IMP

Process View

Homo sapiens

23 genes annotated in human

intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	1.000
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.986
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.983
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.955
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.903	Human
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.880
EP300	E1A binding protein p300	0.750
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.664
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.626
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.561	Human
BRCA1	breast cancer 1, early onset	0.547
CREBBP	CREB binding protein	0.465	Human
BCL2	B-cell CLL/lymphoma 2	0.432
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.400
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.364
NBN	nibrin	0.362
TP53	tumor protein p53	0.342
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.289
ESR1	estrogen receptor 1	0.284
BCL3	B-cell CLL/lymphoma 3	0.281
DCAF7	DDB1 and CUL4 associated factor 7	0.281
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.263	Human
IER3	immediate early response 3	0.257
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.241
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.219
HIPK2	homeodomain interacting protein kinase 2	0.215	Mouse
TNIP2	TNFAIP3 interacting protein 2	0.201
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.194
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.181
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.171	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.159
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.142
RAD18	RAD18 homolog (S. cerevisiae)	0.139
RB1	retinoblastoma 1	0.129
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.108
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.107	Worm
ICAM1	intercellular adhesion molecule 1	0.102
SETD7	SET domain containing (lysine methyltransferase) 7	0.098
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.096
CHUK	conserved helix-loop-helix ubiquitous kinase	0.094
FANCD2	Fanconi anemia, complementation group D2	0.093
PML	promyelocytic leukemia	0.093	Mouse
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.093	Fly
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.092
PARP1	poly (ADP-ribose) polymerase 1	0.088
BTRC	beta-transducin repeat containing	0.087
DAXX	death-domain associated protein	0.085
BAX	BCL2-associated X protein	0.084
NLRC4	NLR family, CARD domain containing 4	0.082
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.079
MSN	moesin	0.079
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.079
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.077
KAT2B	K(lysine) acetyltransferase 2B	0.077
SNIP1	Smad nuclear interacting protein 1	0.077
LZTS2	leucine zipper, putative tumor suppressor 2	0.076
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.069
HDAC1	histone deacetylase 1	0.061
PCNA	proliferating cell nuclear antigen	0.059
KRT5	keratin 5	0.056
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.056
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.055
TP53BP2	tumor protein p53 binding protein, 2	0.055
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.054
BID	BH3 interacting domain death agonist	0.054
BCL2L1	BCL2-like 1	0.052
RPA1	replication protein A1, 70kDa	0.052
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.046
IK	IK cytokine, down-regulator of HLA II	0.044
SP100	SP100 nuclear antigen	0.044
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.042
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.040
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.039
GSK3B	glycogen synthase kinase 3 beta	0.039
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.039
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.038
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.038
FAS	Fas (TNF receptor superfamily, member 6)	0.037
WWOX	WW domain containing oxidoreductase	0.036
IL8	interleukin 8	0.036
BRCA2	breast cancer 2, early onset	0.034	Mouse
SNAI1	snail homolog 1 (Drosophila)	0.034
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.031
YAP1	Yes-associated protein 1	0.030
SMAD2	SMAD family member 2	0.030
TNIP1	TNFAIP3 interacting protein 1	0.030
BAK1	BCL2-antagonist/killer 1	0.029
MSH3	mutS homolog 3 (E. coli)	0.028
IRF1	interferon regulatory factor 1	0.028
AMOTL1	angiomotin like 1	0.027
CXCR4	chemokine (C-X-C motif) receptor 4	0.027
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.027
AR	androgen receptor	0.027
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.027
STX5	syntaxin 5	0.025
STK4	serine/threonine kinase 4	0.025
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.024
PTK2	PTK2 protein tyrosine kinase 2	0.023
POLH	polymerase (DNA directed), eta	0.023
STK3	serine/threonine kinase 3	0.023
RAD50	RAD50 homolog (S. cerevisiae)	0.023
SFN	stratifin	0.023
WRN	Werner syndrome, RecQ helicase-like	0.023
ANXA1	annexin A1	0.022
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.022	Human
CAPG	capping protein (actin filament), gelsolin-like	0.022
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.022
JUB	jub, ajuba homolog (Xenopus laevis)	0.022
RYBP	RING1 and YY1 binding protein	0.021
ATM	ataxia telangiectasia mutated	0.021
S100A4	S100 calcium binding protein A4	0.020
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.020
STRAP	serine/threonine kinase receptor associated protein	0.020
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.020
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.019
SATB2	SATB homeobox 2	0.019
RUNX1	runt-related transcription factor 1	0.019
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.019	Mouse
BCL2A1	BCL2-related protein A1	0.019
ETF1	eukaryotic translation termination factor 1	0.018
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.018
SPRR2A	small proline-rich protein 2A	0.018
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.018
NOTCH1	notch 1	0.018
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.018
BIRC3	baculoviral IAP repeat containing 3	0.017
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.017
PLAUR	plasminogen activator, urokinase receptor	0.017
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.017	Fly
AMOTL2	angiomotin like 2	0.017
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.017
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.016
HUWE1	HECT, UBA and WWE domain containing 1	0.016
STK38L	serine/threonine kinase 38 like	0.016
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.016
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.016
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.016
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.015
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.015	Human
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.015
CREB1	cAMP responsive element binding protein 1	0.015
SIRT1	sirtuin 1	0.014
RAD52	RAD52 homolog (S. cerevisiae)	0.014
SRGN	serglycin	0.014
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.014
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.014
PLK1	polo-like kinase 1	0.014
INADL	InaD-like (Drosophila)	0.014
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.014
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.014
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.014
MAVS	mitochondrial antiviral signaling protein	0.014
AHR	aryl hydrocarbon receptor	0.013
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.013
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.013
TDGF1	teratocarcinoma-derived growth factor 1	0.013
RAD51C	RAD51 homolog C (S. cerevisiae)	0.013
FOXO3	forkhead box O3	0.013
RNF20	ring finger protein 20	0.013
RPA2	replication protein A2, 32kDa	0.013
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.012
CKAP5	cytoskeleton associated protein 5	0.012
MFAP1	microfibrillar-associated protein 1	0.012
MYST1	MYST histone acetyltransferase 1	0.012
IRF2	interferon regulatory factor 2	0.012
TP53BP1	tumor protein p53 binding protein 1	0.012
NMI	N-myc (and STAT) interactor	0.012
MAX	MYC associated factor X	0.012
SAV1	salvador homolog 1 (Drosophila)	0.012
FAM117B	family with sequence similarity 117, member B	0.012
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.012
AMOT	angiomotin	0.012
MSH6	mutS homolog 6 (E. coli)	0.012
BCAR1	breast cancer anti-estrogen resistance 1	0.012
TOP1	topoisomerase (DNA) I	0.012
NCOA1	nuclear receptor coactivator 1	0.011
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.011
PALB2	partner and localizer of BRCA2	0.011
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.011
NCOA3	nuclear receptor coactivator 3	0.011
FANCE	Fanconi anemia, complementation group E	0.011
PPP6C	protein phosphatase 6, catalytic subunit	0.011
FOXO1	forkhead box O1	0.011
ABI2	abl-interactor 2	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
NCOR1	nuclear receptor corepressor 1	0.011
CFLAR	CASP8 and FADD-like apoptosis regulator	0.011
BHLHE40	basic helix-loop-helix family, member e40	0.011
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.011
DZIP1	DAZ interacting protein 1	0.011
RXRA	retinoid X receptor, alpha	0.011
TMEM173	transmembrane protein 173	0.011
VPRBP	Vpr (HIV-1) binding protein	0.011
RAD54B	RAD54 homolog B (S. cerevisiae)	0.011
SFPQ	splicing factor proline/glutamine-rich	0.011
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.011
ANXA5	annexin A5	0.011
NINJ1	ninjurin 1	0.011
GBP1	guanylate binding protein 1, interferon-inducible	0.010
PIAS3	protein inhibitor of activated STAT, 3	0.010
PIM1	pim-1 oncogene	0.010
BCL10	B-cell CLL/lymphoma 10	0.010
MAPK8	mitogen-activated protein kinase 8	0.010
PPP1R3F	protein phosphatase 1, regulatory (inhibitor) subunit 3F	0.010
CARD11	caspase recruitment domain family, member 11	0.010
S100A2	S100 calcium binding protein A2	0.010
RNF38	ring finger protein 38	0.010