IMP

Process View

Homo sapiens

3 genes annotated in human

positive regulation of macrophage chemotaxis

Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of macrophage chemotaxis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of macrophage chemotaxis" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CCL4	chemokine (C-C motif) ligand 4	1.000	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.999
IL8	interleukin 8	0.997
CCL8	chemokine (C-C motif) ligand 8	0.997	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.997
IL1B	interleukin 1, beta	0.987
CXCL2	chemokine (C-X-C motif) ligand 2	0.981
CCL2	chemokine (C-C motif) ligand 2	0.979	Human
CCR1	chemokine (C-C motif) receptor 1	0.978
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.977	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.968
CCL5	chemokine (C-C motif) ligand 5	0.967
CXCL3	chemokine (C-X-C motif) ligand 3	0.953
IL6	interleukin 6 (interferon, beta 2)	0.947
CXCL11	chemokine (C-X-C motif) ligand 11	0.919
CCL13	chemokine (C-C motif) ligand 13	0.904	Human
PLEK	pleckstrin	0.842
ICAM1	intercellular adhesion molecule 1	0.839
IDE	insulin-degrading enzyme	0.789
CD163	CD163 molecule	0.711
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.704
IL7R	interleukin 7 receptor	0.701
CXCL13	chemokine (C-X-C motif) ligand 13	0.697
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.655
DPP4	dipeptidyl-peptidase 4	0.605
SLAMF8	SLAM family member 8	0.595
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.588
CTNND1	catenin (cadherin-associated protein), delta 1	0.573
CXCL5	chemokine (C-X-C motif) ligand 5	0.570
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.538
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.525
IFNG	interferon, gamma	0.501
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.435
CLEC7A	C-type lectin domain family 7, member A	0.432
CCR7	chemokine (C-C motif) receptor 7	0.423
CCL3	chemokine (C-C motif) ligand 3	0.419	Human
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.405
GNLY	granulysin	0.379
TGFB1	transforming growth factor, beta 1	0.373
CCL20	chemokine (C-C motif) ligand 20	0.370	Human
IL2RB	interleukin 2 receptor, beta	0.368
CCL7	chemokine (C-C motif) ligand 7	0.357	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.347
VCAM1	vascular cell adhesion molecule 1	0.322
CCL22	chemokine (C-C motif) ligand 22	0.319
LAT	linker for activation of T cells	0.296
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.295
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.290
FPR3	formyl peptide receptor 3	0.276	Human
CD83	CD83 molecule	0.275
RGS1	regulator of G-protein signaling 1	0.265
PLAUR	plasminogen activator, urokinase receptor	0.253
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.250
AQP9	aquaporin 9	0.250
C5AR1	complement component 5a receptor 1	0.246	Human Mouse
TNF	tumor necrosis factor	0.237
IL18RAP	interleukin 18 receptor accessory protein	0.229
BCL2A1	BCL2-related protein A1	0.218
SELE	selectin E	0.215
PLAU	plasminogen activator, urokinase	0.211
TREM1	triggering receptor expressed on myeloid cells 1	0.196
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.196
IDO1	indoleamine 2,3-dioxygenase 1	0.192
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.189
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.188
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.188
CCL19	chemokine (C-C motif) ligand 19	0.187	Human
MSR1	macrophage scavenger receptor 1	0.186
INHBA	inhibin, beta A	0.179
GAB1	GRB2-associated binding protein 1	0.166
C3AR1	complement component 3a receptor 1	0.157	Human Mouse
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.156
CH25H	cholesterol 25-hydroxylase	0.156
IL10	interleukin 10	0.150
MPEG1	macrophage expressed 1	0.149
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.145
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.143
ADAMDEC1	ADAM-like, decysin 1	0.142
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.135
UBD	ubiquitin D	0.134
STAB1	stabilin 1	0.130
FPR1	formyl peptide receptor 1	0.126	Human
NNMT	nicotinamide N-methyltransferase	0.121
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.121
LAMP3	lysosomal-associated membrane protein 3	0.120
GZMK	granzyme K (granzyme 3; tryptase II)	0.120
SLAMF7	SLAM family member 7	0.117
CYBB	cytochrome b-245, beta polypeptide	0.116
C1QB	complement component 1, q subcomponent, B chain	0.113
PTPRE	protein tyrosine phosphatase, receptor type, E	0.113
TLR2	toll-like receptor 2	0.112
SRGN	serglycin	0.108
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.105
CD68	CD68 molecule	0.101
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.101
ENG	endoglin	0.099
VCAN	versican	0.093
PRF1	perforin 1 (pore forming protein)	0.089
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.085
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.083
CLEC5A	C-type lectin domain family 5, member A	0.083
OSMR	oncostatin M receptor	0.082
CXCR6	chemokine (C-X-C motif) receptor 6	0.076
TRAF1	TNF receptor-associated factor 1	0.075
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.075
IL1RN	interleukin 1 receptor antagonist	0.072
CMKLR1	chemokine-like receptor 1	0.068
C2	complement component 2	0.067
DARC	Duffy blood group, chemokine receptor	0.065
CCRL2	chemokine (C-C motif) receptor-like 2	0.063
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.061
IL2RG	interleukin 2 receptor, gamma	0.060
C1QC	complement component 1, q subcomponent, C chain	0.059
MARCO	macrophage receptor with collagenous structure	0.058
IL18R1	interleukin 18 receptor 1	0.057
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.057
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.056
F13A1	coagulation factor XIII, A1 polypeptide	0.055
GPR84	G protein-coupled receptor 84	0.055
STAT4	signal transducer and activator of transcription 4	0.053
CCR2	chemokine (C-C motif) receptor 2	0.053
CCR3	chemokine (C-C motif) receptor 3	0.053
CD14	CD14 molecule	0.052
CLEC4A	C-type lectin domain family 4, member A	0.051
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.051
CCL11	chemokine (C-C motif) ligand 11	0.051	Human
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.051
NKG7	natural killer cell group 7 sequence	0.050
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.050
NCF2	neutrophil cytosolic factor 2	0.050
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.050
FN1	fibronectin 1	0.048
C3	complement component 3	0.047
ACP5	acid phosphatase 5, tartrate resistant	0.047
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.046
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.046
C1QA	complement component 1, q subcomponent, A chain	0.043
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.042
STC1	stanniocalcin 1	0.042
IL1A	interleukin 1, alpha	0.041
FRMD5	FERM domain containing 5	0.041
CLEC4E	C-type lectin domain family 4, member E	0.041
SLA	Src-like-adaptor	0.041
OASL	2'-5'-oligoadenylate synthetase-like	0.040
SOCS3	suppressor of cytokine signaling 3	0.039
ARRB1	arrestin, beta 1	0.039
CSF1	colony stimulating factor 1 (macrophage)	0.039
MSC	musculin	0.039
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.039
S100A12	S100 calcium binding protein A12	0.039
CCR4	chemokine (C-C motif) receptor 4	0.039
IL21R	interleukin 21 receptor	0.038
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.038
ADORA3	adenosine A3 receptor	0.037
CD86	CD86 molecule	0.036
APOC1	apolipoprotein C-I	0.036
IL2RA	interleukin 2 receptor, alpha	0.036
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.036
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.034
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.033
XCL2	chemokine (C motif) ligand 2	0.033
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.033
SIGLEC7	sialic acid binding Ig-like lectin 7	0.032
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.031
CD69	CD69 molecule	0.031
NLRP3	NLR family, pyrin domain containing 3	0.031
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.031
SPHK1	sphingosine kinase 1	0.031
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.031
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.030
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.030
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.029
CCL23	chemokine (C-C motif) ligand 23	0.029	Human
IL32	interleukin 32	0.029
CLEC10A	C-type lectin domain family 10, member A	0.029
SOD2	superoxide dismutase 2, mitochondrial	0.029
PDPN	podoplanin	0.028
MRC1	mannose receptor, C type 1	0.028
PI3	peptidase inhibitor 3, skin-derived	0.028
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.028
NRP2	neuropilin 2	0.028
ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	0.028
G0S2	G0/G1switch 2	0.028
IL1R2	interleukin 1 receptor, type II	0.028
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.027
CCL21	chemokine (C-C motif) ligand 21	0.027
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.027
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.027
TFEC	transcription factor EC	0.027
PRDM1	PR domain containing 1, with ZNF domain	0.026
FYN	FYN oncogene related to SRC, FGR, YES	0.026
RGS16	regulator of G-protein signaling 16	0.026
DUSP3	dual specificity phosphatase 3	0.026
DPT	dermatopontin	0.025
CD93	CD93 molecule	0.025
PTX3	pentraxin 3, long	0.024
GPR109B	G protein-coupled receptor 109B	0.023
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.023
TFPI2	tissue factor pathway inhibitor 2	0.023
CD84	CD84 molecule	0.023
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.023
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	0.022
CTSW	cathepsin W	0.022
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.022
VSIG4	V-set and immunoglobulin domain containing 4	0.021
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.021
GPR171	G protein-coupled receptor 171	0.021
GPR183	G protein-coupled receptor 183	0.021
GPR65	G protein-coupled receptor 65	0.019
HCK	hemopoietic cell kinase	0.019
SPP1	secreted phosphoprotein 1	0.019
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.019
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.019
CTSL1	cathepsin L1	0.019
CXCR3	chemokine (C-X-C motif) receptor 3	0.019
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.019
CD48	CD48 molecule	0.018
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.018
IL15RA	interleukin 15 receptor, alpha	0.018
TGFBI	transforming growth factor, beta-induced, 68kDa	0.018
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.018
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.018
EBI3	Epstein-Barr virus induced 3	0.018
CD80	CD80 molecule	0.018
EDN1	endothelin 1	0.018
LRRC32	leucine rich repeat containing 32	0.018
CD160	CD160 molecule	0.017
CST7	cystatin F (leukocystatin)	0.017
IGSF6	immunoglobulin superfamily, member 6	0.017
FGL2	fibrinogen-like 2	0.017
HAS2	hyaluronan synthase 2	0.017
TLN1	talin 1	0.017
VEGFC	vascular endothelial growth factor C	0.017
SDS	serine dehydratase	0.017
CXCR2	chemokine (C-X-C motif) receptor 2	0.017
TNC	tenascin C	0.017
PLA1A	phospholipase A1 member A	0.016
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.016
PDCD1LG2	programmed cell death 1 ligand 2	0.015
EVI2A	ecotropic viral integration site 2A	0.015
MMP19	matrix metallopeptidase 19	0.015
SERPINB9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	0.015
SLC15A3	solute carrier family 15, member 3	0.015
FGF2	fibroblast growth factor 2 (basic)	0.015
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.015
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.015
WISP1	WNT1 inducible signaling pathway protein 1	0.015
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.014
TGFBR1	transforming growth factor, beta receptor 1	0.014
XCL1	chemokine (C motif) ligand 1	0.014	Human
KYNU	kynureninase	0.014
LY86	lymphocyte antigen 86	0.014
ALOX5	arachidonate 5-lipoxygenase	0.014
FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	0.014
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.014
APOBEC3A	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A	0.013
S100A9	S100 calcium binding protein A9	0.013
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.013
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.013
FAP	fibroblast activation protein, alpha	0.013
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.013
CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.013
KLRF1	killer cell lectin-like receptor subfamily F, member 1	0.013
MAPK3	mitogen-activated protein kinase 3	0.013
THY1	Thy-1 cell surface antigen	0.013
P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	0.013
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.013
SELL	selectin L	0.012
S100A8	S100 calcium binding protein A8	0.012
TARP	TCR gamma alternate reading frame protein	0.012
IL7	interleukin 7	0.012
IL11	interleukin 11	0.012
HAVCR2	hepatitis A virus cellular receptor 2	0.011
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.011
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.011
EMR2	egf-like module containing, mucin-like, hormone receptor-like 2	0.011
APOL1	apolipoprotein L, 1	0.011
HPGDS	hematopoietic prostaglandin D synthase	0.011
LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	0.011
CTSS	cathepsin S	0.011
FFAR2	free fatty acid receptor 2	0.011
P2RY14	purinergic receptor P2Y, G-protein coupled, 14	0.011
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.011
ADAP2	ArfGAP with dual PH domains 2	0.011
KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	0.011
BST1	bone marrow stromal cell antigen 1	0.011
CXCL16	chemokine (C-X-C motif) ligand 16	0.011
EREG	epiregulin	0.011
TLR7	toll-like receptor 7	0.011
ARHGAP32	Rho GTPase activating protein 32	0.011
LGMN	legumain	0.011
RUNX3	runt-related transcription factor 3	0.011
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.011
EGR2	early growth response 2	0.011
SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	0.011
IL10RA	interleukin 10 receptor, alpha	0.011
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.010
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.010
IL3RA	interleukin 3 receptor, alpha (low affinity)	0.010
ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	0.010
CD28	CD28 molecule	0.010
TPST1	tyrosylprotein sulfotransferase 1	0.010
SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	0.010
SLC43A3	solute carrier family 43, member 3	0.010
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.010