta prime)	0.032
CARD11	caspase recruitment domain family, member 11	0.032
ANXA4	annexin A4	0.031
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.030
COPB1	coatomer protein complex, subunit beta 1	0.030
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.029
CLASP1	cytoplasmic linker associated protein 1	0.029
CDH5	cadherin 5, type 2 (vascular endothelium)	0.029
IL4	interleukin 4	0.028	Mouse
CXCL2	chemokine (C-X-C motif) ligand 2	0.027
IL7R	interleukin 7 receptor	0.026
KRT8	keratin 8	0.026
CCL13	chemokine (C-C motif) ligand 13	0.026	Human
CCL3	chemokine (C-C motif) ligand 3	0.025
RAB10	RAB10, member RAS oncogene family	0.025	Human
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.024
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.024
ITM2B	integral membrane protein 2B	0.024
TNF	tumor necrosis factor	0.024
SNAP25	synaptosomal-associated protein, 25kDa	0.024
RAB5A	RAB5A, member RAS oncogene family	0.024
CCL22	chemokine (C-C motif) ligand 22	0.023	Human
STX12	syntaxin 12	0.021
IFNG	interferon, gamma	0.021
COPA	coatomer protein complex, subunit alpha	0.021
CAV1	caveolin 1, caveolae protein, 22kDa	0.021
SOS1	son of sevenless homolog 1 (Drosophila)	0.021
PDGFA	platelet-derived growth factor alpha polypeptide	0.021
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.021
CMIP	c-Maf-inducing protein	0.020
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.020
IL10	interleukin 10	0.020
CRH	corticotropin releasing hormone	0.019
MLPH	melanophilin	0.019
IL4R	interleukin 4 receptor	0.019	Mouse
CCL7	chemokine (C-C motif) ligand 7	0.019	Human
IL2RB	interleukin 2 receptor, beta	0.019
VCAM1	vascular cell adhesion molecule 1	0.018
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.018
RABIF	RAB interacting factor	0.018
FGFR1	fibroblast growth factor receptor 1	0.017
CCL8	chemokine (C-C motif) ligand 8	0.017	Human
PDE6D	phosphodiesterase 6D, cGMP-specific, rod, delta	0.017
IL1B	interleukin 1, beta	0.017
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.016
ARCN1	archain 1	0.016
ROD1	ROD1 regulator of differentiation 1 (S. pombe)	0.016
INSR	insulin receptor	0.016
KITLG	KIT ligand	0.015
SDCBP	syndecan binding protein (syntenin)	0.015
HEXB	hexosaminidase B (beta polypeptide)	0.015
GSK3B	glycogen synthase kinase 3 beta	0.015
SOS2	son of sevenless homolog 2 (Drosophila)	0.015
PLEK	pleckstrin	0.015
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
COPG	coatomer protein complex, subunit gamma	0.015
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.014
IL10RA	interleukin 10 receptor, alpha	0.014
SRGN	serglycin	0.014
ANXA7	annexin A7	0.014
BAI1	brain-specific angiogenesis inhibitor 1	0.014
ANKRD27	ankyrin repeat domain 27 (VPS9 domain)	0.014
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.014
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.014
CCR4	chemokine (C-C motif) receptor 4	0.013
SEC22B	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)	0.013
MAST1	microtubule associated serine/threonine kinase 1	0.013
PGF	placental growth factor	0.013
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.013
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.013	Human
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.013
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.013
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.013
C1orf93	chromosome 1 open reading frame 93	0.013
APBA3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.013
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.013
ANXA1	annexin A1	0.013	Human
PDGFC	platelet derived growth factor C	0.013
RNF13	ring finger protein 13	0.013
IL18RAP	interleukin 18 receptor accessory protein	0.012
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.012
CD2	CD2 molecule	0.012
CXCR6	chemokine (C-X-C motif) receptor 6	0.012
STAT4	signal transducer and activator of transcription 4	0.012
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.012
AXL	AXL receptor tyrosine kinase	0.012
ZNF775	zinc finger protein 775	0.011
GNLY	granulysin	0.011
BTBD2	BTB (POZ) domain containing 2	0.011
PDZK1	PDZ domain containing 1	0.011
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011	Human
SPRR2A	small proline-rich protein 2A	0.010
HCK	hemopoietic cell kinase	0.010
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.010
SYTL4	synaptotagmin-like 4	0.010
CCR3	chemokine (C-C motif) receptor 3	0.010
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.010
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.010
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.010
CD83	CD83 molecule	0.010
SELE	selectin E	0.010