IMP

Process View

Homo sapiens

3 genes annotated in human

Multi-species View

regulation of mast cell degranulation

GO:0043304

Any process that modulates the frequency, rate, or extent of mast cell degranulation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of mast cell degranulation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of mast cell degranulation" (in gray)

Name	Description	Probability	Func Analog Organism
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.779
TFF1	trefoil factor 1	0.750
IL4R	interleukin 4 receptor	0.680	Mouse
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.648
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.608	Mouse
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.547
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.512
HCK	hemopoietic cell kinase	0.506
SYK	spleen tyrosine kinase	0.503	Mouse Rat
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.464
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.400
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.381
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.352
VAV1	vav 1 guanine nucleotide exchange factor	0.338
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.303
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.303
ZNF746	zinc finger protein 746	0.283
IL4	interleukin 4	0.277	Mouse
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.230
IL2RG	interleukin 2 receptor, gamma	0.225
BTK	Bruton agammaglobulinemia tyrosine kinase	0.193
PLCG1	phospholipase C, gamma 1	0.152
CRH	corticotropin releasing hormone	0.149
LCK	lymphocyte-specific protein tyrosine kinase	0.140
BLNK	B-cell linker	0.111
BAI1	brain-specific angiogenesis inhibitor 1	0.111
GRB2	growth factor receptor-bound protein 2	0.092
ZNF775	zinc finger protein 775	0.072
UBASH3B	ubiquitin associated and SH3 domain containing B	0.069
LAT	linker for activation of T cells	0.069
CARD11	caspase recruitment domain family, member 11	0.064
IRS1	insulin receptor substrate 1	0.057
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.055
SH3BP2	SH3-domain binding protein 2	0.053
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.050
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.045
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.045
CPA3	carboxypeptidase A3 (mast cell)	0.041
FASLG	Fas ligand (TNF superfamily, member 6)	0.041
GAB1	GRB2-associated binding protein 1	0.040
GRAP2	GRB2-related adaptor protein 2	0.039
HK3	hexokinase 3 (white cell)	0.039
C1orf93	chromosome 1 open reading frame 93	0.039
AIF1	allograft inflammatory factor 1	0.037
SIRPB1	signal-regulatory protein beta 1	0.037
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	0.033
CD300C	CD300c molecule	0.031	Human
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.030
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.030
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.028
C15orf29	chromosome 15 open reading frame 29	0.027
BCL10	B-cell CLL/lymphoma 10	0.027
DLG4	discs, large homolog 4 (Drosophila)	0.025
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.023
CMIP	c-Maf-inducing protein	0.023
SLAMF1	signaling lymphocytic activation molecule family member 1	0.022
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.022
VAV2	vav 2 guanine nucleotide exchange factor	0.020
ZC3HC1	zinc finger, C3HC-type containing 1	0.020
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.019
SLA	Src-like-adaptor	0.019
FYB	FYN binding protein	0.018
NSF	N-ethylmaleimide-sensitive factor	0.018
DUSP23	dual specificity phosphatase 23	0.018
EZR	ezrin	0.017
C5AR1	complement component 5a receptor 1	0.017
SIGLEC9	sialic acid binding Ig-like lectin 9	0.017
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.017
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.017
EPHA8	EPH receptor A8	0.017
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.016
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.016	Mouse
CSF3R	colony stimulating factor 3 receptor (granulocyte)	0.016
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.016
FOXF2	forkhead box F2	0.016
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.016
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.015
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.015
DOK4	docking protein 4	0.015
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.015
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.015
CYTH4	cytohesin 4	0.015
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.015
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.015
DOK3	docking protein 3	0.015
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.015
HDC	histidine decarboxylase	0.015
CD33	CD33 molecule	0.014
PIM1	pim-1 oncogene	0.014
TYROBP	TYRO protein tyrosine kinase binding protein	0.014
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.014
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.014
DENND1C	DENN/MADD domain containing 1C	0.014
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.013
MYO1F	myosin IF	0.013
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.013
ABI3	ABI family, member 3	0.013
PDE4DIP	phosphodiesterase 4D interacting protein	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
NFAM1	NFAT activating protein with ITAM motif 1	0.013
GAS7	growth arrest-specific 7	0.013
ACPP	acid phosphatase, prostate	0.013
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.013
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.013
VAV3	vav 3 guanine nucleotide exchange factor	0.012
GPSM3	G-protein signaling modulator 3	0.012
HPGDS	hematopoietic prostaglandin D synthase	0.012
AXL	AXL receptor tyrosine kinase	0.012
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.012
TMF1	TATA element modulatory factor 1	0.012
HMOX2	heme oxygenase (decycling) 2	0.012
FNBP1	formin binding protein 1	0.012
SIGLEC7	sialic acid binding Ig-like lectin 7	0.012
AQP9	aquaporin 9	0.012
FRS2	fibroblast growth factor receptor substrate 2	0.011
PLEKHO2	pleckstrin homology domain containing, family O member 2	0.011
TPSB2	tryptase beta 2 (gene/pseudogene)	0.011
CD300LF	CD300 molecule-like family member f	0.011	Human
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.011
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.011
SLMAP	sarcolemma associated protein	0.011
GRB7	growth factor receptor-bound protein 7	0.011
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.011
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.011
PILRA	paired immunoglobin-like type 2 receptor alpha	0.011
SH2D2A	SH2 domain containing 2A	0.011
CTRC	chymotrypsin C (caldecrin)	0.011
FFAR2	free fatty acid receptor 2	0.011
TBXAS1	thromboxane A synthase 1 (platelet)	0.011
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.010
NCKAP1	NCK-associated protein 1	0.010
CTSG	cathepsin G	0.010
PDK1	pyruvate dehydrogenase kinase, isozyme 1	0.010
SIGLEC5	sialic acid binding Ig-like lectin 5	0.010
HSH2D	hematopoietic SH2 domain containing	0.010
EEA1	early endosome antigen 1	0.010
TCAP	titin-cap (telethonin)	0.010
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.010